Personalised blueprint intestinal health

Informations projet

miGut-Health

N° de convention de subvention: 101095470

DOI

10.3030/101095470

Date de signature de la CE 11 Novembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2026

Financé au titre de

• Health

Coût total

€ 7 131 243,75

Contribution de l’UE

€ 7 126 243,75

Coordonné par

UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (4)

Predictive lifestyle factors

Report on predictive lifestyle factors that correlate with disease activity based on data collected with the IBD Coach eHealth tool.

Study initiation package

Finalization of study materials (e.g. dietary advisory material for study participants, CRFs), study protocol and study registration, preparation of patient recruitment.

“Personas” describing health engagement risk profiles

The “Personas” will consist in the description of prototypical profiles of health engagement risk on the basis of the empirical analysis conducted through the online survey. The Personas will be aimed at depicting different psychosocial risk factors profiles and their real-world impact on health and diet-related engagement behaviours and ultimately suggest priorities of educational actions in order to prevent risks.

Midterm recruitment report

Midterm recruitment will be reported, when approximately half of the study population is recruited including an overview of the number of screened and recruited participants at UKE, any problems in recruitment and, if applicable, a detailed description of implemented and planned measures to compensate for any incurred delays.

Websites, patent fillings, videos etc. (2)

Public project website

The website will inform the public about the project’s aims, updates and results. The website will be continuously updated throughout the project’s lifetime.

Audio-visual material 1

A set of different audio-visual material including one larger production - Part 1.

Other (1)

Extension of AI-assisted MyFoodRepo app for diet tracking

The MyFoodRepo app will be locally adapted in order to be usable in countries where project studies will be performed.

Publications

Peer reviewed articles (18)

Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease

Auteurs: Shixian Hu, Arno R. Bourgonje, Ranko Gacesa, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen, Eleonora A. M. Festen, Arnau Vich
Publié dans: Nature Communication, Numéro 15, 1470 (2024), 2024, ISSN 2041-1723
Éditeur: Nature Communications
DOI: 10.1038/s41467-024-45855-2

The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases—Results From the Prospective Population‐Based Copenhagen Inflammatory Bowel Disease Inception Cohort

Auteurs: Mohamed Attauabi, Gorm Roager Madsen, Flemming Bendtsen, Johan Burisch, Jakob Benedict Seidelin
Publié dans: United European Gastroenterology Journal, 2025, ISSN 2050-6406
Éditeur: Wiley
DOI: 10.1002/UEG2.12737

Preclinical Protein Signatures of Crohn’s Disease and Ulcerative Colitis: A Nested Case-Control Study Within Large Population-Based Cohorts

Auteurs: Olle Grännö, Daniel Bergemalm, Benita Salomon, Carl Mårten Lindqvist, Charlotte R. H. Hedin, Marie Carlson, Katharina Dannenberg, Erik Andersson, Åsa V. Keita, Maria K. Magnusson, Carl Eriksson, Vivekananda Lanka, Patrik K.E. Magnusson, Mauro D’Amato...
Publié dans: Gastroenterology, Numéro 6, 2024, ISSN 1528-0012
Éditeur: Elsevier Inc.
DOI: 10.1053/j.gastro.2024.11.006

Bulk T cell repertoire sequencing (TCR-Seq) is a powerful technology for understanding inflammation-mediated diseases

Auteurs: Aya K.H. Mahdy, Evgeniya Lokes, Valentina Schöpfel, Valeriia Kriukova, Olga V. Britanova, Tim A. Steiert, Andre Franke, Hesham ElAbd
Publié dans: Journal of Autoimmunity, Numéro 149, 2024, ISSN 0896-8411
Éditeur: Elsevier BV
DOI: 10.1016/J.JAUT.2024.103337

The gut microbiome across the cardiovascular risk spectrum

Auteurs: Femke M Prins, Valerie Collij, Hilde E Groot, Johannes R Björk, J Casper Swarte, Sergio Andreu-Sánchez, Bernadien H Jansen, Jingyuan Fu, Hermie J M Harmsen, Alexandra Zhernakova, Erik Lipsic, Pim va
Publié dans: European Journal of Preventive Cardiology, Numéro 31, 2024, ISSN 2047-4873
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/EURJPC/ZWAD377

Comparing Environmental Risk Factors at Diagnosis in Faroese and Danish Patients with Inflammatory Bowel Disease

Auteurs: Nielsen, Kári Rubek; Modin, Frederikke Agerbo; Midjord, Jóngerð; Vang, Amanda; Berbisá, Marjun á.Fríðriksmørk; Johannesen, Herborg Líggjasardóttir; Dahlerup, Jens Frederik; Andersen, Vibeke; Neumann, Anders; Kjeldsen, Jens; Pedersen, Natalia; Langholz, Ebbe; Munkholm, Pia; Hammer, Turid; Burisch, Johan
Publié dans: Digestive Diseases and Sciences, Numéro 69, 2024, ISSN 1573-2568
Éditeur: Springer Nature
DOI: 10.1007/S10620-024-08721-1

Food-Related Behavioral Patterns in Patients with Inflammatory Bowel Diseases: The Role of Food Involvement and Health Engagement

Auteurs: Lorenzo Palamenghi, Dilara Usta, Salvo Leone, Gunedalina Graffigna
Publié dans: Nutrients, Numéro 16(8), 1185, 2024, ISSN 2072-6643
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16081185

Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases

Auteurs: Vich Vila A, Zhang J, Liu M, Faber KN, Weersma RK
Publié dans: Gut, Numéro 73, 2024, ISSN 1468-3288
Éditeur: BMJ Group
DOI: 10.1136/GUTJNL-2023-329969

The Substantial Role of Sleep, Stress, and Physical Activity in Persistent High Levels of Fatigue in Patients With Inflammatory Bowel Disease: A Longitudinal Trajectory Study

Auteurs: Quirine M Bredero, Joke Fleer, Denise M Blom, Arno R Bourgonje, Gerard Dijkstra, Maya J Schroevers
Publié dans: Journal of Crohn's and Colitis, Numéro 19, 2025, ISSN 1873-9946
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/ECCO-JCC/JJAE163

Reasons for (Not) Seeking Care for Fatigue and Care Needs Among Patients With Inflammatory Bowel Disease: A Qualitative Interview Study

Auteurs: Quirine M. Bredero, Milou M. Ter Avest, Gerard Dijkstra, Joke Fleer, Maya J. Schroevers
Publié dans: Journal of Advanced Nursing, 2025, ISSN 0309-2402
Éditeur: Wiley
DOI: 10.1111/JAN.16837

The gut microbiome in end-stage lung disease and lung transplantation

Auteurs: Shuyan Zhang, J. Casper Swarte, Ranko Gacesa, Tim J. Knobbe, Daan Kremer, Bernadien H. Jansen, Martin H. de Borst, null null, Hermie J. M. Harmsen, Michiel E. Erasmus, Erik A. M. Verschuuren, Stephan J. L. Bakker, C. Tji Gan, Rinse K. Weersma, Johannes R. Björk, Coby Annema, Stephan J. L. Bakker, Stefan P. Berger, Hans Blokzijl, Frank A. J. A. Bodewes, Marieke T. de Boer, Kevin Damman, Martin H. de Borst, Arjan Diepstra, Gerard Dijkstra, Rianne M. Douwes, Caecilia S. E. Doorenbos, Michele F. Eisenga, Michiel E. Erasmus, C. Tji Gan, Eelko Hak, Bouke G. Hepkema, Frank Klont, Tim J. Knobbe, Daan Kremer, Henri G. D. Leuvenink, Willem S. Lexmond, Vincent E. de Meijer, Hubert G. M. Niesters, Gertrude J. Nieuwenhuis-Moeke, L. Joost van Pelt, Robert A. Pol, Robert J. Porte, Adelta V. Ranchor, Marion J. Siebelink, Riemer J. H. J. A. Slart, J. Casper Swarte, Daan J. Touw, Marius C. van den Heuvel, Coretta van Leer-Buter, Marco van Londen, Erik A. M. Verschuuren, Michel J. Vos, Rinse K. Weersma, Antonio W. Gomes Neto, Jan Stephan F. Sanders
Publié dans: mSystems, Numéro 9, 2024, ISSN 2379-5077
Éditeur: American Society for Microbiology
DOI: 10.1128/MSYSTEMS.01312-23

Lifestyle and psychosocial factors in inflammatory bowel disease: Prevalence, impact, motivation, and support needs

Auteurs: Karlijn Demers, Evelien M. B. Hendrix, Ashkan Rezazadeh Ardabili, Quirine M. Bredero, Ad A. van Bodegraven, Daniëlle van der Horst, Daisy M. A. E. Jonkers, Merel L. Kimman, Zlatan Mujagic, Mariëlle
Publié dans: PLOS One, Numéro 20, 2025, ISSN 1932-6203
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0331092

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

Auteurs: Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstanti
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1536302

Decoding the etiology of immune-mediated inflammatory diseases statistically

Auteurs: Hesham ElAbd, Aya K. H. Mahdy
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1610662

Psychological stress and eating behaviors as interacting influences on patient–reported disease activity in Italian patients with inflammatory bowel disease

Auteurs: Dilara Usta, Marta Acampora, Andresa Costa Pereira, Mariarosaria Savarese, Maria Stella De Rocchis, Luisa Avedano, Salvo Leone, Guendalina Graffigna, null null, Andre Franke, Jurgita Skiecevičienė,
Publié dans: Scientific Reports, 2025, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-29573-3

T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Auteurs: Hesham ElAbd, Mitchell Pesesky, Gabriel Innocenti, Brian K. Chung, Aya K. H. Mahdy, Valeriia Kriukova, Laila Kulsvehagen, Dennis Strobbe, Claudia Stühler, Gabriele Mayr, Damon H. May, Melanie Prinzen
Publié dans: Nature Medicine, Numéro 31, 2025, ISSN 1078-8956
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03692-W

Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

Auteurs: J. Casper Swarte, Tim J. Knobbe, Johannes R. Björk, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, null null, C. Annema, F. A. J. A. Bodewes, M. T. de Boer, K. Damman, A. Diepstra, G. Dijkstra, C. S. E. Doorenbos, M. F. Eisenga, M. E. Erasmus, C. T. Gan, A. W. Gomes Neto, E. Hak, B. G. Hepkema, F. Klont, H. G. D. Leuvenink, W. S. Lexmond, G. J. Nieuwenhuis-Moeke, H. G. M. Niesters, L. J. van Pelt, A. V. Ranchor, J. S. F. Sanders, M. J. Siebelink, R. J. H. J. A. Slart, D. J. Touw, M. C. van den Heuvel, C. van Leer-Buter, M. van Londen, E. A. M. Verschuuren, M. J. Vos, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Publié dans: Nature Communications, Numéro 14, 2023, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41467-023-43431-8

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Auteurs: Arno R. Bourgonje; Sergio Andreu-Sánchez; Thomas Vogl; Shixian Hu; Arnau Vich Vila; Ranko Gacesa; Sigal Leviatan; Alexander Kurilshikov; Shelley Klompus; Iris N. Kalka; Hendrik M. van Dullemen; Adina Weinberger; Marijn C. Visschedijk; Eleonora A.M. Festen; Klaas Nico Faber; Cisca Wijmenga; Gerard Dijkstra; Eran Segal; Jingyuan Fu; Alexandra Zhernakova; Rinse K. Weersma
Publié dans: Immunity, Numéro Vol. 56, issue 6, 2023, ISSN 1097-4180
Éditeur: Cell Press
DOI: 10.1016/j.immuni.2023.04.017