Personalised blueprint intestinal health

Project Information

miGut-Health

Grant agreement ID: 101095470

DOI

10.3030/101095470

EC signature date 11 November 2022

Start date 1 January 2023

End date 31 December 2026

Funded under

• Health

Total cost

€ 7 131 243,75

EU contribution

€ 7 126 243,75

Coordinated by

UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (23)

Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease

Author(s): Shixian Hu, Arno R. Bourgonje, Ranko Gacesa, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen, Eleonora A. M. Festen, Arnau Vich
Published in: Nature Communication, Issue 15, 1470 (2024), 2024, ISSN 2041-1723
Publisher: Nature Communications
DOI: 10.1038/s41467-024-45855-2

The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases—Results From the Prospective Population‐Based Copenhagen Inflammatory Bowel Disease Inception Cohort

Author(s): Mohamed Attauabi, Gorm Roager Madsen, Flemming Bendtsen, Johan Burisch, Jakob Benedict Seidelin
Published in: United European Gastroenterology Journal, 2025, ISSN 2050-6406
Publisher: Wiley
DOI: 10.1002/UEG2.12737

Preclinical Protein Signatures of Crohn’s Disease and Ulcerative Colitis: A Nested Case-Control Study Within Large Population-Based Cohorts

Author(s): Olle Grännö, Daniel Bergemalm, Benita Salomon, Carl Mårten Lindqvist, Charlotte R. H. Hedin, Marie Carlson, Katharina Dannenberg, Erik Andersson, Åsa V. Keita, Maria K. Magnusson, Carl Eriksson, Vivekananda Lanka, Patrik K.E. Magnusson, Mauro D’Amato...
Published in: Gastroenterology, Issue 6, 2024, ISSN 1528-0012
Publisher: Elsevier Inc.
DOI: 10.1053/j.gastro.2024.11.006

Synergy between culturomics and metagenomics of health status-associated gut bacteria originating from non-IBD and IBD populations

Author(s): N. Plomp, R. Gacesa, J. Slager, J. N. Samsom, K. N. Faber, I. H. Jonkers, S. Withoff, C. Wijmenga, R. K. Weersma, H. J. M. Harmsen
Published in: Scientific Reports, Issue 15, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-29138-4

Bulk T cell repertoire sequencing (TCR-Seq) is a powerful technology for understanding inflammation-mediated diseases

Author(s): Aya K.H. Mahdy, Evgeniya Lokes, Valentina Schöpfel, Valeriia Kriukova, Olga V. Britanova, Tim A. Steiert, Andre Franke, Hesham ElAbd
Published in: Journal of Autoimmunity, Issue 149, 2024, ISSN 0896-8411
Publisher: Elsevier BV
DOI: 10.1016/J.JAUT.2024.103337

The gut microbiome across the cardiovascular risk spectrum

Author(s): Femke M Prins, Valerie Collij, Hilde E Groot, Johannes R Björk, J Casper Swarte, Sergio Andreu-Sánchez, Bernadien H Jansen, Jingyuan Fu, Hermie J M Harmsen, Alexandra Zhernakova, Erik Lipsic, Pim va
Published in: European Journal of Preventive Cardiology, Issue 31, 2024, ISSN 2047-4873
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EURJPC/ZWAD377

Comparing Environmental Risk Factors at Diagnosis in Faroese and Danish Patients with Inflammatory Bowel Disease

Author(s): Nielsen, Kári Rubek; Modin, Frederikke Agerbo; Midjord, Jóngerð; Vang, Amanda; Berbisá, Marjun á.Fríðriksmørk; Johannesen, Herborg Líggjasardóttir; Dahlerup, Jens Frederik; Andersen, Vibeke; Neumann, Anders; Kjeldsen, Jens; Pedersen, Natalia; Langholz, Ebbe; Munkholm, Pia; Hammer, Turid; Burisch, Johan
Published in: Digestive Diseases and Sciences, Issue 69, 2024, ISSN 1573-2568
Publisher: Springer Nature
DOI: 10.1007/S10620-024-08721-1

Food-Related Behavioral Patterns in Patients with Inflammatory Bowel Diseases: The Role of Food Involvement and Health Engagement

Author(s): Lorenzo Palamenghi, Dilara Usta, Salvo Leone, Gunedalina Graffigna
Published in: Nutrients, Issue 16(8), 1185, 2024, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16081185

Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease

Author(s): Aya K. H. Mahdy, Valentina Schöpfel, Gert Huppertz-Hauss, Gøri Perminow, Florian Tran, Corinna Bang, Johannes R. Hov, May-Bente Bengtson, Petr Ricanek, Randi Opheim, Tone Bergene Aabrekk, Trond Espen Detlie, Vendel A. Kristensen, Mathilde Poyet, Marte Lie Høivik, Andre Franke, Hesham ElAbd
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1638522

Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases

Author(s): Vich Vila A, Zhang J, Liu M, Faber KN, Weersma RK
Published in: Gut, Issue 73, 2024, ISSN 1468-3288
Publisher: BMJ Group
DOI: 10.1136/GUTJNL-2023-329969

The Substantial Role of Sleep, Stress, and Physical Activity in Persistent High Levels of Fatigue in Patients With Inflammatory Bowel Disease: A Longitudinal Trajectory Study

Author(s): Quirine M Bredero, Joke Fleer, Denise M Blom, Arno R Bourgonje, Gerard Dijkstra, Maya J Schroevers
Published in: Journal of Crohn's and Colitis, Issue 19, 2025, ISSN 1873-9946
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ECCO-JCC/JJAE163

Reasons for (Not) Seeking Care for Fatigue and Care Needs Among Patients With Inflammatory Bowel Disease: A Qualitative Interview Study

Author(s): Quirine M. Bredero, Milou M. Ter Avest, Gerard Dijkstra, Joke Fleer, Maya J. Schroevers
Published in: Journal of Advanced Nursing, 2025, ISSN 0309-2402
Publisher: Wiley
DOI: 10.1111/JAN.16837

The gut microbiome in end-stage lung disease and lung transplantation

Author(s): Shuyan Zhang, J. Casper Swarte, Ranko Gacesa, Tim J. Knobbe, Daan Kremer, Bernadien H. Jansen, Martin H. de Borst, null null, Hermie J. M. Harmsen, Michiel E. Erasmus, Erik A. M. Verschuuren, Stephan J. L. Bakker, C. Tji Gan, Rinse K. Weersma, Johannes R. Björk, Coby Annema, Stephan J. L. Bakker, Stefan P. Berger, Hans Blokzijl, Frank A. J. A. Bodewes, Marieke T. de Boer, Kevin Damman, Martin H. de Borst, Arjan Diepstra, Gerard Dijkstra, Rianne M. Douwes, Caecilia S. E. Doorenbos, Michele F. Eisenga, Michiel E. Erasmus, C. Tji Gan, Eelko Hak, Bouke G. Hepkema, Frank Klont, Tim J. Knobbe, Daan Kremer, Henri G. D. Leuvenink, Willem S. Lexmond, Vincent E. de Meijer, Hubert G. M. Niesters, Gertrude J. Nieuwenhuis-Moeke, L. Joost van Pelt, Robert A. Pol, Robert J. Porte, Adelta V. Ranchor, Marion J. Siebelink, Riemer J. H. J. A. Slart, J. Casper Swarte, Daan J. Touw, Marius C. van den Heuvel, Coretta van Leer-Buter, Marco van Londen, Erik A. M. Verschuuren, Michel J. Vos, Rinse K. Weersma, Antonio W. Gomes Neto, Jan Stephan F. Sanders
Published in: mSystems, Issue 9, 2024, ISSN 2379-5077
Publisher: American Society for Microbiology
DOI: 10.1128/MSYSTEMS.01312-23

Lifestyle and psychosocial factors in inflammatory bowel disease: Prevalence, impact, motivation, and support needs

Author(s): Karlijn Demers, Evelien M. B. Hendrix, Ashkan Rezazadeh Ardabili, Quirine M. Bredero, Ad A. van Bodegraven, Daniëlle van der Horst, Daisy M. A. E. Jonkers, Merel L. Kimman, Zlatan Mujagic, Mariëlle
Published in: PLOS One, Issue 20, 2025, ISSN 1932-6203
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0331092

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

Author(s): Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstanti
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1536302

Decoding the etiology of immune-mediated inflammatory diseases statistically

Author(s): Hesham ElAbd, Aya K. H. Mahdy
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1610662

Incidence, Disease Burden, and Clinical Presentation of Patients Newly Diagnosed With Inflammatory Bowel Disease in a Population-Based Inception Cohort

Author(s): Mohamed Attauabi, Gorm Roager Madsen, Flemming Bendtsen, Jakob Benedict Seidelin, Johan Burisch
Published in: Journal of Crohn's and Colitis, Issue 19, 2025, ISSN 1873-9946
Publisher: Oxford University Press (OUP)
DOI: 10.1093/ECCO-JCC/JJAE176

Psychological stress and eating behaviors as interacting influences on patient–reported disease activity in Italian patients with inflammatory bowel disease

Author(s): Dilara Usta, Marta Acampora, Andresa Costa Pereira, Mariarosaria Savarese, Maria Stella De Rocchis, Luisa Avedano, Salvo Leone, Guendalina Graffigna, null null, Andre Franke, Jurgita Skiecevičienė,
Published in: Scientific Reports, 2025, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-29573-3

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history

Author(s): Hesham ElAbd, Aya K. H. Mahdy, Eike Matthias Wacker, Maria Gretsova, David Ellinghaus, Astrid Dempfile, Andre Franke
Published in: Communications Biology, Issue 9, 2026, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42003-025-09140-2

T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Author(s): Hesham ElAbd, Mitchell Pesesky, Gabriel Innocenti, Brian K. Chung, Aya K. H. Mahdy, Valeriia Kriukova, Laila Kulsvehagen, Dennis Strobbe, Claudia Stühler, Gabriele Mayr, Damon H. May, Melanie Prinzen
Published in: Nature Medicine, Issue 31, 2025, ISSN 1078-8956
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03692-W

Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

Author(s): J. Casper Swarte, Tim J. Knobbe, Johannes R. Björk, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, null null, C. Annema, F. A. J. A. Bodewes, M. T. de Boer, K. Damman, A. Diepstra, G. Dijkstra, C. S. E. Doorenbos, M. F. Eisenga, M. E. Erasmus, C. T. Gan, A. W. Gomes Neto, E. Hak, B. G. Hepkema, F. Klont, H. G. D. Leuvenink, W. S. Lexmond, G. J. Nieuwenhuis-Moeke, H. G. M. Niesters, L. J. van Pelt, A. V. Ranchor, J. S. F. Sanders, M. J. Siebelink, R. J. H. J. A. Slart, D. J. Touw, M. C. van den Heuvel, C. van Leer-Buter, M. van Londen, E. A. M. Verschuuren, M. J. Vos, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41467-023-43431-8

Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages

Author(s): Aya K. H. Mahdy, Hesham ElAbd, Érika Endo Kokubun, Valeriia Kriukova, Mitchell Pesesky, Damon H. May, Christine Olbjørn, Gøri Perminow, May-Bente Bengtson, Petr Ricanek, Svend Andersen, Trond Espen Detlie, Vendel A. Kristensen, Bjørn Moum, Morten H. Vatn, Jørgen Jahnsen, Bernd Bokemeyer, Johannes Roksund Hov, Jonas Halfvarson, Stefan Schreiber, Bryan Howie, Harlan S. Robins, Marte Lie Høivik, Andre Franke, null null
Published in: Genome Medicine, Issue 18, 2026, ISSN 1756-994X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01575-W

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Author(s): Arno R. Bourgonje; Sergio Andreu-Sánchez; Thomas Vogl; Shixian Hu; Arnau Vich Vila; Ranko Gacesa; Sigal Leviatan; Alexander Kurilshikov; Shelley Klompus; Iris N. Kalka; Hendrik M. van Dullemen; Adina Weinberger; Marijn C. Visschedijk; Eleonora A.M. Festen; Klaas Nico Faber; Cisca Wijmenga; Gerard Dijkstra; Eran Segal; Jingyuan Fu; Alexandra Zhernakova; Rinse K. Weersma
Published in: Immunity, Issue Vol. 56, issue 6, 2023, ISSN 1097-4180
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.04.017