Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy

Información del proyecto

CardioSCOPE

Identificador del acuerdo de subvención: 101086397

DOI

10.3030/101086397

Fecha de la firma de la CE 13 Octubre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 1 518 000,00

Coordinado por

UNIVERSITA DEGLI STUDI DI MILANO
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Plan for dissemination and exloitation including communication activities

Other (4)

SOP for analytical phase

set of optimized protocols related to the analytical phase

Study protocol

Set of optimized protocols related to patient recruitment and sample collection

SOP for ML/AI and bioinformatics

set of optimized protocols related to data integration and bioinformatics

SOP for pre-analytical phase

set of optimized protocols related to the preanalytical phase

Data Management Plan (1)

Data management plan

a report outlining the strategies and ethical requirements for collecting storing processing and sharing data generated during the project

Publicaciones

Peer reviewed articles (22)

Editorial: Multiomic approaches in atherosclerosis

Autores: Sopić, Miron; Mitić, Tijana; Sluimer, Judith; Magni, Paolo; Devaux, Yvan
Publicado en: Vascular Pharmacology, 2025
Editor: ELSEVIER
DOI: 10.1016/J.VPH.2025.107501

Risk Factors and Immunoinflammatory Mechanisms Leading to Atherosclerosis: Focus on the Role of Oral Microbiota Dysbiosis

Autores: Riccardo Mattia Ricciardi; Alessia Cipollone; Damiano D’Ardes; Davide Di Giacomo; Pamela Pignatelli; Francesco Cipollone; Maria Cristina Curia; Paolo Magni; Marco Bucci
Publicado en: Microorganisms, 2023, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/MICROORGANISMS11061479

Costus afer Ker Gawl (Bush cane) extracts modulate glucose uptake, triglyceride accumulation and oxidative stress in human SW 872 liposarcoma and HepG2 hepatocarcinoma cells

Autores: Achille Parfait NWAKIBAN ATCHAN; Jules-Roger KUIATE; Gabriel AGBOR AGBOR; François Ferriere; Mario Dell’Agli; Paolo Magni; Armelle Deutou Tchamgoue
Publicado en: Crossref, 2025
Editor: RESEARCH SQUARE
DOI: 10.21203/RS.3.RS-5690853/V1

An integrated view of the pathophysiological crosstalk between adipose tissue, bone and cardiovascular system in men and women

Autores: Fationa Tolaj Klinaku; Laura Comi; Claudia Giglione; Paolo Magni
Publicado en: Journal of Endocrinological Investigation, 2024, ISSN 1720-8386
Editor: Springer
DOI: 10.1007/S40618-024-02516-X

Toward Precision Medicine in Atherosclerotic Cardiovascular Disease: Insights from Omics Data into Sex Differences

Autores: Munjas, Jelena; Vladimirov, Sandra; Ratković, Tamara; Comi, Laura; Giglione, Claudia; Tanasković, Ilija; Gojković, Tamara; Rakić, Branka; Davidović, Aleksandar; Vukmirović, Luka; Milanov, Marko; Cvijanović, Dane; Magni, Paolo; Sopić, Miron
Publicado en: Current Atherosclerosis Reports, 2025
Editor: SPRINGER NATURE
DOI: 10.1007/S11883-025-01380-1

Multiomics tools for improved atherosclerotic cardiovascular disease management

Autores: Sopić, Miron; Vilne, Baiba; Gerdts, Eva; Trindade, Fábio; Uchida, Shizuka; Khatib, Soliman; Wettinger, Stephanie Bezzina; Devaux, Yvan; Magni, Paolo
Publicado en: Trends in Molecular Medicine, 2023, ISSN 1471-4914
Editor: Elsevier BV
DOI: 10.1016/J.MOLMED.2023.09.004

LncRNAs as Regulators of Atherosclerotic Plaque Stability

Autores: Aleksa Petkovic; Sanja Erceg; Jelena Munjas; Ana Ninic; Sandra Vladimirov; Aleksandar Davidovic; Luka Vukmirovic; Marko Milanov; Dane Cvijanovic; Tijana Mitic; Miron Sopic
Publicado en: Cells, 2023, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells12141832

Current status and challenges of multi-omics research using animal models of atherosclerosis

Autores: Tijana Mitić; Adriana Georgescu; Nicoleta Alexandru-Moise; Michael J. Davies; Cecile Vindis; Susana Novella; Eva Gerdts; Georgios Kararigas; Stephanie Bezzina Wettinger; Melissa M. Formosa; Brenda R. Kwak; Filippo Molica; Nuria Amigo; Andrea Caporali; Fernando de la Cuesta; Ignacio Fernando Hall; Angeliki Chroni; Fabio Martelli; Johannes A. Schmid; Paolo Magni; Dimitris Kardassis
Publicado en: Journal of Molecular and Cellular Cardiology Plus, 2025
Editor: ELSEVIER
DOI: 10.1016/J.JMCCPL.2025.100476

Navigating the path of reproducibility in microRNA-based biomarker research with ring trials

Autores: Sopić, Miron; Devaux, Yvan; de Gonzalo-Calvo, David
Publicado en: Clinical Chemistry and Laboratory Medicine (CCLM), 2024
Editor: DE GRUYTER BRILL
DOI: 10.1515/CCLM-2024-0531

Additional file 1 of Web discussions on cardiovascular diseases: pre-COVID-19 evaluation and impact of the COVID-19 pandemic – Web listening analysis in the Italian population

Autores: Cecchini, Isabella; Biroli, Matteo; Massaroni, Katia; Folco, Emanuela; Montebelli, Maria Rita; Ciancamerla, Giuseppe; Giudice, Daniela; Pedretti, Roberto Franco Enrico; Magni, Paolo
Publicado en: 2024
Editor: FIGSHARE
DOI: 10.6084/M9.FIGSHARE.27928424.V1

Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development

Autores: Alyssa J. J. Paganoni; Rossella Cannarella; Roberto Oleari; Federica Amoruso; Renata Antal; Marco Ruzza; Chiara Olivieri; Rosita A. Condorelli; Sandro La Vignera; Fationa Tolaj; Anna Cariboni; Aldo E. Calogero; Paolo Magni
Publicado en: International Journal of Molecular Sciences; Volume 24; Edición 17; Pages: 13073, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/IJMS241713073

Multiomics in atherosclerotic cardiovascular disease

Autores: Nordestgaard, Liv Tybjærg; Wolford, Brooke N.; de Gonzalo-Calvo, David; Sopić, Miron; Devaux, Yvan; Matic, Ljubica; Wettinger, Stephanie Bezzina; Schmid, Johannes A.; Amigó, Núria; Masana, Lluís; Catapano, Alberico L.; Kardassis, Dimitris; Magni, Paolo
Publicado en: Atherosclerosis, 2025
Editor: ELSEVIER
DOI: 10.1016/J.ATHEROSCLEROSIS.2025.120414

Nutraceutical alternatives to red yeast rice extract/monacolin K for moderate hypercholesterolaemia: Current evidence and knowledge gaps: Nutraceuticals and hypercholesterolaemia

Autores: Comi, Laura; Giglione, Claudia; Tolaj, Fationa; Parolini, Cinzia; Olivieri, Chiara; Ruzza, Marco; Tollemeto, Valentina; Zurlo, Maria; Pialorsi, Federico; Seneci, Antonio; Magni, Paolo
Publicado en: European Atherosclerosis Journal, 2023
Editor: European Atherosclerosis Journal
DOI: 10.56095/EAJ.V1I3.20

Single-cell RNA sequencing (scRNA-seq) and its insights into cellular heterogeneity in atherosclerosis

Autores: Yu, Baixue; Sopić, Miron; Sluimer, Judith C.
Publicado en: Vascular Pharmacology, 2025
Editor: ELSEVIER
DOI: 10.1016/J.VPH.2025.107499

Adherence to Mediterranean Diet: A Population-Based Longitudinal Cohort Study

Autores: Elisa Mattavelli; Elena Olmastroni; Manuela Casula; Liliana Grigore; Fabio Pellegatta; Andrea Baragetti; Paolo Magni; Alberico L. Catapano
Publicado en: Nutrients; Volume 15; Edición 8; Pages: 1844, 2023, ISSN 2072-6643
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/NU15081844

Evaluation of Metabolic Dysfunction-Associated Fatty Liver Disease-Related Pathogenic Mechanisms in Human Steatotic Liver Cell-Based Model: Beneficial Effects of Prunus domestica L. subsp. syriaca Extract

Autores: Laura Comi; Claudia Giglione; Fationa Tolaj Klinaku; Lorenzo Da Dalt; Hammad Ullah; Maria Daglia; Paolo Magni
Publicado en: Nutrients, 2025
Editor: MDPI
DOI: 10.3390/NU17071249

British Journal of Pharmacology

Autores: Miron Sopić; Sandra Vladimirov; Jelena Munjas; Tijana Mitić; Ignacio Fernando Hall; Amela Jusic; Dusan Ruzic; Yvan Devaux
Publicado en: British Journal of Pharmacology, 2024, ISSN 0007-1188
Editor: British Pharmacological Society
DOI: 10.1111/BPH.16412

Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities

Autores: Comi, Laura; Giglione, Claudia; Klinaku, Fationa Tolaj; Pialorsi, Federico; Tollemeto, Valentina; Zurlo, Maria; Seneci, Antonio; Magni, Paolo
Publicado en: Food Frontiers, 2024
Editor: WILEY
DOI: 10.1002/FFT2.535

Integration of epigenetic regulatory mechanisms in heart failure

Autores: Sopić, Miron; Robinson, Emma L.; Emanueli, Costanza; Srivastava, Prashant; Angione, Claudio; Gaetano, Carlo; Condorelli, Gianluigi; Martelli, Fabio; Pedrazzini, Thierry; Devaux, Yvan
Publicado en: Basic Research in Cardiology, 2023, ISSN 0300-8428
Editor: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/S00395-023-00986-3

The converging roles of microRNAs and lipid metabolism in atherosclerotic cardiovascular disease and cancer

Autores: Vladimirov, Sandra; Tomašević, Marija; Popov, Nemanja; Munjas, Jelena; de Gonzalo-Calvo, David; Sopić, Miron
Publicado en: Seminars in Cancer Biology, 2025
Editor: ELSEVIER
DOI: 10.1016/J.SEMCANCER.2025.06.005

BMC Public Health

Autores: Cecchini I.; Biroli M.; Massaroni K.; Folco E.; Montebelli M. R.; Ciancamerla G.; Giudice D.; Pedretti R. F. E.; Magni P.
Publicado en: BMC Public Health, 2024, ISSN 1471-2458
Editor: BMC
DOI: 10.1186/S12889-024-20615-5

Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges

Autores: Sopić, Miron; Karaduzovic-Hadziabdic, Kanita; Kardassis, Dimitris; Maegdefessel, Lars; Martelli, Fabio; Meerson, Ari; Munjas, Jelena ; Niculescu, Loredan S.; Stoll, Monika; Magni, Paolo; Devaux, Yvan;
Publicado en: Journal of Molecular and Cellular Cardiology Plus, 2023, ISSN 2772-9761
Editor: ELSEVIER
DOI: 10.1016/J.JMCCPL.2023.100048