ENDING COVID 19 VARIANTS OF CONCERN THROUGH COHORT STUDIES: END-VOC

Informations projet

END-VOC

N° de convention de subvention: 101046314

DOI

10.3030/101046314

Projet clôturé

Date de signature de la CE 17 Août 2022

Date de début 1 Mai 2022

Date de fin 31 Octobre 2025

Financé au titre de

• Health

Coût total

€ 10 496 136,50

Contribution de l’UE

€ 10 496 136,50

Coordonné par

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (21)

Travel surveillance network established

Integrated travel surveillance network established with new VOC reporting mechanism

Mutation prediction pipeline

Application of mutation prediction pipeline to assess transmissibility of all SARSCoV2 lineages including VOCs regularly and close to real time

Website
Mathematical transmission dynamic model update

Updated version of the mathematical model to include multiple variants applicability to all partner Cohorts

Data warehouse

Data warehouse and acquisition platform

Risk factors for long COVID

Initial analysis of risk factors for Long COVID by VOC

Data Management Plan (Interim version)

Updated data management plan

Biospecimen Handbook

Handbook for biospecimen collections

In vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

Development of in vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

DEC plan
Mechanism of VOC transmission using genetic models

Study on the mechanisms of transmission in VOCs and VOIs based on genetic models

Protocols/questionnaires

Common protocols with questionnaires and procedures for prospective data harmonization and retrospective data reconciliation

Data Management Plan (draft version)

A Data Management Plan DMP following the HE guidelines will address the relevant aspects of making data FAIR including what data the project will generate whether and how it will be made accessible for verification and reuse and how it will be curated and preserved The DMP will include details of the security technical and organisational measures to be taken in the context of the transfer of data from nonEU countries to prevent unauthorised access to personal data and safeguard the rights and freedoms of the data subjectsresearch participants

Data standards/harmonisation

Establish data standardisation and harmonisation processes

Sequencing pipeline optimisation completed

Optimise sequencing pipeline and provide support to cohorts

Infographics to disseminate key results

Infographics with key messages or results will be produced throughout the project

Risk factor for COVID and clinical outcome analysis protocol

Established protocol for analysis of risk factor and clinical outcome data

Central Code Repository

Central code repository, software documentation and versioning system

Best practice guidelines for governance structures and processes

Document outlining best practice for governance structures and processes to be used by the consortium

Impact Monitoring Framework

A framework to allow monitoring of impact

Cohort network and inclusion

Establish network and inclusion of population and clinical cohorts

Publications

Peer reviewed articles (33)

Exploring early COVID-19 therapies, variants, and viral clearance dynamics: Insights from a high-risk outpatients study

Auteurs: Marta Colaneri, Maddalena Matone, Federico Fassio, Alessia Lai, Annalisa Bergna, Carla della Ventura, Lucia Galli, Giovanni Scaglione, Andrea Gori, Monica Schiavini
Publié dans: Diagnostic Microbiology and Infectious Disease, Numéro 110, 2024, ISSN 0732-8893
Éditeur: Elsevier BV
DOI: 10.1016/J.DIAGMICROBIO.2024.116452

High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination

Auteurs: Rocío Rubio, Dídac Macià, Diana Barrios, Marta Vidal, Alfons Jiménez, Luis M. Molinos-Albert, Natalia Díaz, Mar Canyelles, Maria Lara-Escandell, Cyril Planchais, Pere Santamaria, Carlo Carolis, L
Publié dans: Microbes and Infection, Numéro 27, 2025, ISSN 1286-4579
Éditeur: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105423

The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews

Auteurs: Federico Fama, Rebecca Fattore, Paolo Raimondo, Fabio Brivio, Darcy Holmes, Toussaint Muheberimana, Tarek Nayfeh, Alessandra Bandera, Andrea Gori, Matteo Passerini, Marta Colaneri
Publié dans: Frontiers in Medicine, Numéro 12, 2025, ISSN 2296-858X
Éditeur: Frontiers Media SA
DOI: 10.3389/FMED.2025.1624459

Risk, determinants, and persistence of long-COVID in a population-based cohort study in Catalonia

Auteurs: Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Laura Delgado-Ortiz, Xavier Farré, Natàlia Blay, Neil Pearce, Magda Bosch de Basea, Eva Alonso N
Publié dans: BMC Medicine, Numéro 23, 2025, ISSN 1741-7015
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-03974-7

Occupational determinants of Long COVID in the population-based COVICAT cohort

Auteurs: Sara De Matteis, Dario Consonni, Ana Espinosa, Rafael de Cid, Natalia Blay Magriña, Gemma Castaño-Vinyals, Marianna Karachaliou, Miguel Angel Alba Hidalgo, Kyriaki Papantoniou, Judith Garcia, Manoli
Publié dans: Occupational and Environmental Medicine, 2025, ISSN 1351-0711
Éditeur: BMJ
DOI: 10.1136/OEMED-2025-110398

Effectiveness of COVID-19 vaccines against severe COVID-19 among patients with cancer in Catalonia, Spain

Auteurs: Felippe Lazar Neto, Núria Mercadé-Besora, Berta Raventós, Laura Pérez-Crespo, Gilberto Castro Junior, Otavio T. Ranzani, Talita Duarte-Salles
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-49285-Y

Integrating Statistical Methods and Machine Learning Techniques to Analyze and Classify COVID-19 Symptom Severity

Auteurs: Yaqeen Raddad, Ahmad Hasasneh, Obada Abdallah, Camil Rishmawi, Nouar Qutob
Publié dans: Big Data and Cognitive Computing, Numéro 8, 2025, ISSN 2504-2289
Éditeur: MDPI AG
DOI: 10.3390/BDCC8120192

Antibody responses to common viruses according to COVID‐19 severity and postacute sequelae of COVID‐19

Auteurs: Marianna Karachaliou, Otavio Ranzani, Ana Espinosa, Susana Iraola‐Guzmán, Gemma Castaño‐Vinyals, Marta Vidal, Alfons Jiménez, Marc Bañuls, Eva Alonso Nogués, Ruth Aguilar, Judith Garcia‐Aym
Publié dans: Journal of Medical Virology, Numéro 96, 2025, ISSN 0146-6615
Éditeur: Wiley
DOI: 10.1002/JMV.29862

Long-term outcomes of SARS-CoV-2 variants and other respiratory infections: evidence from the Virus Watch prospective cohort in England

Auteurs: Sarah Beale, Alexei Yavlinsky, Wing L. E. Fong, Vincent G. Nguyen, Jana Kovar, Theo Vos, Sarah Wulf Hanson, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Publié dans: Epidemiology and Infection, Numéro 152, 2024, ISSN 0950-2688
Éditeur: Cambridge University Press (CUP)
DOI: 10.1017/S0950268824000748

Anti-nucleocapsid and anti-spike antibody trajectories in people with post-covid condition versus acute-only infections: a nested longitudinal case-control study within the Virus Watch prospective coh

Auteurs: Sarah Beale, Alexei Yavlinsky, Gemma Moncunill, Wing Lam Erica Fong, Vincent Grigori Nguyen, Jana Kovar, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58766-7

EU’s Extraterritorial Obligations for Global Medicine Access Under the Convention on the Rights of Persons with Disability (CPRD)

Auteurs: Katrina Perehudoff
Publié dans: Journal of Law, Medicine & Ethics, Numéro 53, 2025, ISSN 1073-1105
Éditeur: Cambridge University Press (CUP)
DOI: 10.1017/JME.2025.10144

Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

Auteurs: Carla Martín Pérez, Sílvia Ruiz-Rius, Anna Ramírez-Morros, Marta Vidal, D. Herbert Opi, Pere Santamaria, Julià Blanco, Josep Vidal-Alaball, James G. Beeson, Luis M. Molinos-Albert, Ruth Aguilar,
Publié dans: Journal of Infection, Numéro 90, 2025, ISSN 0163-4453
Éditeur: Elsevier BV
DOI: 10.1016/J.JINF.2025.106473

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Auteurs: Tan, C.C.S., Trew, J., Peacock, T.P. et al.
Publié dans: Nature Communications, Numéro 14, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-023-38717-w

Prevalence, risk factors, and impact of long COVID in a socially vulnerable community in Brazil: a prospective cohort study

Auteurs: Pedro Azambuja, Leonardo S.L. Bastos, Amanda A. Batista-da-Silva, Grazielle Viana Ramos, Pedro Kurtz, Carolina M.C. Dias, Everton P. da Silva, Luna E. Arouca, Jesus Soares, James J. Sejvar, Louise Sig
Publié dans: The Lancet Regional Health - Americas, Numéro 37, 2024, ISSN 2667-193X
Éditeur: Elsevier BV
DOI: 10.1016/J.LANA.2024.100839

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Auteurs: Canuti M, Monti MC, Bobbio C, Muscatello A, Muheberimana T, Baldi SL, Blasi F, Canetta C, Costantino G, Nobili A, Peyvandi F, Tettamanti M, Villa S, Aliberti S, Raviglione MC, Gori A, Bandera A and COVID-19 Network Study Group
Publié dans: Frontiers in Medicine, Numéro Vol. 10, 2023, ISSN 2296-858X
Éditeur: Frontiers Media
DOI: 10.3389/fmed.2023.1260950

TB as a risk factor for severe COVID-19 mortality

Auteurs: I.C. Borges, F.M. Lino, A. Luna-Muschi, M.N. Litvoc, M.I.B.F. Lopes, H.R. Higashino, Á.F. da Costa, R.H.M. Pereira, H.I. Nakaya, J.D.A. de Araújo, G.M. Orlandi, M.J.P. Rújula, T.R.M.P. Carvalhanas,
Publié dans: The International Journal of Tuberculosis and Lung Disease, Numéro 29, 2025, ISSN 1027-3719
Éditeur: International Union Against Tuberculosis and Lung Disease
DOI: 10.5588/IJTLD.24.0503

Prognostic Significance of NLR and PLR in COVID-19: A Multi-Cohort Validation Study

Auteurs: Marta Colaneri, Camilla Genovese, Federico Fassio, Marta Canuti, Andrea Giacomelli, Anna Lisa Ridolfo, Erika Asperges, Giuseppe Albi, Raffaele Bruno, Spinello Antinori, Antonio Muscatello, Bianca Mari
Publié dans: Infectious Diseases and Therapy, Numéro 13, 2024, ISSN 2193-8229
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S40121-024-00967-6

Advancing vaccines justice through international regulatory pathways

Auteurs: Katrina Perehudoff, Pramiti Parwani, Seraphine Bruinsma
Publié dans: Global Public Health, Numéro 20, 2025, ISSN 1744-1692
Éditeur: Informa UK Limited
DOI: 10.1080/17441692.2025.2566730

Estimating the risk of post-COVID condition in deprived communities, migrants and ethnic minorities in England: findings from Virus Watch—a prospective community cohort study

Auteurs: Wing Lam Erica Fong, Sarah Beale, Vincent Nguyen, Jana Kovar, Alexei Yavlinsky, Andrew C Hayward, Ibrahim Abubakar, Sander MJ van Kuijk, Robert Aldridge
Publié dans: Journal of Epidemiology and Community Health, Numéro 80, 2026, ISSN 0143-005X
Éditeur: BMJ
DOI: 10.1136/JECH-2024-223491

Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later

Auteurs: Rocío Rubio, Alexei Yavlinsky, Marina Escalera Zamudio, Luis M. Molinos-Albert, Carla Martín Pérez, Edwards Pradenas, Mar Canyelles, Cèlia Torres, Cedric Tan, Leo Swadling, Anna Ramírez-Morros, B
Publié dans: Journal of Infection, Numéro 90, 2025, ISSN 0163-4453
Éditeur: Elsevier BV
DOI: 10.1016/J.JINF.2024.106402

Cohort Profile: Virus Watch—understanding community incidence, symptom profiles and transmission of COVID-19 in relation to population movement and behaviour

Auteurs: T. Byrne, J. Kovar, S. Beale, I. Braithwaite, E. Fragaszy, W. L. E. Fong, C. Geismar, S. Hoskins, A. M D Navaratnam, V. Nguyen, P. Patel, M. Shrotri, A. Yavlinsky, P. Hardelid, L. Wijlaars, E. Nastouli, M. Spyer, A. Aryee, I. Cox, ..., R. W Aldridge
Publié dans: International Journal of Epidemiology, Numéro Vol.10, Numéro 5, 2023, ISSN 1464-3685
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyad087

VEGFA sex-specific signature is associated to long COVID symptom persistence

Auteurs: Xavier Farré, Natalia Blay, Susana Iraola-Guzmán, Francisco Fernández-Jiménez, Sayoa Alzate-Piñol, Laia Llucià-Carol, Ana Espinosa, Gemma Castaño-Vinyals, Carlota Dobaño, Gemma Moncunill, Mari
Publié dans: BMC Medicine, Numéro 23, 2025, ISSN 1741-7015
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-04402-6

Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection

Auteurs: Carla Martín Pérez, Anna Ramírez-Morros, Alfons Jiménez, Marta Vidal, Edwards Pradenas, Diana Barrios, Mar Canyelles, Rocío Rubio, Inocencia Cuamba, Luis Izquierdo, Pere Santamaria, Benjamin Trin
Publié dans: Communications Medicine, Numéro 5, 2025, ISSN 2730-664X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S43856-025-00943-2

The burden, clinical features and outcomes of SARS-CoV-2, Influenza and co-infections during concurrently out-of-season outbreaks in Brazil

Auteurs: Tarsila Vieceli, Julio Croda, Leonardo S.L. Bastos, Fernando A. Bozza, Otavio T. Ranzani
Publié dans: Public Health, Numéro 238, 2025, ISSN 0033-3506
Éditeur: Elsevier BV
DOI: 10.1016/J.PUHE.2024.10.016

Environmental Exposures and Long COVID in a Prospective Population-Based Study in Catalonia (COVICAT Study)

Auteurs: Apolline Saucy, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Barbara N. Harding, Marianna Karachaliou, Otavio Ranzani, Rafael De Cid, Judith Garcia-Aymerich, Manolis Kogevinas
Publié dans: Environmental Health Perspectives, Numéro 132, 2024, ISSN 0091-6765
Éditeur: Environmental Health Perspectives
DOI: 10.1289/EHP15377

Malaria and other infections induce polyreactive antibodies that impact SARS‐CoV‐2 seropositivity estimations in endemic settings

Auteurs: Ruth Aguilar, Alfons Jiménez, Rebeca Santano, Marta Vidal, Oumou Maiga‐Ascofare, Ricardo Strauss, Joseph Bonney, Melvin Agbogbatey, Odin Goovaerts, Eric E. A. Boham, Evan A. Adu, Inocencia Cuamba,
Publié dans: Journal of Medical Virology, Numéro 96, 2025, ISSN 0146-6615
Éditeur: Wiley
DOI: 10.1002/JMV.29713

Impact of early antiviral therapy on SARS-CoV-2 clearance time in high-risk COVID-19 subjects: A propensity score matching study

Auteurs: Marta Colaneri, Federico Fama, Federico Fassio, Darcy Holmes, Giovanni Scaglione, Chiara Mariani, Lucia Galli, Alessia Lai, Spinello Antinori, Andrea Gori, Agostino Riva, Monica Schiavini
Publié dans: International Journal of Infectious Diseases, Numéro 149, 2025, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/J.IJID.2024.107265

Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination

Auteurs: Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamar
Publié dans: BMC Medicine, Numéro 22, 2024, ISSN 1741-7015
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12916-024-03304-3

Mpox global emergency: strengthening African leadership

Auteurs: Ibrahim Abubakar, Julius Lutwama, Catherine Kyobutungi, Osman Sankoh
Publié dans: The Lancet, Numéro 404, 2024, ISSN 0140-6736
Éditeur: Elsevier BV
DOI: 10.1016/S0140-6736(24)02068-3EXTERNALLINK

The evolutionary drivers and correlates of viral host jumps

Auteurs: Cedric C. S. Tan, Lucy van Dorp, Francois Balloux
Publié dans: Nature Ecology & Evolution, Numéro 8, 2024, ISSN 2397-334X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41559-024-02353-4

Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic

Auteurs: Luis M. Molinos-Albert, Rocío Rubio, Carla Martín-Pérez, Edwards Pradenas, Cèlia Torres, Alfons Jiménez, Mar Canyelles, Marta Vidal, Diana Barrios, Silvia Marfil, Ester Aparicio, Anna Ramírez-Mo
Publié dans: Cell Reports, Numéro 44, 2025, ISSN 2211-1247
Éditeur: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115498

Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach

Auteurs: Darcy Holmes, Marta Colaneri, Emanuele Palomba, Andrea Gori
Publié dans: Frontiers in Medicine, Numéro 10, 2024, ISSN 2296-858X
Éditeur: Frontiers Media
DOI: 10.3389/fmed.2023.1280951

Estimating long COVID-19 prevalence across definitions and forms of sample selection

Auteurs: Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Alessandra Bandera, Andrea Gori, Amedeo Ferdinando Capetti
Publié dans: Frontiers in Epidemiology, Numéro 5, 2025, ISSN 2674-1199
Éditeur: Frontiers Media SA
DOI: 10.3389/FEPID.2025.1597799