Understanding Lung Cancer related risk factors and their Impact

Informations projet

LUCIA

N° de convention de subvention: 101096473

DOI

10.3030/101096473

Date de signature de la CE 5 Decembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2026

Financé au titre de

• Health

Coût total

€ 13 516 869,00

Contribution de l’UE

€ 13 516 869,00

Coordonné par

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (10)

Clinical protocol and regulatory authorization report: General population Screening

Clinical protocol for the cohort study in the general population screening and the regulatory authorizations will be collected.

Common work plan for scientific collaboration under the ‘Understanding’ cluster
Communication, Dissemination and Exploitation Plan

Outlines the key activities, identifies stakeholders, and provides timelines, and indicators, including project website release.

Policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting-M12
Data Management Plan-6M

Document describing the principles and initial plans of the project for data management (M06).The preparation of the Data Management Plan will include a common chapter on the ‘Understanding’ cluster. The aim of the chapter is to address commonalities in data standards, data validation, data protection and fostering data exchange, in particular when it comes to sharing project data with a future federated UNCAN.eu data platform. Therefore, interactions are envisaged with the 4.UNCAN.eu (http://uncaninitiative.eu/) coordination and support action which is preparing a blueprint for UNCAN.eu.

Conclusions of common annual meeting of the ‘Understanding’ cluster-M12
Policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting-M24
Conclusions of common annual meeting of the ‘Understanding’ cluster-M24
LUCIA Management Report-9M

LUCIA Management Report- Initial report on M9 describing IPR, impact, and technology steering aspects of the project.

Clinical protocol and regulatory authorization report: Precision Screening and Diagnosis

The design of clinical protocol established by the clinical partners for the precision screening and diagnosis phases and the regulatory authorizations will be collected.

Websites, patent fillings, videos etc. (2)

Project website maintenance
Common video and/or a common cluster brochure

Common video and/or a common cluster brochure (cluster 'understanding')

Publications

Peer reviewed articles (24)

Short-term effects of electronic cigarette smoking on cardiorespiratory parameters, volatile organic compounds and inflammatory markers

Auteurs: Suha Rizik; Ronen Bar-Yoseph; Moneera Hanna; Fahed Hakim; Yoav Broza; Amir Sader; Yazeed Toukan; Hossam Haick; Lea Bentur; Michal Gur
Publié dans: ERJ Open Research, Numéro 01096-2024, 2025, ISSN 2312-0541
Éditeur: European Respiratory Society (ERS)
DOI: 10.1183/23120541.01096-2024

Scientific Reports

Auteurs: Jacob Levman; Yoav Y. Broza
Publié dans: Scientific Reports, Numéro 9436, 2025, ISSN 2045-2322
Éditeur: Springer Nature
DOI: 10.1038/S41598-025-89820-5

Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals

Auteurs: Guillermo Palou-Márquez; Fran Supek
Publié dans: Genome Biology, Numéro 316, 2024, ISSN 1474-760X
Éditeur: Springer Nature
DOI: 10.1186/S13059-025-03727-Y

Nature Communications

Auteurs: Ahmed Khalil; Fran Supek
Publié dans: Nature Communications, Numéro 16 (42209), 2025, ISSN 2041-1723
Éditeur: Nature Portfolio
DOI: 10.1038/S41467-025-59397-8

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Auteurs: Ignasi Toledano; Fran Supek; Ben Lehner
Publié dans: Nature Genetics, 2024, ISSN 1546-1718
Éditeur: Nature Portfolio
DOI: 10.1101/2023.08.07.552350

Next‐Gen Wearables Unlocking Chemical Secrets

Auteurs: Hossam Haick
Publié dans: Advanced Sensor Research, Numéro 3, 2024, ISSN 2751-1219
Éditeur: Wiley
DOI: 10.1002/adsr.202300203

Genome Medicine

Auteurs: Ferrer-Torres, Patricia; Galvan-Femenia, Ivan; Supek, Fran
Publié dans: Genome Medicine, Numéro 76, 2025, ISSN 1756-994X
Éditeur: BioMed Central
DOI: 10.1186/S13073-025-01497-7

Computers in Biology and Medicine

Auteurs: B. Farina, R. Carbajo Benito, D. Montalvo-García, D. Bermejo-Peláez, L. Seijo Maceiras, M.J. Ledesma-Carbayo
Publié dans: Computers in Biology and Medicine, Numéro 196, 2025, ISSN 0010-4825
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/J.COMPBIOMED.2025.110813

Risk-Adapted Lung Cancer Screening Starting Ages for Former Smokers

Auteurs: Clara Frick, Lára R. Hallsson, Uwe Siebert, Megha Bhardwaj, Ben Schöttker, Hermann Brenner
Publié dans: JAMA Network Open, Numéro 8, 2025, ISSN 2574-3805
Éditeur: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2025.51281

Nature Communications

Auteurs: Jian Yang; Xia Gong; Ying Zheng; Hong Duan; Shuijin Chen; Tong Wu; Changqing Yi; Lelun Jiang; Hossam Haick
Publié dans: Nature Communications, Numéro 16 (6260), 2025, ISSN 2041-1723
Éditeur: Nature Portfolio
DOI: 10.1038/S41467-025-61549-9

Long Term Evaluation of Quantitative Cumulative Irradiation in Patients Suffering from ILDs

Auteurs: Berg, Julien; Frix, Anne-Noëlle; Henket, Monique; GESTER, Fanny; Winandy, Marie-Laurence; CANIVET, Perrine; Njock, Makon-Sébastien; THYS, Marie; DESIR, Colin; Meunier, Paul; Louis, Renaud; Malchair,
Publié dans: Diagnostics, Numéro 14(19), 2024, ISSN 2075-4418
Éditeur: MDPI
DOI: 10.3390/DIAGNOSTICS14192136

Nature Communications

Auteurs: Elizaveta Besedina; Fran Supek
Publié dans: Nature Communications, Numéro 15 (6139), 2024, ISSN 2041-1723
Éditeur: Nature Portfolio
DOI: 10.1038/S41467-024-50552-1

Spin-induced nanomaterials for detection of chiral volatile organic compounds

Auteurs: Arnab Maity, Hossam Haick
Publié dans: Applied Physics Reviews, Numéro 10, 2023, ISSN 1931-9401
Éditeur: AIP Publishing
DOI: 10.1063/5.0146656

Self‐Sustaining Triboelectric Nanosensors for Real‐Time Urine Analysis in Smart Toilets

Auteurs: Indrajit Mondal, Elias Mansour, Youbin Zheng, Ritu Gupta, Hossam Haick
Publié dans: Small, 2024, ISSN 1613-6810
Éditeur: Wiley
DOI: 10.1002/smll.202403385

Protocol to fabricate wearable stretchable microneedle-based sensors

Auteurs: Rawan Omar, Youbin Zheng, Hossam Haick
Publié dans: STAR Protocols, 2023, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2023.102751

Spin‐Controlled Helical Quantum Sieve Chiral Spectrometer

Auteurs: Arnab Maity, Yael Hershkovitz‐Pollak, Ritu Gupta, Weiwei Wu, Hossam Haick
Publié dans: Advanced Materials, Numéro 35, 2023, ISSN 0935-9648
Éditeur: Wiley
DOI: 10.1002/adma.202209125

Advances in volatile organic compounds detection: From fundamental research to real-world applications

Auteurs: Haick, H.
Publié dans: Applied Physics Review, Numéro 11, 2024, ISSN 1931-9401
Éditeur: AIP Publishing
DOI: 10.1063/5.0230205

Liquid Biopsy-Based Volatile Organic Compounds from Blood and Urine and Their Combined Data Sets for Highly Accurate Detection of Cancer

Auteurs: Reef Einoch Amor, Jeremy Levy, Yoav Y. Broza, Reinis Vangravs, Shelley Rapoport, Min Zhang, Weiwei Wu, Marcis Leja, Joachim A. Behar, Hossam Haick
Publié dans: ACS Sensors, Numéro 8, 2023, ISSN 2379-3694
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/acssensors.2c02422

Chemical Tomography of Cancer Organoids and Cyto‐Proteo‐Genomic Development Stages Through Chemical Communication Signals

Auteurs: Arnab Maity; Vivian Darsa Maidantchik; Keren Weidenfeld; Sarit Larisch; Dalit Barkan; Hossam Haick
Publié dans: Advanced Materials, Numéro 2413017, 2025, ISSN 1521-4095
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/ADMA.202413017

Biodegradable, Humidity-Insensitive Mask-Integrated E-Nose for Sustainable and Non-Invasive Continuous Breath Analysis

Auteurs: Indrajit Mondal, Adan Zoabi, Hossam Haick
Publié dans: Advanced Functional Materials, Numéro 2413017, 2025, ISSN 1616-3028
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/ADFM.202425193

Pitfalls in interpreting calibration in comparative evaluations of risk models for precision lung cancer screening

Auteurs: Brenner, Hermann; Frick, Clara; Seum, Teresa; Bhardwaj, Megha
Publié dans: npj Precision Oncology, Numéro 281, 2024, ISSN 2397-768X
Éditeur: Springer Nature
DOI: 10.1038/S41698-024-00785-6

Mobile Diagnostic Clinics

Auteurs: Roni Baron, Hossam Haick
Publié dans: ACS Sensors, Numéro 9, 2024, ISSN 2379-3694
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c00636

Head-to-head comparisons of risk discrimination by questionnaire-based lung cancer risk prediction models: a systematic review and meta-analysis

Auteurs: Clara Frick; Teresa Seum; Megha Bhardwaj; Tim Holland-Letz; Ben Schöttker; Hermann Brenner
Publié dans: eClinicalMedicine, 2025, ISSN 2589-5370
Éditeur: The Lancet Group
DOI: 10.1016/J.ECLINM.2025.103075

Next generation proteomics improves lung cancer risk prediction.

Auteurs: Megha Bhardwaj, Clara Frick, Ben Schöttker, B Holleczek, Hermann Brenner
Publié dans: Molecular Oncology, Numéro early view, 2025, ISSN 1574-7891
Éditeur: Elsevier BV
DOI: 10.1002/1878-0261.70166

Conference proceedings (3)

Risk-adapted lung cancer screening starting ages for former smokers

Auteurs: Clara Frick, Lara R Hallson, Uwe Siebert, Megha Bhardwaj, Ben Schöttker, Hermann Brenner
Publié dans: Numéro 15, 2025
Éditeur: NKI Netherlands Cancer Institute

Lung-CABO: Lung Cancer Concepts Association Biological Ontology

Auteurs: Delia Aminta Moreno-Perdomo, Paloma Tejera-Nevado, Lucía Prieto-Santamaría, Guillermo Vigueras, Antonio Jesus Diaz-Honrubia, Alejandro Rodríguez-González
Publié dans: 2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS), 2025, ISSN 2372-9198
Éditeur: IEEE
DOI: 10.1109/CBMS65348.2025.00136

Survival Stacking Ensemble Model for Lung Cancer Risk Prediction

Auteurs: Alonso, Eduardo; Calle, Xabier; Gurrutxaga, Ibai; Beristain, Andoni
Publié dans: Studies in Health Technology and Informatics ISBN: 9781643685540, Numéro 321, 2024
Éditeur: IOS Press Ebooks
DOI: 10.3233/SHTI241083

Monographic books (1)

Nature-Inspired Sensors

Auteurs: Haick, H.
Publié dans: 2024
Éditeur: Elsevier
DOI: 10.1016/C2022-0-01670-6

Other (1)

Transforming Lung Cancer Screening – Insights from the LUCIA Social Lab

Auteurs: Yaghma B. V. (Ivett Jakab, Emad Yaghmaei)
Publié dans: 2025
Éditeur: Yaghma