Towards Cancer Patient Empowerment for Optimal Use of Antithrombotic Therapy at the End of Life

Projektinformationen

SERENITY

ID Finanzhilfevereinbarung: 101057292

DOI

10.3030/101057292

EK-Unterschriftsdatum 24 Mai 2022

Startdatum 1 Oktober 2022

Enddatum 30 September 2027

Finanziert unter

• Health

Gesamtkosten

€ 4 483 532,50

EU-Beitrag

€ 4 483 530,50

Koordiniert durch

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (7)

Midterm progress report on realist review

The midterm progress report will summarise the fundings half way the duration of this particular study. The final manuscript will be ready for submission by month 12. The results of the review are used to inform the creators of the shared decision support tool(WP5) as well as the methodology for the RCT (WP6).

Paper published on qualitative interviews

NDR, together with the other WP participants, will prepare and publish at least one academic paper based on the results of the qualitative interviews.

Midterm recruitment report of of qualitative studies

The midterm recruitment report will report upon the progress of the study and the number of clinicians and patients interviewed halfway the duration of this qualitative study.

Paper published on the flash mob research

Based on the report on the results of the flash mob research on clinicaltrials.gov, an academic paper will be prepared and published by UMCM.

Report on Delphi platform setup

Report describing the setup of the Delphi platform.

Report on findings of the realist review on PROSPERO

This report will summarise the findings of the realist review. The results of the review are used to inform the creators of the shared decision support tool (WP5) as well as the methodology for the RCT (WP6).

Initial dissemination and exploitation plan including communication activities

The initial dissemination plan will set the overall objectives for all communications and dissemination efforts within SERENITY. A strategy for the developing and disseminating of position papers, guidelines, and information pamphlets in lay language, organising webinars, and developing eLearning modules on the optimal use of the shared decision support tool will be drafted. The dissemination and communication plan will be finalised after internal discussions and alignment with the major scientific and patient organisations in Europe relevant to the topic.

Websites, patent fillings, videos etc. (1)

Project website and logo

Both a project logo and website will be designed as described in section 2.2 and launched within the first 3 months of the project.

Veröffentlichungen

Peer reviewed articles (11)

Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer

Autoren: E.S.L. Martens, D. Becker, C. Abele, D. Abbel, W.P. Achterberg, J.J. Bax, L. Bertoletti, M.E. Edwards, C. Font, A. Gava, J. Goedegebuur, A.A. Højen, M.V. Huisman, M.J.H.A. Kruip, I. Mahé, S.P. Mooijaart, M. Pearson, K. Seddon, S. Szmit, S.I.R. Noble, F.A. Klok, S.V. Konstantinides
Veröffentlicht in: Thrombosis Research, Ausgabe 245, 2024, ISSN 0049-3848
Herausgeber: Elsevier BV
DOI: 10.1016/J.THROMRES.2024.109205

Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: a Danish nationwide cohort study

Autoren: Mette Søgaard, Marie Ørskov, Martin Jensen, Jamilla Goedegebuur, Eva K. Kempers, Chantal Visser, Eric C.T. Geijteman, Denise Abbel, Simon P. Mooijaart, Geert-Jan Geersing, Johanneke Portielje, Adrian Edwards, Sarah J. Aldridge, Ashley Akbari, Anette A. Højen, Frederikus A. Klok, Simon Noble, Suzanne Cannegieter, Anne Gulbech Ording
Veröffentlicht in: Journal of Thrombosis and Haemostasis, Ausgabe 23, 2025, ISSN 1538-7836
Herausgeber: Elsevier BV
DOI: 10.1016/J.JTHA.2024.09.023

Discontinuation of Anticoagulants and Occurrence of Bleeding and Thromboembolic Events in Vitamin K Antagonist Users with a Life-limiting Disease

Autoren: Eva Kempers, Chantal Visser, Eric Geijteman, Jamilla Goedegebuur, Johanneke Portielje, Mette Sogaard, Anne Gulbech Ording, Carline van den Dries, Denise Abbel, Geert-Jan Geersing, Sarah Aldridge, Kate Lifford, Ashley Akbari, Sjef van de Leur, Melchior Nie
Veröffentlicht in: Thrombosis and Haemostasis, 2025, ISSN 0340-6245
Herausgeber: Schattauer
DOI: 10.1055/A-2524-5334

Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Results of a European Delphi study

Autoren: Isabelle Mahé, Skerdi Haviari, Nassima Si Mohammed, Anette Arbjerg Højen, Carme Font, Stavros Konstantinides, Marieke J.H.A. Kruip, Luigi Maiorana, Sebastian Szmit, Denise Abbel, Laurent Bertoletti, Adrian Edwards, Michelle Edwards, Alessandra Gava, Jacobijn Gussekloo, Miriam J. Johnson, Rashmi Kumar, Johan Langendoen, Kate J. Lifford, Simon Mooijaart, Mark Pearson, Johanneke Portielje, Kathy Seddon, Stella Trompet, Hélène Helfer, Frederikus A. Klok, Simon Noble, Camille Couffignal
Veröffentlicht in: Thrombosis Research, Ausgabe 258, 2025, ISSN 0049-3848
Herausgeber: Elsevier BV
DOI: 10.1016/J.THROMRES.2025.109573

“Who am I to say that I'm not going to take it”: patient perspectives on decisions about antithrombotic therapy in the context of advanced cancer

Autoren: Elin Baddeley, Carme Font, Isabelle Mahé, Michelle Edwards, Stephanie Sivell, Kate J. Lifford, Victoria Mailen Arfuch, Nuri Coma-Auli, Mette Søgaard, Helle Enggaard, Hélène Helfer, Nassima Si Mohammed, Kathy Seddon, Mark Pearson, Simone P. Mooijaart, Sebastian Szmit, F.A. Klok, Simon Noble, Anette Arbjerg Højen
Veröffentlicht in: Thrombosis Research, Ausgabe 253, 2025, ISSN 0049-3848
Herausgeber: Elsevier BV
DOI: 10.1016/J.THROMRES.2025.109399

Anti‐thrombotic therapy in patients with cancer at the end of life and associated clinical outcomes: A cohort study using population‐linked routinely collected data

Autoren: Sarah J. Aldridge, Ashley Akbari, Adrian Edwards, Kate J. Lifford, Denise Abbel, Suzanne Cannegieter, Jamilla Goedegebuur, Eva K. Kempers, Mette Søgaard, Chantal Visser, Geert‐Jan Geersing, Marieke J. H. Kruip, Anne Gulbech Ording, Carline van den Dries, Eric C. T. Geijteman, Erik Klok, Isabelle Mahé, Simon P. Mooijaart, Sebastian Szmit, Simon Noble
Veröffentlicht in: British Journal of Haematology, 2025, ISSN 0007-1048
Herausgeber: Wiley
DOI: 10.1111/BJH.70032

Thrombosis Research

Autoren: J, Goedegebuur; D, Abbel; F A, Klok; S I R, Noble
Veröffentlicht in: Scientia, 2023, ISSN 0049-3848
Herausgeber: Pergamon Press
DOI: 10.1016/j.thromres.2023.05.008

Quality of vitamin K antagonist treatment during the last year of life

Autoren: Chantal Visser, Eva K. Kempers, Jamilla Goedegebuur, Denise Abbel, Sarah J. Aldridge, Adrian Edwards, Michelle Edwards, Geert‐Jan Geersing, Anne Gulbech Ording, Sjef J. C. M. van de Leur, Kate J. Lifford, Isabelle Mahé, Simon P. Mooijaart, Melchior C. Nierman, Johanneke E. A. Portielje, Mette Søgaard, Sebastian Szmit, Nynke M. Wiersma, Simon I. R. Noble, Frederikus A. Klok, Qingui Chen, Suzanne C. Cannegieter, Eric C. T. Geijteman, Marieke J. H. A. Kruip, null null
Veröffentlicht in: HemaSphere, Ausgabe 9, 2025, ISSN 2572-9241
Herausgeber: Wiley
DOI: 10.1002/HEM3.70135

Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study

Autoren: Imene Deneche, Camille Couffignal, Nassima Si Mohammed, Anette Arbjerg Højen, Carme Font, Stavros Konstantinides, Marieke Kruip, Luigi Maiorana, Sebastian Szmit, Denise Abbel, Laurent Bertoletti, Sus
Veröffentlicht in: Thrombosis Update, Ausgabe 19, 2025, ISSN 2666-5727
Herausgeber: Elsevier BV
DOI: 10.1016/J.TRU.2025.100209

Involving patients and the public in cancer associated thrombosis research: A strategy for success

Autoren: Michelle Edwards, Kathy Seddon, Elin Baddeley, Anne Gulbech Ording, Mark Pearson, Isabelle Mahe, Simon Mooijaart, Frederikus A. Klok, Simon I.R. Noble
Veröffentlicht in: Thrombosis Update, Ausgabe 18, 2025, ISSN 2666-5727
Herausgeber: Elsevier BV
DOI: 10.1016/j.tru.2024.100196

Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis

Autoren: Justin Jagosh, Mark Pearson, Sarah Greenley, Anthony Maraveyas, Gamze Keser, Fliss E. M. Murtagh, Simon Noble, Michelle Edwards, Adrian Edwards, Anette Arbjerg Højen, Kathy Seddon, Frederikus A. Klok, Simon P. Mooijaart, Eric C. T. Geijteman, Miriam J. Johnson
Veröffentlicht in: PLOS Medicine, Ausgabe 22, 2025, ISSN 1549-1676
Herausgeber: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PMED.1004663