Tracing virus-specific CD8+ T cell clonotype zonation and function in humans

Project Information

TRACE

Grant agreement ID: 101041484

DOI

10.3030/101041484

EC signature date 18 February 2022

Start date 1 June 2022

End date 31 May 2027

Funded under

• European Research Council (ERC)

Total cost

€ 1 499 932,50

EU contribution

€ 1 499 932,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

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Deliverables

Data sets, microdata, etc (1)

Data Management Plan

A detailed data management plan DMP will be provided and periodically updated The DMP will ensure that all data and methods collected throughout the project follow the FAIR rules and define when data will be made available and shared with relevant stakeholders The DMP will provide a complete and extensive itemization of all technologies data to be collected including origin and means of creation format and associated metadata standards and the storage capacity needed to ensure conservation File formats will be chosen which are widely readable and common practice for the respective results The DMP will set the rules on how to report and store all data linked with TRACE to enable Open Access to data The PIs institution is the primary responsible of compliance to the DMP to ensure that access to repositories and sufficient capacity of data storage is provided for the project Data will be provided in standard digital readable formats eg xls rtf csv pdf Vocabulary documents will be provided with each data file

Publications

Peer reviewed articles (5)

Human circulating and tissue-resident memory CD8+ T cells

Author(s): Buggert M, Price DA, Mackay LK, Betts MR
Published in: Nature Immunology, Issue 24, 1076–1086, 2023, ISSN 1529-2916
Publisher: Springer Nature
DOI: 10.1038/s41590-023-01538-6

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states

Author(s): Müller TR, Sekine T, Trubach D, Niessl J, Chen P, Bergman P, Blennow O, Hansson L, Mielke S, Nowak P, Vesterbacka J, Akber M, Olofsson A, Amaya Hernandez SP, Gao Y, Cai C, Söderdahl G, Smith CIE, Österborg A, Loré K, Sällberg Chen M, Ljungman P, Ljunggre
Published in: Science Translational Medicine, Issue Vol 15, Issue 704, 2023, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/SCITRANSLMED.ADG9452

SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19

Author(s): Cai C, Gao Y, Adamo S, Rivera-Ballesteros O, Hansson L, Österborg A, Bergman P, Sandberg JK, Ljunggren HG, Björkström NK, Strålin K, Llewellyn-Lacey S, Price DA, Qin C, Grifoni A, Weiskopf D, Wherry EJ, Sette A, Aleman S, Buggert M
Published in: Science Immunology, Issue Vol 8, Issue 90, 2023, ISSN 2470-9468
Publisher: American Association for the Advancement of Science
DOI: 10.1126/SCIIMMUNOL.ADH0687

Proceedings of the National Academy of Sciences of the United States of America

Author(s): Humbert, Marion; Olofsson, Anna; Wullimann, David; Niessl, Julia; Hodcroft, Emma B; Cai, Curtis; Gao, Yu; Sohlberg, Ebba; Dyrdak, Robert; Mikaeloff, Flora; Neogi, Ujjwal; Albert, Jan; Malmberg, Karl-Johan; Lund-Johansen, Fridtjof; Aleman, Soo; Björkhem-Bergman, Linda; Jenmalm, Maria C; Ljunggren, Hans-Gustaf; Buggert, Marcus; Karlsson, Annika C
Published in: PNAS, 2023, ISSN 0027-8424
Publisher: National Academy of Sciences (NAS)
DOI: 10.48350/180100

Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox

Author(s): Adamo S, Gao Y, Sekine T, Akhirunnesa M, Wu J, Storgärd E, Westergren V, Filén F, Treutiger CJ, Sandberg JK, Sällberg M, Bergman P, Llewellyn-Lacey S, Ljunggren HG, Price DA, Ekström AM, Sette A, Grifoni A, Buggert M
Published in: Cell Host & Microbe, 2023, ISSN 1934-6069
Publisher: Cell Press
DOI: 10.1016/J.CHOM.2023.04.015