Project description
AI-based platform for managing complex diseases
Atrial fibrillation (AF) can lead to the formation of blood clots in the heart, resulting in strokes. The EU-funded ARISTOTELES project will establish a multinational data platform for developing AI approaches to manage complex diseases with comorbidities through various pathways. Employing innovative AI technology, the project seeks to assist patients dealing with AF and other intricate diseases. The integration of AI into clinical practice aims to create personalised risk assessment and management tools using patient data in an ethical manner. The focus of AF treatment is on a more comprehensive approach, emphasising timely diagnosis and treatment to mitigate disease progression, reduce disability, lower hospitalisations and decrease mortality rates. Additionally, it enhances patient adherence to treatment regimens.
Objective
The ARISTOTELES project aims to build a multinational harmonized data platform to develop and implement novel artificial intelligence (AI) approaches for management of complex diseases, where progression and manifestations of comorbidities are via multiple interacting pathways. We aim to apply our novel approach to a population of great need due to atrial fibrillation (AF), but our outputs can be extended to other complex diseases with multimorbidity. By integrating AIs into clinical practice, our platform will form a backbone for acceptable, responsible, and respectful uses of patient/participant data to develop and validate novel trustworthy AI tools for more personalized risk assessment and management. This represents a paradigm shift in AF treatment, moving from a focus on individual risk factors and selected outcomes (eg. stroke) to a holistic approach, underpinning timely diagnostic and therapeutic interventions to reduce disease progression, disability, hospitalizations and mortality, as well as improve patient adherence to lifestyle modifications, medications, and other treatment regimens.
ARISTOTELES will be delivered through 8 inter-linking work-packages (WPs): WP1 is study management/coordination. WP2 provides the ethical/legal requirements for the development of a trustworthy AI. WP3 addresses stakeholder understanding of AI, needs assessment, and engagement in all the phases of the AI development. In WP4, granular data on genotype and phenotype characteristics, are harmonized from different datasets into a common platform. In WP5, AI algorithms/tools are developed and connected to an interactive output interface for patients and clinicians. In WP6, we test the AI tool developed in WP5 in a clinical trial simulation (in silico trial). In WP7 a multicenter randomized trial runs across multiple countries including both primary care and secondary care. WP7 and WP8 drive the clinical implementation and dissemination of results.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.1 - Health throughout the Life Course
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2022-STAYHLTH-01-two-stage
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
41121 Modena
Italy
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Participants (10)
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9220 Aalborg
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30003 Murcia
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1000 Bruxelles / Brussel
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30655 Murcia
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0313 Oslo
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020021 Bucuresti
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741 00 RETHIMNO
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50121 FIRENZE
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92100 Boulogne-Billancourt
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3004-531 Coimbra
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Partners (7)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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28002 Madrid
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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41122 MODENA
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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L7 9NJ LIVERPOOL
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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L69 7ZX LIVERPOOL
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M13 9PL Manchester
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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L3 5AH LIVERPOOL
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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WC1E 6BT London
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