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Leistungen
D3.4. Demonstrated microfluidic set-up validated in lab conditions with parameters and measured outcomes (M42) (MIC, i3S, INRIM, INL, NUI). This deliverable relates to T3.4, comprising results of the validation of the microfluidic system operations, complemented with a relevant statistical assessment of its reliability and out-comes.
Short brief: relevant policy status (öffnet in neuem Fenster)D8.1 Short brief about the relevant policy status (M18) (IDEA, PROA). This deliverable relates to T8.1, compris-ing the first mapping of needs and options to impose, modify or develop new regulations based on existing in¬for¬ma¬tion.
Report on the held DICO workshops - Update 2 (öffnet in neuem Fenster)D6.10 Report on the held DICO workshops - Update 2 (M36) (TPC). This deliverable relates to T6.4.
Performed experiments with statistical analysis (öffnet in neuem Fenster)D5.2 Summary report of the performed in vitro experiments with statistical reliability analysis (M42) (INL, MIC, ES, SEQ). This deliverable relates to T5.2, reporting on main performing experiments, their outcomes and respective statistical analysis.
Training activities & STEMs outcomes - Update 3 (öffnet in neuem Fenster)D6.14 Report on training activities and STEMs outcomes - Update 3 (M48) (MLSC, TPC, ES). This deliverable re-lates to T6.4.
Project business and stakeholders pitches (öffnet in neuem Fenster)D7.7 Project business and stakeholders pitches (M48) (PROA, SEQ, CI, ES, EVCYT, MIC, TPC, IDEA, MSLC). This deliverable relates to T7.5, reporting the plans and pathways to access specific markets segments and poten-tial alliances, with options to access to finance.
Report on the held DICO workshops - Update 1 (öffnet in neuem Fenster)D6.9 Report on the held DICO workshops - Update 1 (M18) (TPC). This deliverable relates to T6.4.
Mechanical properties of bioprinted constructs (öffnet in neuem Fenster)D2.3. Report on analysed and optimized mechanical properties of the bioprinted constructs for LIFESAVER elements (M30) (SEQ, i3S, INL, INRIM). This deliverable relates to T2.2 comprising the results of biomechani-cal assessment of the properties of the bioprinted constructs and data on normal uterine and decidua vis-costiffness, memory parameters with tissue orientation, location, anisotropy, frequency, applicable defor-mation strain (to the extent required for the objectives of the LIFESAVER).
Short brief: policy update recommendations (öffnet in neuem Fenster)D8.3 Short brief about the policy update recommendations (M48) (IDEA). This deliverable relates to T8.1 and T8.4, integrating policy update recommendations based on LIFESAVER results.
Bioink characterisation results (öffnet in neuem Fenster)D2.2. Bioinks physical, chemical and biological characterisation results (M18) (CELLINK, SEQ, NUI, INL, i3S, EVCYT). This deliverable relates to the second subtask of the Task T2.1 comprising results of characterized properties of the bioinks, relevant for bioprinting (flowability, construct rigidisation, viscosity, shear properties, nozzle compatibility, rate, printing precision, etc.) and for the cells com¬pa¬ti¬bi¬lity during and after the printing pro-cess.
Landscape analysis of current policy framework (öffnet in neuem Fenster)D8.2 Analytical report with landscape analysis of current policy framework relevant to LIFESAVER and a gap analysis (M36) (IDEA, PROA). This deliverable relates to T8.1, T8.2 and T8.4, including overview of the cur¬rent state of the art of EU policies regarding chemicals and pharmaceuticals related to LIFESAVER.
Testing results with blank runs (öffnet in neuem Fenster)D3.3. Testing results of microfluidic system with blank runs (M25) (ELV, i3S, NUI, INL, INRIM). This deliverable relates to T3.3 comprising results of the baseline (blank) tests for demonstration of the feasibility of the mi-crofluidic system operations.
Training activities & STEMs outcomes - Update 1 (öffnet in neuem Fenster)D6.12 Report on training activities and STEMs outcomes - Update 1 (M18) (MLSC, TPC, ES). This deliverable re-lates to T6.4.
Optimized BDT parameters and SOPs (öffnet in neuem Fenster)D1.3 Report on optimized parameters for the LIFESAVER device and SOPs recommendations (M36) (INRIM, ES, SEQ, i3S, INL, NUI). This deliverable relates to T1.3 comprising re¬com¬¬men¬dations for the in vitro/in silico twinning and obtained biofidelity, high¬lighting the limitations and appli¬ca¬tion limits of the LIFESAVER
Report on the held DICO workshops - Update 3 (öffnet in neuem Fenster)D6.11 Report on the held DICO workshops - Update 3 (M48) (TPC). This deliverable relates to T6.4.
General outcome of the LIFESAVER technology (öffnet in neuem Fenster)D5.3 Report on the general outcomes, features and limitations of the LIFESAVER technology (M48) (i3S, ES, INRIM, MIC). This deliverable relates to T5.3, comprising results real-to-virtual testing correlations (biodigital twinning) and of quantifications of endpoints which expected to have a higher reproducibility than other methods, allowing also the design of future clinical trials and environmental exposure margins to be assessed with much smaller cohorts.
Training activities & STEMs outcomes - Update 2 (öffnet in neuem Fenster)D6.13 Report on training activities and STEMs outcomes - Update 2 (M36) (MLSC, TPC, ES). This deliverable re-lates to T6.4.
Existing relevant regulatory constraints (öffnet in neuem Fenster)D8.4 Analytical report on existing regulatory constraints relevant to the LIFESAVER objectives (M40) (IDEA). This deliverable relates to T8.3, providing data on possible regulatory constrains needed to be addressed.
D5.1 Demonstrated the first operational version of the LIFESAVER microfluidic system with proper controls and interfaces (M18) (ELV, INL, i3S). This deliverable relates to T5.1 including results of the demonstration of the feasibility of operation of the microfluidic hardware with the proper controls and ad sensors.
Feasible hACM tissues for RACE construction (öffnet in neuem Fenster)D2.1. Demonstration of feasible hACM-based tissues prepared for RACE construction (M24) (EVCYT, UCSC, i3S, NUI, INRIM). This deliverable relates to the first subtask of the Task T2.1 comprising results and demon-stration of suitability of autologous/allogenic from another hACM source to be re-printed back in a controlled manner.
MCDA tool for analysis of biodigital twin data (öffnet in neuem Fenster)D4.4 Demonstrated MCDA tool for analysis of the biodigital twin data (M36) (ES, INRIM, SEQ). This deliverable connects with T4.4, including demonstration of the application of the MCDA method integrating LIFESAVER outcomes and endpoints.
Improved feasible bioprinted REPE construct (öffnet in neuem Fenster)D2.4. Demonstration of improved and feasible bioprinted REPE construct (M36) (CELLINK, INL, i3S, NUI, EVCYT). This deliverable is linked to T2.3 comprising the results and demonstration of the imporved biofabricated REPE element for in vitro testing.
D8.5 Policy toolbox regarding chemicals and medicines safety for pregnant women health (M48) (IDEA). This deliverable relates to T8.5, comprising results on development and summarization of the policy toolbox for policy recommendations to help policy makers to identify the best approach to design policy measures.
D6.3 The final DMP report (M48) (ES, ALL). This deliverable relates to T6.2, reflecting the final version of the DMP plan.
Project website opened (öffnet in neuem Fenster)D6.1 Project website opened (M3) (TPC, ES). This deliverable relates to T6.1.
D6.2 Release of DMP (M6) (ES, ALL). This deliverable is related to Open Research Data Pilot (ORDP). This deliv-erable relates to T6.2.
Veröffentlichungen
Autoren:
Green Deal Support Office
Veröffentlicht in:
2024
Herausgeber:
Green Deal Support Office
Autoren:
Green Deal Support Office
Veröffentlicht in:
2023
Herausgeber:
Green Deal Support Office
Autoren:
Green Deal Support Office
Veröffentlicht in:
2025
Herausgeber:
Green Deal Support Office
Autoren:
IMI ConcePTION & LIFESAVER
Veröffentlicht in:
2024
Herausgeber:
IMI-ConcPTION
Autoren:
ALTERNATIVE & LIFESAVER
Veröffentlicht in:
2024
Herausgeber:
ALTERNATIVE
Autoren:
Microfluidics Innovation Center - Lisa Muiznieks
Veröffentlicht in:
2024
Herausgeber:
Microfluidics
Autoren:
Green Deal Support Office
Veröffentlicht in:
2024
Herausgeber:
Green Deal Support Office
Autoren:
Green Deal Support Office
Veröffentlicht in:
2023
Herausgeber:
Green Deal Support Office
Autoren:
Sara Ficai, Andrea Papait, Marta Magatti, Alice Masserdotti, Michael Gasik, Antonietta Rosa Silini, Ornella Parolini
Veröffentlicht in:
Cell Death Discovery, Ausgabe 11, 2025, Seite(n) 327, ISSN 2058-7716
Herausgeber:
Springer-Nature
DOI:
10.1101/2024.08.29.610279
Autoren:
Miguel António Dias Neves, Inês Mendes Pinto
Veröffentlicht in:
ACS Sensors, Ausgabe 9, 2024, Seite(n) 1756-1762, ISSN 2379-3694
Herausgeber:
American Chemical Society
DOI:
10.1021/acssensors.3c02762
Autoren:
Daniel C. Moreira, Duarte Nuno Carvalho, Evelyn C. Santos, João B. Relvas, Miguel António Dias Neves, Inēs Mendes Pinto
Veröffentlicht in:
Advanced Materials Technologies, Ausgabe 9, 2024, ISSN 2365-709X
Herausgeber:
Wiley-VCH GmbH
DOI:
10.1002/admt.202301464
Autoren:
Jessica Petiti, Laura Revel, Carla Divieto
Veröffentlicht in:
Biosensors, Ausgabe 14, 2024, Seite(n) 156, ISSN 2079-6374
Herausgeber:
Multidisciplinary Digital Publishing Institute (MDPI)
DOI:
10.3390/bios14040156
Autoren:
Alice Masserdotti, Michael Gasik, Regina Grillari-Voglauer, Johannes Grillari, Anna Cargnoni, Paola Chiodelli, Andrea Papait, Marta Magatti, Jacopo Romoli, Sara Ficai, Lorena Di Pietro, Wanda Lattanzi, Antonietta Rosa Silini, Ornella Parolini
Veröffentlicht in:
Frontiers in Cell and Developmental Biology, Ausgabe 12, 2024, ISSN 2296-634X
Herausgeber:
Springer Nature
DOI:
10.3389/fcell.2024.1411582
Autoren:
Petiti Jessica, Caria Sabrina, Revel Laura, Pegoraro Mattia, and Divieto Carla
Veröffentlicht in:
Cells, 2024, ISSN 2073-4409
Herausgeber:
Multidisciplinary Digital Publishing Institute
DOI:
10.3390/cells13231959
Rechte des geistigen Eigentums
Antrags-/Publikationsnummer:
20
2217875843
Datum:
2022-07-28
Antragsteller:
SEQVERA LTD. OY
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