PROTO - Advanced PeRsOnalized Therapies for Osteoarthritis – TACKLING INFLAMMATION TO IMPROVE PATIENT OUTCOMES

Informazioni relative al progetto

PROTO

ID dell’accordo di sovvenzione: 101095635

DOI 10.3030/101095635

Data della firma CE 17 Novembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2027

Finanziato da

• Health

Costo totale € 7 447 875,25

Contributo UE € 7 447 875,00

Coordinato da

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germania

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Siti web, brevetti, video ecc. (1)

Project website, project branding and visual identity

Definition of the project visual identity, design and development of project website

Documenti, relazioni (3)

Establishment BtP Platform

Mobile/Responsive Patient Portal app development, supporting back end and legal/regulatory review (wth the aim to ensure patient connectivity during and after the trial and support informed decision making by relevant stakeholders).

Full appointment of the management and external advisory Boards

Details of the name of members of the board

Dissemination and Communication Plan

Initial plan, including communication activities

Piano di gestione dei dati (1)

DMP

Data Management Plan

Pubblicazioni

Articoli sottoposti a revisione paritaria (12)

The Design of a Sample Rapid Magnetic Resonance Imaging (MRI) Acquisition Protocol Supporting Assessment of Multiple Articular Tissues and Pathologies in Knee Osteoarthritis

Autori: """Felix Eckstein, Thula Cannon Walter-Rittel, Akshay Chaudhari, Nicholas Brisson, Tazio Maleitzke, Georg N. Duda, Anna Wisser, Wolfgang Wirth, Tobias Winkler"""
Pubblicato in: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Editore: Elsevier
DOI: 10.1016/j.ocarto.2024.100505

Nesting behavior is associated with body weight and grip strength loss in mice suffering from experimental arthritis

Autori: Tamara Dietrich, Annette Aigner, Alexander Hildebrandt, Jérôme Weber, Mara Meyer Günderoth, Katharina Hohlbaum, Johannes Keller, Serafeim Tsitsilonis & Tazio Maleitzke
Pubblicato in: Scientific Reports, 2023, ISSN 2045-2322
Editore: nature Publishing group
DOI: 10.1038/s41598-023-49720-y

Best Practice and Research in Clinical Rheumatology

Autori: Mobasheri A, Thudium CS, Bay-Jensen AC, Maleitzke T, Geissler S, Duda GN, Winkler T.
Pubblicato in: Best Pract Res Clin Rheumatol, 2023, ISSN 1521-6942
Editore: Wiley
DOI: 10.1016/j.berh.2023.101852

Advances in Extracellular Vesicle Research Over the Past Decade: Source and Isolation Method are Connected with Cargo and Function.

Autori: Poupardin R, Wolf M, Maeding N, Paniushkina L, Geissler S, Bergese P, Witwer KW, Schallmoser K, Fuhrmann G, Strunk D.
Pubblicato in: Advanced Healthcare materials, 2024, ISSN 2192-2659
Editore: wiley
DOI: 10.1002/adhm.202303941

The dual pro inflammatory and bone protective role of calcitonin gene related peptide alpha in age related osteoarthritis.

Autori: Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
Pubblicato in: Arthritis Research & Therapy, 2023, ISSN 1478-6354
Editore: Bio Med Center
DOI: 10.1186/s13075-023-03215-3

Chondrocyte Isolation from Loose Bodies-An Option for Reducing Donor Site Morbidity for Autologous Chondrocyte Implantation

Autori: Martin Textor, Arndt Hoburg, Rex Lehnigk, Carsten Perka, Georg Duda, Simon Reinke, Antje Blankenstein, Sarah Hochmann, Andreas Stockinger, Herbert Resch, Martin Wolf, Dirk Strunk, Sven Geissler
Pubblicato in: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editore: MDPI
DOI: 10.3390/ijms24021484

Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?

Autori: Felix Eckstein, Reinhard Putz, Wolfgang Wirth
Pubblicato in: Osteoarthritis & Cartilage Open, 2024, ISSN 2665-9131
Editore: Elsevier
DOI: 10.1016/j.ocarto.2024.100485

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis

Autori: Kovács, Patrik; Pushparaj, Peter Natesan; Takács, Roland; Mobasheri, Ali; Matta, Csaba
Pubblicato in: Frontiers in immunology , 2023, ISSN 1664-3224
Editore: Frontiers media
DOI: 10.3389/fimmu.2023.1103097

Minimal information for studies of extracellular vesicles (MISEV2023)

Autori: Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Dirk Strunk, Martin Wolf, et al
Pubblicato in: Journal of Extracellular Vesicles, 2024, ISSN 2001-3078
Editore: Wiley
DOI: 10.1002/jev2.12404

A sample rapid MRI acquisition protocol supporting assessment of multiple articular tissues and pathologies in early and advanced knee osteoarthritis

Autori: Wisser A, Walter-Rittel TC, Chaudhari A, Brisson NM, Maleitzke T, Duda GN, Wirth W, Winkler T, Eckstein F
Pubblicato in: Osteoarthritis Imaging, 2024, ISSN 2772-6541
Editore: Elsevier
DOI: 10.1016/j.ostima.2024.100221

Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review

Autori: Primorac, Dragan; Molnar, Vilim; Tsoukas, Dimitrios; Uzieliene, Ilona; Tremolada, Carlo; Brlek, Petar; Klarić, Emil; Vidović, Dinko; Zekušić, Marija; Pachaleva, Jolita; Bernotiene, Eiva; Wilson, Adrian; Mobasheri, Ali 
Pubblicato in: Croatian medical journal , 2024, ISSN 0353-9504
Editore: Medicinska naklada
DOI: 10.3325/cmj.2024.65.268

In Vitro Transcribed mRNA Immunogenicity Induces Chemokine-Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

Autori: Drzeniek NM, Kahwaji N, Picht S, Dimitriou IM, Schlickeiser S, Moradian H, Geissler S, Schmueck-Henneresse M, Gossen M, Volk HD.
Pubblicato in: Advanced Science, 2024, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202308447