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CORDIS

MicrobiomE-associaTEd boosters Of immune Responses (METEOR study): experimental charac-terization and clinical exploitation.

Descrizione del progetto

Modulatori della risposta immunitaria associati a microbiomi

Le interazioni tra le cellule ospiti e i sottoprodotti dei batteri possono influenzare il loro metabolismo, modificando l’esito della malattia. Finanziato dal programma di azioni Marie Skłodowska-Curie, il progetto METEOR mira a sviluppare strategie sperimentali per identificare nuovi agenti terapeutici, utilizzando amplificatori associati al microbioma della risposta immunitaria alle infezioni. La ricerca si avvarrà della culturomica diretta, di saggi di stimolazione immunitaria e di una serie di strumenti multiomici per caratterizzare i profili immunitari funzionali associati alle risposte immunitarie protettive e implementare l’estrazione dei dati attraverso un approccio di integrazione della bioinformatica. L’obiettivo è studiare il microbiota intestinale di diversi comparti e le comunità microbiche di tessuti correlati alla malattia. I candidati specifici selezionati saranno convalidati in studi preclinici e clinici come agenti terapeutici per il miglioramento delle risposte immunitarie specifiche della malattia.

Obiettivo

I became fascinated by pathogen-host interactions at the end of my PhD, working with Hepatitis C virus, and later in my first postdoctoral phase working with Influenza A and SARS-2 viruses, when I learned the OMIC technologies power. Finally, I found out about the world of microbiota-associated interactions and how Dr. Serrano’s studies unveiled these complex networks with a clinical perspective. Most microbiota studies are based on the description of the different bacterial species profiles. How-ever, the interactions between the byproducts derived from cells and bacteria can affect reciprocally to host and microbial metabolism, modifying the outcome of the disease. With my expertise on experi-mental settings, Dr Serrano’s clinical-research view, and the strong collaborations with expert partners in bioinformatics and multi-omics, for my next career step I aim to develop experimental strategies to better identify new potential therapeutic agents. Specifically, to clinically exploit MIcrobiome-associated BOosters of Immune responses to infectious Diseases (MIBOIDs) that define the nature of the host-microbiota interaction I will implement a protocol based on directed culturomics, immune stimulations assays, bacterial species description and multi-omic toolbox to characterize the functional immune profiles associated with highly protective immune responses, and data mining through a mul-tiparametric bioinformatic integration approach. We aim to test several conditions such as describing gut microbiota from different compartments, microbial communities from localized disease-related tissues, and to describe the most functionally relevant. Finally, after the production and validation of the specific candidates in vitro, this project will lead to future validation in preclinical and clinical studies to get specific MIBOIDs to be exploited as therapeutic agents aimed at improving disease-specific immune responses, prevention and cure for several diseases.

Meccanismo di finanziamento

HORIZON-AG-UN - HORIZON Unit Grant

Coordinatore

FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO RAMON Y CAJAL
Contribution nette de l'UE
€ 192 865,12
Indirizzo
CTRA COLMENAR VLEJO KM 9.100
28034 Madrid
Spagna

Mostra sulla mappa

Regione
Comunidad de Madrid Comunidad de Madrid Madrid
Tipo di attività
Other
Collegamenti
Costo totale
Nessun dato

Partner (2)