ENDING COVID 19 VARIANTS OF CONCERN THROUGH COHORT STUDIES: END-VOC

Projektinformationen

END-VOC

ID Finanzhilfevereinbarung: 101046314

DOI

10.3030/101046314

Projekt abgeschlossen

EK-Unterschriftsdatum 17 August 2022

Startdatum 1 Mai 2022

Enddatum 31 Oktober 2025

Finanziert unter

• Health

Gesamtkosten

€ 10 496 136,50

EU-Beitrag

€ 10 496 136,50

Koordiniert durch

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (21)

Travel surveillance network established

Integrated travel surveillance network established with new VOC reporting mechanism

Mutation prediction pipeline

Application of mutation prediction pipeline to assess transmissibility of all SARSCoV2 lineages including VOCs regularly and close to real time

Website
Mathematical transmission dynamic model update

Updated version of the mathematical model to include multiple variants applicability to all partner Cohorts

Data warehouse

Data warehouse and acquisition platform

Risk factors for long COVID

Initial analysis of risk factors for Long COVID by VOC

Data Management Plan (Interim version)

Updated data management plan

Biospecimen Handbook

Handbook for biospecimen collections

In vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

Development of in vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

DEC plan
Mechanism of VOC transmission using genetic models

Study on the mechanisms of transmission in VOCs and VOIs based on genetic models

Protocols/questionnaires

Common protocols with questionnaires and procedures for prospective data harmonization and retrospective data reconciliation

Data Management Plan (draft version)

A Data Management Plan DMP following the HE guidelines will address the relevant aspects of making data FAIR including what data the project will generate whether and how it will be made accessible for verification and reuse and how it will be curated and preserved The DMP will include details of the security technical and organisational measures to be taken in the context of the transfer of data from nonEU countries to prevent unauthorised access to personal data and safeguard the rights and freedoms of the data subjectsresearch participants

Data standards/harmonisation

Establish data standardisation and harmonisation processes

Sequencing pipeline optimisation completed

Optimise sequencing pipeline and provide support to cohorts

Infographics to disseminate key results

Infographics with key messages or results will be produced throughout the project

Risk factor for COVID and clinical outcome analysis protocol

Established protocol for analysis of risk factor and clinical outcome data

Central Code Repository

Central code repository, software documentation and versioning system

Best practice guidelines for governance structures and processes

Document outlining best practice for governance structures and processes to be used by the consortium

Impact Monitoring Framework

A framework to allow monitoring of impact

Cohort network and inclusion

Establish network and inclusion of population and clinical cohorts

Veröffentlichungen

Peer reviewed articles (33)

Exploring early COVID-19 therapies, variants, and viral clearance dynamics: Insights from a high-risk outpatients study

Autoren: Marta Colaneri, Maddalena Matone, Federico Fassio, Alessia Lai, Annalisa Bergna, Carla della Ventura, Lucia Galli, Giovanni Scaglione, Andrea Gori, Monica Schiavini
Veröffentlicht in: Diagnostic Microbiology and Infectious Disease, Ausgabe 110, 2024, ISSN 0732-8893
Herausgeber: Elsevier BV
DOI: 10.1016/J.DIAGMICROBIO.2024.116452

High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination

Autoren: Rocío Rubio, Dídac Macià, Diana Barrios, Marta Vidal, Alfons Jiménez, Luis M. Molinos-Albert, Natalia Díaz, Mar Canyelles, Maria Lara-Escandell, Cyril Planchais, Pere Santamaria, Carlo Carolis, L
Veröffentlicht in: Microbes and Infection, Ausgabe 27, 2025, ISSN 1286-4579
Herausgeber: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105423

The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews

Autoren: Federico Fama, Rebecca Fattore, Paolo Raimondo, Fabio Brivio, Darcy Holmes, Toussaint Muheberimana, Tarek Nayfeh, Alessandra Bandera, Andrea Gori, Matteo Passerini, Marta Colaneri
Veröffentlicht in: Frontiers in Medicine, Ausgabe 12, 2025, ISSN 2296-858X
Herausgeber: Frontiers Media SA
DOI: 10.3389/FMED.2025.1624459

Risk, determinants, and persistence of long-COVID in a population-based cohort study in Catalonia

Autoren: Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Laura Delgado-Ortiz, Xavier Farré, Natàlia Blay, Neil Pearce, Magda Bosch de Basea, Eva Alonso N
Veröffentlicht in: BMC Medicine, Ausgabe 23, 2025, ISSN 1741-7015
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-03974-7

Occupational determinants of Long COVID in the population-based COVICAT cohort

Autoren: Sara De Matteis, Dario Consonni, Ana Espinosa, Rafael de Cid, Natalia Blay Magriña, Gemma Castaño-Vinyals, Marianna Karachaliou, Miguel Angel Alba Hidalgo, Kyriaki Papantoniou, Judith Garcia, Manoli
Veröffentlicht in: Occupational and Environmental Medicine, 2025, ISSN 1351-0711
Herausgeber: BMJ
DOI: 10.1136/OEMED-2025-110398

Effectiveness of COVID-19 vaccines against severe COVID-19 among patients with cancer in Catalonia, Spain

Autoren: Felippe Lazar Neto, Núria Mercadé-Besora, Berta Raventós, Laura Pérez-Crespo, Gilberto Castro Junior, Otavio T. Ranzani, Talita Duarte-Salles
Veröffentlicht in: Nature Communications, Ausgabe 15, 2024, ISSN 2041-1723
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-49285-Y

Integrating Statistical Methods and Machine Learning Techniques to Analyze and Classify COVID-19 Symptom Severity

Autoren: Yaqeen Raddad, Ahmad Hasasneh, Obada Abdallah, Camil Rishmawi, Nouar Qutob
Veröffentlicht in: Big Data and Cognitive Computing, Ausgabe 8, 2025, ISSN 2504-2289
Herausgeber: MDPI AG
DOI: 10.3390/BDCC8120192

Antibody responses to common viruses according to COVID‐19 severity and postacute sequelae of COVID‐19

Autoren: Marianna Karachaliou, Otavio Ranzani, Ana Espinosa, Susana Iraola‐Guzmán, Gemma Castaño‐Vinyals, Marta Vidal, Alfons Jiménez, Marc Bañuls, Eva Alonso Nogués, Ruth Aguilar, Judith Garcia‐Aym
Veröffentlicht in: Journal of Medical Virology, Ausgabe 96, 2025, ISSN 0146-6615
Herausgeber: Wiley
DOI: 10.1002/JMV.29862

Long-term outcomes of SARS-CoV-2 variants and other respiratory infections: evidence from the Virus Watch prospective cohort in England

Autoren: Sarah Beale, Alexei Yavlinsky, Wing L. E. Fong, Vincent G. Nguyen, Jana Kovar, Theo Vos, Sarah Wulf Hanson, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Veröffentlicht in: Epidemiology and Infection, Ausgabe 152, 2024, ISSN 0950-2688
Herausgeber: Cambridge University Press (CUP)
DOI: 10.1017/S0950268824000748

Anti-nucleocapsid and anti-spike antibody trajectories in people with post-covid condition versus acute-only infections: a nested longitudinal case-control study within the Virus Watch prospective coh

Autoren: Sarah Beale, Alexei Yavlinsky, Gemma Moncunill, Wing Lam Erica Fong, Vincent Grigori Nguyen, Jana Kovar, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Veröffentlicht in: Nature Communications, Ausgabe 16, 2025, ISSN 2041-1723
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58766-7

EU’s Extraterritorial Obligations for Global Medicine Access Under the Convention on the Rights of Persons with Disability (CPRD)

Autoren: Katrina Perehudoff
Veröffentlicht in: Journal of Law, Medicine & Ethics, Ausgabe 53, 2025, ISSN 1073-1105
Herausgeber: Cambridge University Press (CUP)
DOI: 10.1017/JME.2025.10144

Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

Autoren: Carla Martín Pérez, Sílvia Ruiz-Rius, Anna Ramírez-Morros, Marta Vidal, D. Herbert Opi, Pere Santamaria, Julià Blanco, Josep Vidal-Alaball, James G. Beeson, Luis M. Molinos-Albert, Ruth Aguilar,
Veröffentlicht in: Journal of Infection, Ausgabe 90, 2025, ISSN 0163-4453
Herausgeber: Elsevier BV
DOI: 10.1016/J.JINF.2025.106473

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Autoren: Tan, C.C.S., Trew, J., Peacock, T.P. et al.
Veröffentlicht in: Nature Communications, Ausgabe 14, 2023, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41467-023-38717-w

Prevalence, risk factors, and impact of long COVID in a socially vulnerable community in Brazil: a prospective cohort study

Autoren: Pedro Azambuja, Leonardo S.L. Bastos, Amanda A. Batista-da-Silva, Grazielle Viana Ramos, Pedro Kurtz, Carolina M.C. Dias, Everton P. da Silva, Luna E. Arouca, Jesus Soares, James J. Sejvar, Louise Sig
Veröffentlicht in: The Lancet Regional Health - Americas, Ausgabe 37, 2024, ISSN 2667-193X
Herausgeber: Elsevier BV
DOI: 10.1016/J.LANA.2024.100839

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Autoren: Canuti M, Monti MC, Bobbio C, Muscatello A, Muheberimana T, Baldi SL, Blasi F, Canetta C, Costantino G, Nobili A, Peyvandi F, Tettamanti M, Villa S, Aliberti S, Raviglione MC, Gori A, Bandera A and COVID-19 Network Study Group
Veröffentlicht in: Frontiers in Medicine, Ausgabe Vol. 10, 2023, ISSN 2296-858X
Herausgeber: Frontiers Media
DOI: 10.3389/fmed.2023.1260950

TB as a risk factor for severe COVID-19 mortality

Autoren: I.C. Borges, F.M. Lino, A. Luna-Muschi, M.N. Litvoc, M.I.B.F. Lopes, H.R. Higashino, Á.F. da Costa, R.H.M. Pereira, H.I. Nakaya, J.D.A. de Araújo, G.M. Orlandi, M.J.P. Rújula, T.R.M.P. Carvalhanas,
Veröffentlicht in: The International Journal of Tuberculosis and Lung Disease, Ausgabe 29, 2025, ISSN 1027-3719
Herausgeber: International Union Against Tuberculosis and Lung Disease
DOI: 10.5588/IJTLD.24.0503

Prognostic Significance of NLR and PLR in COVID-19: A Multi-Cohort Validation Study

Autoren: Marta Colaneri, Camilla Genovese, Federico Fassio, Marta Canuti, Andrea Giacomelli, Anna Lisa Ridolfo, Erika Asperges, Giuseppe Albi, Raffaele Bruno, Spinello Antinori, Antonio Muscatello, Bianca Mari
Veröffentlicht in: Infectious Diseases and Therapy, Ausgabe 13, 2024, ISSN 2193-8229
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/S40121-024-00967-6

Advancing vaccines justice through international regulatory pathways

Autoren: Katrina Perehudoff, Pramiti Parwani, Seraphine Bruinsma
Veröffentlicht in: Global Public Health, Ausgabe 20, 2025, ISSN 1744-1692
Herausgeber: Informa UK Limited
DOI: 10.1080/17441692.2025.2566730

Estimating the risk of post-COVID condition in deprived communities, migrants and ethnic minorities in England: findings from Virus Watch—a prospective community cohort study

Autoren: Wing Lam Erica Fong, Sarah Beale, Vincent Nguyen, Jana Kovar, Alexei Yavlinsky, Andrew C Hayward, Ibrahim Abubakar, Sander MJ van Kuijk, Robert Aldridge
Veröffentlicht in: Journal of Epidemiology and Community Health, Ausgabe 80, 2026, ISSN 0143-005X
Herausgeber: BMJ
DOI: 10.1136/JECH-2024-223491

Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later

Autoren: Rocío Rubio, Alexei Yavlinsky, Marina Escalera Zamudio, Luis M. Molinos-Albert, Carla Martín Pérez, Edwards Pradenas, Mar Canyelles, Cèlia Torres, Cedric Tan, Leo Swadling, Anna Ramírez-Morros, B
Veröffentlicht in: Journal of Infection, Ausgabe 90, 2025, ISSN 0163-4453
Herausgeber: Elsevier BV
DOI: 10.1016/J.JINF.2024.106402

Cohort Profile: Virus Watch—understanding community incidence, symptom profiles and transmission of COVID-19 in relation to population movement and behaviour

Autoren: T. Byrne, J. Kovar, S. Beale, I. Braithwaite, E. Fragaszy, W. L. E. Fong, C. Geismar, S. Hoskins, A. M D Navaratnam, V. Nguyen, P. Patel, M. Shrotri, A. Yavlinsky, P. Hardelid, L. Wijlaars, E. Nastouli, M. Spyer, A. Aryee, I. Cox, ..., R. W Aldridge
Veröffentlicht in: International Journal of Epidemiology, Ausgabe Vol.10, Ausgabe 5, 2023, ISSN 1464-3685
Herausgeber: Oxford University Press
DOI: 10.1093/ije/dyad087

VEGFA sex-specific signature is associated to long COVID symptom persistence

Autoren: Xavier Farré, Natalia Blay, Susana Iraola-Guzmán, Francisco Fernández-Jiménez, Sayoa Alzate-Piñol, Laia Llucià-Carol, Ana Espinosa, Gemma Castaño-Vinyals, Carlota Dobaño, Gemma Moncunill, Mari
Veröffentlicht in: BMC Medicine, Ausgabe 23, 2025, ISSN 1741-7015
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-04402-6

Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection

Autoren: Carla Martín Pérez, Anna Ramírez-Morros, Alfons Jiménez, Marta Vidal, Edwards Pradenas, Diana Barrios, Mar Canyelles, Rocío Rubio, Inocencia Cuamba, Luis Izquierdo, Pere Santamaria, Benjamin Trin
Veröffentlicht in: Communications Medicine, Ausgabe 5, 2025, ISSN 2730-664X
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S43856-025-00943-2

The burden, clinical features and outcomes of SARS-CoV-2, Influenza and co-infections during concurrently out-of-season outbreaks in Brazil

Autoren: Tarsila Vieceli, Julio Croda, Leonardo S.L. Bastos, Fernando A. Bozza, Otavio T. Ranzani
Veröffentlicht in: Public Health, Ausgabe 238, 2025, ISSN 0033-3506
Herausgeber: Elsevier BV
DOI: 10.1016/J.PUHE.2024.10.016

Environmental Exposures and Long COVID in a Prospective Population-Based Study in Catalonia (COVICAT Study)

Autoren: Apolline Saucy, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Barbara N. Harding, Marianna Karachaliou, Otavio Ranzani, Rafael De Cid, Judith Garcia-Aymerich, Manolis Kogevinas
Veröffentlicht in: Environmental Health Perspectives, Ausgabe 132, 2024, ISSN 0091-6765
Herausgeber: Environmental Health Perspectives
DOI: 10.1289/EHP15377

Malaria and other infections induce polyreactive antibodies that impact SARS‐CoV‐2 seropositivity estimations in endemic settings

Autoren: Ruth Aguilar, Alfons Jiménez, Rebeca Santano, Marta Vidal, Oumou Maiga‐Ascofare, Ricardo Strauss, Joseph Bonney, Melvin Agbogbatey, Odin Goovaerts, Eric E. A. Boham, Evan A. Adu, Inocencia Cuamba,
Veröffentlicht in: Journal of Medical Virology, Ausgabe 96, 2025, ISSN 0146-6615
Herausgeber: Wiley
DOI: 10.1002/JMV.29713

Impact of early antiviral therapy on SARS-CoV-2 clearance time in high-risk COVID-19 subjects: A propensity score matching study

Autoren: Marta Colaneri, Federico Fama, Federico Fassio, Darcy Holmes, Giovanni Scaglione, Chiara Mariani, Lucia Galli, Alessia Lai, Spinello Antinori, Andrea Gori, Agostino Riva, Monica Schiavini
Veröffentlicht in: International Journal of Infectious Diseases, Ausgabe 149, 2025, ISSN 1201-9712
Herausgeber: Elsevier BV
DOI: 10.1016/J.IJID.2024.107265

Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination

Autoren: Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamar
Veröffentlicht in: BMC Medicine, Ausgabe 22, 2024, ISSN 1741-7015
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S12916-024-03304-3

Mpox global emergency: strengthening African leadership

Autoren: Ibrahim Abubakar, Julius Lutwama, Catherine Kyobutungi, Osman Sankoh
Veröffentlicht in: The Lancet, Ausgabe 404, 2024, ISSN 0140-6736
Herausgeber: Elsevier BV
DOI: 10.1016/S0140-6736(24)02068-3EXTERNALLINK

The evolutionary drivers and correlates of viral host jumps

Autoren: Cedric C. S. Tan, Lucy van Dorp, Francois Balloux
Veröffentlicht in: Nature Ecology & Evolution, Ausgabe 8, 2024, ISSN 2397-334X
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41559-024-02353-4

Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic

Autoren: Luis M. Molinos-Albert, Rocío Rubio, Carla Martín-Pérez, Edwards Pradenas, Cèlia Torres, Alfons Jiménez, Mar Canyelles, Marta Vidal, Diana Barrios, Silvia Marfil, Ester Aparicio, Anna Ramírez-Mo
Veröffentlicht in: Cell Reports, Ausgabe 44, 2025, ISSN 2211-1247
Herausgeber: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115498

Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach

Autoren: Darcy Holmes, Marta Colaneri, Emanuele Palomba, Andrea Gori
Veröffentlicht in: Frontiers in Medicine, Ausgabe 10, 2024, ISSN 2296-858X
Herausgeber: Frontiers Media
DOI: 10.3389/fmed.2023.1280951

Estimating long COVID-19 prevalence across definitions and forms of sample selection

Autoren: Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Alessandra Bandera, Andrea Gori, Amedeo Ferdinando Capetti
Veröffentlicht in: Frontiers in Epidemiology, Ausgabe 5, 2025, ISSN 2674-1199
Herausgeber: Frontiers Media SA
DOI: 10.3389/FEPID.2025.1597799