Projektbeschreibung
Endoskopie zur Untersuchung von Tiefenhirnschlägen
Ein Tiefenhirnschlag entsteht, wenn der Blutfluss zu einer kleinen Arterie tief im Gehirn blockiert wird. Tiefenhirnschläge sind jedoch meist klein und verursachen keine Symptome. Das vom Europäischen Forschungsrat finanzierte Projekt StrokeGATE wird die Auswirkungen eines Tiefenhirnschlags untersuchen. Die Forschenden beabsichtigen, eine zuvor entwickelte hochauflösende Bildgebungsmethode zu nutzen, mit der die Hirnaktivität auf der Ebene einzelner Zellen gemessen werden kann. Diese Methode verwendet ein haarfeines Multimode-Faserendoskop, das in Tiermodellen eingesetzt wird, um Veränderungen in der neuronalen Konnektivität und Signalübertragung zu beobachten. Wichtig ist, dass im Rahmen des Projekts holografische Methoden zur Rekonstruktion endoskopischer Bilder eingeführt werden, um ein besseres Verständnis des Tiefenhirnschlags zu erhalten.
Ziel
The origin project LIFEGATE introduced the prospect of multimode fibre based holographic endoscope as a unique tool for high-resolution in-vivo imaging of structures residing deep inside the brain of animal models. It harnesses the power of controlled light transport through hair-thin MMFs to image and measure brain functions at single cell and sub-cellular level in virtually any brain structure, at unlimited depth and in uniquely atraumatic manner, thereby unlocking a variety of opportunities when answering urgent bio-medical questions.
The proposed ERC-PoC project StrokeGATE aims to utilise achievements of the origin project to introduce a novel, complete technological platform for investigating the impact of deep-brain stroke in living animal models. The geometry of the most advanced holographic endoscope currently built will be modified to allow induction of stroke of controlled magnitude, representing a powerful extension of the instrument’s applicability from the perspective of the users in neuroscience. Already available imaging capacity of the instrument will facilitate its navigation into the desired brain structure and, once the stroke is induced, monitoring changes to structural connectivity of the neurones within a circuit as well as development / suppression of signalling activity.
LIFEGATE has already established a solid pathway to commercialisation through a start-up endeavour. Although intellectual property is expected to be generated during the execution of StrokeGATE, its main translational value lies in demonstrating the utility of MMF endoscopes across the relevant community of researchers who by now had only limited chances to fully appreciate the potential of such radically new and disruptive technological arrival. Successful accomplishment of StrokeGATE will unlock the exploitability of holographic endoscopy across a wider topical range of biomedical research, and reduce its translational barriers.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Thema/Themen
Finanzierungsplan
HORIZON-ERC-POC - HORIZON ERC Proof of Concept GrantsGastgebende Einrichtung
61264 BRNO
Tschechien