Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy

Informations projet

CardioSCOPE

N° de convention de subvention: 101086397

DOI

10.3030/101086397

Date de signature de la CE 13 Octobre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2026

Financé au titre de

• Marie Skłodowska-Curie Actions (MSCA)

Coût total

Aucune donnée

Contribution de l’UE

€ 1 518 000,00

Coordonné par

UNIVERSITA DEGLI STUDI DI MILANO
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Plan for dissemination and exloitation including communication activities

Other (4)

SOP for analytical phase

set of optimized protocols related to the analytical phase

Study protocol

Set of optimized protocols related to patient recruitment and sample collection

SOP for ML/AI and bioinformatics

set of optimized protocols related to data integration and bioinformatics

SOP for pre-analytical phase

set of optimized protocols related to the preanalytical phase

Data Management Plan (1)

Data management plan

a report outlining the strategies and ethical requirements for collecting storing processing and sharing data generated during the project

Publications

Peer reviewed articles (22)

Editorial: Multiomic approaches in atherosclerosis

Auteurs: Sopić, Miron; Mitić, Tijana; Sluimer, Judith; Magni, Paolo; Devaux, Yvan
Publié dans: Vascular Pharmacology, 2025
Éditeur: ELSEVIER
DOI: 10.1016/J.VPH.2025.107501

Risk Factors and Immunoinflammatory Mechanisms Leading to Atherosclerosis: Focus on the Role of Oral Microbiota Dysbiosis

Auteurs: Riccardo Mattia Ricciardi; Alessia Cipollone; Damiano D’Ardes; Davide Di Giacomo; Pamela Pignatelli; Francesco Cipollone; Maria Cristina Curia; Paolo Magni; Marco Bucci
Publié dans: Microorganisms, 2023, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/MICROORGANISMS11061479

Costus afer Ker Gawl (Bush cane) extracts modulate glucose uptake, triglyceride accumulation and oxidative stress in human SW 872 liposarcoma and HepG2 hepatocarcinoma cells

Auteurs: Achille Parfait NWAKIBAN ATCHAN; Jules-Roger KUIATE; Gabriel AGBOR AGBOR; François Ferriere; Mario Dell’Agli; Paolo Magni; Armelle Deutou Tchamgoue
Publié dans: Crossref, 2025
Éditeur: RESEARCH SQUARE
DOI: 10.21203/RS.3.RS-5690853/V1

An integrated view of the pathophysiological crosstalk between adipose tissue, bone and cardiovascular system in men and women

Auteurs: Fationa Tolaj Klinaku; Laura Comi; Claudia Giglione; Paolo Magni
Publié dans: Journal of Endocrinological Investigation, 2024, ISSN 1720-8386
Éditeur: Springer
DOI: 10.1007/S40618-024-02516-X

Toward Precision Medicine in Atherosclerotic Cardiovascular Disease: Insights from Omics Data into Sex Differences

Auteurs: Munjas, Jelena; Vladimirov, Sandra; Ratković, Tamara; Comi, Laura; Giglione, Claudia; Tanasković, Ilija; Gojković, Tamara; Rakić, Branka; Davidović, Aleksandar; Vukmirović, Luka; Milanov, Marko; Cvijanović, Dane; Magni, Paolo; Sopić, Miron
Publié dans: Current Atherosclerosis Reports, 2025
Éditeur: SPRINGER NATURE
DOI: 10.1007/S11883-025-01380-1

Multiomics tools for improved atherosclerotic cardiovascular disease management

Auteurs: Sopić, Miron; Vilne, Baiba; Gerdts, Eva; Trindade, Fábio; Uchida, Shizuka; Khatib, Soliman; Wettinger, Stephanie Bezzina; Devaux, Yvan; Magni, Paolo
Publié dans: Trends in Molecular Medicine, 2023, ISSN 1471-4914
Éditeur: Elsevier BV
DOI: 10.1016/J.MOLMED.2023.09.004

LncRNAs as Regulators of Atherosclerotic Plaque Stability

Auteurs: Aleksa Petkovic; Sanja Erceg; Jelena Munjas; Ana Ninic; Sandra Vladimirov; Aleksandar Davidovic; Luka Vukmirovic; Marko Milanov; Dane Cvijanovic; Tijana Mitic; Miron Sopic
Publié dans: Cells, 2023, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells12141832

Current status and challenges of multi-omics research using animal models of atherosclerosis

Auteurs: Tijana Mitić; Adriana Georgescu; Nicoleta Alexandru-Moise; Michael J. Davies; Cecile Vindis; Susana Novella; Eva Gerdts; Georgios Kararigas; Stephanie Bezzina Wettinger; Melissa M. Formosa; Brenda R. Kwak; Filippo Molica; Nuria Amigo; Andrea Caporali; Fernando de la Cuesta; Ignacio Fernando Hall; Angeliki Chroni; Fabio Martelli; Johannes A. Schmid; Paolo Magni; Dimitris Kardassis
Publié dans: Journal of Molecular and Cellular Cardiology Plus, 2025
Éditeur: ELSEVIER
DOI: 10.1016/J.JMCCPL.2025.100476

Navigating the path of reproducibility in microRNA-based biomarker research with ring trials

Auteurs: Sopić, Miron; Devaux, Yvan; de Gonzalo-Calvo, David
Publié dans: Clinical Chemistry and Laboratory Medicine (CCLM), 2024
Éditeur: DE GRUYTER BRILL
DOI: 10.1515/CCLM-2024-0531

Additional file 1 of Web discussions on cardiovascular diseases: pre-COVID-19 evaluation and impact of the COVID-19 pandemic – Web listening analysis in the Italian population

Auteurs: Cecchini, Isabella; Biroli, Matteo; Massaroni, Katia; Folco, Emanuela; Montebelli, Maria Rita; Ciancamerla, Giuseppe; Giudice, Daniela; Pedretti, Roberto Franco Enrico; Magni, Paolo
Publié dans: 2024
Éditeur: FIGSHARE
DOI: 10.6084/M9.FIGSHARE.27928424.V1

Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development

Auteurs: Alyssa J. J. Paganoni; Rossella Cannarella; Roberto Oleari; Federica Amoruso; Renata Antal; Marco Ruzza; Chiara Olivieri; Rosita A. Condorelli; Sandro La Vignera; Fationa Tolaj; Anna Cariboni; Aldo E. Calogero; Paolo Magni
Publié dans: International Journal of Molecular Sciences; Volume 24; Numéro 17; Pages: 13073, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/IJMS241713073

Multiomics in atherosclerotic cardiovascular disease

Auteurs: Nordestgaard, Liv Tybjærg; Wolford, Brooke N.; de Gonzalo-Calvo, David; Sopić, Miron; Devaux, Yvan; Matic, Ljubica; Wettinger, Stephanie Bezzina; Schmid, Johannes A.; Amigó, Núria; Masana, Lluís; Catapano, Alberico L.; Kardassis, Dimitris; Magni, Paolo
Publié dans: Atherosclerosis, 2025
Éditeur: ELSEVIER
DOI: 10.1016/J.ATHEROSCLEROSIS.2025.120414

Nutraceutical alternatives to red yeast rice extract/monacolin K for moderate hypercholesterolaemia: Current evidence and knowledge gaps: Nutraceuticals and hypercholesterolaemia

Auteurs: Comi, Laura; Giglione, Claudia; Tolaj, Fationa; Parolini, Cinzia; Olivieri, Chiara; Ruzza, Marco; Tollemeto, Valentina; Zurlo, Maria; Pialorsi, Federico; Seneci, Antonio; Magni, Paolo
Publié dans: European Atherosclerosis Journal, 2023
Éditeur: European Atherosclerosis Journal
DOI: 10.56095/EAJ.V1I3.20

Single-cell RNA sequencing (scRNA-seq) and its insights into cellular heterogeneity in atherosclerosis

Auteurs: Yu, Baixue; Sopić, Miron; Sluimer, Judith C.
Publié dans: Vascular Pharmacology, 2025
Éditeur: ELSEVIER
DOI: 10.1016/J.VPH.2025.107499

Adherence to Mediterranean Diet: A Population-Based Longitudinal Cohort Study

Auteurs: Elisa Mattavelli; Elena Olmastroni; Manuela Casula; Liliana Grigore; Fabio Pellegatta; Andrea Baragetti; Paolo Magni; Alberico L. Catapano
Publié dans: Nutrients; Volume 15; Numéro 8; Pages: 1844, 2023, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/NU15081844

Evaluation of Metabolic Dysfunction-Associated Fatty Liver Disease-Related Pathogenic Mechanisms in Human Steatotic Liver Cell-Based Model: Beneficial Effects of Prunus domestica L. subsp. syriaca Extract

Auteurs: Laura Comi; Claudia Giglione; Fationa Tolaj Klinaku; Lorenzo Da Dalt; Hammad Ullah; Maria Daglia; Paolo Magni
Publié dans: Nutrients, 2025
Éditeur: MDPI
DOI: 10.3390/NU17071249

British Journal of Pharmacology

Auteurs: Miron Sopić; Sandra Vladimirov; Jelena Munjas; Tijana Mitić; Ignacio Fernando Hall; Amela Jusic; Dusan Ruzic; Yvan Devaux
Publié dans: British Journal of Pharmacology, 2024, ISSN 0007-1188
Éditeur: British Pharmacological Society
DOI: 10.1111/BPH.16412

Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities

Auteurs: Comi, Laura; Giglione, Claudia; Klinaku, Fationa Tolaj; Pialorsi, Federico; Tollemeto, Valentina; Zurlo, Maria; Seneci, Antonio; Magni, Paolo
Publié dans: Food Frontiers, 2024
Éditeur: WILEY
DOI: 10.1002/FFT2.535

Integration of epigenetic regulatory mechanisms in heart failure

Auteurs: Sopić, Miron; Robinson, Emma L.; Emanueli, Costanza; Srivastava, Prashant; Angione, Claudio; Gaetano, Carlo; Condorelli, Gianluigi; Martelli, Fabio; Pedrazzini, Thierry; Devaux, Yvan
Publié dans: Basic Research in Cardiology, 2023, ISSN 0300-8428
Éditeur: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/S00395-023-00986-3

The converging roles of microRNAs and lipid metabolism in atherosclerotic cardiovascular disease and cancer

Auteurs: Vladimirov, Sandra; Tomašević, Marija; Popov, Nemanja; Munjas, Jelena; de Gonzalo-Calvo, David; Sopić, Miron
Publié dans: Seminars in Cancer Biology, 2025
Éditeur: ELSEVIER
DOI: 10.1016/J.SEMCANCER.2025.06.005

BMC Public Health

Auteurs: Cecchini I.; Biroli M.; Massaroni K.; Folco E.; Montebelli M. R.; Ciancamerla G.; Giudice D.; Pedretti R. F. E.; Magni P.
Publié dans: BMC Public Health, 2024, ISSN 1471-2458
Éditeur: BMC
DOI: 10.1186/S12889-024-20615-5

Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges

Auteurs: Sopić, Miron; Karaduzovic-Hadziabdic, Kanita; Kardassis, Dimitris; Maegdefessel, Lars; Martelli, Fabio; Meerson, Ari; Munjas, Jelena ; Niculescu, Loredan S.; Stoll, Monika; Magni, Paolo; Devaux, Yvan;
Publié dans: Journal of Molecular and Cellular Cardiology Plus, 2023, ISSN 2772-9761
Éditeur: ELSEVIER
DOI: 10.1016/J.JMCCPL.2023.100048