ENDING COVID 19 VARIANTS OF CONCERN THROUGH COHORT STUDIES: END-VOC

Informazioni relative al progetto

END-VOC

ID dell’accordo di sovvenzione: 101046314

DOI

10.3030/101046314

Progetto chiuso

Data della firma CE 17 Agosto 2022

Data di avvio 1 Maggio 2022

Data di completamento 30 Aprile 2025

Finanziato da

• Health

Costo totale

€ 10 496 136,51

Contributo UE

€ 10 496 136,50

Coordinato da

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (21)

Travel surveillance network established

Integrated travel surveillance network established with new VOC reporting mechanism

Mutation prediction pipeline

Application of mutation prediction pipeline to assess transmissibility of all SARSCoV2 lineages including VOCs regularly and close to real time

Website
Mathematical transmission dynamic model update

Updated version of the mathematical model to include multiple variants applicability to all partner Cohorts

Data warehouse

Data warehouse and acquisition platform

Risk factors for long COVID

Initial analysis of risk factors for Long COVID by VOC

Data Management Plan (Interim version)

Updated data management plan

Biospecimen Handbook

Handbook for biospecimen collections

In vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

Development of in vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

DEC plan
Mechanism of VOC transmission using genetic models

Study on the mechanisms of transmission in VOCs and VOIs based on genetic models

Protocols/questionnaires

Common protocols with questionnaires and procedures for prospective data harmonization and retrospective data reconciliation

Data Management Plan (draft version)

A Data Management Plan DMP following the HE guidelines will address the relevant aspects of making data FAIR including what data the project will generate whether and how it will be made accessible for verification and reuse and how it will be curated and preserved The DMP will include details of the security technical and organisational measures to be taken in the context of the transfer of data from nonEU countries to prevent unauthorised access to personal data and safeguard the rights and freedoms of the data subjectsresearch participants

Data standards/harmonisation

Establish data standardisation and harmonisation processes

Sequencing pipeline optimisation completed

Optimise sequencing pipeline and provide support to cohorts

Infographics to disseminate key results

Infographics with key messages or results will be produced throughout the project

Risk factor for COVID and clinical outcome analysis protocol

Established protocol for analysis of risk factor and clinical outcome data

Central Code Repository

Central code repository, software documentation and versioning system

Best practice guidelines for governance structures and processes

Document outlining best practice for governance structures and processes to be used by the consortium

Impact Monitoring Framework

A framework to allow monitoring of impact

Cohort network and inclusion

Establish network and inclusion of population and clinical cohorts

Pubblicazioni

Peer reviewed articles (4)

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Autori: Tan, C.C.S., Trew, J., Peacock, T.P. et al.
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38717-w

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Autori: Canuti M, Monti MC, Bobbio C, Muscatello A, Muheberimana T, Baldi SL, Blasi F, Canetta C, Costantino G, Nobili A, Peyvandi F, Tettamanti M, Villa S, Aliberti S, Raviglione MC, Gori A, Bandera A and COVID-19 Network Study Group
Pubblicato in: Frontiers in Medicine, Numero Vol. 10, 2023, ISSN 2296-858X
Editore: Frontiers Media
DOI: 10.3389/fmed.2023.1260950

Cohort Profile: Virus Watch—understanding community incidence, symptom profiles and transmission of COVID-19 in relation to population movement and behaviour

Autori: T. Byrne, J. Kovar, S. Beale, I. Braithwaite, E. Fragaszy, W. L. E. Fong, C. Geismar, S. Hoskins, A. M D Navaratnam, V. Nguyen, P. Patel, M. Shrotri, A. Yavlinsky, P. Hardelid, L. Wijlaars, E. Nastouli, M. Spyer, A. Aryee, I. Cox, ..., R. W Aldridge
Pubblicato in: International Journal of Epidemiology, Numero Vol.10, Numero 5, 2023, ISSN 1464-3685
Editore: Oxford University Press
DOI: 10.1093/ije/dyad087

Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach

Autori: Darcy Holmes, Marta Colaneri, Emanuele Palomba, Andrea Gori
Pubblicato in: Frontiers in Medicine, Numero 10, 2024, ISSN 2296-858X
Editore: Frontiers Media
DOI: 10.3389/fmed.2023.1280951