ENDING COVID 19 VARIANTS OF CONCERN THROUGH COHORT STUDIES: END-VOC

Información del proyecto

END-VOC

Identificador del acuerdo de subvención: 101046314

DOI

10.3030/101046314

Proyecto cerrado

Fecha de la firma de la CE 17 Agosto 2022

Fecha de inicio 1 Mayo 2022

Fecha de finalización 31 Octubre 2025

Financiado con arreglo a

• Health

Coste total

€ 10 496 136,50

Aportación de la UE

€ 10 496 136,50

Coordinado por

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (21)

Travel surveillance network established

Integrated travel surveillance network established with new VOC reporting mechanism

Mutation prediction pipeline

Application of mutation prediction pipeline to assess transmissibility of all SARSCoV2 lineages including VOCs regularly and close to real time

Website
Mathematical transmission dynamic model update

Updated version of the mathematical model to include multiple variants applicability to all partner Cohorts

Data warehouse

Data warehouse and acquisition platform

Risk factors for long COVID

Initial analysis of risk factors for Long COVID by VOC

Data Management Plan (Interim version)

Updated data management plan

Biospecimen Handbook

Handbook for biospecimen collections

In vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

Development of in vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

DEC plan
Mechanism of VOC transmission using genetic models

Study on the mechanisms of transmission in VOCs and VOIs based on genetic models

Protocols/questionnaires

Common protocols with questionnaires and procedures for prospective data harmonization and retrospective data reconciliation

Data Management Plan (draft version)

A Data Management Plan DMP following the HE guidelines will address the relevant aspects of making data FAIR including what data the project will generate whether and how it will be made accessible for verification and reuse and how it will be curated and preserved The DMP will include details of the security technical and organisational measures to be taken in the context of the transfer of data from nonEU countries to prevent unauthorised access to personal data and safeguard the rights and freedoms of the data subjectsresearch participants

Data standards/harmonisation

Establish data standardisation and harmonisation processes

Sequencing pipeline optimisation completed

Optimise sequencing pipeline and provide support to cohorts

Infographics to disseminate key results

Infographics with key messages or results will be produced throughout the project

Risk factor for COVID and clinical outcome analysis protocol

Established protocol for analysis of risk factor and clinical outcome data

Central Code Repository

Central code repository, software documentation and versioning system

Best practice guidelines for governance structures and processes

Document outlining best practice for governance structures and processes to be used by the consortium

Impact Monitoring Framework

A framework to allow monitoring of impact

Cohort network and inclusion

Establish network and inclusion of population and clinical cohorts

Publicaciones

Peer reviewed articles (33)

Exploring early COVID-19 therapies, variants, and viral clearance dynamics: Insights from a high-risk outpatients study

Autores: Marta Colaneri, Maddalena Matone, Federico Fassio, Alessia Lai, Annalisa Bergna, Carla della Ventura, Lucia Galli, Giovanni Scaglione, Andrea Gori, Monica Schiavini
Publicado en: Diagnostic Microbiology and Infectious Disease, Edición 110, 2024, ISSN 0732-8893
Editor: Elsevier BV
DOI: 10.1016/J.DIAGMICROBIO.2024.116452

High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination

Autores: Rocío Rubio, Dídac Macià, Diana Barrios, Marta Vidal, Alfons Jiménez, Luis M. Molinos-Albert, Natalia Díaz, Mar Canyelles, Maria Lara-Escandell, Cyril Planchais, Pere Santamaria, Carlo Carolis, L
Publicado en: Microbes and Infection, Edición 27, 2025, ISSN 1286-4579
Editor: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105423

The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews

Autores: Federico Fama, Rebecca Fattore, Paolo Raimondo, Fabio Brivio, Darcy Holmes, Toussaint Muheberimana, Tarek Nayfeh, Alessandra Bandera, Andrea Gori, Matteo Passerini, Marta Colaneri
Publicado en: Frontiers in Medicine, Edición 12, 2025, ISSN 2296-858X
Editor: Frontiers Media SA
DOI: 10.3389/FMED.2025.1624459

Risk, determinants, and persistence of long-COVID in a population-based cohort study in Catalonia

Autores: Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Laura Delgado-Ortiz, Xavier Farré, Natàlia Blay, Neil Pearce, Magda Bosch de Basea, Eva Alonso N
Publicado en: BMC Medicine, Edición 23, 2025, ISSN 1741-7015
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-03974-7

Occupational determinants of Long COVID in the population-based COVICAT cohort

Autores: Sara De Matteis, Dario Consonni, Ana Espinosa, Rafael de Cid, Natalia Blay Magriña, Gemma Castaño-Vinyals, Marianna Karachaliou, Miguel Angel Alba Hidalgo, Kyriaki Papantoniou, Judith Garcia, Manoli
Publicado en: Occupational and Environmental Medicine, 2025, ISSN 1351-0711
Editor: BMJ
DOI: 10.1136/OEMED-2025-110398

Effectiveness of COVID-19 vaccines against severe COVID-19 among patients with cancer in Catalonia, Spain

Autores: Felippe Lazar Neto, Núria Mercadé-Besora, Berta Raventós, Laura Pérez-Crespo, Gilberto Castro Junior, Otavio T. Ranzani, Talita Duarte-Salles
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-49285-Y

Integrating Statistical Methods and Machine Learning Techniques to Analyze and Classify COVID-19 Symptom Severity

Autores: Yaqeen Raddad, Ahmad Hasasneh, Obada Abdallah, Camil Rishmawi, Nouar Qutob
Publicado en: Big Data and Cognitive Computing, Edición 8, 2025, ISSN 2504-2289
Editor: MDPI AG
DOI: 10.3390/BDCC8120192

Antibody responses to common viruses according to COVID‐19 severity and postacute sequelae of COVID‐19

Autores: Marianna Karachaliou, Otavio Ranzani, Ana Espinosa, Susana Iraola‐Guzmán, Gemma Castaño‐Vinyals, Marta Vidal, Alfons Jiménez, Marc Bañuls, Eva Alonso Nogués, Ruth Aguilar, Judith Garcia‐Aym
Publicado en: Journal of Medical Virology, Edición 96, 2025, ISSN 0146-6615
Editor: Wiley
DOI: 10.1002/JMV.29862

Long-term outcomes of SARS-CoV-2 variants and other respiratory infections: evidence from the Virus Watch prospective cohort in England

Autores: Sarah Beale, Alexei Yavlinsky, Wing L. E. Fong, Vincent G. Nguyen, Jana Kovar, Theo Vos, Sarah Wulf Hanson, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Publicado en: Epidemiology and Infection, Edición 152, 2024, ISSN 0950-2688
Editor: Cambridge University Press (CUP)
DOI: 10.1017/S0950268824000748

Anti-nucleocapsid and anti-spike antibody trajectories in people with post-covid condition versus acute-only infections: a nested longitudinal case-control study within the Virus Watch prospective coh

Autores: Sarah Beale, Alexei Yavlinsky, Gemma Moncunill, Wing Lam Erica Fong, Vincent Grigori Nguyen, Jana Kovar, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58766-7

EU’s Extraterritorial Obligations for Global Medicine Access Under the Convention on the Rights of Persons with Disability (CPRD)

Autores: Katrina Perehudoff
Publicado en: Journal of Law, Medicine & Ethics, Edición 53, 2025, ISSN 1073-1105
Editor: Cambridge University Press (CUP)
DOI: 10.1017/JME.2025.10144

Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

Autores: Carla Martín Pérez, Sílvia Ruiz-Rius, Anna Ramírez-Morros, Marta Vidal, D. Herbert Opi, Pere Santamaria, Julià Blanco, Josep Vidal-Alaball, James G. Beeson, Luis M. Molinos-Albert, Ruth Aguilar,
Publicado en: Journal of Infection, Edición 90, 2025, ISSN 0163-4453
Editor: Elsevier BV
DOI: 10.1016/J.JINF.2025.106473

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Autores: Tan, C.C.S., Trew, J., Peacock, T.P. et al.
Publicado en: Nature Communications, Edición 14, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-38717-w

Prevalence, risk factors, and impact of long COVID in a socially vulnerable community in Brazil: a prospective cohort study

Autores: Pedro Azambuja, Leonardo S.L. Bastos, Amanda A. Batista-da-Silva, Grazielle Viana Ramos, Pedro Kurtz, Carolina M.C. Dias, Everton P. da Silva, Luna E. Arouca, Jesus Soares, James J. Sejvar, Louise Sig
Publicado en: The Lancet Regional Health - Americas, Edición 37, 2024, ISSN 2667-193X
Editor: Elsevier BV
DOI: 10.1016/J.LANA.2024.100839

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Autores: Canuti M, Monti MC, Bobbio C, Muscatello A, Muheberimana T, Baldi SL, Blasi F, Canetta C, Costantino G, Nobili A, Peyvandi F, Tettamanti M, Villa S, Aliberti S, Raviglione MC, Gori A, Bandera A and COVID-19 Network Study Group
Publicado en: Frontiers in Medicine, Edición Vol. 10, 2023, ISSN 2296-858X
Editor: Frontiers Media
DOI: 10.3389/fmed.2023.1260950

TB as a risk factor for severe COVID-19 mortality

Autores: I.C. Borges, F.M. Lino, A. Luna-Muschi, M.N. Litvoc, M.I.B.F. Lopes, H.R. Higashino, Á.F. da Costa, R.H.M. Pereira, H.I. Nakaya, J.D.A. de Araújo, G.M. Orlandi, M.J.P. Rújula, T.R.M.P. Carvalhanas,
Publicado en: The International Journal of Tuberculosis and Lung Disease, Edición 29, 2025, ISSN 1027-3719
Editor: International Union Against Tuberculosis and Lung Disease
DOI: 10.5588/IJTLD.24.0503

Prognostic Significance of NLR and PLR in COVID-19: A Multi-Cohort Validation Study

Autores: Marta Colaneri, Camilla Genovese, Federico Fassio, Marta Canuti, Andrea Giacomelli, Anna Lisa Ridolfo, Erika Asperges, Giuseppe Albi, Raffaele Bruno, Spinello Antinori, Antonio Muscatello, Bianca Mari
Publicado en: Infectious Diseases and Therapy, Edición 13, 2024, ISSN 2193-8229
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S40121-024-00967-6

Advancing vaccines justice through international regulatory pathways

Autores: Katrina Perehudoff, Pramiti Parwani, Seraphine Bruinsma
Publicado en: Global Public Health, Edición 20, 2025, ISSN 1744-1692
Editor: Informa UK Limited
DOI: 10.1080/17441692.2025.2566730

Estimating the risk of post-COVID condition in deprived communities, migrants and ethnic minorities in England: findings from Virus Watch—a prospective community cohort study

Autores: Wing Lam Erica Fong, Sarah Beale, Vincent Nguyen, Jana Kovar, Alexei Yavlinsky, Andrew C Hayward, Ibrahim Abubakar, Sander MJ van Kuijk, Robert Aldridge
Publicado en: Journal of Epidemiology and Community Health, Edición 80, 2026, ISSN 0143-005X
Editor: BMJ
DOI: 10.1136/JECH-2024-223491

Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later

Autores: Rocío Rubio, Alexei Yavlinsky, Marina Escalera Zamudio, Luis M. Molinos-Albert, Carla Martín Pérez, Edwards Pradenas, Mar Canyelles, Cèlia Torres, Cedric Tan, Leo Swadling, Anna Ramírez-Morros, B
Publicado en: Journal of Infection, Edición 90, 2025, ISSN 0163-4453
Editor: Elsevier BV
DOI: 10.1016/J.JINF.2024.106402

Cohort Profile: Virus Watch—understanding community incidence, symptom profiles and transmission of COVID-19 in relation to population movement and behaviour

Autores: T. Byrne, J. Kovar, S. Beale, I. Braithwaite, E. Fragaszy, W. L. E. Fong, C. Geismar, S. Hoskins, A. M D Navaratnam, V. Nguyen, P. Patel, M. Shrotri, A. Yavlinsky, P. Hardelid, L. Wijlaars, E. Nastouli, M. Spyer, A. Aryee, I. Cox, ..., R. W Aldridge
Publicado en: International Journal of Epidemiology, Edición Vol.10, Edición 5, 2023, ISSN 1464-3685
Editor: Oxford University Press
DOI: 10.1093/ije/dyad087

VEGFA sex-specific signature is associated to long COVID symptom persistence

Autores: Xavier Farré, Natalia Blay, Susana Iraola-Guzmán, Francisco Fernández-Jiménez, Sayoa Alzate-Piñol, Laia Llucià-Carol, Ana Espinosa, Gemma Castaño-Vinyals, Carlota Dobaño, Gemma Moncunill, Mari
Publicado en: BMC Medicine, Edición 23, 2025, ISSN 1741-7015
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-04402-6

Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection

Autores: Carla Martín Pérez, Anna Ramírez-Morros, Alfons Jiménez, Marta Vidal, Edwards Pradenas, Diana Barrios, Mar Canyelles, Rocío Rubio, Inocencia Cuamba, Luis Izquierdo, Pere Santamaria, Benjamin Trin
Publicado en: Communications Medicine, Edición 5, 2025, ISSN 2730-664X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S43856-025-00943-2

The burden, clinical features and outcomes of SARS-CoV-2, Influenza and co-infections during concurrently out-of-season outbreaks in Brazil

Autores: Tarsila Vieceli, Julio Croda, Leonardo S.L. Bastos, Fernando A. Bozza, Otavio T. Ranzani
Publicado en: Public Health, Edición 238, 2025, ISSN 0033-3506
Editor: Elsevier BV
DOI: 10.1016/J.PUHE.2024.10.016

Environmental Exposures and Long COVID in a Prospective Population-Based Study in Catalonia (COVICAT Study)

Autores: Apolline Saucy, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Barbara N. Harding, Marianna Karachaliou, Otavio Ranzani, Rafael De Cid, Judith Garcia-Aymerich, Manolis Kogevinas
Publicado en: Environmental Health Perspectives, Edición 132, 2024, ISSN 0091-6765
Editor: Environmental Health Perspectives
DOI: 10.1289/EHP15377

Malaria and other infections induce polyreactive antibodies that impact SARS‐CoV‐2 seropositivity estimations in endemic settings

Autores: Ruth Aguilar, Alfons Jiménez, Rebeca Santano, Marta Vidal, Oumou Maiga‐Ascofare, Ricardo Strauss, Joseph Bonney, Melvin Agbogbatey, Odin Goovaerts, Eric E. A. Boham, Evan A. Adu, Inocencia Cuamba,
Publicado en: Journal of Medical Virology, Edición 96, 2025, ISSN 0146-6615
Editor: Wiley
DOI: 10.1002/JMV.29713

Impact of early antiviral therapy on SARS-CoV-2 clearance time in high-risk COVID-19 subjects: A propensity score matching study

Autores: Marta Colaneri, Federico Fama, Federico Fassio, Darcy Holmes, Giovanni Scaglione, Chiara Mariani, Lucia Galli, Alessia Lai, Spinello Antinori, Andrea Gori, Agostino Riva, Monica Schiavini
Publicado en: International Journal of Infectious Diseases, Edición 149, 2025, ISSN 1201-9712
Editor: Elsevier BV
DOI: 10.1016/J.IJID.2024.107265

Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination

Autores: Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamar
Publicado en: BMC Medicine, Edición 22, 2024, ISSN 1741-7015
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12916-024-03304-3

Mpox global emergency: strengthening African leadership

Autores: Ibrahim Abubakar, Julius Lutwama, Catherine Kyobutungi, Osman Sankoh
Publicado en: The Lancet, Edición 404, 2024, ISSN 0140-6736
Editor: Elsevier BV
DOI: 10.1016/S0140-6736(24)02068-3EXTERNALLINK

The evolutionary drivers and correlates of viral host jumps

Autores: Cedric C. S. Tan, Lucy van Dorp, Francois Balloux
Publicado en: Nature Ecology & Evolution, Edición 8, 2024, ISSN 2397-334X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41559-024-02353-4

Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic

Autores: Luis M. Molinos-Albert, Rocío Rubio, Carla Martín-Pérez, Edwards Pradenas, Cèlia Torres, Alfons Jiménez, Mar Canyelles, Marta Vidal, Diana Barrios, Silvia Marfil, Ester Aparicio, Anna Ramírez-Mo
Publicado en: Cell Reports, Edición 44, 2025, ISSN 2211-1247
Editor: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115498

Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach

Autores: Darcy Holmes, Marta Colaneri, Emanuele Palomba, Andrea Gori
Publicado en: Frontiers in Medicine, Edición 10, 2024, ISSN 2296-858X
Editor: Frontiers Media
DOI: 10.3389/fmed.2023.1280951

Estimating long COVID-19 prevalence across definitions and forms of sample selection

Autores: Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Alessandra Bandera, Andrea Gori, Amedeo Ferdinando Capetti
Publicado en: Frontiers in Epidemiology, Edición 5, 2025, ISSN 2674-1199
Editor: Frontiers Media SA
DOI: 10.3389/FEPID.2025.1597799