Project description
Innovative dendritic selenium-based prodrugs for cancer treatment
Reactive oxygen species (ROS) are free radicals containing oxygen that reacts with other cell molecules. Under normal physiological conditions, ROS drive regulatory pathways, and cells control the generation of ROS via scavenging systems. Elevated ROS levels are present in almost all cancer cells, where they promote proliferation. However, high levels of ROS can suppress the growth of cancer cells and kill them via activation of cell-cycle inhibitors. Selenium derivatives show chemotherapeutic potential, based on the ability to act as a pro-oxidant at high dosages. Funded by the Marie Skłodowska-Curie Actions programme, the RUPTURE project aims to develop novel anticancer agents based on selenium-containing dendritic carriers, targeting ROS signalling and inducing cell death.
Objective
Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. The radical generated, the location, as well as the local concentration, are essential for the cellular functions of ROS in cancer. Among redox modulating compounds, selenium derivatives have gained substantial attention due to their promising chemotherapeutic potential, which result from seleniums ability to act as a pro-oxidant at high dosage. This proposal is intended to develop novel therapeutic agents based on selenium-containing dendrimers, which act as precision carriers with unparalleled structural perfection. These agents, with a plethora of internally queued selenium-selenium bridges will be activated upon the rupturing of the dendritic carriers by external stimuli. It is herein envisioned that RUPTURE can rise to the challenge, acting as cutting-edge prodrugs that will fine-tune intracellular ROS signalling to effectively deprive cells of ROS-induced tumour-promoting events, thereby tipping the balance to ROS-induced apoptotic signalling.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
100 44 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.