PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES

Información del proyecto

PROTO

Identificador del acuerdo de subvención: 101095635

DOI

10.3030/101095635

Fecha de la firma de la CE 17 Noviembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2027

Financiado con arreglo a

• Health

Coste total

€ 7 447 875,25

Aportación de la UE

€ 7 447 875,00

Coordinado por

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Project website, project branding and visual identity

Definition of the project visual identity, design and development of project website

Documents, reports (3)

Establishment BtP Platform

Mobile/Responsive Patient Portal app development, supporting back end and legal/regulatory review (wth the aim to ensure patient connectivity during and after the trial and support informed decision making by relevant stakeholders).

Full appointment of the management and external advisory Boards

Details of the name of members of the board

Dissemination and Communication Plan

Initial plan, including communication activities

Data Management Plan (1)

DMP

Data Management Plan

Publicaciones

Peer reviewed articles (12)

The Design of a Sample Rapid Magnetic Resonance Imaging (MRI) Acquisition Protocol Supporting Assessment of Multiple Articular Tissues and Pathologies in Knee Osteoarthritis

Autores: """Felix Eckstein, Thula Cannon Walter-Rittel, Akshay Chaudhari, Nicholas Brisson, Tazio Maleitzke, Georg N. Duda, Anna Wisser, Wolfgang Wirth, Tobias Winkler"""
Publicado en: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Editor: Elsevier
DOI: 10.1016/j.ocarto.2024.100505

Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis

Autores: Tamara Dietrich, Annette Aigner, Alexander Hildebrandt, Jérôme Weber, Mara Meyer Günderoth, Katharina Hohlbaum, Johannes Keller, Serafeim Tsitsilonis & Tazio Maleitzke
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: nature Publishing group
DOI: 10.1038/s41598-023-49720-y

Best Practice and Research in Clinical Rheumatology

Autores: Mobasheri A, Thudium CS, Bay-Jensen AC, Maleitzke T, Geissler S, Duda GN, Winkler T.
Publicado en: Best Pract Res Clin Rheumatol, 2023, ISSN 1521-6942
Editor: Wiley
DOI: 10.1016/j.berh.2023.101852

Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function.

Autores: Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D.
Publicado en: Advanced Healthcare materials, 2024, ISSN 2192-2659
Editor: wiley
DOI: 10.1002/adhm.202303941

The dual pro inflammatory and bone protective role of calcitonin gene related peptide alpha in age related osteoarthritis.

Autores: Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
Publicado en: Arthritis Research & Therapy, 2023, ISSN 1478-6354
Editor: Bio Med Center
DOI: 10.1186/s13075-023-03215-3

Chondrocyte Isolation from Loose Bodies-An Option for Reducing Donor Site Morbidity for Autologous Chondrocyte Implantation

Autores: Martin Textor, Arndt Hoburg, Rex Lehnigk, Carsten Perka, Georg Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/ijms24021484

Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?

Autores: Felix Eckstein, Reinhard Putz, Wolfgang Wirth
Publicado en: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Editor: Elsevier
DOI: 10.1016/j.ocarto.2024.100485

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis

Autores: Kovács, Patrik; Pushparaj, Peter Natesan; Takács, Roland; Mobasheri, Ali; Matta, Csaba
Publicado en: Frontiers in immunology , 2023, ISSN 1664-3224
Editor: Frontiers media
DOI: 10.3389/FIMMU.2023.1103097

Minimal information for studies of extracellular vesicles (MISEV2023)

Autores: Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Dirk Strunk, Martin Wolf, et al
Publicado en: Journal of Extracellular Vesicles, 2024, ISSN 2001-3078
Editor: Wiley
DOI: 10.1002/jev2.12404

A sample rapid MRI acquisition protocol supporting assessment of multiple articular tissues and pathologies in early and advanced knee osteoarthritis

Autores: Wisser A, Walter-Rittel TC, Chaudhari A, Brisson NM, Maleitzke T, Duda GN, Wirth W, Winkler T, Eckstein F
Publicado en: Osteoarthritis Imaging, 2024, ISSN 2772-6541
Editor: Elsevier
DOI: 10.1016/j.ostima.2024.100221

Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review

Autores: Primorac, Dragan; Molnar, Vilim; Tsoukas, Dimitrios; Uzieliene, Ilona; Tremolada, Carlo; Brlek, Petar; Klarić, Emil; Vidović, Dinko; Zekušić, Marija; Pachaleva, Jolita; Bernotiene, Eiva; Wilson, Adrian; Mobasheri, Ali 
Publicado en: Croatian medical journal , 2024, ISSN 0353-9504
Editor: Medicinska naklada
DOI: 10.3325/CMJ.2024.65.268

In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

Autores: Drzeniek NM, Kahwaji N, Picht S, Dimitriou IM, Schlickeiser S, Moradian H, Geissler S, Schmueck-Henneresse M, Gossen M, Volk HD.
Publicado en: Advanced Science, 2024, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202308447