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Towards a gene therapy for age-related macular degeneration (AMD)

Project description

Addressing barrier integrity issues in the treatment of age-related macular degeneration

The macula is the part of the eye that is responsible for central vision. Damage to the macula can gradually occur as an individual ages, resulting in vision problems that significantly impact daily life. Research into age-related macular degeneration (AMD) has shown that disrupted endothelial barrier integrity is a significant driving force behind this condition. Based on this discovery, scientists of the EU-funded Opti-AAV project are working towards a novel therapy approach for AMD that involves the local delivery of exosome-encapsulated endothelial cell-specific adeno-associated virus into the blood–retina barrier. The aim is to enable the efficient transduction of retinal endothelial cells, thus preventing the progression of the disease.

Coordinator

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Net EU contribution
€ 150 000,00
Address
College Green Trinity College
D02 CX56 Dublin 2
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Other funding
No data