Addressing barrier integrity issues in the treatment of age-related macular degeneration
The macula is the part of the eye that is responsible for central vision. Damage to the macula can gradually occur as an individual ages, resulting in vision problems that significantly impact daily life. Research into age-related macular degeneration (AMD) has shown that disrupted endothelial barrier integrity is a significant driving force behind this condition. Based on this discovery, scientists of the EU-funded Opti-AAV project are working towards a novel therapy approach for AMD that involves the local delivery of exosome-encapsulated endothelial cell-specific adeno-associated virus into the blood–retina barrier. The aim is to enable the efficient transduction of retinal endothelial cells, thus preventing the progression of the disease.
Fields of science
- HORIZON.1.1 - European Research Council (ERC) Main Programme