Personalised blueprint intestinal health

Informazioni relative al progetto

miGut-Health

ID dell’accordo di sovvenzione: 101095470

DOI

10.3030/101095470

Data della firma CE 11 Novembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2026

Finanziato da

• Health

Costo totale

€ 7 131 243,75

Contributo UE

€ 7 126 243,75

Coordinato da

UNIVERSITATSKLINIKUM SCHLESWIG-HOLSTEIN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (23)

Mucosal host-microbe interactions associate with clinical phenotypes in inflammatory bowel disease

Autori: Shixian Hu, Arno R. Bourgonje, Ranko Gacesa, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen, Eleonora A. M. Festen, Arnau Vich
Pubblicato in: Nature Communication, Numero 15, 1470 (2024), 2024, ISSN 2041-1723
Editore: Nature Communications
DOI: 10.1038/s41467-024-45855-2

The Role of Environmental Factors Prior to Diagnosis on the Activity and Severity of Inflammatory Bowel Diseases—Results From the Prospective Population‐Based Copenhagen Inflammatory Bowel Disease Inception Cohort

Autori: Mohamed Attauabi, Gorm Roager Madsen, Flemming Bendtsen, Johan Burisch, Jakob Benedict Seidelin
Pubblicato in: United European Gastroenterology Journal, 2025, ISSN 2050-6406
Editore: Wiley
DOI: 10.1002/UEG2.12737

Preclinical Protein Signatures of Crohn’s Disease and Ulcerative Colitis: A Nested Case-Control Study Within Large Population-Based Cohorts

Autori: Olle Grännö, Daniel Bergemalm, Benita Salomon, Carl Mårten Lindqvist, Charlotte R. H. Hedin, Marie Carlson, Katharina Dannenberg, Erik Andersson, Åsa V. Keita, Maria K. Magnusson, Carl Eriksson, Vivekananda Lanka, Patrik K.E. Magnusson, Mauro D’Amato...
Pubblicato in: Gastroenterology, Numero 6, 2024, ISSN 1528-0012
Editore: Elsevier Inc.
DOI: 10.1053/j.gastro.2024.11.006

Synergy between culturomics and metagenomics of health status-associated gut bacteria originating from non-IBD and IBD populations

Autori: N. Plomp, R. Gacesa, J. Slager, J. N. Samsom, K. N. Faber, I. H. Jonkers, S. Withoff, C. Wijmenga, R. K. Weersma, H. J. M. Harmsen
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-29138-4

Bulk T cell repertoire sequencing (TCR-Seq) is a powerful technology for understanding inflammation-mediated diseases

Autori: Aya K.H. Mahdy, Evgeniya Lokes, Valentina Schöpfel, Valeriia Kriukova, Olga V. Britanova, Tim A. Steiert, Andre Franke, Hesham ElAbd
Pubblicato in: Journal of Autoimmunity, Numero 149, 2024, ISSN 0896-8411
Editore: Elsevier BV
DOI: 10.1016/J.JAUT.2024.103337

The gut microbiome across the cardiovascular risk spectrum

Autori: Femke M Prins, Valerie Collij, Hilde E Groot, Johannes R Björk, J Casper Swarte, Sergio Andreu-Sánchez, Bernadien H Jansen, Jingyuan Fu, Hermie J M Harmsen, Alexandra Zhernakova, Erik Lipsic, Pim va
Pubblicato in: European Journal of Preventive Cardiology, Numero 31, 2024, ISSN 2047-4873
Editore: Oxford University Press (OUP)
DOI: 10.1093/EURJPC/ZWAD377

Comparing Environmental Risk Factors at Diagnosis in Faroese and Danish Patients with Inflammatory Bowel Disease

Autori: Nielsen, Kári Rubek; Modin, Frederikke Agerbo; Midjord, Jóngerð; Vang, Amanda; Berbisá, Marjun á.Fríðriksmørk; Johannesen, Herborg Líggjasardóttir; Dahlerup, Jens Frederik; Andersen, Vibeke; Neumann, Anders; Kjeldsen, Jens; Pedersen, Natalia; Langholz, Ebbe; Munkholm, Pia; Hammer, Turid; Burisch, Johan
Pubblicato in: Digestive Diseases and Sciences, Numero 69, 2024, ISSN 1573-2568
Editore: Springer Nature
DOI: 10.1007/S10620-024-08721-1

Food-Related Behavioral Patterns in Patients with Inflammatory Bowel Diseases: The Role of Food Involvement and Health Engagement

Autori: Lorenzo Palamenghi, Dilara Usta, Salvo Leone, Gunedalina Graffigna
Pubblicato in: Nutrients, Numero 16(8), 1185, 2024, ISSN 2072-6643
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu16081185

Simultaneous profiling of the blood and gut T and B cell repertoires in Crohn’s disease and symptomatic controls illustrates tissue-specific alterations in the immune repertoire of individuals with Crohn’s disease

Autori: Aya K. H. Mahdy, Valentina Schöpfel, Gert Huppertz-Hauss, Gøri Perminow, Florian Tran, Corinna Bang, Johannes R. Hov, May-Bente Bengtson, Petr Ricanek, Randi Opheim, Tone Bergene Aabrekk, Trond Espen Detlie, Vendel A. Kristensen, Mathilde Poyet, Marte Lie Høivik, Andre Franke, Hesham ElAbd
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1638522

Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases

Autori: Vich Vila A, Zhang J, Liu M, Faber KN, Weersma RK
Pubblicato in: Gut, Numero 73, 2024, ISSN 1468-3288
Editore: BMJ Group
DOI: 10.1136/GUTJNL-2023-329969

The Substantial Role of Sleep, Stress, and Physical Activity in Persistent High Levels of Fatigue in Patients With Inflammatory Bowel Disease: A Longitudinal Trajectory Study

Autori: Quirine M Bredero, Joke Fleer, Denise M Blom, Arno R Bourgonje, Gerard Dijkstra, Maya J Schroevers
Pubblicato in: Journal of Crohn's and Colitis, Numero 19, 2025, ISSN 1873-9946
Editore: Oxford University Press (OUP)
DOI: 10.1093/ECCO-JCC/JJAE163

Reasons for (Not) Seeking Care for Fatigue and Care Needs Among Patients With Inflammatory Bowel Disease: A Qualitative Interview Study

Autori: Quirine M. Bredero, Milou M. Ter Avest, Gerard Dijkstra, Joke Fleer, Maya J. Schroevers
Pubblicato in: Journal of Advanced Nursing, 2025, ISSN 0309-2402
Editore: Wiley
DOI: 10.1111/JAN.16837

The gut microbiome in end-stage lung disease and lung transplantation

Autori: Shuyan Zhang, J. Casper Swarte, Ranko Gacesa, Tim J. Knobbe, Daan Kremer, Bernadien H. Jansen, Martin H. de Borst, null null, Hermie J. M. Harmsen, Michiel E. Erasmus, Erik A. M. Verschuuren, Stephan J. L. Bakker, C. Tji Gan, Rinse K. Weersma, Johannes R. Björk, Coby Annema, Stephan J. L. Bakker, Stefan P. Berger, Hans Blokzijl, Frank A. J. A. Bodewes, Marieke T. de Boer, Kevin Damman, Martin H. de Borst, Arjan Diepstra, Gerard Dijkstra, Rianne M. Douwes, Caecilia S. E. Doorenbos, Michele F. Eisenga, Michiel E. Erasmus, C. Tji Gan, Eelko Hak, Bouke G. Hepkema, Frank Klont, Tim J. Knobbe, Daan Kremer, Henri G. D. Leuvenink, Willem S. Lexmond, Vincent E. de Meijer, Hubert G. M. Niesters, Gertrude J. Nieuwenhuis-Moeke, L. Joost van Pelt, Robert A. Pol, Robert J. Porte, Adelta V. Ranchor, Marion J. Siebelink, Riemer J. H. J. A. Slart, J. Casper Swarte, Daan J. Touw, Marius C. van den Heuvel, Coretta van Leer-Buter, Marco van Londen, Erik A. M. Verschuuren, Michel J. Vos, Rinse K. Weersma, Antonio W. Gomes Neto, Jan Stephan F. Sanders
Pubblicato in: mSystems, Numero 9, 2024, ISSN 2379-5077
Editore: American Society for Microbiology
DOI: 10.1128/MSYSTEMS.01312-23

Lifestyle and psychosocial factors in inflammatory bowel disease: Prevalence, impact, motivation, and support needs

Autori: Karlijn Demers, Evelien M. B. Hendrix, Ashkan Rezazadeh Ardabili, Quirine M. Bredero, Ad A. van Bodegraven, Daniëlle van der Horst, Daisy M. A. E. Jonkers, Merel L. Kimman, Zlatan Mujagic, Mariëlle
Pubblicato in: PLOS One, Numero 20, 2025, ISSN 1932-6203
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0331092

Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq

Autori: Daniil K. Lukyanov, Valeriia V. Kriukova, Kristin Ladell, Irina A. Shagina, Dmitry B. Staroverov, Bella E. Minasian, Anna S. Fedosova, Pavel Shelyakin, Oleg N. Suchalko, Alexander Y. Komkov, Konstanti
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1536302

Decoding the etiology of immune-mediated inflammatory diseases statistically

Autori: Hesham ElAbd, Aya K. H. Mahdy
Pubblicato in: Frontiers in Immunology, Numero 16, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1610662

Incidence, Disease Burden, and Clinical Presentation of Patients Newly Diagnosed With Inflammatory Bowel Disease in a Population-Based Inception Cohort

Autori: Mohamed Attauabi, Gorm Roager Madsen, Flemming Bendtsen, Jakob Benedict Seidelin, Johan Burisch
Pubblicato in: Journal of Crohn's and Colitis, Numero 19, 2025, ISSN 1873-9946
Editore: Oxford University Press (OUP)
DOI: 10.1093/ECCO-JCC/JJAE176

Psychological stress and eating behaviors as interacting influences on patient–reported disease activity in Italian patients with inflammatory bowel disease

Autori: Dilara Usta, Marta Acampora, Andresa Costa Pereira, Mariarosaria Savarese, Maria Stella De Rocchis, Luisa Avedano, Salvo Leone, Guendalina Graffigna, null null, Andre Franke, Jurgita Skiecevičienė,
Pubblicato in: Scientific Reports, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-29573-3

T cell receptor clonotypes predict human leukocyte antigen allele carriage and antigen exposure history

Autori: Hesham ElAbd, Aya K. H. Mahdy, Eike Matthias Wacker, Maria Gretsova, David Ellinghaus, Astrid Dempfile, Andre Franke
Pubblicato in: Communications Biology, Numero 9, 2026, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S42003-025-09140-2

T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis

Autori: Hesham ElAbd, Mitchell Pesesky, Gabriel Innocenti, Brian K. Chung, Aya K. H. Mahdy, Valeriia Kriukova, Laila Kulsvehagen, Dennis Strobbe, Claudia Stühler, Gabriele Mayr, Damon H. May, Melanie Prinzen
Pubblicato in: Nature Medicine, Numero 31, 2025, ISSN 1078-8956
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03692-W

Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

Autori: J. Casper Swarte, Tim J. Knobbe, Johannes R. Björk, Ranko Gacesa, Lianne M. Nieuwenhuis, Shuyan Zhang, Arnau Vich Vila, Daan Kremer, Rianne M. Douwes, Adrian Post, Evelien E. Quint, Robert A. Pol, Bernadien H. Jansen, null null, C. Annema, F. A. J. A. Bodewes, M. T. de Boer, K. Damman, A. Diepstra, G. Dijkstra, C. S. E. Doorenbos, M. F. Eisenga, M. E. Erasmus, C. T. Gan, A. W. Gomes Neto, E. Hak, B. G. Hepkema, F. Klont, H. G. D. Leuvenink, W. S. Lexmond, G. J. Nieuwenhuis-Moeke, H. G. M. Niesters, L. J. van Pelt, A. V. Ranchor, J. S. F. Sanders, M. J. Siebelink, R. J. H. J. A. Slart, D. J. Touw, M. C. van den Heuvel, C. van Leer-Buter, M. van Londen, E. A. M. Verschuuren, M. J. Vos, Martin H. de Borst, Vincent E. de Meijer, Hans Blokzijl, Stefan P. Berger, Eleonora A. M. Festen, Alexandra Zhernakova, Jingyuan Fu, Hermie J. M. Harmsen, Stephan J. L. Bakker, Rinse K. Weersma
Pubblicato in: Nature Communications, Numero 14, 2023, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41467-023-43431-8

Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages

Autori: Aya K. H. Mahdy, Hesham ElAbd, Érika Endo Kokubun, Valeriia Kriukova, Mitchell Pesesky, Damon H. May, Christine Olbjørn, Gøri Perminow, May-Bente Bengtson, Petr Ricanek, Svend Andersen, Trond Espen Detlie, Vendel A. Kristensen, Bjørn Moum, Morten H. Vatn, Jørgen Jahnsen, Bernd Bokemeyer, Johannes Roksund Hov, Jonas Halfvarson, Stefan Schreiber, Bryan Howie, Harlan S. Robins, Marte Lie Høivik, Andre Franke, null null
Pubblicato in: Genome Medicine, Numero 18, 2026, ISSN 1756-994X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01575-W

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Autori: Arno R. Bourgonje; Sergio Andreu-Sánchez; Thomas Vogl; Shixian Hu; Arnau Vich Vila; Ranko Gacesa; Sigal Leviatan; Alexander Kurilshikov; Shelley Klompus; Iris N. Kalka; Hendrik M. van Dullemen; Adina Weinberger; Marijn C. Visschedijk; Eleonora A.M. Festen; Klaas Nico Faber; Cisca Wijmenga; Gerard Dijkstra; Eran Segal; Jingyuan Fu; Alexandra Zhernakova; Rinse K. Weersma
Pubblicato in: Immunity, Numero Vol. 56, issue 6, 2023, ISSN 1097-4180
Editore: Cell Press
DOI: 10.1016/j.immuni.2023.04.017