Centre for Digitalisation of Biology Towards the Next-Generation of Biosustainable Products

Informazioni relative al progetto

DIGIBIO

ID dell’accordo di sovvenzione: 101060066

DOI

10.3030/101060066

Data della firma CE 26 Aprile 2023

Data di avvio 1 Settembre 2023

Data di completamento 31 Agosto 2029

Finanziato da

• Widening participation and spreading excellence

Costo totale

€ 14 942 500,00

Contributo UE

€ 14 942 500,00

Coordinato da

TARTU ULIKOOL
Estonia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (47)

Stomatal CO2 responses at sub- and above-ambient CO2 levels employ different pathways in Arabidopsis

Autori: Kaspar Koolmeister, Ebe Merilo, Hanna Hõrak, Hannes Kollist
Pubblicato in: Plant Physiology, Numero 196, 2024, ISSN 0032-0889
Editore: Oxford University Press (OUP)
DOI: 10.1093/PLPHYS/KIAE320

Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness

Autori: Henri Ingelman, James K. Heffernan, Audrey Harris, Steven D. Brown, Kurshedaktar Majibullah Shaikh, Asfand Yar Saqib, Marina J. Pinheiro, Lorena Azevedo de Lima, Karen Rodriguez Martinez, Ricardo A. Gonzalez-Garcia, Grant Hawkins, Jim Daleiden, Loan Tran, Hunter Zeleznik, Rasmus O. Jensen, Vinicio Reynoso, Heidi Schindel, Jürgen Jänes, Séan D. Simpson, Michael Köpke, Esteban Marcellin, Kaspar Valgepea
Pubblicato in: New Biotechnology, Numero 83, 2024, ISSN 1871-6784
Editore: Elsevier BV
DOI: 10.1016/J.NBT.2024.06.002

The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs.

Autori: Melinda Reuter, Rhys H. Parry, Melanie McDonald, Rommel J. Gestuveo, Rozeena Arif, Alexander A. Khromykh, Benjamin Brennan, Margus Varjak, Alfredo Castello, Lars Redecke, Esther Schnettler, Alain Kohl
Pubblicato in: RNA, 2025, ISSN 1355-8382
Editore: Cold Spring Harbor Laboratory
DOI: 10.1261/RNA.080149.124

Evaluation of enzyme-constrained genome-scale model through metabolic engineering of anaerobic co-production of 2,3-butanediol and glycerol by Saccharomyces cerevisiae

Autori: Gustav Sjöberg, Alīna Reķēna, Matilda Fornstad, Petri-Jaan Lahtvee, Antonius J.A. van Maris
Pubblicato in: Metabolic Engineering, Numero 82, 2024, ISSN 1096-7176
Editore: Elsevier BV
DOI: 10.1016/J.YMBEN.2024.01.007

Exploring the resilience and stability of a defined human gut microbiota consortium: An isothermal microcalorimetric study

Autori: Anna Kattel, Valter Aro, Petri‐Jaan Lahtvee, Jekaterina Kazantseva, Arvi Jõers, Ranno Nahku, Isma Belouah
Pubblicato in: MicrobiologyOpen, Numero 13, 2024, ISSN 2045-8827
Editore: Wiley
DOI: 10.1002/MBO3.1430

Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti‐Alphavirus Therapies

Autori: Sainan Wang, Suresh Mahalingam, Andres Merits
Pubblicato in: Reviews in Medical Virology, Numero 35, 2025, ISSN 1052-9276
Editore: Wiley
DOI: 10.1002/RMV.70030

FHL1 promotes chikungunya and o’nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design

Autori: Wern Hann Ng, Xiang Liu, Zheng L. Ling, Camilla N. O. Santos, Lucas S. Magalhães, Andrew J. Kueh, Marco J. Herold, Adam Taylor, Joseph R. Freitas, Sandra Koit, Sainan Wang, Andrew R. Lloyd, Mauro M. Teixeira, Andres Merits, Roque P. Almeida, Nicholas J. C. King, Suresh Mahalingam
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-023-42330-2

LDLR is used as a cell entry receptor by multiple alphaviruses

Autori: Xiaofeng Zhai, Xiaoling Li, Michael Veit, Ningning Wang, Yu Wang, Andres Merits, Zhiwen Jiang, Yan Qin, Xiaoguang Zhang, Kaili Qi, Houqi Jiao, Wan-Ting He, Ye Chen, Yang Mao, Shuo Su
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-44872-5

Ultrasound effect on a biorefinery lignin-cellulose mixture

Autori: Kait Kaarel Puss, Peeter Paaver, Mart Loog, Siim Salmar
Pubblicato in: Ultrasonics Sonochemistry, Numero 111, 2025, ISSN 1350-4177
Editore: Elsevier BV
DOI: 10.1016/J.ULTSONCH.2024.107071

Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria

Autori: Elisabetta Cacace, Manuela Tietgen, Meike Steinhauer, André Mateus, Tilman G. Schultze, Marina Eckermann, Marco Galardini, Vallo Varik, Alexandra Koumoutsi, Jordan J. Parzeller, Federico Corona, Askarbek Orakov, Michael Knopp, Amber Brauer-Nikonow, Peer Bork, Celia V. Romao, Michael Zimmermann, Peter Cloetens, Mikhail M. Savitski, Athanasios Typas, Stephan Göttig
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58730-5

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

Autori: Wael Kamel, Vincenzo Ruscica, Azman Embarc-Buh, Zaydah R. de Laurent, Manuel Garcia-Moreno, Yana Demyanenko, Richard J. Orton, Marko Noerenberg, Meghana Madhusudhan, Louisa Iselin, Aino I. Järvelin, Maximilian Hannan, Eduardo Kitano, Samantha Moore, Andres Merits, Ilan Davis, Shabaz Mohammed, Alfredo Castello
Pubblicato in: Molecular Cell, Numero 84, 2025, ISSN 1097-2765
Editore: Elsevier BV
DOI: 10.1016/J.MOLCEL.2024.11.015

Exploring Barmah Forest virus pathogenesis: molecular tools to investigate non-structural protein 3 nuclear localization and viral genomic determinants of replication

Autori: Ailar Omler, Margit Mutso, Mihkel Vaher, Joseph R. Freitas, Adam Taylor, Cassandra T. David, Gregory W. Moseley, Xiang Liu, Andres Merits, Suresh Mahalingam
Pubblicato in: mBio, Numero 15, 2024, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/MBIO.00993-24

Phenotypic Variation and Relationships between Grain Yield, Protein Content and Unmanned Aerial Vehicle-Derived Normalized Difference Vegetation Index in Spring Wheat in Nordic–Baltic Environments

Autori: Zaiga Jansone, Zigmārs Rendenieks, Andris Lapāns, Ilmar Tamm, Anne Ingver, Andrii Gorash, Andrius Aleliūnas, Gintaras Brazauskas, Sahameh Shafiee, Tomasz Mróz, Morten Lillemo, Hannes Kollist, Māra Bleidere
Pubblicato in: Agronomy, Numero 14, 2025, ISSN 2073-4395
Editore: MDPI AG
DOI: 10.3390/AGRONOMY14010051

Novel coronaviruses identified in livestock: The urgent need to enhance coronavirus surveillance to mitigate zoonotic risks

Autori: Kaili Qi, Jie Chen, Xing Ma, Dongyan Li, Guy Baele, Xinxin Li, Ying Qin, Xiang Ji, Mengmeng Zhu, Xin-xin Li, Dawei Guo, Andres Merits, Michael Veit, Xiaofeng Zhai, Jin Tian, Ningning Wang, Houqi Jiao
Pubblicato in: Journal of Infection, Numero 91, 2025, ISSN 0163-4453
Editore: Elsevier BV
DOI: 10.1016/J.JINF.2025.106512

Novel universal vaccines to mitigate emerging avian influenza viruses

Autori: Yu Liu, Lifang Wang, Alexander Lai, Mei Kang, Yangrui Qi, Andres Merits, Xinyi Jiao, Xinyu Wang, Xiangrong Yu, Shuo Su, Zhiwen Jiang
Pubblicato in: Trends in Molecular Medicine, 2025, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/J.MOLMED.2025.03.001

ALMT‐independent guard cell R‐type anion currents

Autori: Justyna Jaślan, Irene Marten, Liina Jakobson, Triinu Arjus, Rosalia Deeken, Cecilia Sarmiento, Alexis De Angeli, Mikael Brosché, Hannes Kollist, Rainer Hedrich
Pubblicato in: New Phytologist, Numero 239, 2023, ISSN 0028-646X
Editore: Wiley
DOI: 10.1111/NPH.19124

Synthesis and import of GDP‐<scp>l</scp>‐fucose into the Golgi affect plant–water relations

Autori: Cezary Waszczak, Dmitry Yarmolinsky, Marina Leal Gavarrón, Triin Vahisalu, Maija Sierla, Olena Zamora, Ross Carter, Tuomas Puukko, Nina Sipari, Airi Lamminmäki, Jörg Durner, Dieter Ernst, J. Barbro Winkler, Lars Paulin, Petri Auvinen, Andrew J. Fleming, Mats X. Andersson, Hannes Kollist, Jaakko Kangasjärvi
Pubblicato in: New Phytologist, Numero 241, 2025, ISSN 0028-646X
Editore: Wiley
DOI: 10.1111/NPH.19378

The catalytic tetrad of Aedes aegypti argonaute 2 is critical for the antiviral activity of the exogenous siRNA pathway

Autori: Krittika Dummunee, Rhys H. Parry, Lars Redecke, Margus Varjak, Benjamin Brennan, Alain Kohl, Melanie McFarlane
Pubblicato in: Journal of Biological Chemistry, Numero 301, 2025, ISSN 0021-9258
Editore: Elsevier BV
DOI: 10.1016/J.JBC.2025.108332

4′-Fluorouridine inhibits alphavirus replication and infection <i>in vitro</i> and <i>in vivo</i>

Autori: Peiqi Yin, Nicholas A. May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan Andrews, Zachary Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison
Pubblicato in: mBio, Numero 15, 2024, ISSN 2150-7511
Editore: American Society for Microbiology
DOI: 10.1128/MBIO.00420-24

Dengue Virus Inhibitors as Potential Broad-Spectrum Flavivirus Inhibitors

Autori: Larisa Ivanova, Krystyna Naumenko, Margus Varjak, Sandra Koit, Yehudit Morozovsky, Andres Merits, Mati Karelson, Eva Zusinaite
Pubblicato in: Pharmaceuticals, Numero 18, 2025, ISSN 1424-8247
Editore: MDPI AG
DOI: 10.3390/PH18030283

Genome-wide association study reveals 18 QTL for major agronomic traits in a Nordic–Baltic spring wheat germplasm

Autori: Andrius Aleliūnas, Andrii Gorash, Rita Armonienė, Ilmar Tamm, Anne Ingver, Māra Bleidere, Valentīna Fetere, Hannes Kollist, Tomasz Mroz, Morten Lillemo, Gintaras Brazauskas
Pubblicato in: Frontiers in Plant Science, Numero 15, 2024, ISSN 1664-462X
Editore: Frontiers Media SA
DOI: 10.3389/FPLS.2024.1393170

Boosting photosynthesis opens new opportunities for agriculture sustainability and circular economy: The <scp>BEST</scp>‐<scp>CROP</scp> research and innovation action

Autori: Paolo Pesaresi, Pierre Bono, Stephane Corn, Cristina Crosatti, Sara Daniotti, Jens Due Jensen, Ivo Frébort, Eder Groli, Claire Halpin, Mats Hansson, Goetz Hensel, David S. Horner, Kelly Houston, Ahmed Jahoor, Miloš Klíma, Hannes Kollist, Clément Lacoste, Boubker Laidoudi, Susanna Larocca, Caterina Marè, Nicolas Le Moigne, Chiara Mizzotti, Tomas Morosinotto, Klaus Oldach, Laura Rossini, Sebastian Raubach, Miguel Sanchez‐Garcia, Paul D. Shaw, Rodolphe Sonnier, Alessandro Tondelli, Robbie Waugh, Andreas P.M. Weber, Dmitry Yarmolinsky, Alessandro Zeni, Luigi Cattivelli
Pubblicato in: The Plant Journal, Numero 121, 2025, ISSN 0960-7412
Editore: Wiley
DOI: 10.1111/TPJ.17264

A single-dose intranasal live-attenuated codon deoptimized vaccine provides broad protection against SARS-CoV-2 and its variants

Autori: Xiang Liu, Wern Hann Ng, Eva Zusinaite, Joseph Freitas, Adam Taylor, Venugopal Yerragunta, Shukra Madhaha Aavula, Sambaiah Gorriparthi, Santhakumar Ponsekaran, Rama Lakshmi Bonda, Priyanka Mani, Sridevi V. Nimmagadda, Sainan Wang, Laura Sandra Lello, Ali Zaid, Ujjwal Dua, Sharon A. Taft-Benz, Elizabeth Anderson, Victoria K. Baxter, Sanjay Sarkar, Zheng L. Ling, Thomas M. Ashhurst, Samuel M. S. Cheng, Priyabrata Pattnaik, Anand Kumar Kanakasapapathy, Ralph S. Baric, Felicity J. Burt, Malik Peiris, Mark T. Heise, Nicholas J. C. King, Andres Merits, Rajendra Lingala, Suresh Mahalingam
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-51535-Y

Exploring the potential of microbial biomass and microbial extracted oils in tribology: a sustainable frontier for environmentally acceptable lubricants

Autori: Szymon Bernat, Francesca Di Bartolomeo, Sergio Armada, Emil Valaker, Nemailla Bonturi, Deni Koseto, Tone Haugen, Ann-Karin Kvernbråten, Petr Stavárek, Marek Večeř, Ladislav Zelenka
Pubblicato in: Green Chemistry Letters and Reviews, Numero 17, 2024, ISSN 1751-8253
Editore: Informa UK Limited
DOI: 10.1080/17518253.2024.2330644

The Synthetic Peptide GA-Hecate and Its Analogs Inhibit Multiple Steps of the Chikungunya Virus Infection Cycle In Vitro

Autori: Gabriela Miranda Ayusso, Paulo Ricardo da Silva Sanches, Tamara Carvalho, Igor Andrade Santos, Daniel Oliveira Silva Martins, Maria Letícia Duarte Lima, Pâmela Jóyce Previdelli da Conceição, Cíntia Bittar, Andres Merits, Eduardo Maffud Cilli, Ana Carolina Gomes Jardim, Paula Rahal, Marilia Freitas Calmon
Pubblicato in: Pharmaceuticals, Numero 16, 2025, ISSN 1424-8247
Editore: MDPI AG
DOI: 10.3390/PH16101389

SARS-CoV-2 N protein recruits G3BP to double membrane vesicles to promote translation of viral mRNAs

Autori: Siwen Long, Mykhailo Guzyk, Laura Perez Vidakovics, Xiao Han, Renhua Sun, Megan Wang, Marc D. Panas, Egon Urgard, Jonathan M. Coquet, Andres Merits, Adnane Achour, Gerald M. McInerney
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-54996-3

PanKB: An interactive microbial pangenome knowledgebase for research, biotechnological innovation, and knowledge mining

Autori: Binhuan Sun, Liubov Pashkova, Pascal Aldo Pieters, Archana Sanjay Harke, Omkar Satyavan Mohite, Alberto Santos, Daniel C Zielinski, Bernhard O Palsson, Patrick Victor Phaneuf
Pubblicato in: Nucleic Acids Research, Numero 53, 2025, ISSN 0305-1048
Editore: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE1042

Phenotypic diversity of key adaptive traits in advanced Nordic and Baltic spring wheat (Triticum aestivum L.) breeding material

Autori: Anne Ingver, Andrii Gorash, Elena Ivandi, Vija Strazdina, Andrius Aleliūnas, Tanel Kaart, Valentina Fetere, Egon Meigas, Zaiga Jansone, Sahameh Shafiee, Tomasz Mroz, Mara Bleidere, Ebe Merilo, Morten Lillemo, Hannes Kollist, Gintaras Brazauskas, Ilmar Tamm
Pubblicato in: Euphytica, Numero 220, 2024, ISSN 0014-2336
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10681-024-03404-4

Validation of flavivirus infectious clones carrying fluorescent markers for antiviral drug screening and replication studies

Autori: Liubov Cherkashchenko, Nathalie Gros, Alice Trausch, Aymeric Neyret, Mathilde Hénaut, Gregor Dubois, Matthieu Villeneuve, Christine Chable-Bessia, Sébastien Lyonnais, Andres Merits, Delphine Muriaux
Pubblicato in: Frontiers in Microbiology, Numero 14, 2023, ISSN 1664-302X
Editore: Frontiers Media SA
DOI: 10.3389/FMICB.2023.1201640

CDK signaling via nonconventional CDK phosphorylation sites

Autori: Ervin Valk, Mihkel Örd, Ilona Faustova, Mart Loog
Pubblicato in: Molecular Biology of the Cell, Numero 34, 2023, ISSN 1059-1524
Editore: American Society for Cell Biology (ASCB)
DOI: 10.1091/MBC.E22-06-0196

LDL receptor in alphavirus entry: structural analysis and implications for antiviral therapy

Autori: Ningning Wang, Andres Merits, Michael Veit, Laura Sandra Lello, Shuhan Kong, Houqi Jiao, Jie Chen, Yu Wang, Georgi Dobrikov, Félix A. Rey, Shuo Su
Pubblicato in: Nature Communications, Numero 15, 2024, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-49301-1

Constitutive activation of ABA receptors in Arabidopsis reveals unique regulatory circuitries

Autori: Oded Pri‐Tal, Yufei Sun, Armin Dadras, Janine M. R. Fürst‐Jansen, Gil Zimran, Daphna Michaeli, Akila Wijerathna‐Yapa, Michal Shpilman, Ebe Merilo, Dmitry Yarmolinsky, Idan Efroni, Jan de Vries, Hannes Kollist, Assaf Mosquna
Pubblicato in: New Phytologist, Numero 241, 2025, ISSN 0028-646X
Editore: Wiley
DOI: 10.1111/NPH.19363

Stomatal CO ₂ /bicarbonate sensor consists of two interacting protein kinases, Raf-like HT1 and non-kinase-activity requiring MPK12/MPK4

Autori: Yohei Takahashi, Krystal C. Bosmans, Po-Kai Hsu, Karnelia Paul, Christian Seitz, Chung-Yueh Yeh, Yuh-Shuh Wang, Dmitry Yarmolinsky, Maija Sierla, Triin Vahisalu, Cezary Waszczak, J. Andrew McCammon, Jaakko Kangasjärvi, Li Zhang, Hannes Kollist, Thien Trac, Julian I. Schroeder
Pubblicato in: Science Advances, Numero 8, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ABQ6161

Adaptive laboratory evolution of <i>Clostridium autoethanogenum</i> to metabolize CO₂ and H₂ enhances growth rates in chemostat and unravels proteome and metabolome alterations

Autori: James Heffernan, R. Axayactl Garcia Gonzalez, Vishnu Mahamkali, Tim McCubbin, Dara Daygon, Lian Liu, Robin Palfreyman, Audrey Harris, Michael Koepke, Kaspar Valgepea, Lars Keld Nielsen, Esteban Marcellin
Pubblicato in: Microbial Biotechnology, Numero 17, 2024, ISSN 1751-7915
Editore: Wiley
DOI: 10.1111/1751-7915.14452

Boosted production of antibodies that neutralized different SARS-CoV-2 variants in a COVID-19 convalescent following messenger RNA vaccination - a case study

Autori: Erlend Ravlo, Aleksandr Ianevski, Eirin Starheim, Wei Wang, Ping Ji, Hilde Lysvand, Teemu Smura, Gaily Kivi, Maia-Liisa Voolaid, Kati Plaan, Mart Ustav, Mart Ustav, Eva Zusinaite, Tanel Tenson, Reet Kurg, Valentyn Oksenych, Kirsti Walstad, Svein Arne Nordbø, Mari Kaarbø, Karin Ernits, Magnar Bjørås, Denis E. Kainov, Mona Høysæter Fenstad
Pubblicato in: International Journal of Infectious Diseases, Numero 137, 2024, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2023.10.011

Evidence of Differences in Cellular Regulation of Wolbachia-Mediated Viral Inhibition between Alphaviruses and Flaviviruses

Autori: Stephanie M. Rainey, Daniella A. Lefteri, Christie Darby, Alain Kohl, Andres Merits, Steven P. Sinkins
Pubblicato in: Viruses, Numero 16, 2024, ISSN 1999-4915
Editore: MDPI AG
DOI: 10.3390/V16010115

Translational control of <i>MPS1</i> links protein synthesis with the initiation of cell division and spindle pole body duplication in <i>Saccharomyces cerevisiae</i>

Autori: Heidi M Blank, Annabel Alonso, Amy S Fabritius, Ervin Valk, Mart Loog, Mark Winey, Michael Polymenis
Pubblicato in: GENETICS, Numero 227, 2025, ISSN 1943-2631
Editore: Oxford University Press (OUP)
DOI: 10.1093/GENETICS/IYAE069

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Autori: Nazgul Sakenova, Elisabetta Cacace, Askarbek Orakov, Florian Huber, Vallo Varik, George Kritikos, Jan Michiels, Peer Bork, Pascale Cossart, Camille V. Goemans, Athanasios Typas
Pubblicato in: Nature Microbiology, Numero 10, 2025, ISSN 2058-5276
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41564-024-01857-W

Correction to: Phenotypic diversity of key adaptive traits in advanced Nordic and Baltic spring wheat (Triticum aestivum L.) breeding material

Autori: Anne Ingver, Andrii Gorash, Elena Ivandi, Vija Strazdina, Andrius Aleliūnas, Tanel Kaart, Valentina Fetere, Egon Meigas, Zaiga Jansone, Sahameh Shafiee, Tomasz Mroz, Mara Bleidere, Ebe Merilo, Morten Lillemo, Hannes Kollist, Gintaras Brazauskas, Ilmar Tamm
Pubblicato in: Euphytica, Numero 220, 2024, ISSN 0014-2336
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10681-024-03412-4

Kaurenoic acid is a potent inhibitor of SARS-CoV-2 RNA synthesis, virion assembly, and release in vitro

Autori: Igor Andrade Santos, Victoria Riquena Grosche, Natasha Marques Cassani, Rodrigo Cássio Sola Veneziani, Gustavo Lima Ribeiro, Jairo Kenupp Bastos, Nilson Nicolau-Junior, Andres Merits, Carlos Henrique Gomes Martins, Mark Harris, Ana Carolina Gomes Jardim
Pubblicato in: Frontiers in Microbiology, Numero 16, 2025, ISSN 1664-302X
Editore: Frontiers Media SA
DOI: 10.3389/FMICB.2025.1540934

Enhanced and copper concentration dependent virucidal effect against SARS-CoV-2 of electrospun poly(vinylidene difluoride) filter materials

Autori: Hanna Bulgarin, Thomas Thomberg, Andres Lust, Jaak Nerut, Miriam Koppel, Tavo Romann, Rasmus Palm, Martin Månsson, Marko Vana, Heikki Junninen, Marian Külaviir, Päärn Paiste, Kalle Kirsimäe, Marite Punapart, Liane Viru, Andres Merits, Enn Lust
Pubblicato in: iScience, Numero 27, 2025, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2024.109835

Characterization of duck tembusu virus NS2A membrane topology and functional residues in transmembrane domain-3 on viral proliferation

Autori: Wei Zhang, Miao Zeng, Bowen Jiang, Yao Cheng, Yu He, Zhen Wu, Tao Wang, Mingshu Wang, Renyong Jia, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Andres Merits, Anchun Cheng, Shun Chen
Pubblicato in: Poultry Science, Numero 103, 2025, ISSN 0032-5791
Editore: Elsevier BV
DOI: 10.1016/J.PSJ.2024.104423

Genome-wide association analysis identifies a consistent QTL for powdery mildew resistance on chromosome 3A in Nordic and Baltic spring wheat

Autori: Min Lin, Bulat Islamov, Andrius Aleliūnas, Rita Armonienė, Andrii Gorash, Egon Meigas, Anne Ingver, Ilmar Tamm, Hannes Kollist, Vija Strazdiņa, Māra Bleidere, Gintaras Brazauskas, Morten Lillemo
Pubblicato in: Theoretical and Applied Genetics, Numero 137, 2024, ISSN 0040-5752
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00122-023-04529-1

Low electric current in a bioelectrochemical system facilitates ethanol production from CO using CO-enriched mixed culture

Autori: Chaeho Im, Minsoo Kim, Jung Rae Kim, Kaspar Valgepea, Oskar Modin, Yvonne Nygård, Carl Johan Franzén
Pubblicato in: Frontiers in Microbiology, Numero 15, 2024, ISSN 1664-302X
Editore: Frontiers Media SA
DOI: 10.3389/FMICB.2024.1438758

Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4′-Fluorouridine

Autori: Peiqi Yin, Elizabeth B. Sobolik, Nicholas A. May, Sainan Wang, Atef Fayed, Dariia Vyshenska, Adam M. Drobish, M. Guston Parks, Laura Sandra Lello, Andres Merits, Thomas E. Morrison, Alexander L. Greninger, Margaret Kielian
Pubblicato in: PLOS Pathogens, Numero 21, 2025, ISSN 1553-7374
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PPAT.1012859

The combination of pleconaril, rupintrivir, and remdesivir efficiently inhibits enterovirus infections in vitro, delaying the development of drug-resistant virus variants

Autori: Aleksandr Ianevski, Irene Trøen Frøysa, Hilde Lysvand, Carlemi Calitz, Teemu Smura, Hans-Johnny Schjelderup Nilsen, Erling Høyer, Jan Egil Afset, Adithya Sridhar, Katja C. Wolthers, Eva Zusinaite, Tanel Tenson, Reet Kurg, Valentyn Oksenych, Angel S. Galabov, Adelina Stoyanova, Magnar Bjørås, Denis E. Kainov
Pubblicato in: Antiviral Research, Numero 224, 2024, ISSN 0166-3542
Editore: Elsevier BV
DOI: 10.1016/J.ANTIVIRAL.2024.105842

Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses

Autori: Zhiwen Jiang, Andres Merits, Ying Qin, Gang Xing, Letian Zhang, Jie Chen, Ningning Wang, Margus Varjak, Xiaofeng Zhai, Dongyan Li, Wanjie Song, Shuo Su
Pubblicato in: PLOS Pathogens, Numero 20, 2024, ISSN 1553-7374
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PPAT.1012700