Descrizione del progetto
Rete di ricerca e formazione per studiare i disturbi del tessuto connettivo legati all’età
L’insufficienza muscolo-scheletrica, cardiovascolare e neurodegenerativa sono caratteristiche comuni dell’invecchiamento e anche tratti comuni all’inizio di alcuni disturbi ereditari del tessuto connettivo. Il progetto CHANGE, finanziato dal programma di azioni Marie Skłodowska-Curie, si propone di identificare i percorsi chiave responsabili del declino legato all’età, studiando i disturbi dei tessuti connettivi e l’interazione dei percorsi che portano a risposte cellulari comuni. A tal fine, il progetto istituirà una rete di formazione di 12 dottorandi di cui faranno parte 7 partner accademici e 5 industriali. Utilizzando un approccio interdisciplinare, la rete si concentrerà sulla biologia di base dell’invecchiamento per scoprire le sue firme multisistemiche e creare una mappa integrativa dei processi cellulari legati all’età.
Obiettivo
The increased longevity in developed countries not necessarily goes hand in hand with amelioration of health and quality of life. Musculoskeletal, cardiovascular and neurodegenerative failure are not only hallmarks of the physical and cognitive decline in elderly people, but also represent common traits in several early-onset hereditary connective tissue (CT) disorders. These disorders represent a unique tool for the molecular investigation of such age-related pathologies due to the specific genetic disturbance of cellular homeostasis. The scientific objectives of CHANGE are: (i) to investigate CT disorders to identify key pathways responsible for age-related decline of physiological functions, being aware of gender differences (ii) to learn more about the interdependency of these pathways leading to stereotypic cellular responses including cellular senescence. This knowledge will pave the way for developing innovative treatment strategies for common diseases and frailty associated with ageing. To this end, we will train and establish a network of 10 highly-skilled doctoral candidates (DC) equipped with scientific expertise, transferable skills and societal and environment awareness as a foundation for their future careers. To succeed, CHANGE has built a unique and multidisciplinary network of 7 renowned academic partners and 5 companies (including 2 non-academics as associated partners) working together to train 10 young scientists. The DC network will address the basic biology of ageing from an interdisciplinary perspective, by deeply investigating CT diseases to uncover the pillars of ageing and its multi-systemic signatures. Altogether, CHANGE will provide an integrative map of cellular/extracellular consequences of age-related changes in cartilage, bone, muscle and vasculature as consequences to precocious disease exposure.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Meccanismo di finanziamento
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinatore
27100 Pavia
Italia