Exploring the Prokaryotic-Eukaryotic Conservation of Antiviral immunity: from bacterial immune systems to novel antiviral drugs

Project Information

PECAN

Grant agreement ID: 101040529

DOI

10.3030/101040529

EC signature date 22 April 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 496 500,00

EU contribution

€ 1 496 500,00

Coordinated by

INSTITUT PASTEUR
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Exploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elements

Author(s): Tesson F., Huiting E., Wei L., Ren J., Johnson M., Planel R., Cury J., Feng Y., Bondy-Denomy J., Bernheim A
Published in: bioRxiv, 2024, ISSN 0305-1048
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.08.21.608784

A family of lanthipeptides with anti-phage function

Author(s): Shomar H., Tesson F., Guillaume M., Ongenae V., Le Bot N., Georjon H., Mordret E., Zhang L., van Wezel G., Rozen D., Briegel A., Zirah S., Claessen D., Li Y., Bernheim A.
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.06.26.600839

A Comprehensive Resource for Exploring Antiphage Defense: DefenseFinder, Wiki and Databases

Author(s): Tesson F., Planel R., Egorov A., Georjon H., Vaysset H., Brancotte B., Neron B., Mordret E., Atkinson G., Bernheim A., Cury J.
Published in: Peer Community Journal, 2024, ISSN 2804-3871
Publisher: Peer Community
DOI: 10.24072/pcjournal.470

Cell Host and Microbe

Author(s): Cury J., Haudiquet M., Hernandez-Trejo V., Mordret E., Hanouna A., Rotival M., Tesson F., Bonhomme D., Ofir G., Quintana-Murci L., Benaroch P., Poirier E.Z., Bernheim A.*
Published in: Cell Host and Microbe, 2024, ISSN 1931-3128
Publisher: Cell Press
DOI: 10.1016/j.chom.2024.08.002

Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements

Author(s): Florian Tesson; Erin Huiting; Linlin Wei; Jie Ren; Matthew C. Johnson; Remi Planel; Jean Cury; Yue Feng; Joseph Bondy-Denomy; Aude Bernheim
Published in: Nucleic Acids Research, 2024, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1101/2024.08.21.608784

Strain phylogroup and environmental constraints shape <i>Escherichia coli</i> dynamics and diversity over a 20-year human gut time series

Author(s): Condamine, Bénédicte; Morel-Journel, Thibaut; Tesson, Florian; Royer, Guilhem; Magnan, Mélanie; Bernheim, Aude; Denamur, Erick; Blanquart, François; Clermont, Olivier
Published in: The ISME Journal, 2024, ISSN 1751-7370
Publisher: xford University Press, on behalf of the International Society for Microbial Ecology (ISME)
DOI: 10.1093/ISMEJO/WRAE245

A human homolog of SIR2 antiphage proteins mediates immunity via the TLR pathway

Author(s): Bonhomme D., Vaysset H., Ednacot E.M.Q., Rodrigues V., Cury J., Hernandez Trejo V., Benaroch P., Morehouse B.R., Bernheim A., Poirier E.Z.
Published in: bioRxiv, 2024, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.06.15.547839

Prediction of strain level phage–host interactions across the Escherichia genus using only genomic information

Author(s): Gaborieau B., Vaysset H., Tesson F.*, Charachon I., Dib N., Bernier J., Dequidt T., Georjon H., Clermont O., Hersen P., Debarbieux L., Ricard J.D., Denamur E., Bernheim A.
Published in: Nature Microbiology, 2024, ISSN 2058-5276
Publisher: Nature Publishing Group
DOI: 10.1038/s41564-024-01832-5

Systematic and quantitative view of the anti-viral arsenal of prokaryotes

Author(s): Tesson F., Hervé A., Touchon M., Mordret E., d’Humières C., Cury J., Bernheim A.
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30269-9

Microbiology

Author(s): Georjon H., Tesson F., Shomar H., Bernheim A.
Published in: Microbiology, 2023, ISSN 1350-0872
Publisher: Microbiology Society
DOI: 10.1099/mic.0.001374

The highly diverse antiphage defence systems of bacteria

Author(s): Georjon H., Bernheim A.
Published in: Nature Reviews Microbiology, 2023, ISSN 1740-1526
Publisher: Nature Publishing Group
DOI: 10.1038/s41579-023-00934-x

PLoS Biology

Author(s): Bernheim A., Cury J., Poirier E.Z.
Published in: PloS Biology, 2024, ISSN 1544-9173
Publisher: Public Library of Science
DOI: 10.1371/journal.pbio.3002717

Viperin immunity evolved across the tree of life through serial innovations on a conserved scaffold

Author(s): Helena Shomar; Héloïse Georjon; Yanlei Feng; Bismarck Olympio; Marie Guillaume; Florian Tesson; Jean Cury; Fabai Wu; Aude Bernheim
Published in: Nature Ecology & Evolution, 2024, ISSN 2397-334X
Publisher: Nature Publishing Group
DOI: 10.1038/s41559-024-02463-z

Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons

Author(s): Hugo Vaysset; Chance Meers; Jean Cury; Aude Bernheim; Samuel H. Sternberg
Published in: Nature Microbiology, 2025, ISSN 2058-5276
Publisher: Nature Portfolio
DOI: 10.1101/2024.06.21.599552

A virally-encoded tRNA neutralizes the PARIS antiviral defence system

Author(s): Burman N., Belukhina S., Depardieu F., Wilkinson R., Skutel M., Santiago-Frangos A., Graham A., Livenskyi A., Chechenina A., Morozova N., Zahl T., Henriques W., Buyukyoruk M., Rouillon C., Shyrokova L., Kurata T., Hauryliuk V., Severinov K., Groseille J.,
Published in: Nature, 2024, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07874-3

Current Opinion in Microbiology

Author(s): Tesson F., Bernheim A
Published in: Current Opinion in Microbiology, 2022, ISSN 1369-5274
Publisher: Elsevier
DOI: 10.1016/j.mib.2022.102238