Tracing virus-specific CD8+ T cell clonotype zonation and function in humans

Informazioni relative al progetto

TRACE

ID dell’accordo di sovvenzione: 101041484

DOI

10.3030/101041484

Data della firma CE 18 Febbraio 2022

Data di avvio 1 Giugno 2022

Data di completamento 31 Maggio 2027

Finanziato da

• European Research Council (ERC)

Costo totale

€ 1 499 932,50

Contributo UE

€ 1 499 932,00

Coordinato da

KAROLINSKA INSTITUTET
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data sets, microdata, etc (1)

Data Management Plan

A detailed data management plan DMP will be provided and periodically updated The DMP will ensure that all data and methods collected throughout the project follow the FAIR rules and define when data will be made available and shared with relevant stakeholders The DMP will provide a complete and extensive itemization of all technologies data to be collected including origin and means of creation format and associated metadata standards and the storage capacity needed to ensure conservation File formats will be chosen which are widely readable and common practice for the respective results The DMP will set the rules on how to report and store all data linked with TRACE to enable Open Access to data The PIs institution is the primary responsible of compliance to the DMP to ensure that access to repositories and sufficient capacity of data storage is provided for the project Data will be provided in standard digital readable formats eg xls rtf csv pdf Vocabulary documents will be provided with each data file

Pubblicazioni

Peer reviewed articles (5)

Human circulating and tissue-resident memory CD8+ T cells

Autori: Buggert M, Price DA, Mackay LK, Betts MR
Pubblicato in: Nature Immunology, Numero 24, 1076–1086, 2023, ISSN 1529-2916
Editore: Springer Nature
DOI: 10.1038/s41590-023-01538-6

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states

Autori: Müller TR, Sekine T, Trubach D, Niessl J, Chen P, Bergman P, Blennow O, Hansson L, Mielke S, Nowak P, Vesterbacka J, Akber M, Olofsson A, Amaya Hernandez SP, Gao Y, Cai C, Söderdahl G, Smith CIE, Österborg A, Loré K, Sällberg Chen M, Ljungman P, Ljunggre
Pubblicato in: Science Translational Medicine, Numero Vol 15, Numero 704, 2023, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/SCITRANSLMED.ADG9452

SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19

Autori: Cai C, Gao Y, Adamo S, Rivera-Ballesteros O, Hansson L, Österborg A, Bergman P, Sandberg JK, Ljunggren HG, Björkström NK, Strålin K, Llewellyn-Lacey S, Price DA, Qin C, Grifoni A, Weiskopf D, Wherry EJ, Sette A, Aleman S, Buggert M
Pubblicato in: Science Immunology, Numero Vol 8, Numero 90, 2023, ISSN 2470-9468
Editore: American Association for the Advancement of Science
DOI: 10.1126/SCIIMMUNOL.ADH0687

Proceedings of the National Academy of Sciences of the United States of America

Autori: Humbert, Marion; Olofsson, Anna; Wullimann, David; Niessl, Julia; Hodcroft, Emma B; Cai, Curtis; Gao, Yu; Sohlberg, Ebba; Dyrdak, Robert; Mikaeloff, Flora; Neogi, Ujjwal; Albert, Jan; Malmberg, Karl-Johan; Lund-Johansen, Fridtjof; Aleman, Soo; Björkhem-Bergman, Linda; Jenmalm, Maria C; Ljunggren, Hans-Gustaf; Buggert, Marcus; Karlsson, Annika C
Pubblicato in: PNAS, 2023, ISSN 0027-8424
Editore: National Academy of Sciences (NAS)
DOI: 10.48350/180100

Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox

Autori: Adamo S, Gao Y, Sekine T, Akhirunnesa M, Wu J, Storgärd E, Westergren V, Filén F, Treutiger CJ, Sandberg JK, Sällberg M, Bergman P, Llewellyn-Lacey S, Ljunggren HG, Price DA, Ekström AM, Sette A, Grifoni A, Buggert M
Pubblicato in: Cell Host & Microbe, 2023, ISSN 1934-6069
Editore: Cell Press
DOI: 10.1016/J.CHOM.2023.04.015