PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES

Información del proyecto

PROTO

Identificador del acuerdo de subvención: 101095635

DOI

10.3030/101095635

Fecha de la firma de la CE 17 Noviembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• Health

Coste total

€ 7 447 875,25

Aportación de la UE

€ 7 447 875,00

Coordinado por

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Project website, project branding and visual identity

Definition of the project visual identity, design and development of project website

Documents, reports (3)

Establishment BtP Platform

Mobile/Responsive Patient Portal app development, supporting back end and legal/regulatory review (wth the aim to ensure patient connectivity during and after the trial and support informed decision making by relevant stakeholders).

Full appointment of the management and external advisory Boards

Details of the name of members of the board

Dissemination and Communication Plan

Initial plan, including communication activities

Data Management Plan (1)

DMP

Data Management Plan

Publicaciones

Book chapters (2)

Introduction: Methods for Studying the Plasma Membrane and the Surfaceome

Autores: Roland Takács, Ali Mobasheri, Csaba Matta
Publicado en: Methods in Molecular Biology, The Surfaceome, 2025
Editor: Springer US
DOI: 10.1007/978-1-0716-4434-8_1

Aminooxy Biotin-Based Characterization of the Surfaceome of Chondrogenic Cells

Autores: Patrik Kovács, David J. Boocock, Clare Coveney, Ali Mobasheri, Csaba Matta
Publicado en: Methods in Molecular Biology, The Surfaceome, 2025
Editor: Springer US
DOI: 10.1007/978-1-0716-4434-8_5

Peer reviewed articles (34)

Magnetic Resonance Imaging (MRI) Transverse Relaxation Time (T2) For Non-Invasive Assessment of Cartilage Composition -from Method Development to Automated Processing of Large Clinical Cohorts - A Selfie Review of 15 Years of Funding & Publication

Autores: Felix Eckstein, Neal Bangerter, Wolfgang Wirth
Publicado en: Paracelsus Proceedings of Experimental Medicine, Edición 5, 2026, ISSN 2750-6584
Editor: Cell Physiol Biochem Press GmbH and Co KG
DOI: 10.33594/000000842

The Design of a Sample Rapid Magnetic Resonance Imaging (MRI) Acquisition Protocol Supporting Assessment of Multiple Articular Tissues and Pathologies in Knee Osteoarthritis

Autores: """Felix Eckstein, Thula Cannon Walter-Rittel, Akshay Chaudhari, Nicholas Brisson, Tazio Maleitzke, Georg N. Duda, Anna Wisser, Wolfgang Wirth, Tobias Winkler"""
Publicado en: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Editor: Elsevier
DOI: 10.1016/j.ocarto.2024.100505

Looking Inwards: The Role of Self‐Care, Self‐Management and Self‐Healing in Musculoskeletal Pain

Autores: Joyce McSwan, Catherine E. Panwar, Ali Mobasheri
Publicado en: Musculoskeletal Care, Edición 23, 2025, ISSN 1478-2189
Editor: Wiley
DOI: 10.1002/MSC.70169

Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis

Autores: Tamara Dietrich, Annette Aigner, Alexander Hildebrandt, Jérôme Weber, Mara Meyer Günderoth, Katharina Hohlbaum, Johannes Keller, Serafeim Tsitsilonis & Tazio Maleitzke
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: nature Publishing group
DOI: 10.1038/s41598-023-49720-y

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis

Autores: Paco Mattheus Jacobus Welsing, Said el Bouhaddani, Lin Zhu, Nienke C. Nijhof, Simon C. Mastbergen, Chunyi Wen, Jaume Bacardit, Cristina Ruiz-Romero, Francisco J. Blanco, Ali Mobasheri
Publicado en: Connective Tissue Research, Edición 66, 2025, ISSN 0300-8207
Editor: Informa UK Limited
DOI: 10.1080/03008207.2025.2541291

T-cell repertoire correlates with cytokine imbalance in multiple sclerosis patients

Autores: Lisa Weidner, Rodolphe Poupardin, Tobias Zrzavy, Sandra Laner-Plamberger, Georg Gratz, Tanja Eichhorn, Viktoria Weber, Paulus S. Rommer, Christof Jungbauer, Dirk Strunk
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1604452

Best Practice and Research in Clinical Rheumatology

Autores: Mobasheri A, Thudium CS, Bay-Jensen AC, Maleitzke T, Geissler S, Duda GN, Winkler T.
Publicado en: Best Pract Res Clin Rheumatol, 2023, ISSN 1521-6942
Editor: Wiley
DOI: 10.1016/j.berh.2023.101852

Advanced therapies in orthopaedics

Autores: Tobias Winkler, Sven Geissler, Tazio Maleitzke, Carsten Perka, Georg N Duda, Alexander Hildebrandt
Publicado en: EFORT Open Reviews, Edición 9, 2024, ISSN 2058-5241
Editor: Bioscientifica
DOI: 10.1530/EOR-24-0084

Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function.

Autores: Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D.
Publicado en: Advanced Healthcare materials, 2024, ISSN 2192-2659
Editor: wiley
DOI: 10.1002/adhm.202303941

Development of a Microphysiological Cartilage‐on‐Chip Platform for Dynamic Biomechanical Stimulation of Three‐Dimensional Encapsulated Chondrocytes in Agarose Hydrogels

Autores: Valtteri Peitso, Zahra Sarmadian, João Henriques, Elsa Lauwers, Carlo Alberto Paggi, Ali Mobasheri
Publicado en: Current Protocols, Edición 4, 2024, ISSN 2691-1299
Editor: Wiley
DOI: 10.1002/CPZ1.70079

TissueGene-C induces anti-inflammatory activity and M2 macrophage polarization via activation of prostaglandin E2 signaling

Autores: Huan Tran, Wilma Tauro, Ali Mobasheri, Moon Jong Noh
Publicado en: Cytotherapy, Edición 27, 2025, ISSN 1465-3249
Editor: Elsevier BV
DOI: 10.1016/J.JCYT.2024.11.005

Prime editing as a promising therapeutic strategy for junctional epidermolysis bullosa

Autores: Markus Hierl, Johannes Bischof, Bernadette Liemberger, Thomas Kocher, Stefan Hainzl, Stefanie Gruner, Lisa Trattner, Victoria Reichl, Alfred Klausegger, Clotilde Aussel, Sandra Ammann, Rebecca Raab, Geoffroy Andrieux, Martin Wolf, Sarah Hochmann, Patricia Ebner, Verena Wally, Roland Zauner, Christina Guttmann-Gruber, Iris K. Gratz, Josefina Piñón Hofbauer, Toni Cathomen, Dirk Strunk, Johann W. Bauer, Ulrich Koller
Publicado en: Molecular Therapy, Edición 34, 2026, ISSN 1525-0016
Editor: Elsevier BV
DOI: 10.1016/J.YMTHE.2025.10.054

Skeletal interfaces in health and disease – Where two worlds interact: The Salzburg Leopoldina Symposium 2025 - Bridging disciplines and perspectives

Autores: Felix Eckstein, Reinhard Putz
Publicado en: Annals of Anatomy - Anatomischer Anzeiger, 2026, ISSN 0940-9602
Editor: Elsevier BV
DOI: 10.1016/J.AANAT.2026.152786

The dual pro inflammatory and bone protective role of calcitonin gene related peptide alpha in age related osteoarthritis.

Autores: Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
Publicado en: Arthritis Research & Therapy, 2023, ISSN 1478-6354
Editor: Bio Med Center
DOI: 10.1186/s13075-023-03215-3

Calcitonin treatment for osteoarthritis and rheumatoid arthritis – a systematic review and meta-analysis of preclinical data

Autores: Mara Meyer Günderoth, Alexandra Bannach-Brown, Tobias Winkler, Johannes Keller, Robert Karl Zahn, Tazio Maleitzke
Publicado en: EFORT Open Reviews, Edición 9, 2024, ISSN 2058-5241
Editor: Bioscientifica
DOI: 10.1530/EOR-23-0133

Chondrocyte Isolation from Loose Bodies-An Option for Reducing Donor Site Morbidity for Autologous Chondrocyte Implantation

Autores: Martin Textor, Arndt Hoburg, Rex Lehnigk, Carsten Perka, Georg Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/ijms24021484

Bone health and pregnancy: Osteoporosis and beyond

Autores: Ali Mobasheri, Jean-Yves Reginster, Manju Chandran, Joyce McSwan
Publicado en: Case Reports in Women's Health, Edición 47, 2025, ISSN 2214-9112
Editor: Elsevier BV
DOI: 10.1016/J.CRWH.2025.E00725

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Autores: Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Publicado en: Connective Tissue Research, Edición 66, 2025, ISSN 0300-8207
Editor: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Rapidly progressive osteoarthritis (RPOA) in companion animals treated with bedinvetmab (Librela™): an expected pathophysiological phenomenon or a cause for concern?

Autores: Ali Mobasheri, Peter Hanson, Jonathan Larkin
Publicado en: Frontiers in Veterinary Science, Edición 12, 2025, ISSN 2297-1769
Editor: Frontiers Media SA
DOI: 10.3389/FVETS.2025.1640217

Long-term in vitro maintenance of plasma cells in a hydrogel-enclosed human bone marrow microphysiological 3D model system

Autores: Stefania Martini, Norman Michael Drzeniek, Regina Stark, Matthias Reiner Kollert, Weijie Du, Simon Reinke, Melanie Ort, Sebastian Hardt, Iuliia Kotko, Jonas Kath, Stephan Schlickeiser, Sven Geißler, Dimitrios Laurin Wagner, Anna-Catharina Krebs, Hans-Dieter Volk
Publicado en: Biofabrication, Edición 16, 2024, ISSN 1758-5082
Editor: IOP Publishing
DOI: 10.1088/1758-5090/AD5DFE

Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?

Autores: Felix Eckstein, Reinhard Putz, Wolfgang Wirth
Publicado en: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Editor: Elsevier
DOI: 10.1016/j.ocarto.2024.100485

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis

Autores: Kovács, Patrik; Pushparaj, Peter Natesan; Takács, Roland; Mobasheri, Ali; Matta, Csaba
Publicado en: Frontiers in immunology , 2023, ISSN 1664-3224
Editor: Frontiers media
DOI: 10.3389/FIMMU.2023.1103097

Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression

Autores: Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Publicado en: Theranostics, Edición 15, 2025, ISSN 1838-7640
Editor: Ivyspring International Publisher
DOI: 10.7150/THNO.117788

Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction

Autores: Evelyne Demkes, Aina Cervera-Barea, Patricia Ebner-Peking, Martin Wolf, Sarah Hochmann, Amy S. Scheren, Mayke Bijsterveld, C. Marlies van Oostveen, Marlijn Jansen, Joyce Visser, Wiebke Triebert, Caroline Halloin, Johannes G. G. Dobbe, Judith de Vos, Melanie Schürz, Joachim Danmayr, Maurice C. G. Aalders, Gerard J. J. Boink, Klaus Neef, Dirk Strunk, Robert Zweigerdt, Saskia C. A. de Jager, Joost P. G. Sluijter
Publicado en: Journal of Cardiovascular Translational Research, Edición 18, 2025, ISSN 1937-5387
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S12265-025-10596-0

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Autores: Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Publicado en: Osteoarthritis and Cartilage Open, Edición 7, 2025, ISSN 2665-9131
Editor: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities

Autores: João Henriques, Francis Berenbaum, Ali Mobasheri
Publicado en: Osteoarthritis and Cartilage Open, Edición 6, 2024, ISSN 2665-9131
Editor: Elsevier BV
DOI: 10.1016/J.OCARTO.2024.100511

Minimal information for studies of extracellular vesicles (MISEV2023)

Autores: Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Dirk Strunk, Martin Wolf, et al
Publicado en: Journal of Extracellular Vesicles, 2024, ISSN 2001-3078
Editor: Wiley
DOI: 10.1002/jev2.12404

A sample rapid MRI acquisition protocol supporting assessment of multiple articular tissues and pathologies in early and advanced knee osteoarthritis

Autores: Wisser A, Walter-Rittel TC, Chaudhari A, Brisson NM, Maleitzke T, Duda GN, Wirth W, Winkler T, Eckstein F
Publicado en: Osteoarthritis Imaging, 2024, ISSN 2772-6541
Editor: Elsevier
DOI: 10.1016/j.ostima.2024.100221

Comment on “Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomized trials: A systematic review and network meta-analysis (Pereira et al., 2025)”

Autores: Alberto Migliore, Ali Mobasheri, Jean-Yves Reginster, Emmanuel Maheu
Publicado en: Osteoarthritis and Cartilage, Edición 33, 2025, ISSN 1063-4584
Editor: Elsevier BV
DOI: 10.1016/J.JOCA.2025.03.007

Prognostic implications of a CD8+ TEMRA to CD4+Treg imbalance in mandibular fracture healing: a prospective analysis of immune profiles

Autores: Jan Oliver Voss, Fabio Pivetta, Aboelyazid Elkilany, Katharina Schmidt-Bleek, Georg N. Duda, Kento Odaka, Ioanna Maria Dimitriou, Melanie Jasmin Ort, Mathias Streitz, Max Heiland, Steffen Koerdt, Simon Reinke, Sven Geissler
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1476009

Comment on “Surgical restabilization reduces the progression of post-traumatic osteoarthritis initiated by ACL rupture in mice” by Lin et al. (2024), and recommendations for non-invasive knee joint injury models

Autores: Tazio Maleitzke, Johanna Bolander, Ali Mobasheri, Florian N. Fleckenstein, Felix Eckstein, Nicholas M. Brisson, Tobias Winkler
Publicado en: Osteoarthritis and Cartilage, Edición 33, 2025, ISSN 1063-4584
Editor: Elsevier BV
DOI: 10.1016/J.JOCA.2025.02.002

Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review

Autores: Primorac, Dragan; Molnar, Vilim; Tsoukas, Dimitrios; Uzieliene, Ilona; Tremolada, Carlo; Brlek, Petar; Klarić, Emil; Vidović, Dinko; Zekušić, Marija; Pachaleva, Jolita; Bernotiene, Eiva; Wilson, Adrian; Mobasheri, Ali 
Publicado en: Croatian medical journal , 2024, ISSN 0353-9504
Editor: Medicinska naklada
DOI: 10.3325/CMJ.2024.65.268

In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

Autores: Drzeniek NM, Kahwaji N, Picht S, Dimitriou IM, Schlickeiser S, Moradian H, Geissler S, Schmueck-Henneresse M, Gossen M, Volk HD.
Publicado en: Advanced Science, 2024, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202308447

Insights into chondrocyte populations in cartilaginous tissues at the single-cell level

Autores: Csaba Matta, Roland Takács, Mona Dvir-Ginzberg, Stephen M. Richardson, Karoliina Pelttari, Girish Pattappa, Makarand V. Risbud, Ali Mobasheri
Publicado en: Nature Reviews Rheumatology, Edición 21, 2025, ISSN 1759-4790
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41584-025-01275-0