Description du projet
Comprendre dans quelle mesure nous pouvons prédire l’adaptation convergente
Malgré les énormes progrès théoriques réalisés dans le domaine de la biologie évolutive, il reste encore beaucoup à découvrir sur la convergence dans les organismes multicellulaires complexes. Ces connaissances sont précieuses pour comprendre différents phénomènes tels que la résistance aux agents pathogènes, aux pesticides ou à la pollution. Le projet CONstrainCONverge, financé par l’UE, étudie les mécanismes évolutifs qui sous-tendent la prévisibilité dans l’évolution adaptative. Fusionnant la génomique évolutive et la génétique moléculaire, la transcriptomique, la génomique statistique et les expériences fonctionnelles, ce projet veut faire la lumière sur les contraintes génétiques de l’adaptation convergente aux environnements stressants. Le modèle végétal utilisé sera l’Arabidopsis alpine, car ses huit populations ayant évolué indépendamment constituent une source idéale d’expérimentation.
Objectif
Is evolution predictable? In CONstrainCONverge, I aim to understand evolutionary mechanisms governing predictability in adaptive evolution, by asking why some genes are more likely reused by adaptation than others. Despite a rich theoretical background, systematic analysis of the mechanisms underlying convergence is lacking in complex multicellular organisms. That limits application of convergent evolutionary concepts in repeated evolution of socio-economically relevant traits such as resistance to pathogens, pesticides or pollution. To fill in this gap, I will study genetic constraints of convergent adaptation towards stressful alpine environments in plant model genus Arabidopsis. Eight independently evolved populations of alpine Arabidopsis provide a unique model of environmental adaptation, allowing to leverage an unprecedented range of genetic and experimental resources to address fundamental evolutionary questions. During my PhD I characterized this system from a population genomic point of view, preparing a ground for experimental genetic validations. In the outgoing phase, I will bring this experience to the host lab of Prof. Peichel at the University of Bern (UBERN), an expert in the evolutionary genetics of convergence in fishes. Systematic training in the host lab and three international research visits will broaden my bioinformatics and experimental skills. I will learn new multidisciplinary approaches bridging the fields of evolutionary genomics and molecular genetics through the combination of transcriptomics, statistical genomics, and functional experiments. I will return to Charles University (CU) to share the newly gained skills with local researchers and gain further training in functional genetics and transferable skills under the supervision of Prof. Lafon Placette, aiming to improve my teaching and leadership skills and establish my own research group in evolutionary genetics, a virtually non-existent field in Czech research environment.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global FellowshipsCoordinateur
116 36 Praha 1
Tchéquie