Project description DEENESFRITPL Rapid bacterial disease diagnostics for aquaculture Outbreaks of bacterial diseases represent a persistent challenge to fish farming leading to significant economic loss. In nature, microorganisms exist in diverse communities. Consequently, a combination of species can cause infections. However, the co-species involvement in disease progression is poorly understood and represents a significant diagnostic challenge. The Marie Skłodowska-Curie Actions (MSCA) funded chelOMICS project proposes an ambitious multidisciplinary initiative to understand host-pathogen interactions in aquaculture fish as relates to vibriosis, photobacteriosis, and furunculosis, three major bacterial diseases. The project will apply modern multi-omics tools, metabolomics and metagenomics. chelOMICS will focus on the metabolome of siderophores, which are key virulence factors during infection, and their use as biomarkers for early disease diagnostics. Show the project objective Hide the project objective Objective Outbreaks of bacterial diseases pose a persistent challenge to fish farming around the world causing significant economic loss. To improve efficiency, safety, and sustainability of aquaculture new health monitoring and rapid disease diagnostics approaches are required. Here, we propose an ambitious multidisciplinary project that implements modern multi-omics tools, in particular metabolomics and metagenomics, to provide a holistic understanding of host-pathogen interactions in farmed fish in the context of three major bacterial diseases; vibriosis, photobacteriosis, and furunculosis. This project will focus specifically on the metabolome of siderophores, iron chelating microbial metabolites that are key virulence factors during infection, and their use as biomarkers for early disease diagnostics. In nature, microorganisms exist in diverse communities and therefore infections can be caused by a combination of species yet the involvement of co-species in disease progression is poorly understood and represents a great diagnostic challenge. I have gained extensive skills in metabolomics through my PhD in Australia and postdoctoral experience in Germany. This project will enable me to go one step further; I will use different bioinformatic tools as well as imaging analytical chemistry (MALDI-IMS) approaches to integrate metabolomics and microbiome data and answer important ecological questions in aquaculture. I am highly motivated to take on this new challenge and acquire new scientific and transferable skills, which will strengthen my profile as an independent researcher and increase my opportunities for a permanent position after the fellowship. Fields of science natural scienceschemical sciencesanalytical chemistryagricultural sciencesagriculture, forestry, and fisheriesfisheriesnatural sciencesbiological sciencesmicrobiologybacteriology Keywords Siderophores multi-omics aquaculture diseases disease diagnostics holobiont concept Programme(s) HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme Topic(s) HORIZON-MSCA-2021-PF-01-01 - MSCA Postdoctoral Fellowships 2021 Call for proposal HORIZON-MSCA-2021-PF-01 See other projects for this call Funding Scheme HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships Coordinator UNIVERSIDADE DA CORUNA Net EU contribution € 181 152,96 Address CALLE DE LA MAESTRANZA 9 15001 La Coruna Spain See on map Region Noroeste Galicia A Coruña Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partners (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany Net EU contribution € 0,00 Address HOFGARTENSTRASSE 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data GRIFFITH UNIVERSITY Australia Net EU contribution € 0,00 Address KESSELS ROAD NATHAN 4111 Brisbane See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
