Cell control mechanism: the role of autophagy receptors
Autophagy or self-eating is a homeostatic process that degrades and removes unnecessary components from cells. However, when it comes to macromolecular complexes that involve the association of multiple macromolecules, such as proteins and RNA, the exact mechanism by which such dysfunctional assemblies are sensed by the cell remains elusive. The working hypothesis of the IntrinsicReceptors project, funded by the European Research Council, is that intrinsic receptors are implicated in the autophagy of macromolecular complexes. Researchers aim to identify candidate receptors and study how they are regulated. Given that many age-related diseases, such as Alzheimer’s disease, are characterised by aberrant accumulation of dysfunctional complexes, project results will pave the way for the design of novel interventions.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme