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Intrinsic autophagy receptors: identity and cellular mechanisms.

Project description

Cell control mechanism: the role of autophagy receptors

Autophagy or self-eating is a homeostatic process that degrades and removes unnecessary components from cells. However, when it comes to macromolecular complexes that involve the association of multiple macromolecules, such as proteins and RNA, the exact mechanism by which such dysfunctional assemblies are sensed by the cell remains elusive. The working hypothesis of the IntrinsicReceptors project, funded by the European Research Council, is that intrinsic receptors are implicated in the autophagy of macromolecular complexes. Researchers aim to identify candidate receptors and study how they are regulated. Given that many age-related diseases, such as Alzheimer’s disease, are characterised by aberrant accumulation of dysfunctional complexes, project results will pave the way for the design of novel interventions.

Coordinator

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Net EU contribution
€ 1 495 000,00
Address
Hofgartenstrasse 8
80539 Munchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00