Understanding Lung Cancer related risk factors and their Impact

Project Information

LUCIA

Grant agreement ID: 101096473

DOI

10.3030/101096473

EC signature date 5 December 2022

Start date 1 January 2023

End date 31 December 2026

Funded under

• Health

Total cost

€ 13 516 869,00

EU contribution

€ 13 516 869,00

Coordinated by

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (10)

Clinical protocol and regulatory authorization report: General population Screening

Clinical protocol for the cohort study in the general population screening and the regulatory authorizations will be collected.

Common work plan for scientific collaboration under the ‘Understanding’ cluster
Communication, Dissemination and Exploitation Plan

Outlines the key activities, identifies stakeholders, and provides timelines, and indicators, including project website release.

Policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting-M12
Data Management Plan-6M

Document describing the principles and initial plans of the project for data management (M06).The preparation of the Data Management Plan will include a common chapter on the ‘Understanding’ cluster. The aim of the chapter is to address commonalities in data standards, data validation, data protection and fostering data exchange, in particular when it comes to sharing project data with a future federated UNCAN.eu data platform. Therefore, interactions are envisaged with the 4.UNCAN.eu (http://uncaninitiative.eu/) coordination and support action which is preparing a blueprint for UNCAN.eu.

Conclusions of common annual meeting of the ‘Understanding’ cluster-M12
Policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting-M24
Conclusions of common annual meeting of the ‘Understanding’ cluster-M24
LUCIA Management Report-9M

LUCIA Management Report- Initial report on M9 describing IPR, impact, and technology steering aspects of the project.

Clinical protocol and regulatory authorization report: Precision Screening and Diagnosis

The design of clinical protocol established by the clinical partners for the precision screening and diagnosis phases and the regulatory authorizations will be collected.

Websites, patent fillings, videos etc. (2)

Project website maintenance
Common video and/or a common cluster brochure

Common video and/or a common cluster brochure (cluster 'understanding')

Publications

Peer reviewed articles (24)

Short-term effects of electronic cigarette smoking on cardiorespiratory parameters, volatile organic compounds and inflammatory markers

Author(s): Suha Rizik; Ronen Bar-Yoseph; Moneera Hanna; Fahed Hakim; Yoav Broza; Amir Sader; Yazeed Toukan; Hossam Haick; Lea Bentur; Michal Gur
Published in: ERJ Open Research, Issue 01096-2024, 2025, ISSN 2312-0541
Publisher: European Respiratory Society (ERS)
DOI: 10.1183/23120541.01096-2024

Scientific Reports

Author(s): Jacob Levman; Yoav Y. Broza
Published in: Scientific Reports, Issue 9436, 2025, ISSN 2045-2322
Publisher: Springer Nature
DOI: 10.1038/S41598-025-89820-5

Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals

Author(s): Guillermo Palou-Márquez; Fran Supek
Published in: Genome Biology, Issue 316, 2024, ISSN 1474-760X
Publisher: Springer Nature
DOI: 10.1186/S13059-025-03727-Y

Nature Communications

Author(s): Ahmed Khalil; Fran Supek
Published in: Nature Communications, Issue 16 (42209), 2025, ISSN 2041-1723
Publisher: Nature Portfolio
DOI: 10.1038/S41467-025-59397-8

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Author(s): Ignasi Toledano; Fran Supek; Ben Lehner
Published in: Nature Genetics, 2024, ISSN 1546-1718
Publisher: Nature Portfolio
DOI: 10.1101/2023.08.07.552350

Next‐Gen Wearables Unlocking Chemical Secrets

Author(s): Hossam Haick
Published in: Advanced Sensor Research, Issue 3, 2024, ISSN 2751-1219
Publisher: Wiley
DOI: 10.1002/adsr.202300203

Genome Medicine

Author(s): Ferrer-Torres, Patricia; Galvan-Femenia, Ivan; Supek, Fran
Published in: Genome Medicine, Issue 76, 2025, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/S13073-025-01497-7

Computers in Biology and Medicine

Author(s): B. Farina, R. Carbajo Benito, D. Montalvo-García, D. Bermejo-Peláez, L. Seijo Maceiras, M.J. Ledesma-Carbayo
Published in: Computers in Biology and Medicine, Issue 196, 2025, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/J.COMPBIOMED.2025.110813

Risk-Adapted Lung Cancer Screening Starting Ages for Former Smokers

Author(s): Clara Frick, Lára R. Hallsson, Uwe Siebert, Megha Bhardwaj, Ben Schöttker, Hermann Brenner
Published in: JAMA Network Open, Issue 8, 2025, ISSN 2574-3805
Publisher: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2025.51281

Nature Communications

Author(s): Jian Yang; Xia Gong; Ying Zheng; Hong Duan; Shuijin Chen; Tong Wu; Changqing Yi; Lelun Jiang; Hossam Haick
Published in: Nature Communications, Issue 16 (6260), 2025, ISSN 2041-1723
Publisher: Nature Portfolio
DOI: 10.1038/S41467-025-61549-9

Long Term Evaluation of Quantitative Cumulative Irradiation in Patients Suffering from ILDs

Author(s): Berg, Julien; Frix, Anne-Noëlle; Henket, Monique; GESTER, Fanny; Winandy, Marie-Laurence; CANIVET, Perrine; Njock, Makon-Sébastien; THYS, Marie; DESIR, Colin; Meunier, Paul; Louis, Renaud; Malchair,
Published in: Diagnostics, Issue 14(19), 2024, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/DIAGNOSTICS14192136

Nature Communications

Author(s): Elizaveta Besedina; Fran Supek
Published in: Nature Communications, Issue 15 (6139), 2024, ISSN 2041-1723
Publisher: Nature Portfolio
DOI: 10.1038/S41467-024-50552-1

Spin-induced nanomaterials for detection of chiral volatile organic compounds

Author(s): Arnab Maity, Hossam Haick
Published in: Applied Physics Reviews, Issue 10, 2023, ISSN 1931-9401
Publisher: AIP Publishing
DOI: 10.1063/5.0146656

Self‐Sustaining Triboelectric Nanosensors for Real‐Time Urine Analysis in Smart Toilets

Author(s): Indrajit Mondal, Elias Mansour, Youbin Zheng, Ritu Gupta, Hossam Haick
Published in: Small, 2024, ISSN 1613-6810
Publisher: Wiley
DOI: 10.1002/smll.202403385

Protocol to fabricate wearable stretchable microneedle-based sensors

Author(s): Rawan Omar, Youbin Zheng, Hossam Haick
Published in: STAR Protocols, 2023, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2023.102751

Spin‐Controlled Helical Quantum Sieve Chiral Spectrometer

Author(s): Arnab Maity, Yael Hershkovitz‐Pollak, Ritu Gupta, Weiwei Wu, Hossam Haick
Published in: Advanced Materials, Issue 35, 2023, ISSN 0935-9648
Publisher: Wiley
DOI: 10.1002/adma.202209125

Advances in volatile organic compounds detection: From fundamental research to real-world applications

Author(s): Haick, H.
Published in: Applied Physics Review, Issue 11, 2024, ISSN 1931-9401
Publisher: AIP Publishing
DOI: 10.1063/5.0230205

Liquid Biopsy-Based Volatile Organic Compounds from Blood and Urine and Their Combined Data Sets for Highly Accurate Detection of Cancer

Author(s): Reef Einoch Amor, Jeremy Levy, Yoav Y. Broza, Reinis Vangravs, Shelley Rapoport, Min Zhang, Weiwei Wu, Marcis Leja, Joachim A. Behar, Hossam Haick
Published in: ACS Sensors, Issue 8, 2023, ISSN 2379-3694
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acssensors.2c02422

Chemical Tomography of Cancer Organoids and Cyto‐Proteo‐Genomic Development Stages Through Chemical Communication Signals

Author(s): Arnab Maity; Vivian Darsa Maidantchik; Keren Weidenfeld; Sarit Larisch; Dalit Barkan; Hossam Haick
Published in: Advanced Materials, Issue 2413017, 2025, ISSN 1521-4095
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ADMA.202413017

Biodegradable, Humidity-Insensitive Mask-Integrated E-Nose for Sustainable and Non-Invasive Continuous Breath Analysis

Author(s): Indrajit Mondal, Adan Zoabi, Hossam Haick
Published in: Advanced Functional Materials, Issue 2413017, 2025, ISSN 1616-3028
Publisher: Wiley-VCH GmbH
DOI: 10.1002/ADFM.202425193

Pitfalls in interpreting calibration in comparative evaluations of risk models for precision lung cancer screening

Author(s): Brenner, Hermann; Frick, Clara; Seum, Teresa; Bhardwaj, Megha
Published in: npj Precision Oncology, Issue 281, 2024, ISSN 2397-768X
Publisher: Springer Nature
DOI: 10.1038/S41698-024-00785-6

Mobile Diagnostic Clinics

Author(s): Roni Baron, Hossam Haick
Published in: ACS Sensors, Issue 9, 2024, ISSN 2379-3694
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c00636

Head-to-head comparisons of risk discrimination by questionnaire-based lung cancer risk prediction models: a systematic review and meta-analysis

Author(s): Clara Frick; Teresa Seum; Megha Bhardwaj; Tim Holland-Letz; Ben Schöttker; Hermann Brenner
Published in: eClinicalMedicine, 2025, ISSN 2589-5370
Publisher: The Lancet Group
DOI: 10.1016/J.ECLINM.2025.103075

Next generation proteomics improves lung cancer risk prediction.

Author(s): Megha Bhardwaj, Clara Frick, Ben Schöttker, B Holleczek, Hermann Brenner
Published in: Molecular Oncology, Issue early view, 2025, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.1002/1878-0261.70166

Conference proceedings (3)

Risk-adapted lung cancer screening starting ages for former smokers

Author(s): Clara Frick, Lara R Hallson, Uwe Siebert, Megha Bhardwaj, Ben Schöttker, Hermann Brenner
Published in: Issue 15, 2025
Publisher: NKI Netherlands Cancer Institute

Lung-CABO: Lung Cancer Concepts Association Biological Ontology

Author(s): Delia Aminta Moreno-Perdomo, Paloma Tejera-Nevado, Lucía Prieto-Santamaría, Guillermo Vigueras, Antonio Jesus Diaz-Honrubia, Alejandro Rodríguez-González
Published in: 2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS), 2025, ISSN 2372-9198
Publisher: IEEE
DOI: 10.1109/CBMS65348.2025.00136

Survival Stacking Ensemble Model for Lung Cancer Risk Prediction

Author(s): Alonso, Eduardo; Calle, Xabier; Gurrutxaga, Ibai; Beristain, Andoni
Published in: Studies in Health Technology and Informatics ISBN: 9781643685540, Issue 321, 2024
Publisher: IOS Press Ebooks
DOI: 10.3233/SHTI241083

Monographic books (1)

Nature-Inspired Sensors

Author(s): Haick, H.
Published in: 2024
Publisher: Elsevier
DOI: 10.1016/C2022-0-01670-6

Other (1)

Transforming Lung Cancer Screening – Insights from the LUCIA Social Lab

Author(s): Yaghma B. V. (Ivett Jakab, Emad Yaghmaei)
Published in: 2025
Publisher: Yaghma