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Personalized Drug Response: IMplementation and Evaluation in CKD

Objective

Chronic Kidney Disease (CKD) is one of the major causes of death in high income countries and its prevalence is growing rapidly. New therapies for the treatment of CKD have shown clear efficacy at a population level. Yet, individual patients respond differently with many patients showing suboptimal efficacy. This indicates that a ‘one size fits all’ approach is no longer sustainable.
Currently there are no validated pharmacodynamic biomarkers in CKD that aid in guiding optimal therapy for individual patients. Furthermore, there remains a large gap between biomarker research and actual implementation of biomarker based care in daily clinical practice.
Thus, there is an urgent need to validate and translate biomarkers as tools for daily clinical practice. PRIME-CKD has a unique advantage to address this challenge as it builds on recently discovered pharmacodynamic biomarkers for CKD treatment, and has access to a vast amount of clinical data, bio-samples. PRIME CKD will:
1) Provide a breakthrough in the pharmacotherapy of CKD with the validation and implementation of pharmacodynamic biomarkers which will advance personalized medicine.
2) Scientifically validate innovative clinical trial elements, pipelines and qualification procedures that can be used by researchers, diagnostics industries and regulatory authorities.
3) Establish a Stakeholder Network to truly engage patients, clinicians and other stakeholders in implementation of personalized medicines
4) Develop a roadmap for biomarker use in daily clinical practice for the optimal treatment of CKD.

These results will enable clinicians to match patients with CKD with the most effective available drug within the shortest possible timeframe leading to less disease burden and progression of disease, enhanced quality of life and increased cost-efficiency. PRIME-CKD results will thus unlock the potential of biomarkers in healthcare and close the gap between biomarker research and clinical use in daily practice.

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Net EU contribution
€ 2 150 504,73
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,50

Participants (14)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UMCG RESEARCH BV
Netherlands
Net EU contribution
€ 160 318,40
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN
United States
Net EU contribution
€ 710 073,75
Address
South Street 3003 1068
46109 1274 Ann Arbor

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 565 775,00
Address
Paradisgatan 5c
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 1 243 525,00
Address
Kongens Vaenge 2
3400 Hillerod

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Region
Danmark Hovedstaden Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
RENALYTIX AI LIMITED
Ireland
Net EU contribution
€ 837 573,75
Address
29 Lower Patrick Street
R95 NXR0 Kilkenny

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ireland Southern South-East
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
Net EU contribution
€ 542 300,00
Address
Martinistrasse 52
20251 Hamburg

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI
Italy
Net EU contribution
€ 450 921,13
Address
Viale Abramo Lincoln 5
81100 Caserta

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Region
Sud Campania Caserta
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
Net EU contribution
€ 351 252,50
Address
Via Zamboni 33
40126 Bologna

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Region
Nord-Est Emilia-Romagna Bologna
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

IRCCS AZIENDA OSPEDALIERO- UNIVERSITARIA DI BOLOGNA
Italy
Net EU contribution
€ 350 808,75
Address
Via Albertoni 15
40138 Bologna

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Region
Nord-Est Emilia-Romagna Bologna
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA
Spain
Net EU contribution
€ 419 312,50
Address
Av Menendez Pelayo 4
46010 Valencia

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Research Organisations
Other funding
€ 0,00
HESSELS EN GROB BV
Netherlands
Net EU contribution
€ 101 250,00
Address
Veldbrugweg 37
7364 AG Lieren

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
AGENTSCHAP COLLEGE TER BEOORDELING VAN GENEESMIDDELEN
Netherlands
Net EU contribution
€ 536 625,00
Address
Graadt Van Roggenweg 500
3531AH Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
UNIVERSITATSKLINIKUM ERLANGEN
Germany
Net EU contribution
€ 639 375,00
Address
Maximiliansplatz 2
91054 Erlangen

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Region
Bayern Mittelfranken Erlangen, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
NIERSTICHTING NEDERLAND
Netherlands
Net EU contribution
€ 182 625,00
Address
Groot Hertoginnelaan 34
1405 EE Bussum

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Region
West-Nederland Noord-Holland Het Gooi en Vechtstreek
Activity type
Other
Other funding
€ 0,00

Partners (2)

UNIVERSITY OF LEICESTER
United Kingdom
Net EU contribution
€ 0,00
Address
University Road
LE1 7RH Leicester

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Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST
United Kingdom
Net EU contribution
€ 0,00
Address
Infirmary Square Leicester Royal Infirmary Balmoral Building Level 3
LE1 5WW Leicester

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Region
East Midlands (England) Leicestershire, Rutland and Northamptonshire Leicester
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
No data