PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES

Project Information

PROTO

Grant agreement ID: 101095635

DOI

10.3030/101095635

EC signature date 17 November 2022

Start date 1 January 2023

End date 31 December 2027

Funded under

• Health

Total cost

€ 7 447 875,25

EU contribution

€ 7 447 875,00

Coordinated by

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website, project branding and visual identity

Definition of the project visual identity, design and development of project website

Documents, reports (3)

Establishment BtP Platform

Mobile/Responsive Patient Portal app development, supporting back end and legal/regulatory review (wth the aim to ensure patient connectivity during and after the trial and support informed decision making by relevant stakeholders).

Full appointment of the management and external advisory Boards

Details of the name of members of the board

Dissemination and Communication Plan

Initial plan, including communication activities

Data Management Plan (1)

DMP

Data Management Plan

Publications

Book chapters (2)

Introduction: Methods for Studying the Plasma Membrane and the Surfaceome

Author(s): Roland Takács, Ali Mobasheri, Csaba Matta
Published in: Methods in Molecular Biology, The Surfaceome, 2025
Publisher: Springer US
DOI: 10.1007/978-1-0716-4434-8_1

Aminooxy Biotin-Based Characterization of the Surfaceome of Chondrogenic Cells

Author(s): Patrik Kovács, David J. Boocock, Clare Coveney, Ali Mobasheri, Csaba Matta
Published in: Methods in Molecular Biology, The Surfaceome, 2025
Publisher: Springer US
DOI: 10.1007/978-1-0716-4434-8_5

Peer reviewed articles (34)

Magnetic Resonance Imaging (MRI) Transverse Relaxation Time (T2) For Non-Invasive Assessment of Cartilage Composition -from Method Development to Automated Processing of Large Clinical Cohorts - A Selfie Review of 15 Years of Funding & Publication

Author(s): Felix Eckstein, Neal Bangerter, Wolfgang Wirth
Published in: Paracelsus Proceedings of Experimental Medicine, Issue 5, 2026, ISSN 2750-6584
Publisher: Cell Physiol Biochem Press GmbH and Co KG
DOI: 10.33594/000000842

The Design of a Sample Rapid Magnetic Resonance Imaging (MRI) Acquisition Protocol Supporting Assessment of Multiple Articular Tissues and Pathologies in Knee Osteoarthritis

Author(s): """Felix Eckstein, Thula Cannon Walter-Rittel, Akshay Chaudhari, Nicholas Brisson, Tazio Maleitzke, Georg N. Duda, Anna Wisser, Wolfgang Wirth, Tobias Winkler"""
Published in: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Publisher: Elsevier
DOI: 10.1016/j.ocarto.2024.100505

Looking Inwards: The Role of Self‐Care, Self‐Management and Self‐Healing in Musculoskeletal Pain

Author(s): Joyce McSwan, Catherine E. Panwar, Ali Mobasheri
Published in: Musculoskeletal Care, Issue 23, 2025, ISSN 1478-2189
Publisher: Wiley
DOI: 10.1002/MSC.70169

Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis

Author(s): Tamara Dietrich, Annette Aigner, Alexander Hildebrandt, Jérôme Weber, Mara Meyer Günderoth, Katharina Hohlbaum, Johannes Keller, Serafeim Tsitsilonis & Tazio Maleitzke
Published in: Scientific Reports, 2023, ISSN 2045-2322
Publisher: nature Publishing group
DOI: 10.1038/s41598-023-49720-y

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis

Author(s): Paco Mattheus Jacobus Welsing, Said el Bouhaddani, Lin Zhu, Nienke C. Nijhof, Simon C. Mastbergen, Chunyi Wen, Jaume Bacardit, Cristina Ruiz-Romero, Francisco J. Blanco, Ali Mobasheri
Published in: Connective Tissue Research, Issue 66, 2025, ISSN 0300-8207
Publisher: Informa UK Limited
DOI: 10.1080/03008207.2025.2541291

T-cell repertoire correlates with cytokine imbalance in multiple sclerosis patients

Author(s): Lisa Weidner, Rodolphe Poupardin, Tobias Zrzavy, Sandra Laner-Plamberger, Georg Gratz, Tanja Eichhorn, Viktoria Weber, Paulus S. Rommer, Christof Jungbauer, Dirk Strunk
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1604452

Best Practice and Research in Clinical Rheumatology

Author(s): Mobasheri A, Thudium CS, Bay-Jensen AC, Maleitzke T, Geissler S, Duda GN, Winkler T.
Published in: Best Pract Res Clin Rheumatol, 2023, ISSN 1521-6942
Publisher: Wiley
DOI: 10.1016/j.berh.2023.101852

Advanced therapies in orthopaedics

Author(s): Tobias Winkler, Sven Geissler, Tazio Maleitzke, Carsten Perka, Georg N Duda, Alexander Hildebrandt
Published in: EFORT Open Reviews, Issue 9, 2024, ISSN 2058-5241
Publisher: Bioscientifica
DOI: 10.1530/EOR-24-0084

Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function.

Author(s): Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D.
Published in: Advanced Healthcare materials, 2024, ISSN 2192-2659
Publisher: wiley
DOI: 10.1002/adhm.202303941

Development of a Microphysiological Cartilage‐on‐Chip Platform for Dynamic Biomechanical Stimulation of Three‐Dimensional Encapsulated Chondrocytes in Agarose Hydrogels

Author(s): Valtteri Peitso, Zahra Sarmadian, João Henriques, Elsa Lauwers, Carlo Alberto Paggi, Ali Mobasheri
Published in: Current Protocols, Issue 4, 2024, ISSN 2691-1299
Publisher: Wiley
DOI: 10.1002/CPZ1.70079

TissueGene-C induces anti-inflammatory activity and M2 macrophage polarization via activation of prostaglandin E2 signaling

Author(s): Huan Tran, Wilma Tauro, Ali Mobasheri, Moon Jong Noh
Published in: Cytotherapy, Issue 27, 2025, ISSN 1465-3249
Publisher: Elsevier BV
DOI: 10.1016/J.JCYT.2024.11.005

Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa

Author(s): Markus Hierl, Johannes Bischof, Bernadette Liemberger, Thomas Kocher, Stefan Hainzl, Stefanie Gruner, Lisa Trattner, Victoria Reichl, Alfred Klausegger, Clotilde Aussel, Sandra Ammann, Rebecca Raab, Geoffroy Andrieux, Martin Wolf, Sarah Hochmann, Patricia Ebner, Verena Wally, Roland Zauner, Christina Guttmann-Gruber, Iris K. Gratz, Josefina Piñón Hofbauer, Toni Cathomen, Dirk Strunk, Johann W. Bauer, Ulrich Koller
Published in: Molecular Therapy, Issue 34, 2026, ISSN 1525-0016
Publisher: Elsevier BV
DOI: 10.1016/J.YMTHE.2025.10.054

Skeletal interfaces in health and disease – Where two worlds interact: The Salzburg Leopoldina Symposium 2025 - Bridging disciplines and perspectives

Author(s): Felix Eckstein, Reinhard Putz
Published in: Annals of Anatomy - Anatomischer Anzeiger, 2026, ISSN 0940-9602
Publisher: Elsevier BV
DOI: 10.1016/J.AANAT.2026.152786

The dual pro inflammatory and bone protective role of calcitonin gene related peptide alpha in age related osteoarthritis.

Author(s): Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
Published in: Arthritis Research & Therapy, 2023, ISSN 1478-6354
Publisher: Bio Med Center
DOI: 10.1186/s13075-023-03215-3

Calcitonin treatment for osteoarthritis and rheumatoid arthritis – a systematic review and meta-analysis of preclinical data

Author(s): Mara Meyer Günderoth, Alexandra Bannach-Brown, Tobias Winkler, Johannes Keller, Robert Karl Zahn, Tazio Maleitzke
Published in: EFORT Open Reviews, Issue 9, 2024, ISSN 2058-5241
Publisher: Bioscientifica
DOI: 10.1530/EOR-23-0133

Chondrocyte Isolation from Loose Bodies-An Option for Reducing Donor Site Morbidity for Autologous Chondrocyte Implantation

Author(s): Martin Textor, Arndt Hoburg, Rex Lehnigk, Carsten Perka, Georg Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: MDPI
DOI: 10.3390/ijms24021484

Bone health and pregnancy: Osteoporosis and beyond

Author(s): Ali Mobasheri, Jean-Yves Reginster, Manju Chandran, Joyce McSwan
Published in: Case Reports in Women's Health, Issue 47, 2025, ISSN 2214-9112
Publisher: Elsevier BV
DOI: 10.1016/J.CRWH.2025.E00725

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Author(s): Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Published in: Connective Tissue Research, Issue 66, 2025, ISSN 0300-8207
Publisher: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Rapidly progressive osteoarthritis (RPOA) in companion animals treated with bedinvetmab (Librela™): an expected pathophysiological phenomenon or a cause for concern?

Author(s): Ali Mobasheri, Peter Hanson, Jonathan Larkin
Published in: Frontiers in Veterinary Science, Issue 12, 2025, ISSN 2297-1769
Publisher: Frontiers Media SA
DOI: 10.3389/FVETS.2025.1640217

Long-term in vitro maintenance of plasma cells in a hydrogel-enclosed human bone marrow microphysiological 3D model system

Author(s): Stefania Martini, Norman Michael Drzeniek, Regina Stark, Matthias Reiner Kollert, Weijie Du, Simon Reinke, Melanie Ort, Sebastian Hardt, Iuliia Kotko, Jonas Kath, Stephan Schlickeiser, Sven Geißler, Dimitrios Laurin Wagner, Anna-Catharina Krebs, Hans-Dieter Volk
Published in: Biofabrication, Issue 16, 2024, ISSN 1758-5082
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/AD5DFE

Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?

Author(s): Felix Eckstein, Reinhard Putz, Wolfgang Wirth
Published in: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Publisher: Elsevier
DOI: 10.1016/j.ocarto.2024.100485

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis

Author(s): Kovács, Patrik; Pushparaj, Peter Natesan; Takács, Roland; Mobasheri, Ali; Matta, Csaba
Published in: Frontiers in immunology , 2023, ISSN 1664-3224
Publisher: Frontiers media
DOI: 10.3389/FIMMU.2023.1103097

Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression

Author(s): Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Published in: Theranostics, Issue 15, 2025, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/THNO.117788

Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction

Author(s): Evelyne Demkes, Aina Cervera-Barea, Patricia Ebner-Peking, Martin Wolf, Sarah Hochmann, Amy S. Scheren, Mayke Bijsterveld, C. Marlies van Oostveen, Marlijn Jansen, Joyce Visser, Wiebke Triebert, Caroline Halloin, Johannes G. G. Dobbe, Judith de Vos, Melanie Schürz, Joachim Danmayr, Maurice C. G. Aalders, Gerard J. J. Boink, Klaus Neef, Dirk Strunk, Robert Zweigerdt, Saskia C. A. de Jager, Joost P. G. Sluijter
Published in: Journal of Cardiovascular Translational Research, Issue 18, 2025, ISSN 1937-5387
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S12265-025-10596-0

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Author(s): Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Published in: Osteoarthritis and Cartilage Open, Issue 7, 2025, ISSN 2665-9131
Publisher: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities

Author(s): João Henriques, Francis Berenbaum, Ali Mobasheri
Published in: Osteoarthritis and Cartilage Open, Issue 6, 2024, ISSN 2665-9131
Publisher: Elsevier BV
DOI: 10.1016/J.OCARTO.2024.100511

Minimal information for studies of extracellular vesicles (MISEV2023)

Author(s): Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Dirk Strunk, Martin Wolf, et al
Published in: Journal of Extracellular Vesicles, 2024, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/jev2.12404

A sample rapid MRI acquisition protocol supporting assessment of multiple articular tissues and pathologies in early and advanced knee osteoarthritis

Author(s): Wisser A, Walter-Rittel TC, Chaudhari A, Brisson NM, Maleitzke T, Duda GN, Wirth W, Winkler T, Eckstein F
Published in: Osteoarthritis Imaging, 2024, ISSN 2772-6541
Publisher: Elsevier
DOI: 10.1016/j.ostima.2024.100221

Comment on “Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomized trials: A systematic review and network meta-analysis (Pereira et al., 2025)”

Author(s): Alberto Migliore, Ali Mobasheri, Jean-Yves Reginster, Emmanuel Maheu
Published in: Osteoarthritis and Cartilage, Issue 33, 2025, ISSN 1063-4584
Publisher: Elsevier BV
DOI: 10.1016/J.JOCA.2025.03.007

Prognostic implications of a CD8+ TEMRA to CD4+Treg imbalance in mandibular fracture healing: a prospective analysis of immune profiles

Author(s): Jan Oliver Voss, Fabio Pivetta, Aboelyazid Elkilany, Katharina Schmidt-Bleek, Georg N. Duda, Kento Odaka, Ioanna Maria Dimitriou, Melanie Jasmin Ort, Mathias Streitz, Max Heiland, Steffen Koerdt, Simon Reinke, Sven Geissler
Published in: Frontiers in Immunology, Issue 15, 2024, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1476009

Comment on “Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice” by Lin et al. (2024), and recommendations for non-invasive knee joint injury models

Author(s): Tazio Maleitzke, Johanna Bolander, Ali Mobasheri, Florian N. Fleckenstein, Felix Eckstein, Nicholas M. Brisson, Tobias Winkler
Published in: Osteoarthritis and Cartilage, Issue 33, 2025, ISSN 1063-4584
Publisher: Elsevier BV
DOI: 10.1016/J.JOCA.2025.02.002

Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review

Author(s): Primorac, Dragan; Molnar, Vilim; Tsoukas, Dimitrios; Uzieliene, Ilona; Tremolada, Carlo; Brlek, Petar; Klarić, Emil; Vidović, Dinko; Zekušić, Marija; Pachaleva, Jolita; Bernotiene, Eiva; Wilson, Adrian; Mobasheri, Ali 
Published in: Croatian medical journal , 2024, ISSN 0353-9504
Publisher: Medicinska naklada
DOI: 10.3325/CMJ.2024.65.268

In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

Author(s): Drzeniek NM, Kahwaji N, Picht S, Dimitriou IM, Schlickeiser S, Moradian H, Geissler S, Schmueck-Henneresse M, Gossen M, Volk HD.
Published in: Advanced Science, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202308447

Insights into chondrocyte populations in cartilaginous tissues at the single-cell level

Author(s): Csaba Matta, Roland Takács, Mona Dvir-Ginzberg, Stephen M. Richardson, Karoliina Pelttari, Girish Pattappa, Makarand V. Risbud, Ali Mobasheri
Published in: Nature Reviews Rheumatology, Issue 21, 2025, ISSN 1759-4790
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41584-025-01275-0