ENDING COVID 19 VARIANTS OF CONCERN THROUGH COHORT STUDIES: END-VOC

Informacje na temat projektu

END-VOC

Identyfikator umowy o grant: 101046314

DOI

10.3030/101046314

Projekt został zamknięty

Data podpisania przez KE 17 Sierpnia 2022

Data rozpoczęcia 1 Maja 2022

Data zakończenia 31 Października 2025

Finansowanie w ramach

• Health

Koszt całkowity

€ 10 496 136,50

Wkład UE

€ 10 496 136,50

Koordynowany przez

UNIVERSITY COLLEGE LONDON
United Kingdom

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (21)

Travel surveillance network established

Integrated travel surveillance network established with new VOC reporting mechanism

Mutation prediction pipeline

Application of mutation prediction pipeline to assess transmissibility of all SARSCoV2 lineages including VOCs regularly and close to real time

Website
Mathematical transmission dynamic model update

Updated version of the mathematical model to include multiple variants applicability to all partner Cohorts

Data warehouse

Data warehouse and acquisition platform

Risk factors for long COVID

Initial analysis of risk factors for Long COVID by VOC

Data Management Plan (Interim version)

Updated data management plan

Biospecimen Handbook

Handbook for biospecimen collections

In vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

Development of in vitro SARS-CoV-2 model of various VOCs for antiviral screening studies

DEC plan
Mechanism of VOC transmission using genetic models

Study on the mechanisms of transmission in VOCs and VOIs based on genetic models

Protocols/questionnaires

Common protocols with questionnaires and procedures for prospective data harmonization and retrospective data reconciliation

Data Management Plan (draft version)

A Data Management Plan DMP following the HE guidelines will address the relevant aspects of making data FAIR including what data the project will generate whether and how it will be made accessible for verification and reuse and how it will be curated and preserved The DMP will include details of the security technical and organisational measures to be taken in the context of the transfer of data from nonEU countries to prevent unauthorised access to personal data and safeguard the rights and freedoms of the data subjectsresearch participants

Data standards/harmonisation

Establish data standardisation and harmonisation processes

Sequencing pipeline optimisation completed

Optimise sequencing pipeline and provide support to cohorts

Infographics to disseminate key results

Infographics with key messages or results will be produced throughout the project

Risk factor for COVID and clinical outcome analysis protocol

Established protocol for analysis of risk factor and clinical outcome data

Central Code Repository

Central code repository, software documentation and versioning system

Best practice guidelines for governance structures and processes

Document outlining best practice for governance structures and processes to be used by the consortium

Impact Monitoring Framework

A framework to allow monitoring of impact

Cohort network and inclusion

Establish network and inclusion of population and clinical cohorts

Publikacje

Peer reviewed articles (33)

Exploring early COVID-19 therapies, variants, and viral clearance dynamics: Insights from a high-risk outpatients study

Autorzy: Marta Colaneri, Maddalena Matone, Federico Fassio, Alessia Lai, Annalisa Bergna, Carla della Ventura, Lucia Galli, Giovanni Scaglione, Andrea Gori, Monica Schiavini
Opublikowane w: Diagnostic Microbiology and Infectious Disease, Numer 110, 2024, ISSN 0732-8893
Wydawca: Elsevier BV
DOI: 10.1016/J.DIAGMICROBIO.2024.116452

High-resolution kinetics and cellular determinants of SARS-CoV-2 antibody response over two years after COVID-19 vaccination

Autorzy: Rocío Rubio, Dídac Macià, Diana Barrios, Marta Vidal, Alfons Jiménez, Luis M. Molinos-Albert, Natalia Díaz, Mar Canyelles, Maria Lara-Escandell, Cyril Planchais, Pere Santamaria, Carlo Carolis, L
Opublikowane w: Microbes and Infection, Numer 27, 2025, ISSN 1286-4579
Wydawca: Elsevier BV
DOI: 10.1016/J.MICINF.2024.105423

The impact of SARS-CoV-2 VOCs on clinical outcomes: an overview of reviews

Autorzy: Federico Fama, Rebecca Fattore, Paolo Raimondo, Fabio Brivio, Darcy Holmes, Toussaint Muheberimana, Tarek Nayfeh, Alessandra Bandera, Andrea Gori, Matteo Passerini, Marta Colaneri
Opublikowane w: Frontiers in Medicine, Numer 12, 2025, ISSN 2296-858X
Wydawca: Frontiers Media SA
DOI: 10.3389/FMED.2025.1624459

Risk, determinants, and persistence of long-COVID in a population-based cohort study in Catalonia

Autorzy: Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Laura Delgado-Ortiz, Xavier Farré, Natàlia Blay, Neil Pearce, Magda Bosch de Basea, Eva Alonso N
Opublikowane w: BMC Medicine, Numer 23, 2025, ISSN 1741-7015
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-03974-7

Occupational determinants of Long COVID in the population-based COVICAT cohort

Autorzy: Sara De Matteis, Dario Consonni, Ana Espinosa, Rafael de Cid, Natalia Blay Magriña, Gemma Castaño-Vinyals, Marianna Karachaliou, Miguel Angel Alba Hidalgo, Kyriaki Papantoniou, Judith Garcia, Manoli
Opublikowane w: Occupational and Environmental Medicine, 2025, ISSN 1351-0711
Wydawca: BMJ
DOI: 10.1136/OEMED-2025-110398

Effectiveness of COVID-19 vaccines against severe COVID-19 among patients with cancer in Catalonia, Spain

Autorzy: Felippe Lazar Neto, Núria Mercadé-Besora, Berta Raventós, Laura Pérez-Crespo, Gilberto Castro Junior, Otavio T. Ranzani, Talita Duarte-Salles
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-49285-Y

Integrating Statistical Methods and Machine Learning Techniques to Analyze and Classify COVID-19 Symptom Severity

Autorzy: Yaqeen Raddad, Ahmad Hasasneh, Obada Abdallah, Camil Rishmawi, Nouar Qutob
Opublikowane w: Big Data and Cognitive Computing, Numer 8, 2025, ISSN 2504-2289
Wydawca: MDPI AG
DOI: 10.3390/BDCC8120192

Antibody responses to common viruses according to COVID‐19 severity and postacute sequelae of COVID‐19

Autorzy: Marianna Karachaliou, Otavio Ranzani, Ana Espinosa, Susana Iraola‐Guzmán, Gemma Castaño‐Vinyals, Marta Vidal, Alfons Jiménez, Marc Bañuls, Eva Alonso Nogués, Ruth Aguilar, Judith Garcia‐Aym
Opublikowane w: Journal of Medical Virology, Numer 96, 2025, ISSN 0146-6615
Wydawca: Wiley
DOI: 10.1002/JMV.29862

Long-term outcomes of SARS-CoV-2 variants and other respiratory infections: evidence from the Virus Watch prospective cohort in England

Autorzy: Sarah Beale, Alexei Yavlinsky, Wing L. E. Fong, Vincent G. Nguyen, Jana Kovar, Theo Vos, Sarah Wulf Hanson, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Opublikowane w: Epidemiology and Infection, Numer 152, 2024, ISSN 0950-2688
Wydawca: Cambridge University Press (CUP)
DOI: 10.1017/S0950268824000748

Anti-nucleocapsid and anti-spike antibody trajectories in people with post-covid condition versus acute-only infections: a nested longitudinal case-control study within the Virus Watch prospective coh

Autorzy: Sarah Beale, Alexei Yavlinsky, Gemma Moncunill, Wing Lam Erica Fong, Vincent Grigori Nguyen, Jana Kovar, Andrew C. Hayward, Ibrahim Abubakar, Robert W. Aldridge
Opublikowane w: Nature Communications, Numer 16, 2025, ISSN 2041-1723
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58766-7

EU’s Extraterritorial Obligations for Global Medicine Access Under the Convention on the Rights of Persons with Disability (CPRD)

Autorzy: Katrina Perehudoff
Opublikowane w: Journal of Law, Medicine & Ethics, Numer 53, 2025, ISSN 1073-1105
Wydawca: Cambridge University Press (CUP)
DOI: 10.1017/JME.2025.10144

Post-vaccination IgG4 and IgG2 class switch associates with increased risk of SARS-CoV-2 infections

Autorzy: Carla Martín Pérez, Sílvia Ruiz-Rius, Anna Ramírez-Morros, Marta Vidal, D. Herbert Opi, Pere Santamaria, Julià Blanco, Josep Vidal-Alaball, James G. Beeson, Luis M. Molinos-Albert, Ruth Aguilar,
Opublikowane w: Journal of Infection, Numer 90, 2025, ISSN 0163-4453
Wydawca: Elsevier BV
DOI: 10.1016/J.JINF.2025.106473

Genomic screening of 16 UK native bat species through conservationist networks uncovers coronaviruses with zoonotic potential

Autorzy: Tan, C.C.S., Trew, J., Peacock, T.P. et al.
Opublikowane w: Nature Communications, Numer 14, 2023, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-023-38717-w

Prevalence, risk factors, and impact of long COVID in a socially vulnerable community in Brazil: a prospective cohort study

Autorzy: Pedro Azambuja, Leonardo S.L. Bastos, Amanda A. Batista-da-Silva, Grazielle Viana Ramos, Pedro Kurtz, Carolina M.C. Dias, Everton P. da Silva, Luna E. Arouca, Jesus Soares, James J. Sejvar, Louise Sig
Opublikowane w: The Lancet Regional Health - Americas, Numer 37, 2024, ISSN 2667-193X
Wydawca: Elsevier BV
DOI: 10.1016/J.LANA.2024.100839

The role of immune suppression in COVID-19 hospitalization: clinical and epidemiological trends over three years of SARS-CoV-2 epidemic

Autorzy: Canuti M, Monti MC, Bobbio C, Muscatello A, Muheberimana T, Baldi SL, Blasi F, Canetta C, Costantino G, Nobili A, Peyvandi F, Tettamanti M, Villa S, Aliberti S, Raviglione MC, Gori A, Bandera A and COVID-19 Network Study Group
Opublikowane w: Frontiers in Medicine, Numer Vol. 10, 2023, ISSN 2296-858X
Wydawca: Frontiers Media
DOI: 10.3389/fmed.2023.1260950

TB as a risk factor for severe COVID-19 mortality

Autorzy: I.C. Borges, F.M. Lino, A. Luna-Muschi, M.N. Litvoc, M.I.B.F. Lopes, H.R. Higashino, Á.F. da Costa, R.H.M. Pereira, H.I. Nakaya, J.D.A. de Araújo, G.M. Orlandi, M.J.P. Rújula, T.R.M.P. Carvalhanas,
Opublikowane w: The International Journal of Tuberculosis and Lung Disease, Numer 29, 2025, ISSN 1027-3719
Wydawca: International Union Against Tuberculosis and Lung Disease
DOI: 10.5588/IJTLD.24.0503

Prognostic Significance of NLR and PLR in COVID-19: A Multi-Cohort Validation Study

Autorzy: Marta Colaneri, Camilla Genovese, Federico Fassio, Marta Canuti, Andrea Giacomelli, Anna Lisa Ridolfo, Erika Asperges, Giuseppe Albi, Raffaele Bruno, Spinello Antinori, Antonio Muscatello, Bianca Mari
Opublikowane w: Infectious Diseases and Therapy, Numer 13, 2024, ISSN 2193-8229
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/S40121-024-00967-6

Advancing vaccines justice through international regulatory pathways

Autorzy: Katrina Perehudoff, Pramiti Parwani, Seraphine Bruinsma
Opublikowane w: Global Public Health, Numer 20, 2025, ISSN 1744-1692
Wydawca: Informa UK Limited
DOI: 10.1080/17441692.2025.2566730

Estimating the risk of post-COVID condition in deprived communities, migrants and ethnic minorities in England: findings from Virus Watch—a prospective community cohort study

Autorzy: Wing Lam Erica Fong, Sarah Beale, Vincent Nguyen, Jana Kovar, Alexei Yavlinsky, Andrew C Hayward, Ibrahim Abubakar, Sander MJ van Kuijk, Robert Aldridge
Opublikowane w: Journal of Epidemiology and Community Health, Numer 80, 2026, ISSN 0143-005X
Wydawca: BMJ
DOI: 10.1136/JECH-2024-223491

Initial antigen encounter determines robust T-cell immunity against SARS-CoV-2 BA.2.86 variant three years later

Autorzy: Rocío Rubio, Alexei Yavlinsky, Marina Escalera Zamudio, Luis M. Molinos-Albert, Carla Martín Pérez, Edwards Pradenas, Mar Canyelles, Cèlia Torres, Cedric Tan, Leo Swadling, Anna Ramírez-Morros, B
Opublikowane w: Journal of Infection, Numer 90, 2025, ISSN 0163-4453
Wydawca: Elsevier BV
DOI: 10.1016/J.JINF.2024.106402

Cohort Profile: Virus Watch—understanding community incidence, symptom profiles and transmission of COVID-19 in relation to population movement and behaviour

Autorzy: T. Byrne, J. Kovar, S. Beale, I. Braithwaite, E. Fragaszy, W. L. E. Fong, C. Geismar, S. Hoskins, A. M D Navaratnam, V. Nguyen, P. Patel, M. Shrotri, A. Yavlinsky, P. Hardelid, L. Wijlaars, E. Nastouli, M. Spyer, A. Aryee, I. Cox, ..., R. W Aldridge
Opublikowane w: International Journal of Epidemiology, Numer Vol.10, Numer 5, 2023, ISSN 1464-3685
Wydawca: Oxford University Press
DOI: 10.1093/ije/dyad087

VEGFA sex-specific signature is associated to long COVID symptom persistence

Autorzy: Xavier Farré, Natalia Blay, Susana Iraola-Guzmán, Francisco Fernández-Jiménez, Sayoa Alzate-Piñol, Laia Llucià-Carol, Ana Espinosa, Gemma Castaño-Vinyals, Carlota Dobaño, Gemma Moncunill, Mari
Opublikowane w: BMC Medicine, Numer 23, 2025, ISSN 1741-7015
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S12916-025-04402-6

Determinants of antibody levels and protection against omicron BQ.1/XBB breakthrough infection

Autorzy: Carla Martín Pérez, Anna Ramírez-Morros, Alfons Jiménez, Marta Vidal, Edwards Pradenas, Diana Barrios, Mar Canyelles, Rocío Rubio, Inocencia Cuamba, Luis Izquierdo, Pere Santamaria, Benjamin Trin
Opublikowane w: Communications Medicine, Numer 5, 2025, ISSN 2730-664X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S43856-025-00943-2

The burden, clinical features and outcomes of SARS-CoV-2, Influenza and co-infections during concurrently out-of-season outbreaks in Brazil

Autorzy: Tarsila Vieceli, Julio Croda, Leonardo S.L. Bastos, Fernando A. Bozza, Otavio T. Ranzani
Opublikowane w: Public Health, Numer 238, 2025, ISSN 0033-3506
Wydawca: Elsevier BV
DOI: 10.1016/J.PUHE.2024.10.016

Environmental Exposures and Long COVID in a Prospective Population-Based Study in Catalonia (COVICAT Study)

Autorzy: Apolline Saucy, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Barbara N. Harding, Marianna Karachaliou, Otavio Ranzani, Rafael De Cid, Judith Garcia-Aymerich, Manolis Kogevinas
Opublikowane w: Environmental Health Perspectives, Numer 132, 2024, ISSN 0091-6765
Wydawca: Environmental Health Perspectives
DOI: 10.1289/EHP15377

Malaria and other infections induce polyreactive antibodies that impact SARS‐CoV‐2 seropositivity estimations in endemic settings

Autorzy: Ruth Aguilar, Alfons Jiménez, Rebeca Santano, Marta Vidal, Oumou Maiga‐Ascofare, Ricardo Strauss, Joseph Bonney, Melvin Agbogbatey, Odin Goovaerts, Eric E. A. Boham, Evan A. Adu, Inocencia Cuamba,
Opublikowane w: Journal of Medical Virology, Numer 96, 2025, ISSN 0146-6615
Wydawca: Wiley
DOI: 10.1002/JMV.29713

Impact of early antiviral therapy on SARS-CoV-2 clearance time in high-risk COVID-19 subjects: A propensity score matching study

Autorzy: Marta Colaneri, Federico Fama, Federico Fassio, Darcy Holmes, Giovanni Scaglione, Chiara Mariani, Lucia Galli, Alessia Lai, Spinello Antinori, Andrea Gori, Agostino Riva, Monica Schiavini
Opublikowane w: International Journal of Infectious Diseases, Numer 149, 2025, ISSN 1201-9712
Wydawca: Elsevier BV
DOI: 10.1016/J.IJID.2024.107265

Correlates of protection and determinants of SARS-CoV-2 breakthrough infections 1 year after third dose vaccination

Autorzy: Carla Martín Pérez, Ruth Aguilar, Alfons Jiménez, Gemma Salmerón, Mar Canyelles, Rocío Rubio, Marta Vidal, Inocencia Cuamba, Diana Barrios, Natalia Díaz, Rebeca Santano, Pau Serra, Pere Santamar
Opublikowane w: BMC Medicine, Numer 22, 2024, ISSN 1741-7015
Wydawca: Springer Science and Business Media LLC
DOI: 10.1186/S12916-024-03304-3

Mpox global emergency: strengthening African leadership

Autorzy: Ibrahim Abubakar, Julius Lutwama, Catherine Kyobutungi, Osman Sankoh
Opublikowane w: The Lancet, Numer 404, 2024, ISSN 0140-6736
Wydawca: Elsevier BV
DOI: 10.1016/S0140-6736(24)02068-3EXTERNALLINK

The evolutionary drivers and correlates of viral host jumps

Autorzy: Cedric C. S. Tan, Lucy van Dorp, Francois Balloux
Opublikowane w: Nature Ecology & Evolution, Numer 8, 2024, ISSN 2397-334X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41559-024-02353-4

Long-lasting antibody B-cell responses to SARS-CoV-2 three years after the onset of the pandemic

Autorzy: Luis M. Molinos-Albert, Rocío Rubio, Carla Martín-Pérez, Edwards Pradenas, Cèlia Torres, Alfons Jiménez, Mar Canyelles, Marta Vidal, Diana Barrios, Silvia Marfil, Ester Aparicio, Anna Ramírez-Mo
Opublikowane w: Cell Reports, Numer 44, 2025, ISSN 2211-1247
Wydawca: Elsevier BV
DOI: 10.1016/J.CELREP.2025.115498

Exploring post-SEPSIS and post-COVID-19 syndromes: crossovers from pathophysiology to therapeutic approach

Autorzy: Darcy Holmes, Marta Colaneri, Emanuele Palomba, Andrea Gori
Opublikowane w: Frontiers in Medicine, Numer 10, 2024, ISSN 2296-858X
Wydawca: Frontiers Media
DOI: 10.3389/fmed.2023.1280951

Estimating long COVID-19 prevalence across definitions and forms of sample selection

Autorzy: Pietro Giorgio Lovaglio, Fabio Borgonovo, Alessandro Manzo Margiotta, Mohamed Mowafy, Marta Colaneri, Alessandra Bandera, Andrea Gori, Amedeo Ferdinando Capetti
Opublikowane w: Frontiers in Epidemiology, Numer 5, 2025, ISSN 2674-1199
Wydawca: Frontiers Media SA
DOI: 10.3389/FEPID.2025.1597799