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Training AlliancE for Novel Microbiome-Modulating TherapieS

Description du projet

Une plateforme de formation à la découverte de médicaments axée sur les modifications thérapeutiques du microbiote

Financé par le programme Actions Marie Skłodowska-Curie, le projet TALENTS a pour ambition de mettre sur pied une alliance internationale pour la formation interdisciplinaire de quinze candidats au doctorat, en qualité de chercheurs de la prochaine génération de médicaments. Les projets individuels sont structurés de manière à se concentrer sur l’étude du microbiome et des modifications thérapeutiques du microbiote, sur les alternatives aux antibiotiques traditionnels visant à réduire le risque de développement de résistances, et sur les modes d’administration de nouveaux agents thérapeutiques. L’objectif global consiste à développer de nouveaux modèles de maladies ainsi que de nouvelles méthodes analytiques. En mettant en évidence les corrélations et les liens entre le microbiote et l’origine des maladies, TALENTS fera progresser la recherche de traitements innovants modulant le microbiome.

Objectif

TALENTS aims to build up an international programme for interdisciplinary and transsectorial training of 15 doctoral candidates (DCs) as needed for the next generation of drug researchers. Research projects are structured in 3 clusters (PCs): PC1 will investigate the microbiome by transcriptomic and metagenomic analysis of diseases to identify and isolate microorganisms/metabolites for therapeutically modifying the microbiota. PC2 will focus on pathoblockers targeting virulence factors as alternative to traditional antibiotics with lower risk of resistance development. PC3 will address the delivery needs across biological barriers, to achieve efficient and targeted transport to the site of action. Throughout the PC structure of 15 individual, but interconnected research projects, we aim to develop and exchange disease models, analytical methods and microbiome-related results. By generating knowledge on correlations and causalities between microbiota and disease TALENTS will advance the development of novel microbiome-modulating therapies
TALENTS is builds on an earlier joint venture of Saarland University, University Clinics Saarland and Helmholtz Institute for Pharmaceutical Research Saarland to foster transdisciplinary doctoral training between different faculties and institutions. In addition, TALENTS is intersectorial by implementing a unique supervision structure for each DC with an external expert advisor and translation-oriented training for individual career development, also including secondments in a complementary industrial or clinical sector. Working on challenging research projects, the candidates will acquire specific knowledge and skills at the interface of clinical medicine, microbiology and pharmaceutical science, pivotal for state-of-the-art infection research and microbiome interventions.
By collaborations of experts from natural sciences, medicine, and bioinformatics, TALENTS provides high-level multidisciplinary and intersectorial training.

Coordinateur

UNIVERSITAT DES SAARLANDES
Contribution nette de l'UE
€ 1 512 000,00
Adresse
CAMPUS
66123 Saarbrucken
Allemagne

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Région
Saarland Saarland Regionalverband Saarbrücken
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée

Partenaires (16)