Advanced Characterisation Methodologies to assess and predict the Health and Environmental Risks of Advanced Materials

Leistungen

] In alignment with the Industry Commons initiative, MACRAMÉ will build on the results of Task 1.2 to plan and guide the specific cooperation with and dissemination to related sectors and projects; this task will (a) elaborate concepts for engagement with industry communities and their related policy-informing and –making bodies, standardising (i.e. ISO, CEN, nat. bodies) and harmonising (i.e. OECD) bodies, and related projects (i.e. Horizon 2020/Europe), (b) identify stakeholders and organise workshops, and (c) set-up a strategic MACRAMÉ Engagement Roadmap, which builds on the successful ‘REFINE Knowledge Exchange’- and the ‘NanoHarmony’-engagement-processes, and sets sequence/‘time-dependent’ criteria for the MACRAMÉ communication actions in alignment with WP6. The Roadmap will include a dissemination plan for the data-driven hyperconnectivity and interoperability (WP3), and coordinate the execution of the prescribed communication in other WPs (i.e. concerning standardisation- and harmonisation-bodies). The 1st MACRAMÉ Risk Assessors Summit will be held in collaboration with a WP5-standardisation & harmonisation workshop (M12, hosted by BAuA), to reflect with stakeholders from academia, industry, and regulation and standardisation agencies on (a) the status and needs of the regulatory frameworks for the safety of AdMas during the life-cycle of a product, and (b) how the Project plans contribute to this topic. The 2nd MACRAMÉ Risk Assessor Summit (M36) will discuss the MACRAMÉ results and lessons learned with all relevant stakeholders to propose future actions. It will be held at the OECD (alternatively at LIST or RIVM).

Report on the MACRAMÉ Control Material Library

Task 2.1 will generate and characterise a Control Material Library (CML) for AdMas representative of the MACRAMÉ Use-Cases, including (i) the AdMas (e.g. FLG, MLG, GO, CNTs, PLGA NPs), (ii) representative finished products composed of matrices with/without the incorporated AdMas, (iii) AdMas and finished products subjected to simulated controlled ageing, incineration or pyrolysis, and (iv) materials with known toxicity, possibly belonging to AdMas that will serve as benchmark materials in Task 2.3. The materials will be characterised in their pristine state or after incubation in complex environmental/biological matrices. For the physical-chemical characterisation of the critical attributes of the materials included in the CML, advanced methods (incl. SEM, SEM/EDS, AFM, optical microscopy and their combination toward correlative approaches based on constellation matching algorithms, XPS, SMLS and cryo-TEM, DLS, NTA, EDS or Raman) will be used, and alternative methodologies to the gold standard approaches will be developed; this will allow the characterisation of the following attributes: (i) size, (ii) lateral size, (iii) oxidation state (e.g. for GRM) (iv) physical stability in environmental media and biological fluids, (v) distribution of AdMas in the finished products, and (vi) propensity of AdMas to degradation.

Summary Report about the 1st Risk Assessors Summit

] In alignment with the Industry Commons initiative, MACRAMÉ will build on the results of Task 1.2 to plan and guide the specific cooperation with and dissemination to related sectors and projects; this task will (a) elaborate concepts for engagement with industry communities and their related policy-informing and –making bodies, standardising (i.e. ISO, CEN, nat. bodies) and harmonising (i.e. OECD) bodies, and related projects (i.e. Horizon 2020/Europe), (b) identify stakeholders and organise workshops, and (c) set-up a strategic MACRAMÉ Engagement Roadmap, which builds on the successful ‘REFINE Knowledge Exchange’- and the ‘NanoHarmony’-engagement-processes, and sets sequence/‘time-dependent’ criteria for the MACRAMÉ communication actions in alignment with WP6. The Roadmap will include a dissemination plan for the data-driven hyperconnectivity and interoperability (WP3), and coordinate the execution of the prescribed communication in other WPs (i.e. concerning standardisation- and harmonisation-bodies). The 1st MACRAMÉ Risk Assessors Summit will be held in collaboration with a WP5-standardisation & harmonisation workshop (M12, hosted by BAuA), to reflect with stakeholders from academia, industry, and regulation and standardisation agencies on (a) the status and needs of the regulatory frameworks for the safety of AdMas during the life-cycle of a product, and (b) how the Project plans contribute to this topic. The 2nd MACRAMÉ Risk Assessor Summit (M36) will discuss the MACRAMÉ results and lessons learned with all relevant stakeholders to propose future actions. It will be held at the OECD (alternatively at LIST or RIVM).

Report on Stakeholder Involvement & Knowledge Transfer in the first 18 month

Task 5.2 will establish link to relevant activities and initiatives as the Malta-Initiative, VAMAS, EURL ECVAM, the NanoSafety Cluster projects, EURAMET, the Graphene Flagship, NCI-NCL, and PARC to ensure cooperation on (ongoing) standardisation and harmonisation advancements. Sub-Task 5.2.1: MACRAMÉ Workshops - Three MACRAMÉ Workshops (M12, M22, M34) will give an overview of ongoing harmonisation and standardisation projects in the field of nano- and AdMas. Current needs and issues will be discussed, including opportunities for projects to present their work in open sessions and for expert input in closed sessions. Two virtual workshops and one face-to-face (back-to-back with the 1st MACRAMÉ Risk Assessors Summit) are planned. Sub-Task 5.2.2: Improve Knowledge on Harmonisation & Standardisation activities – [Lead: LIST] This Sub-Task will improve the knowledge of industry, scientists and researchers on the harmonisation and standardisation landscape, processes and impact to increase the visibility of these key initiatives and the involvement of new experts on targeted actions. The different bodies, their respective roles and interactions will be introduced and the steps necessary for the harmonisation and standardisation process explained. The Task will use the training material produced in NanoHarmony on the OECD process of TG development, and further broaden the focus to standardisation and validation topics. OECD, ISO, CEN, ASTM, VAMAS and EURL ECVAM representatives will be invited to give insights and thus raise awareness of harmonisation and standardisation processes. Five MACRAMÉ Webinars (M12, M17, M24, M28, M35) will be held, as well as several sessions at summer schools and relevant meetings.

Report on Stakeholder Involvement & Knowledge Transfer during the Project

Task 5.2 will establish link to relevant activities and initiatives as the Malta-Initiative, VAMAS, EURL ECVAM, the NanoSafety Cluster projects, EURAMET, the Graphene Flagship, NCI-NCL, and PARC to ensure cooperation on (ongoing) standardisation and harmonisation advancements. Sub-Task 5.2.1: MACRAMÉ Workshops - Three MACRAMÉ Workshops (M12, M22, M36) will give an overview of ongoing harmonisation and standardisation projects in the field of nano- and AdMas. Current needs and issues will be discussed, including opportunities for projects to present their work in open sessions and for expert input in closed sessions. Two virtual workshops and one face-to-face (back-to-back with the 1st MACRAMÉ Risk Assessors Summit) are planned. Sub-Task 5.2.2: Improve Knowledge on Harmonisation & Standardisation activities – [Lead: LIST] This Sub-Task will improve the knowledge of industry, scientists and researchers on the harmonisation and standardisation landscape, processes and impact to increase the visibility of these key initiatives and the involvement of new experts on targeted actions. The different bodies, their respective roles and interactions will be introduced and the steps necessary for the harmonisation and standardisation process explained. The Task will use the training material produced in NanoHarmony on the OECD process of TG development, and further broaden the focus to standardisation and validation topics. OECD, ISO, CEN, ASTM, VAMAS and EURL ECVAM representatives will be invited to give insights and thus raise awareness of harmonisation and standardisation processes. Five MACRAMÉ Webinars (M12, M17, M24, M28, M35) will be held, as well as several sessions at summer schools and relevant meetings.

Ecotoxicity (Hazard) & RA of Use-Cases (incl. Decision Tree)

Ecotoxicity (Hazard) and Risk Assessment of industrially relevant Materials from the Use Cases - A quantitative hazard and risk assessment (occupational, consumer, environmental) on the most relevant stages of the life-cycle of Use-Cases will be performed using data from Task 4.2 on exposure, and implementing the safety information from Task 2.5. Information on in-vitro/in-vivo extrapolation (Task 4.3) will also be assessed. In addition to literature data, new ecotoxicological laboratory data will be acquired on algae (OECD 201, ISO10253), daphnia (OECD 202, 211, ISO6341-2012) and fish cell lines (OECD 249), extending the utility of the assays themselves (e.g. fish barrier models) and feeding into the LCA. All samples from the 5 Use-Cases will be tested on fish cell lines (Figure 3), and selected samples will be tested on algae and daphnia. This data will be used to develop a MACRAMÉ Decision Tree for environmental health assessment (based on OECD THRESH FISH).

Summary Report about the 2nd Risk Assessors Summit

] In alignment with the Industry Commons initiative, MACRAMÉ will build on the results of Task 1.2 to plan and guide the specific cooperation with and dissemination to related sectors and projects; this task will (a) elaborate concepts for engagement with industry communities and their related policy-informing and –making bodies, standardising (i.e. ISO, CEN, nat. bodies) and harmonising (i.e. OECD) bodies, and related projects (i.e. Horizon 2020/Europe), (b) identify stakeholders and organise workshops, and (c) set-up a strategic MACRAMÉ Engagement Roadmap, which builds on the successful ‘REFINE Knowledge Exchange’- and the ‘NanoHarmony’-engagement-processes, and sets sequence/‘time-dependent’ criteria for the MACRAMÉ communication actions in alignment with WP6. The Roadmap will include a dissemination plan for the data-driven hyperconnectivity and interoperability (WP3), and coordinate the execution of the prescribed communication in other WPs (i.e. concerning standardisation- and harmonisation-bodies). The 1st MACRAMÉ Risk Assessors Summit will be held in collaboration with a WP5-standardisation & harmonisation workshop (M12, hosted by BAuA), to reflect with stakeholders from academia, industry, and regulation and standardisation agencies on (a) the status and needs of the regulatory frameworks for the safety of AdMas during the life-cycle of a product, and (b) how the Project plans contribute to this topic. The 2nd MACRAMÉ Risk Assessor Summit (M36) will discuss the MACRAMÉ results and lessons learned with all relevant stakeholders to propose future actions. It will be held at the OECD (alternatively at LIST or RIVM).

Report on Data Provision for Method Optimisation and Use-Case Completion

The data integration and aggregation will be based on: (a) Interfaces to major standard data warehouses based on the existing application programming interfaces (APIs) of these systems to be able to integrate the public data from previous and ongoing projects at any stage of the method development and application. This will profit from large-scale European initiatives like EOSC, IndustryCommons, and OntoCommons providing harmonised access to data from many different disciplines. Domain-specific resources eNanoMapper and the NanoCommons Knowledge Base, will offer access to results of EU and OECD projects listed in the WP1 description. Where data is not fully publicly available, Task 3.3 will negotiate solutions with the data providers for project-wide access solutions. Automated workflows for mining additional databases and extracting data from publications will be implemented for each of the Use-Cases, based on a set of agreed search terms, and inclusion/exclusion and quality control criteria. Experimental data gaps will be filled based on modelling and simulations, re-using approaches provided as background by the Partners or developed in projects (e.g. NanoCommons, NanoSolveIT, NanoInformaTIX). Existing integration and knowledge extraction pipelines (e.g,. localisation approaches for aggregation of imaging or spectroscopy techniques) will be evaluated for potential transfer to other Partners to develop guidance for future AI-/ML-based decision support systems.

MACRAMÉ Harmonisation & Standardisation Roadmap Summary Report for MACRAMÉ Methods and Models

The advancement of MACRAMÉ Methods into harmonisation and standardisation is achieved through: (a) the preparation of strategic MACRAMÉ Roadmaps for harmonisation/standardisation of the Methods and (b) establishing channels to standardisation/harmonisation bodies (i.e. to ISO (TC 229) / CEN (TC 352) / ASTM E56 and OECD (WPMN/WNT)) and linking to other initiatives and activities. Each of the methods or models worked on in WP2/WP4 will be considered separately for their use in risk assessment and in a regulatory context. The relevant committees for harmonisation/standardisation will be identified. Steps towards a successful and timely standardisation or harmonisation will be tailored to the specific committee and the method in multiple roadmaps, with each addressing different ‘destinations’ and consisting of: (i) a conceptual part (i.e. implementation of the method for risk assessment and/or testing for regulatory purposes), and (ii) a strategy (i.e. required steps towards harmonisation/standardisation). These will be summarised in the MACRAMÉ Roadmap Summary report (D5.1), which will be transferred to WP2/WP4 for implementation. Based on the roadmaps, topics for standardisation or harmonisation will be proposed to the relevant bodies identified, as well as VAMAS and EURL ECVAM to promote the organisation of ILC studies for the validation of the MACRAMÉ methods and models.

Summary Report of MACRAMÉ Reporting Guidelines (incl. Reporting Templates)

All MACRAMÉ partners will work together on the definition of reporting standards and corresponding SOP/protocol and (meta)data reporting formats and corresponding datasets. Continuous centralised data stewardship will ensure the highest degree of timely publication of data of high quality following the FAIR principles implemented as the route of knowledge transfer between the WPs and then for open and FAIR sharing with all stakeholders. To achieve this, the Task will be supported by a data shepherd supporting all partners and started with a data stewardship workshop in collaboration with WP1, which will analyse the current data management practises at individual partner to define the starting point for the Information Hub (Task 3.1). Frequent re-evaluation of the completeness of the provided information for the use cases of WP4 and for standardisation of the MACRAMÉ methods will be performed. The resulting MACRAMÉ Reporting Templates with example data-sets will be used to define improved reporting guidelines implementing the concept of method-specific reporting and will be proposed to the scientific community and standardisation bodies (VAMAS, OECD).

Assessment Report of environmental & economic Sustainability of Use-Cases

Assessment of the Environmental Sustainability of the five Use-Cases - The environmental and economic impacts of the industrial Use-Cases will be assessed by means of LCA and LCC, The LCA study will address the product footprint (e.g. impacts on climate change, resources use, water use) of the AdMas by using EF3.0 as impact assessment method, using SimaPro and ecoinvent data v3.8. The developed CFs for impact categories human-/ecotoxicity will be applied to calculate the potential human and environmental impacts due to release of AdMas at each life-cycle stage. Data from Task 4.2 (MFA) on EoL of AdMas will be integrated into the LCA to evaluate sustainability of different EoL scenarios.

Report: ‘MACRAMÉ Safety & Sustainability Matrix’

Development of a ‘MACRAMÉ Safety & Sustainability Matrix’ - The MACRAMÉ data will provide input to a prototype labelling scheme which clearly shows the degree to which environmental and green concerns have been addressed by product manufacturers s, by benchmarking and comparison to existing standards.

Scientific Document to support the Development of a GD for in-vitro HA

Task 2.5 will make use of the optimised analytical methods and improved biological systems for inhalation hazard assessment to characterise the five Use-Cases (WP4, Figure 3), assessing potential hazards arising from the use of AdMas at different stages of their life-cycle. This will include: (i) potential release of the AdMas at the exposure points in biological/environmental matrices, during transport, or cleaning of the manufacturing sites, (ii) the quantification of the AdMas in the finished products, (iii) the modifications and release of the AdMas during consumer/professional usage, and (iv) EoL-scenario. Samples will be provided by WP4.

Sampling & Sample-Provision Protocols for AdMas in complex Matrices

Based on the collaboratively re-fined R&I Strategy and its benchmarks, Task 4.1 will define and agree sampling protocols tailored to the exposure points, and the test requirements (e.g. blinding for validation studies (LIST)), and will collect and deliver the required quantities of material to the WP2 partners for investigation and characterisation: Sub-Task 4.1.1: Develop & refine AdMa@CM Sampling & Sample-Provision Protocols (M02–M34) - Sampling and sample-provision protocols for AdMas and AdMa-bearing composites (i.e. AdMa@CM), as well as other relevant control samples, will be developed and implemented, in agreement with WP2 partners; these will be based on the specific Exposure Points conditions (see Figure 3). Subtask 4.1.2: Collect and deliver Use-Case Samples (M02-34) - Industrial partners will provide both pristine materials as used in their products, and samples collected from selected release hotspots to provide a representative selection of the value-chains (e.g. consumer use and end-of-life (incineration and landfilling)), following all special requirements for sample collection and preparation, ensuring sufficient material is delivered for characterisation, analysis and evaluation in WP2.

Report on Data Preparation and Quality Control for Grouping and Read-Across

Results produced by MACRAMÉ will be evaluated for their use in the ECETOC NanoApp and the various IATAs developed and validated via OECD IATA Case-Studies (OECD Project on “Updating GD on grouping of chemicals section 6.9 manufactured nanomaterials”, Jan. 2022, (confidential information, personal communication. Task 3.4 will be linked to ongoing activity via IUPAC InChI Trust and CODATA on extension of the InChI to nanomaterials, integration of the CODATA Universal Description system which considers materials provenance and similarity, to evaluate their utility for assessing similarity of nanoforms for different applications.

Report on Life-Cycle-Inventory Data-Set and Characterisation Factors of the AdMas in market-relevant Use-Cases

This Task will generate the currently missing elements within the LCA for AdMas. Characterisation Factor (CFs) for the impact categories of human toxicity and ecotoxicity and LCI Dataset, for each industrial Use-Case and for each life-cycle stage (manufacturing, use and EoL) will be established; data from the MFA (Task 4.2) provides the basis for the LCI, together with nano-emission information along each life-cycle stage of the AdMas. The human toxicity and freshwater ecotoxicity CFs for AdMas-related emissions will be calculated. The CFs will be developed in accordance with USEtox. The fate and exposure factors combine MFA (Task 4.2) and data from WP2, linked to SimpleBox4Nano (for environmental fate). The developed effect factor will use WP2 data & Task 4.5. An in-vitro/in-vivo extrapolation (NanoRIGO) will be applied using the WP2 models, representing a large step towards more realistic exposure conditions.

Life-Cycle-based Evaluation of AdMas in complex Matrices

A Material Flow Analysis (MFA) will be performed to provide an overall assessment of the releases of materials at each life-cycle stage, based on production amounts and transfer coefficients from one stage of the life-cycle to another. MACRAMÉ will overcome the current limitation of MFAs by linking to the advanced, quantitative imaging techniques (developed and applied in WP2) to generate specific data on the forms and quantities of AdMa(@CM)s. Focus will be on evaluating the end-of-life (EoL), where uncontrolled release and exposure is likely to occur. The MFA analysis is then used to generate data on potential occupational and consumer exposure, and to fate models (e.g. SimpleBox4nano) to obtain predicted environmental concentrations (PECs).

Final Recommendations on Needs for Test Guideline & Standards Developments

Task 5.3 will develop recommendations on the needs for TG developments and standardisation of test methods by building on the background analysis of WP1 and MACRAMÉ results. The focus of the recommendations will be on (a) the MACRAMÉ Material Families (i.e. GRM, carbon fibres, PLGA), (b) the needs for testing of market-relevant AdMa(@CM)s and in their value-chains. The resulting Milestone report (M24) will contain the informed recommendations, which will subsequently be disseminated to the relevant stakeholders for feedback; the final Deliverable (D5.4) on informed recommendations will include the stakeholder view and will be published in the form of a perspective paper.

Need Assessment Report of regulatory & policy Frameworks

To analyse the challenges and needs of relevant regulatory and policy frameworks outlined in Section 1.2 above with regard to AdMas and their LCA and LCC, this Task will conduct a background analysis of the regulatory preparedness across market sectors. Information requirements will be determined by (a) performing and building on a gap-analysis, such as the one conducted in the REFINE Project,(b) coordinating efforts with ‘Information Requirement’-work currently conducted by RIVM (for the OECD WPMN), and (c) arranging the use of and value-add to the results obtained in NMBP-13 projects. In addition, overarching EU strategies will be analysed to complete the Needs Analysis: (a) European Green Deal (2021), (b) the EU’s Chemical Strategy for Sustainability (2020) (with a special consideration of “one substance - on assessment”), and new Safe and Sustainable by Design (SSbD) concepts. The findings of the analyses will be validated through communication with and consultation of regulators at the European and international level (i.e. through the OECD WPMN, through bilateral collaborations (see Section 3.2)), and through the External Advisory Board (e.g. Germany, U.S. EPA)), to align efforts and to maximise impact.

Final ROMP (incl. Knowledge Exchange & FAIR Data-Sharing)

All MACRAMÉ partners will work together on the definition of reporting standards and corresponding SOP/protocol and (meta)data reporting formats and corresponding datasets. Continuous centralised data stewardship will ensure the highest degree of timely publication of data of high quality following the FAIR principles implemented as the route of knowledge transfer between the WPs and then for open and FAIR sharing with all stakeholders. To achieve this, the Task will be supported by a data shepherd supporting all partners and started with a data stewardship workshop in collaboration with WP1, which will analyse the current data management practises at individual partner to define the starting point for the Information Hub (Task 3.1). Frequent re-evaluation of the completeness of the provided information for the use cases of WP4 and for standardisation of the MACRAMÉ methods will be performed. The resulting MACRAMÉ Reporting Templates with example data-sets will be used to define improved reporting guidelines implementing the concept of method-specific reporting and will be proposed to the scientific community and standardisation bodies (VAMAS, OECD).

Information Hub and ‘Data Exchange Format’-Specifications and initial ROMP

This Task will provide a one-stop-shop for harmonised and interoperable MACRAMÉ (Meta)Data-Exchange with all customised tools for curation, storing and sharing: the provision will be made in two parts: (i) Providing, integrating and customising tools for information management and sharing, (electronic lab notebooks, instance maps & data packages) optimised for different tasks & users: All tools will be adapted to address the requirements of the improved reporting guidelines developed in Task 3.2. Advanced cloud technology will allow collaborative research on multiple levels (e.g., within single or multiple-partner teams, for case-study and/or round-robin work) in a secure and traceable way. (ii) Direct linking to analysis and modelling software from Task 3.3 and 3.4 and standard data resources for long-term storage and FAIR sharing of data: in collaboration with Task 3.2, MACRAM’s data concepts and guidance will be implemented in the form of extended reporting and exchange formats (machine-readable, semantically annotated) interoperable and aligned with major European Initiatives (IndustryCommons, EU NanoSafety Cluster and European Materials Characterisation Council). Automatic data upload to standard repositories (NanoCommons, eNanomapper, CHADA repositories) will be possible, initiated by the data owner. The data-management and -sharing processes adopted by the MACRAMÉ consortium will be documented and constantly updated in the research output management plan (ROMP), an extension of a DMP, which will guide partners in their preparation of technology documentation, protocols, (meta)data, software and results. The ROMP will also provide measures for addressing problems or challenges encountered in data curation and management.

MACRAMÉ Public Website

A Project Corporate Identity (CI) will be developed; it will be composed of a Project logo, the layout for flyers and website, a template for presentations, and a layout for the Project’s newsletters. The website will be launched in M01 (initial Project website), later updated to a full website in M05. Printed and digital means will be used for targeted communication and dissemination (Section 2.2).

Veröffentlichungen

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MACRAMÉ – Advanced characterisation methodologies to assess and predict the health and environmental risks of advanced materials

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Steel in Translation

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DOI: 10.3390/SU151914453

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DOI: 10.1021/ACSNANO.5C03040

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DOI: 10.1016/J.YRTPH.2023.105360

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DOI: 10.1002/smll.202308148

Challenges and Future Directions in Assessing the Quality and Completeness of Advanced Materials Safety Data for Re‐Usability: A Position Paper From the Nanosafety Community

Autoren: Verónica I. Dumit, Irini Furxhi, Penny Nymark, Antreas Afantitis, Ammar Ammar, Monica J. B. Amorim, Dalila Antunes, Svetlana Avramova, Chiara L. Battistelli, Gianpietro Basei, Cecilia Bossa, Emil Cimpan, Mihaela Roxana Cimpan, Dmitri Ciornii, Anna Costa, Camilla Delpivo, Maria Dusinska, Ana Sofia Fonseca, Steffi Friedrichs, Vasile‐Dan Hodoroaba, Danail Hristozov, Panagiotis Isigonis, Nina Jeliazkova, Nikolay Kochev, Eva Kranjc, Dieter Maier, Georgia Melagraki, Anastasios G. Papadiamantis, Tomasz Puzyn, Hubert Rauscher, Katie Reilly, Araceli Sánchez Jiménez, Janeck J. Scott‐Fordsmand, Neeraj Shandilya, Hyun Kil Shin, Gergana Tancheva, Jeaphianne P. M. van Rijn, Egon L. Willighagen, Ewelina Wyrzykowska, Martine I. Bakker, Damjana Drobne, Thomas E. Exner, Martin Himly, Iseult Lynch
Veröffentlicht in: Advanced Sustainable Systems, Ausgabe 10, 2026, ISSN 2366-7486
Herausgeber: Wiley
DOI: 10.1002/ADSU.202500567

Determining the impact of common microplastic extraction methods from soil matrices on the biodegradable polymers polylactic acid and polyhydroxybutyrate

Autoren: Grace Davies, Sarmite Kernchen, Martin G. J. Löder, Louisa Brenninkmeijer, Christian Laforsch, Stefan Krause, Iseult Lynch
Veröffentlicht in: Microplastics and Nanoplastics, Ausgabe 6, 2026, ISSN 2662-4966
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S43591-025-00167-0

Bridging the gap: Innovative human-based in vitro approaches for nanomaterials hazard assessment and their role in safe and sustainable by design, risk assessment, and life cycle assessment

Autoren: Jimeng Wu, Govind Gupta, Tina Buerki-Thurnherr, Bernd Nowack, Peter Wick,
Veröffentlicht in: NanoImpact, ISSN 2452-0748
Herausgeber: Science Direct
DOI: 10.1016/J.IMPACT.2024.100533

Beilstein Journal of Nanotechnology

Autoren: Punz et al.
Veröffentlicht in: Beilstein Archives, 2024, ISSN 2190-4286
Herausgeber: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bxiv.2024.26.v1

Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop

Autoren: Timothy W. Gant, Alistair Boxall, Daniel Burgwinkel, Maryam Zare Jeddi, Ivo Djidrovski, Steffi Friedrichs, Barry Hardy, Thomas Hartung, Daniela Holland, Andreas Karwath, Anne Kienhuis, Nicole Kleinstreuer, Zhoumeng Lin, Emma L. Marczylo, Antonino Marvuglia, Hua Qian, Bennard van Ravenzwaay, Paul Rees, Haralambos Sarimveis, Tewes Tralau, Lucy Wilmot, Adam Zalewski, David Rouquié
Veröffentlicht in: Archives of Toxicology, Ausgabe 100, 2026, ISSN 0340-5761
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04286-8

Metadata stewardship in nanosafety research: learning from the past, preparing for an “on-the-fly” FAIR future

Autoren: T. E. Exner et al.
Veröffentlicht in: Frontiers in Physics, Ausgabe 11, 2023, ISSN 2296-424X
Herausgeber: Frontiers Media
DOI: 10.3389/fphy.2023.1233879

PM <sub>2.5</sub> -Induced Multinucleation of Bronchial Epithelial Cells due to Microtubule Overacetylation and Disruption of Microtubule-Associated Proteins

Autoren: Liyan Xiao, Jinyan Pang, Zhiling Guo, Kexin Zhang, Zhiqin Xiong, Man Yang, Ji Wang, Yang Li, Iseult Lynch
Veröffentlicht in: Environment & Health, 2026, ISSN 2833-8278
Herausgeber: American Chemical Society (ACS)
DOI: 10.1021/ENVHEALTH.5C00580

Biomolecular Transformations Shape the Environmental Fate of Nanoscale and Emerging Materials

Autoren: Swaroop Chakraborty, Iseult Lynch
Veröffentlicht in: Accounts of Chemical Research, Ausgabe 58, 2025, ISSN 0001-4842
Herausgeber: American Chemical Society (ACS)
DOI: 10.1021/ACS.ACCOUNTS.5C00587

Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis

Autoren: Dirk Broßell, Asmus Meyer-Plath, Oliver Gräb, Elisabeth Heunisch, Kerstin Kämpf, Andrea Haase, Martin Wiemann
Veröffentlicht in: Particle and Fibre Toxicology, Ausgabe 23, 2026, ISSN 1743-8977
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S12989-026-00666-9

Beyond microbeads: Examining the role of cosmetics in microplastic pollution and spotlighting unanswered questions

Autoren: Anna Kukkola, Andrew J. Chetwynd, Stefan Krause, Iseult Lynch
Veröffentlicht in: Journal of Hazardous Materials, Ausgabe 476, 2025, ISSN 0304-3894
Herausgeber: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2024.135053

Wisdom of Crowds for Supporting the Safety Evaluation of Nanomaterials

Autoren: Laura Aliisa Saarimäki; Michele Fratello; Giusy del Giudice; Emanuele Di Lieto; Antreas Afantitis; Harri Alenius; Eliodoro Chiavazzo; Mary Gulumian; Piia Karisola; Iseult Lynch; Giulia Mancardi; Georgia Melagraki; Paolo Netti; Anastasios G. Papadiamantis; Willie Peijnenburg; Hélder A Santos; Tommaso Serchi; Mohammad-Ali Shahbazi; Tobias Stoeger; Eugenia Valsami-Jones; Paola Vivo; Ivana Vinković Vrček; Ulla Vogel; Peter Wick; David A. Winkler; Angela Serra; Dario Greco
Veröffentlicht in: Environmental Science & Technology, 2025, ISSN 0000-0000
Herausgeber: ACS Publications
DOI: 10.2139/SSRN.5066370

MACRAMÉ Deliverable Report D3.1: Information Hub, Data Exchange Format Specifications, and initial Research Output Management Plan (ROMP)

Autoren: Exner, Thomas E.; Brajnik, Maja; Friedrichs, Steffi; Dokler, Joh; Vandebriel, Rob
Veröffentlicht in: Zenodo, 2023
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.15002806

MACRAMÉ Deliverable Report D2.1: Report on the MACRAMÉ Control Material Library - first annual report

Autoren: Caputo, Fanny; Favre, Georges; Delcour, Simon; Wiemann, Martin; Serchi, Tommaso; Meyer-Plath, Asmus Andres; Günday-Türeli, Nazende; Weltring, Klaus-Michael; Gupta, Govind; Wick, Peter; Buerki-Thurnherr, Tina; Friedrichs, Steffi
Veröffentlicht in: Zenodo, 2023
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.15125882

MACRAMÉ Deliverable Report D1.2: Needs Assessment Report of Regulatory & Policy Frameworks

Autoren: Ouhajji S. et al
Veröffentlicht in: Zenodo
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.204268635281/

MACRAMÉ Deliverable Report D1.3: Summary Report about the 1st Regulatory Risk Assessors Summit

Autoren: Haase, Daniel; Weltring, Klaus-Michael; Spring, Kathleen; Vandebriel, Rob; Heunisch, Elisabeth; Pohl, Anna; Bleeker, Eric A.J.; Suarez-Merino, Blanca; Durand, Cyrille; Katsumiti, Alberto; Rodríguez-Llopis, Isabel; Friedrichs, Steffi
Veröffentlicht in: Zenodo, 2023
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.15125693

MACRAMÉ Deliverable Report D4.1: Sampling & Sample-Provision Protocols for Advanced Materials in complex Matrices

Autoren: Suarez-Merino, Blanca; JOSHI, DEVENDRA; Durand, Cyrille; Gupta, Govind; Katsumiti, Alberto; Günday-Türeli, Nazende; Chupin, Lucie; Pohl, Anna; Heise, Martin; Vezzali, Matteo; Wick, Peter; Buerki-Thurnherr, Tina; Friedrichs, Steffi
Veröffentlicht in: Zenodo, 2024
Herausgeber: Zenodo
DOI: 10.5281/ZENODO.15126026

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