PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES

Project Information

PROTO

Grant agreement ID: 101095635

DOI

10.3030/101095635

EC signature date 17 November 2022

Start date 1 January 2023

End date 31 December 2027

Funded under

• Health

Total cost

€ 7 447 875,25

EU contribution

€ 7 447 875,00

Coordinated by

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website, project branding and visual identity

Definition of the project visual identity, design and development of project website

Documents, reports (3)

Establishment BtP Platform

Mobile/Responsive Patient Portal app development, supporting back end and legal/regulatory review (wth the aim to ensure patient connectivity during and after the trial and support informed decision making by relevant stakeholders).

Full appointment of the management and external advisory Boards

Details of the name of members of the board

Dissemination and Communication Plan

Initial plan, including communication activities

Data Management Plan (1)

DMP

Data Management Plan

Publications

Peer reviewed articles (12)

The Design of a Sample Rapid Magnetic Resonance Imaging (MRI) Acquisition Protocol Supporting Assessment of Multiple Articular Tissues and Pathologies in Knee Osteoarthritis

Author(s): """Felix Eckstein, Thula Cannon Walter-Rittel, Akshay Chaudhari, Nicholas Brisson, Tazio Maleitzke, Georg N. Duda, Anna Wisser, Wolfgang Wirth, Tobias Winkler"""
Published in: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Publisher: Elsevier
DOI: 10.1016/j.ocarto.2024.100505

Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis

Author(s): Tamara Dietrich, Annette Aigner, Alexander Hildebrandt, Jérôme Weber, Mara Meyer Günderoth, Katharina Hohlbaum, Johannes Keller, Serafeim Tsitsilonis & Tazio Maleitzke
Published in: Scientific Reports, 2023, ISSN 2045-2322
Publisher: nature Publishing group
DOI: 10.1038/s41598-023-49720-y

Best Practice and Research in Clinical Rheumatology

Author(s): Mobasheri A, Thudium CS, Bay-Jensen AC, Maleitzke T, Geissler S, Duda GN, Winkler T.
Published in: Best Pract Res Clin Rheumatol, 2023, ISSN 1521-6942
Publisher: Wiley
DOI: 10.1016/j.berh.2023.101852

Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function.

Author(s): Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D.
Published in: Advanced Healthcare materials, 2024, ISSN 2192-2659
Publisher: wiley
DOI: 10.1002/adhm.202303941

The dual pro inflammatory and bone protective role of calcitonin gene related peptide alpha in age related osteoarthritis.

Author(s): Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
Published in: Arthritis Research & Therapy, 2023, ISSN 1478-6354
Publisher: Bio Med Center
DOI: 10.1186/s13075-023-03215-3

Chondrocyte Isolation from Loose Bodies-An Option for Reducing Donor Site Morbidity for Autologous Chondrocyte Implantation

Author(s): Martin Textor, Arndt Hoburg, Rex Lehnigk, Carsten Perka, Georg Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Published in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Publisher: MDPI
DOI: 10.3390/ijms24021484

Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?

Author(s): Felix Eckstein, Reinhard Putz, Wolfgang Wirth
Published in: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Publisher: Elsevier
DOI: 10.1016/j.ocarto.2024.100485

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis

Author(s): Kovács, Patrik; Pushparaj, Peter Natesan; Takács, Roland; Mobasheri, Ali; Matta, Csaba
Published in: Frontiers in immunology , 2023, ISSN 1664-3224
Publisher: Frontiers media
DOI: 10.3389/FIMMU.2023.1103097

Minimal information for studies of extracellular vesicles (MISEV2023)

Author(s): Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Dirk Strunk, Martin Wolf, et al
Published in: Journal of Extracellular Vesicles, 2024, ISSN 2001-3078
Publisher: Wiley
DOI: 10.1002/jev2.12404

A sample rapid MRI acquisition protocol supporting assessment of multiple articular tissues and pathologies in early and advanced knee osteoarthritis

Author(s): Wisser A, Walter-Rittel TC, Chaudhari A, Brisson NM, Maleitzke T, Duda GN, Wirth W, Winkler T, Eckstein F
Published in: Osteoarthritis Imaging, 2024, ISSN 2772-6541
Publisher: Elsevier
DOI: 10.1016/j.ostima.2024.100221

Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review

Author(s): Primorac, Dragan; Molnar, Vilim; Tsoukas, Dimitrios; Uzieliene, Ilona; Tremolada, Carlo; Brlek, Petar; Klarić, Emil; Vidović, Dinko; Zekušić, Marija; Pachaleva, Jolita; Bernotiene, Eiva; Wilson, Adrian; Mobasheri, Ali 
Published in: Croatian medical journal , 2024, ISSN 0353-9504
Publisher: Medicinska naklada
DOI: 10.3325/CMJ.2024.65.268

In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

Author(s): Drzeniek NM, Kahwaji N, Picht S, Dimitriou IM, Schlickeiser S, Moradian H, Geissler S, Schmueck-Henneresse M, Gossen M, Volk HD.
Published in: Advanced Science, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202308447