ENDING COVID 19 VARIANTS OF CONCERN THROUGH COHORT STUDIES: END-VOC

Informazioni relative al progetto

END-VOC

ID dell’accordo di sovvenzione: 101046314

DOI

10.3030/101046314

Progetto chiuso

Data della firma CE 17 Agosto 2022

Data di avvio 1 Maggio 2022

Data di completamento 31 Ottobre 2025

Finanziato da

• Health

Costo totale

€ 10 496 136,50

Contributo UE

€ 10 496 136,50

Coordinato da

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (52)

Travel surveillance network established

Integrated travel surveillance network established with new VOC reporting mechanism

Mutation prediction pipeline

Application of mutation prediction pipeline to assess transmissibility of all SARSCoV2 lineages including VOCs regularly and close to real time

ReCoDID and END-VOC roadmap

Roadmap based on collaboration with ReCoDID showing how prospective data collection can be designed, structured and communicated to maximise the coherence and harmonisation capabilities both across communities and across future and past cohort data.

Access/efficacy of treatment by VOC

Report on accessibility and efficacy of available treatment strategies and options by VOC

Website
Risk communication guidelines to inform future pandemics

Guidelines for risk communication strategies for future pandemics

IC Risk

Quantification of risk for IC groups of patients

Mathematical transmission dynamic model update

Updated version of the mathematical model to include multiple variants applicability to all partner Cohorts

Predictors for long COVID outcome

Predictors of outcome of Long COVID by VOC

Data warehouse

Data warehouse and acquisition platform

Portability assessment report

Assess portability of method to other pathogen genomic datasets

Risk factors for long COVID

Initial analysis of risk factors for Long COVID by VOC

Predictors of favourable outcome by VOC

Report on predictors of favourable outcome disaggregated by VOCs and VOIs

Staff Exchange visits

Report on Staff Exchange visits and Knowledge sharing outcomes

Data Management Plan (Interim version)

Updated data management plan

Mathematical transmission dynamic model calibration

Calibration of the mathematical model for selected partner countries/settings including estimates of basic reproduction number for the most important VOC and VOI

Biospecimen Handbook

Handbook for biospecimen collections

Economic costs and impact of VOCs report

Report on economic cost of pandemics and impact of VOCs

Strategic recommendations for future epidemics and pandemic

Policy paper

Vaccine effectiveness for new VOCs and/or for second generations vaccines

Report on effectiveness of COVID-19 vaccines against new VOCs/VOIs and/or evaluation of second generation vaccines

Data Management Plan (Final version)

Final version of the data management plan

Evaluating the accuracy of machine learning algorithms

Estimate measures of accuracy including where appropriate sensitivity, specificity, positive predictive value, Area Under the Curve (AUC) and Receiver Characteristic Operator (ROC)

In vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

Development of in vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

DEC plan
Host evolution analysis

Report on propensity of within host evolution during chronic infections to give rise to features characteristic of VOCs

Legal guidance to support effective consortium -wide data and privacy arrangements

Legal guidance document related to data security, protection, privacy and arrangements for data sharing and pooling

Regulatory regimes publication

Peer-reviewed paper on regulatory regimes

Report on inter-laboratory exercises

Report with results of the inter-laboratory exercises

Public opinions publications

Peer-reviewed paper on public opinions

Mechanism of VOC transmission using genetic models

Study on the mechanisms of transmission in VOCs and VOIs based on genetic models

Genomic epidemiology by VOC

Genomic epidemiology study of transmission dynamics of VOCs based on community, travel associated, and sentinel surveillance

Protocols/questionnaires

Common protocols with questionnaires and procedures for prospective data harmonization and retrospective data reconciliation

Data Management Plan (draft version)

A Data Management Plan DMP following the HE guidelines will address the relevant aspects of making data FAIR including what data the project will generate whether and how it will be made accessible for verification and reuse and how it will be curated and preserved The DMP will include details of the security technical and organisational measures to be taken in the context of the transfer of data from nonEU countries to prevent unauthorised access to personal data and safeguard the rights and freedoms of the data subjectsresearch participants

Data standards/harmonisation

Establish data standardisation and harmonisation processes

Sequencing pipeline optimisation completed

Optimise sequencing pipeline and provide support to cohorts

Virtual Biobank directory

END-VOC biobank samples in Virtual Biobank Directory

Infographics to disseminate key results

Infographics with key messages or results will be produced throughout the project

Best governance practice guidelines for existing and future cohorts

Scientific publication on best governance practices for cohort consortia

Risk factor for COVID and clinical outcome analysis protocol

Established protocol for analysis of risk factor and clinical outcome data

Central Code Repository

Central code repository, software documentation and versioning system

Vaccine induced antibody by VOC

Report on vaccine induced antibody, neutralising and cellular immune responses against VOCs/VOIs

Data analytics guidance

Data analytics guidance documents tailored to COVID-19 cohorts

Best practice guidelines for governance structures and processes

Document outlining best practice for governance structures and processes to be used by the consortium

Global health threat agenda and recommendations

Research agenda and plan for global health threats

Long COVID Burden and Impact

Report on the burden of disease and socioeconomic impact of long COVID

Policy briefs summarising key recommendations

Policy briefs for enhancing translation of evidence into policies will be produced throughout the project

Clinical protocol recommendations for future threats

Recommendations for clinical protocol formulation for future infectious threats

Report on the results of the Bioinformatics pipeline

Bioinformatics pipeline, building on established workflows, supporting lineage characterisation, mutation profiling and identification of new variants, released to all cohorts

Impact Monitoring Framework

A framework to allow monitoring of impact

Immune response kinetics

Report on kinetics of immune responses and correlates of protection analyses

Cohort network and inclusion

Establish network and inclusion of population and clinical cohorts

New VOC / VOI reported to partner cohorts and public health authorities

Feedback newly detected candidate VOC/VOI to partner cohorts for integrated surveillance and study of the clinical impact

Pubblicazioni

Peer reviewed articles (34)

Exploring early COVID-19 therapies, variants, and viral clearance dynamics: Insights from a high-risk outpatients study

Autori: Marta Colaneri, Maddalena Matone, Federico Fassio, Alessia Lai, Annalisa Bergna, Carla della Ventura, Lucia Galli, Giovanni Scaglione, Andrea Gori, Monica Schiavini
Pubblicato in: Diagnostic Microbiology and Infectious Disease, Numero 110, 2024, ISSN 0732-8893
Editore: Elsevier BV
DOI: 10.1016/J.DIAGMICROBIO.2024.116452

High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination

Autori: Rocío Rubio, Dídac Macià, Diana Barrios, Marta Vidal, Alfons Jiménez, Luis M. Molinos-Albert, Natalia Díaz, Mar Canyelles, Maria Lara-Escandell, Cyril Planchais, Pere Santamaria, Carlo Carolis, L
Pubblicato in: Microbes and Infection, Numero 27, 2025, ISSN 1286-4579
Editore: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105423

The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews

Autori: Federico Fama, Rebecca Fattore, Paolo Raimondo, Fabio Brivio, Darcy Holmes, Toussaint Muheberimana, Tarek Nayfeh, Alessandra Bandera, Andrea Gori, Matteo Passerini, Marta Colaneri
Pubblicato in: Frontiers in Medicine, Numero 12, 2025, ISSN 2296-858X
Editore: Frontiers Media SA
DOI: 10.3389/FMED.2025.1624459

Risk, determinants, and persistence of long-COVID in a population-based cohort study in Catalonia

Autori: Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Laura Delgado-Ortiz, Xavier Farré, Natàlia Blay, Neil Pearce, Magda Bosch de Basea, Eva Alonso N
Pubblicato in: BMC Medicine, Numero 23, 2025, ISSN 1741-7015
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-03974-7

Occupational determinants of Long COVID in the population-based COVICAT cohort

Autori: Sara De Matteis, Dario Consonni, Ana Espinosa, Rafael de Cid, Natalia Blay Magriña, Gemma Castaño-Vinyals, Marianna Karachaliou, Miguel Angel Alba Hidalgo, Kyriaki Papantoniou, Judith Garcia, Manoli
Pubblicato in: Occupational and Environmental Medicine, 2025, ISSN 1351-0711
Editore: BMJ
DOI: 10.1136/OEMED-2025-110398

Effectiveness of COVID-19 vaccines against severe COVID-19 among patients with cancer in Catalonia, Spain

Autori: Felippe Lazar Neto, Núria Mercadé-Besora, Berta Raventós, Laura Pérez-Crespo, Gilberto Castro Junior, Otavio T. Ranzani, Talita Duarte-Salles
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-49285-Y

Integrating Statistical Methods and Machine Learning Techniques to Analyze and Classify COVID-19 Symptom Severity

Autori: Yaqeen Raddad, Ahmad Hasasneh, Obada Abdallah, Camil Rishmawi, Nouar Qutob
Pubblicato in: Big Data and Cognitive Computing, Numero 8, 2025, ISSN 2504-2289
Editore: MDPI AG
DOI: 10.3390/BDCC8120192

Antibody responses to common viruses according to COVID‐19 severity and postacute sequelae of COVID‐19

Autori: Marianna Karachaliou, Otavio Ranzani, Ana Espinosa, Susana Iraola‐Guzmán, Gemma Castaño‐Vinyals, Marta Vidal, Alfons Jiménez, Marc Bañuls, Eva Alonso Nogués, Ruth Aguilar, Judith Garcia‐Aym
Pubblicato in: Journal of Medical Virology, Numero 96, 2025, ISSN 0146-6615
Editore: Wiley
DOI: 10.1002/JMV.29862

Long-term outcomes of SARS-CoV-2 variants and other respiratory infections: evidence from the Virus Watch prospective cohort in England

Autori: Sarah Beale, Alexei Yavlinsky, Wing L. E. Fong, Vincent G. Nguyen, Jana Kovar, Theo Vos, Sarah Wulf Hanson, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Pubblicato in: Epidemiology and Infection, Numero 152, 2024, ISSN 0950-2688
Editore: Cambridge University Press (CUP)
DOI: 10.1017/S0950268824000748

Anti-nucleocapsid and anti-spike antibody trajectories in people with post-covid condition versus acute-only infections: a nested longitudinal case-control study within the Virus Watch prospective coh

Autori: Sarah Beale, Alexei Yavlinsky, Gemma Moncunill, Wing Lam Erica Fong, Vincent Grigori Nguyen, Jana Kovar, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58766-7

EU’s Extraterritorial Obligations for Global Medicine Access Under the Convention on the Rights of Persons with Disability (CPRD)

Autori: Katrina Perehudoff
Pubblicato in: Journal of Law, Medicine & Ethics, Numero 53, 2025, ISSN 1073-1105
Editore: Cambridge University Press (CUP)
DOI: 10.1017/JME.2025.10144

Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

Autori: Carla Martín Pérez, Sílvia Ruiz-Rius, Anna Ramírez-Morros, Marta Vidal, D. Herbert Opi, Pere Santamaria, Julià Blanco, Josep Vidal-Alaball, James G. Beeson, Luis M. Molinos-Albert, Ruth Aguilar,
Pubblicato in: Journal of Infection, Numero 90, 2025, ISSN 0163-4453
Editore: Elsevier BV
DOI: 10.1016/J.JINF.2025.106473

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Autori: Tan, C.C.S., Trew, J., Peacock, T.P. et al.
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-023-38717-w

Prevalence, risk factors, and impact of long COVID in a socially vulnerable community in Brazil: a prospective cohort study

Autori: Pedro Azambuja, Leonardo S.L. Bastos, Amanda A. Batista-da-Silva, Grazielle Viana Ramos, Pedro Kurtz, Carolina M.C. Dias, Everton P. da Silva, Luna E. Arouca, Jesus Soares, James J. Sejvar, Louise Sig
Pubblicato in: The Lancet Regional Health - Americas, Numero 37, 2024, ISSN 2667-193X
Editore: Elsevier BV
DOI: 10.1016/J.LANA.2024.100839

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Autori: Canuti M, Monti MC, Bobbio C, Muscatello A, Muheberimana T, Baldi SL, Blasi F, Canetta C, Costantino G, Nobili A, Peyvandi F, Tettamanti M, Villa S, Aliberti S, Raviglione MC, Gori A, Bandera A and COVID-19 Network Study Group
Pubblicato in: Frontiers in Medicine, Numero Vol. 10, 2023, ISSN 2296-858X
Editore: Frontiers Media
DOI: 10.3389/fmed.2023.1260950

TB as a risk factor for severe COVID-19 mortality

Autori: I.C. Borges, F.M. Lino, A. Luna-Muschi, M.N. Litvoc, M.I.B.F. Lopes, H.R. Higashino, Á.F. da Costa, R.H.M. Pereira, H.I. Nakaya, J.D.A. de Araújo, G.M. Orlandi, M.J.P. Rújula, T.R.M.P. Carvalhanas,
Pubblicato in: The International Journal of Tuberculosis and Lung Disease, Numero 29, 2025, ISSN 1027-3719
Editore: International Union Against Tuberculosis and Lung Disease
DOI: 10.5588/IJTLD.24.0503

Prognostic Significance of NLR and PLR in COVID-19: A Multi-Cohort Validation Study

Autori: Marta Colaneri, Camilla Genovese, Federico Fassio, Marta Canuti, Andrea Giacomelli, Anna Lisa Ridolfo, Erika Asperges, Giuseppe Albi, Raffaele Bruno, Spinello Antinori, Antonio Muscatello, Bianca Mari
Pubblicato in: Infectious Diseases and Therapy, Numero 13, 2024, ISSN 2193-8229
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S40121-024-00967-6

Advancing vaccines justice through international regulatory pathways

Autori: Katrina Perehudoff, Pramiti Parwani, Seraphine Bruinsma
Pubblicato in: Global Public Health, Numero 20, 2025, ISSN 1744-1692
Editore: Informa UK Limited
DOI: 10.1080/17441692.2025.2566730

Estimating the risk of post-COVID condition in deprived communities, migrants and ethnic minorities in England: findings from Virus Watch—a prospective community cohort study

Autori: Wing Lam Erica Fong, Sarah Beale, Vincent Nguyen, Jana Kovar, Alexei Yavlinsky, Andrew C Hayward, Ibrahim Abubakar, Sander MJ van Kuijk, Robert Aldridge
Pubblicato in: Journal of Epidemiology and Community Health, Numero 80, 2026, ISSN 0143-005X
Editore: BMJ
DOI: 10.1136/JECH-2024-223491

Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later

Autori: Rocío Rubio, Alexei Yavlinsky, Marina Escalera Zamudio, Luis M. Molinos-Albert, Carla Martín Pérez, Edwards Pradenas, Mar Canyelles, Cèlia Torres, Cedric Tan, Leo Swadling, Anna Ramírez-Morros, B
Pubblicato in: Journal of Infection, Numero 90, 2025, ISSN 0163-4453
Editore: Elsevier BV
DOI: 10.1016/J.JINF.2024.106402

Cohort Profile: Virus Watch—understanding community incidence, symptom profiles and transmission of COVID-19 in relation to population movement and behaviour

Autori: T. Byrne, J. Kovar, S. Beale, I. Braithwaite, E. Fragaszy, W. L. E. Fong, C. Geismar, S. Hoskins, A. M D Navaratnam, V. Nguyen, P. Patel, M. Shrotri, A. Yavlinsky, P. Hardelid, L. Wijlaars, E. Nastouli, M. Spyer, A. Aryee, I. Cox, ..., R. W Aldridge
Pubblicato in: International Journal of Epidemiology, Numero Vol.10, Numero 5, 2023, ISSN 1464-3685
Editore: Oxford University Press
DOI: 10.1093/ije/dyad087

Primary SARS-CoV-2 exposure by vaccination or infection shapes immune responses to omicron variants among a Spanish cohort

Autori: Otavio Ranzani, Carla Martín Pérez, Rocío Rubio, Anna Ramírez-Morros, Alfons Jimenez, Marta Vidal, Mar Canyelles, Cèlia Torres, Diana Barrios, Inocencia Cuamba, Pere Santamaria, Pau Serra, Luis Izquierdo, Josep Vidal-Alaball, Luis M. Molinos-Albert, Ruth Aguilar, Anna Ruiz-Comellas, Gemma Moncunill, Carlota Dobaño
Pubblicato in: Nature Communications, Numero 17, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67577-9

VEGFA sex-specific signature is associated to long COVID symptom persistence

Autori: Xavier Farré, Natalia Blay, Susana Iraola-Guzmán, Francisco Fernández-Jiménez, Sayoa Alzate-Piñol, Laia Llucià-Carol, Ana Espinosa, Gemma Castaño-Vinyals, Carlota Dobaño, Gemma Moncunill, Mari
Pubblicato in: BMC Medicine, Numero 23, 2025, ISSN 1741-7015
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-04402-6

Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection

Autori: Carla Martín Pérez, Anna Ramírez-Morros, Alfons Jiménez, Marta Vidal, Edwards Pradenas, Diana Barrios, Mar Canyelles, Rocío Rubio, Inocencia Cuamba, Luis Izquierdo, Pere Santamaria, Benjamin Trin
Pubblicato in: Communications Medicine, Numero 5, 2025, ISSN 2730-664X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S43856-025-00943-2

The burden, clinical features and outcomes of SARS-CoV-2, Influenza and co-infections during concurrently out-of-season outbreaks in Brazil

Autori: Tarsila Vieceli, Julio Croda, Leonardo S.L. Bastos, Fernando A. Bozza, Otavio T. Ranzani
Pubblicato in: Public Health, Numero 238, 2025, ISSN 0033-3506
Editore: Elsevier BV
DOI: 10.1016/J.PUHE.2024.10.016

Environmental Exposures and Long COVID in a Prospective Population-Based Study in Catalonia (COVICAT Study)

Autori: Apolline Saucy, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Barbara N. Harding, Marianna Karachaliou, Otavio Ranzani, Rafael De Cid, Judith Garcia-Aymerich, Manolis Kogevinas
Pubblicato in: Environmental Health Perspectives, Numero 132, 2024, ISSN 0091-6765
Editore: Environmental Health Perspectives
DOI: 10.1289/EHP15377

Malaria and other infections induce polyreactive antibodies that impact SARS‐CoV‐2 seropositivity estimations in endemic settings

Autori: Ruth Aguilar, Alfons Jiménez, Rebeca Santano, Marta Vidal, Oumou Maiga‐Ascofare, Ricardo Strauss, Joseph Bonney, Melvin Agbogbatey, Odin Goovaerts, Eric E. A. Boham, Evan A. Adu, Inocencia Cuamba,
Pubblicato in: Journal of Medical Virology, Numero 96, 2025, ISSN 0146-6615
Editore: Wiley
DOI: 10.1002/JMV.29713

Impact of early antiviral therapy on SARS-CoV-2 clearance time in high-risk COVID-19 subjects: A propensity score matching study

Autori: Marta Colaneri, Federico Fama, Federico Fassio, Darcy Holmes, Giovanni Scaglione, Chiara Mariani, Lucia Galli, Alessia Lai, Spinello Antinori, Andrea Gori, Agostino Riva, Monica Schiavini
Pubblicato in: International Journal of Infectious Diseases, Numero 149, 2025, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2024.107265

Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination

Autori: Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamar
Pubblicato in: BMC Medicine, Numero 22, 2024, ISSN 1741-7015
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12916-024-03304-3

Mpox global emergency: strengthening African leadership

Autori: Ibrahim Abubakar, Julius Lutwama, Catherine Kyobutungi, Osman Sankoh
Pubblicato in: The Lancet, Numero 404, 2024, ISSN 0140-6736
Editore: Elsevier BV
DOI: 10.1016/S0140-6736(24)02068-3EXTERNALLINK

The evolutionary drivers and correlates of viral host jumps

Autori: Cedric C. S. Tan, Lucy van Dorp, Francois Balloux
Pubblicato in: Nature Ecology & Evolution, Numero 8, 2024, ISSN 2397-334X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41559-024-02353-4

Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic

Autori: Luis M. Molinos-Albert, Rocío Rubio, Carla Martín-Pérez, Edwards Pradenas, Cèlia Torres, Alfons Jiménez, Mar Canyelles, Marta Vidal, Diana Barrios, Silvia Marfil, Ester Aparicio, Anna Ramírez-Mo
Pubblicato in: Cell Reports, Numero 44, 2025, ISSN 2211-1247
Editore: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115498

Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach

Autori: Darcy Holmes, Marta Colaneri, Emanuele Palomba, Andrea Gori
Pubblicato in: Frontiers in Medicine, Numero 10, 2024, ISSN 2296-858X
Editore: Frontiers Media
DOI: 10.3389/fmed.2023.1280951

Estimating long COVID-19 prevalence across definitions and forms of sample selection

Autori: Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Alessandra Bandera, Andrea Gori, Amedeo Ferdinando Capetti
Pubblicato in: Frontiers in Epidemiology, Numero 5, 2025, ISSN 2674-1199
Editore: Frontiers Media SA
DOI: 10.3389/FEPID.2025.1597799