PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES

Informations projet

PROTO

N° de convention de subvention: 101095635

DOI

10.3030/101095635

Date de signature de la CE 17 Novembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2027

Financé au titre de

• Health

Coût total

€ 7 447 875,25

Contribution de l’UE

€ 7 447 875,00

Coordonné par

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Project website, project branding and visual identity

Definition of the project visual identity, design and development of project website

Documents, reports (3)

Establishment BtP Platform

Mobile/Responsive Patient Portal app development, supporting back end and legal/regulatory review (wth the aim to ensure patient connectivity during and after the trial and support informed decision making by relevant stakeholders).

Full appointment of the management and external advisory Boards

Details of the name of members of the board

Dissemination and Communication Plan

Initial plan, including communication activities

Data Management Plan (1)

DMP

Data Management Plan

Publications

Peer reviewed articles (12)

The Design of a Sample Rapid Magnetic Resonance Imaging (MRI) Acquisition Protocol Supporting Assessment of Multiple Articular Tissues and Pathologies in Knee Osteoarthritis

Auteurs: """Felix Eckstein, Thula Cannon Walter-Rittel, Akshay Chaudhari, Nicholas Brisson, Tazio Maleitzke, Georg N. Duda, Anna Wisser, Wolfgang Wirth, Tobias Winkler"""
Publié dans: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Éditeur: Elsevier
DOI: 10.1016/j.ocarto.2024.100505

Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis

Auteurs: Tamara Dietrich, Annette Aigner, Alexander Hildebrandt, Jérôme Weber, Mara Meyer Günderoth, Katharina Hohlbaum, Johannes Keller, Serafeim Tsitsilonis & Tazio Maleitzke
Publié dans: Scientific Reports, 2023, ISSN 2045-2322
Éditeur: nature Publishing group
DOI: 10.1038/s41598-023-49720-y

Best Practice and Research in Clinical Rheumatology

Auteurs: Mobasheri A, Thudium CS, Bay-Jensen AC, Maleitzke T, Geissler S, Duda GN, Winkler T.
Publié dans: Best Pract Res Clin Rheumatol, 2023, ISSN 1521-6942
Éditeur: Wiley
DOI: 10.1016/j.berh.2023.101852

Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function.

Auteurs: Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D.
Publié dans: Advanced Healthcare materials, 2024, ISSN 2192-2659
Éditeur: wiley
DOI: 10.1002/adhm.202303941

The dual pro inflammatory and bone protective role of calcitonin gene related peptide alpha in age related osteoarthritis.

Auteurs: Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
Publié dans: Arthritis Research & Therapy, 2023, ISSN 1478-6354
Éditeur: Bio Med Center
DOI: 10.1186/s13075-023-03215-3

Chondrocyte Isolation from Loose Bodies-An Option for Reducing Donor Site Morbidity for Autologous Chondrocyte Implantation

Auteurs: Martin Textor, Arndt Hoburg, Rex Lehnigk, Carsten Perka, Georg Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Publié dans: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Éditeur: MDPI
DOI: 10.3390/ijms24021484

Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?

Auteurs: Felix Eckstein, Reinhard Putz, Wolfgang Wirth
Publié dans: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Éditeur: Elsevier
DOI: 10.1016/j.ocarto.2024.100485

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis

Auteurs: Kovács, Patrik; Pushparaj, Peter Natesan; Takács, Roland; Mobasheri, Ali; Matta, Csaba
Publié dans: Frontiers in immunology , 2023, ISSN 1664-3224
Éditeur: Frontiers media
DOI: 10.3389/FIMMU.2023.1103097

Minimal information for studies of extracellular vesicles (MISEV2023)

Auteurs: Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Dirk Strunk, Martin Wolf, et al
Publié dans: Journal of Extracellular Vesicles, 2024, ISSN 2001-3078
Éditeur: Wiley
DOI: 10.1002/jev2.12404

A sample rapid MRI acquisition protocol supporting assessment of multiple articular tissues and pathologies in early and advanced knee osteoarthritis

Auteurs: Wisser A, Walter-Rittel TC, Chaudhari A, Brisson NM, Maleitzke T, Duda GN, Wirth W, Winkler T, Eckstein F
Publié dans: Osteoarthritis Imaging, 2024, ISSN 2772-6541
Éditeur: Elsevier
DOI: 10.1016/j.ostima.2024.100221

Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review

Auteurs: Primorac, Dragan; Molnar, Vilim; Tsoukas, Dimitrios; Uzieliene, Ilona; Tremolada, Carlo; Brlek, Petar; Klarić, Emil; Vidović, Dinko; Zekušić, Marija; Pachaleva, Jolita; Bernotiene, Eiva; Wilson, Adrian; Mobasheri, Ali 
Publié dans: Croatian medical journal , 2024, ISSN 0353-9504
Éditeur: Medicinska naklada
DOI: 10.3325/CMJ.2024.65.268

In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

Auteurs: Drzeniek NM, Kahwaji N, Picht S, Dimitriou IM, Schlickeiser S, Moradian H, Geissler S, Schmueck-Henneresse M, Gossen M, Volk HD.
Publié dans: Advanced Science, 2024, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202308447