Predictive REagent-Antibody Replacement Technology stage 2-Translation

Project Information

PRe-ART-2T

Grant agreement ID: 101058027

DOI

10.3030/101058027

Project closed

EC signature date 17 March 2022

Start date 1 June 2022

End date 31 May 2025

Funded under

• The European Innovation Council (EIC)

Total cost

€ 800 000,00

EU contribution

€ 800 000,00

Coordinated by

UNIVERSITAT BAYREUTH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

New, Externally-hosted PRe-ART website and project logo

New Externallyhosted PReART website created and project logo

Publications

Peer reviewed articles (8)

Modular peptide binders – development of a predictive technology as alternative for reagent antibodies

Author(s): Plückthun, A. , Gisdon, F.J., Kynast, J.P. Ayyildiz, M., Hine, A. V., Höcker, B.
Published in: Biol. Chem., 2022, ISSN 1083-351X
Publisher: De Gruyter
DOI: 10.1515/hsz-2021-0384

Unexpected dynamics in femtomolar complexes of binding proteins with peptides

Author(s): Cucuzza, S., Sitnik, M., Jurt, S., Michel, E., Dai, W., Müntener, T., Ernst, P., Häussinger, D., Plückthun, A. & Zerbe, O.
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-43596-2

Modular binder technology by NGS-aided, high-resolution selection in yeast of designed armadillo modules

Author(s): Yvonne Stark, Faye Menard, Jeliazko R. Jeliazkov, Patrick Ernst, Anupama Chembath, Mohammed Ashraf, Anna V. Hine, Andreas Plückthun
Published in: Proceedings of the National Academy of Sciences, Issue 121, 2024, ISSN 0027-8424
Publisher: Proceedings of the National Academy of Sciences
DOI: 10.1073/PNAS.2318198121

Improved Repeat Protein Stability by Combined Consensus and Computational Protein Design

Author(s): Michel, E., Cucuzza, S., Mittl, P.R.E., Zerbe, O., Plückthun, A.
Published in: Biochemistry, Issue 62, 2022, ISSN 0006-2960
Publisher: ACS
DOI: 10.1021/acs.biochem.2c00083

Atligator Web: A Graphical User Interface for Analysis and Design of Protein–Peptide Interactions.

Author(s): Kynast J.P., Höcker B.
Published in: Biodesign Research, Issue 5, 2023, ISSN 2693-1257
Publisher: Science Partner Journals
DOI: 10.34133/bdr.0011

Evaluation of Physics‐Based Protein Design Methods for Predicting Single Residue Effects on Peptide Binding Specificities

Author(s): Merve Ayyildiz, Jakob Noske, Florian J. Gisdon, Josef P. Kynast, Birte Höcker
Published in: Journal of Computational Chemistry, Issue 46, 2025, ISSN 0192-8651
Publisher: Wiley
DOI: 10.1002/JCC.70160

PocketOptimizer 2.0: A modular framework for computer-aided ligand-binding design

Author(s): Noske, J., Kynast, J.P., Lemm, D., Schmidt, S. & Höcker, B.
Published in: Protein Science, 2022, ISSN 0961-8368
Publisher: Wiley
DOI: 10.1002/pro.4516

ATLIGATOR: Editing protein interactions with an atlas-based approach

Author(s): Kynast J.P., Schwägerl F., Höcker B
Published in: Bioinformatics, 2022, ISSN 0000-0000
Publisher: ISCB
DOI: 10.1093/bioinformatics/btac685

Conference proceedings (2)

Computational design of specific binding pockets for phosphorylated amino acids within Armadillo repeat proteins

Author(s): Ayyildiz, M.
Published in: 74th Mosbacher Kolloquium on Immune engineering, Issue Abstract O 03, 2023
Publisher: German Society for Biochemistry and Molecular Biology website

PRe-ART - Creating synthetic replacements for reagent antibodies

Author(s): Chembath, A., Ashraf, M., Wagstaffe, B.P.G., Stark, Y., Michel, E., Rohrbach, A., Kynast, J., Gisdon, F., Ayyildiz, M., Höcker, B., Plückthun, A., Hine, A.V.
Published in: Synthetic Biology UK, 2022, Issue Abstract P043, 2022
Publisher: Biochemical Society