Understanding Lung Cancer related risk factors and their Impact

Informazioni relative al progetto

LUCIA

ID dell’accordo di sovvenzione: 101096473

DOI

10.3030/101096473

Data della firma CE 5 Dicembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2026

Finanziato da

• Health

Costo totale

€ 13 516 869,00

Contributo UE

€ 13 516 869,00

Coordinato da

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (10)

Clinical protocol and regulatory authorization report: General population Screening

Clinical protocol for the cohort study in the general population screening and the regulatory authorizations will be collected.

Common work plan for scientific collaboration under the ‘Understanding’ cluster
Communication, Dissemination and Exploitation Plan

Outlines the key activities, identifies stakeholders, and provides timelines, and indicators, including project website release.

Policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting-M12
Data Management Plan-6M

Document describing the principles and initial plans of the project for data management (M06).The preparation of the Data Management Plan will include a common chapter on the ‘Understanding’ cluster. The aim of the chapter is to address commonalities in data standards, data validation, data protection and fostering data exchange, in particular when it comes to sharing project data with a future federated UNCAN.eu data platform. Therefore, interactions are envisaged with the 4.UNCAN.eu (http://uncaninitiative.eu/) coordination and support action which is preparing a blueprint for UNCAN.eu.

Conclusions of common annual meeting of the ‘Understanding’ cluster-M12
Policy brief formulating recommendations based on the research and innovation strand of the ‘Understanding’ annual cluster meeting-M24
Conclusions of common annual meeting of the ‘Understanding’ cluster-M24
LUCIA Management Report-9M

LUCIA Management Report- Initial report on M9 describing IPR, impact, and technology steering aspects of the project.

Clinical protocol and regulatory authorization report: Precision Screening and Diagnosis

The design of clinical protocol established by the clinical partners for the precision screening and diagnosis phases and the regulatory authorizations will be collected.

Websites, patent fillings, videos etc. (2)

Project website maintenance
Common video and/or a common cluster brochure

Common video and/or a common cluster brochure (cluster 'understanding')

Pubblicazioni

Peer reviewed articles (24)

Short-term effects of electronic cigarette smoking on cardiorespiratory parameters, volatile organic compounds and inflammatory markers

Autori: Suha Rizik; Ronen Bar-Yoseph; Moneera Hanna; Fahed Hakim; Yoav Broza; Amir Sader; Yazeed Toukan; Hossam Haick; Lea Bentur; Michal Gur
Pubblicato in: ERJ Open Research, Numero 01096-2024, 2025, ISSN 2312-0541
Editore: European Respiratory Society (ERS)
DOI: 10.1183/23120541.01096-2024

Scientific Reports

Autori: Jacob Levman; Yoav Y. Broza
Pubblicato in: Scientific Reports, Numero 9436, 2025, ISSN 2045-2322
Editore: Springer Nature
DOI: 10.1038/S41598-025-89820-5

Variable efficiency of nonsense-mediated mRNA decay across human tissues, tumors and individuals

Autori: Guillermo Palou-Márquez; Fran Supek
Pubblicato in: Genome Biology, Numero 316, 2024, ISSN 1474-760X
Editore: Springer Nature
DOI: 10.1186/S13059-025-03727-Y

Nature Communications

Autori: Ahmed Khalil; Fran Supek
Pubblicato in: Nature Communications, Numero 16 (42209), 2025, ISSN 2041-1723
Editore: Nature Portfolio
DOI: 10.1038/S41467-025-59397-8

Genome-scale quantification and prediction of pathogenic stop codon readthrough by small molecules

Autori: Ignasi Toledano; Fran Supek; Ben Lehner
Pubblicato in: Nature Genetics, 2024, ISSN 1546-1718
Editore: Nature Portfolio
DOI: 10.1101/2023.08.07.552350

Next‐Gen Wearables Unlocking Chemical Secrets

Autori: Hossam Haick
Pubblicato in: Advanced Sensor Research, Numero 3, 2024, ISSN 2751-1219
Editore: Wiley
DOI: 10.1002/adsr.202300203

Genome Medicine

Autori: Ferrer-Torres, Patricia; Galvan-Femenia, Ivan; Supek, Fran
Pubblicato in: Genome Medicine, Numero 76, 2025, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/S13073-025-01497-7

Computers in Biology and Medicine

Autori: B. Farina, R. Carbajo Benito, D. Montalvo-García, D. Bermejo-Peláez, L. Seijo Maceiras, M.J. Ledesma-Carbayo
Pubblicato in: Computers in Biology and Medicine, Numero 196, 2025, ISSN 0010-4825
Editore: Pergamon Press Ltd.
DOI: 10.1016/J.COMPBIOMED.2025.110813

Risk-Adapted Lung Cancer Screening Starting Ages for Former Smokers

Autori: Clara Frick, Lára R. Hallsson, Uwe Siebert, Megha Bhardwaj, Ben Schöttker, Hermann Brenner
Pubblicato in: JAMA Network Open, Numero 8, 2025, ISSN 2574-3805
Editore: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2025.51281

Nature Communications

Autori: Jian Yang; Xia Gong; Ying Zheng; Hong Duan; Shuijin Chen; Tong Wu; Changqing Yi; Lelun Jiang; Hossam Haick
Pubblicato in: Nature Communications, Numero 16 (6260), 2025, ISSN 2041-1723
Editore: Nature Portfolio
DOI: 10.1038/S41467-025-61549-9

Long Term Evaluation of Quantitative Cumulative Irradiation in Patients Suffering from ILDs

Autori: Berg, Julien; Frix, Anne-Noëlle; Henket, Monique; GESTER, Fanny; Winandy, Marie-Laurence; CANIVET, Perrine; Njock, Makon-Sébastien; THYS, Marie; DESIR, Colin; Meunier, Paul; Louis, Renaud; Malchair,
Pubblicato in: Diagnostics, Numero 14(19), 2024, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/DIAGNOSTICS14192136

Nature Communications

Autori: Elizaveta Besedina; Fran Supek
Pubblicato in: Nature Communications, Numero 15 (6139), 2024, ISSN 2041-1723
Editore: Nature Portfolio
DOI: 10.1038/S41467-024-50552-1

Spin-induced nanomaterials for detection of chiral volatile organic compounds

Autori: Arnab Maity, Hossam Haick
Pubblicato in: Applied Physics Reviews, Numero 10, 2023, ISSN 1931-9401
Editore: AIP Publishing
DOI: 10.1063/5.0146656

Self‐Sustaining Triboelectric Nanosensors for Real‐Time Urine Analysis in Smart Toilets

Autori: Indrajit Mondal, Elias Mansour, Youbin Zheng, Ritu Gupta, Hossam Haick
Pubblicato in: Small, 2024, ISSN 1613-6810
Editore: Wiley
DOI: 10.1002/smll.202403385

Protocol to fabricate wearable stretchable microneedle-based sensors

Autori: Rawan Omar, Youbin Zheng, Hossam Haick
Pubblicato in: STAR Protocols, 2023, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2023.102751

Spin‐Controlled Helical Quantum Sieve Chiral Spectrometer

Autori: Arnab Maity, Yael Hershkovitz‐Pollak, Ritu Gupta, Weiwei Wu, Hossam Haick
Pubblicato in: Advanced Materials, Numero 35, 2023, ISSN 0935-9648
Editore: Wiley
DOI: 10.1002/adma.202209125

Advances in volatile organic compounds detection: From fundamental research to real-world applications

Autori: Haick, H.
Pubblicato in: Applied Physics Review, Numero 11, 2024, ISSN 1931-9401
Editore: AIP Publishing
DOI: 10.1063/5.0230205

Liquid Biopsy-Based Volatile Organic Compounds from Blood and Urine and Their Combined Data Sets for Highly Accurate Detection of Cancer

Autori: Reef Einoch Amor, Jeremy Levy, Yoav Y. Broza, Reinis Vangravs, Shelley Rapoport, Min Zhang, Weiwei Wu, Marcis Leja, Joachim A. Behar, Hossam Haick
Pubblicato in: ACS Sensors, Numero 8, 2023, ISSN 2379-3694
Editore: American Chemical Society (ACS)
DOI: 10.1021/acssensors.2c02422

Chemical Tomography of Cancer Organoids and Cyto‐Proteo‐Genomic Development Stages Through Chemical Communication Signals

Autori: Arnab Maity; Vivian Darsa Maidantchik; Keren Weidenfeld; Sarit Larisch; Dalit Barkan; Hossam Haick
Pubblicato in: Advanced Materials, Numero 2413017, 2025, ISSN 1521-4095
Editore: Wiley-VCH GmbH
DOI: 10.1002/ADMA.202413017

Biodegradable, Humidity-Insensitive Mask-Integrated E-Nose for Sustainable and Non-Invasive Continuous Breath Analysis

Autori: Indrajit Mondal, Adan Zoabi, Hossam Haick
Pubblicato in: Advanced Functional Materials, Numero 2413017, 2025, ISSN 1616-3028
Editore: Wiley-VCH GmbH
DOI: 10.1002/ADFM.202425193

Pitfalls in interpreting calibration in comparative evaluations of risk models for precision lung cancer screening

Autori: Brenner, Hermann; Frick, Clara; Seum, Teresa; Bhardwaj, Megha
Pubblicato in: npj Precision Oncology, Numero 281, 2024, ISSN 2397-768X
Editore: Springer Nature
DOI: 10.1038/S41698-024-00785-6

Mobile Diagnostic Clinics

Autori: Roni Baron, Hossam Haick
Pubblicato in: ACS Sensors, Numero 9, 2024, ISSN 2379-3694
Editore: American Chemical Society (ACS)
DOI: 10.1021/acssensors.4c00636

Head-to-head comparisons of risk discrimination by questionnaire-based lung cancer risk prediction models: a systematic review and meta-analysis

Autori: Clara Frick; Teresa Seum; Megha Bhardwaj; Tim Holland-Letz; Ben Schöttker; Hermann Brenner
Pubblicato in: eClinicalMedicine, 2025, ISSN 2589-5370
Editore: The Lancet Group
DOI: 10.1016/J.ECLINM.2025.103075

Next generation proteomics improves lung cancer risk prediction.

Autori: Megha Bhardwaj, Clara Frick, Ben Schöttker, B Holleczek, Hermann Brenner
Pubblicato in: Molecular Oncology, Numero early view, 2025, ISSN 1574-7891
Editore: Elsevier BV
DOI: 10.1002/1878-0261.70166

Conference proceedings (3)

Risk-adapted lung cancer screening starting ages for former smokers

Autori: Clara Frick, Lara R Hallson, Uwe Siebert, Megha Bhardwaj, Ben Schöttker, Hermann Brenner
Pubblicato in: Numero 15, 2025
Editore: NKI Netherlands Cancer Institute

Lung-CABO: Lung Cancer Concepts Association Biological Ontology

Autori: Delia Aminta Moreno-Perdomo, Paloma Tejera-Nevado, Lucía Prieto-Santamaría, Guillermo Vigueras, Antonio Jesus Diaz-Honrubia, Alejandro Rodríguez-González
Pubblicato in: 2025 IEEE 38th International Symposium on Computer-Based Medical Systems (CBMS), 2025, ISSN 2372-9198
Editore: IEEE
DOI: 10.1109/CBMS65348.2025.00136

Survival Stacking Ensemble Model for Lung Cancer Risk Prediction

Autori: Alonso, Eduardo; Calle, Xabier; Gurrutxaga, Ibai; Beristain, Andoni
Pubblicato in: Studies in Health Technology and Informatics ISBN: 9781643685540, Numero 321, 2024
Editore: IOS Press Ebooks
DOI: 10.3233/SHTI241083

Monographic books (1)

Nature-Inspired Sensors

Autori: Haick, H.
Pubblicato in: 2024
Editore: Elsevier
DOI: 10.1016/C2022-0-01670-6

Other (1)

Transforming Lung Cancer Screening – Insights from the LUCIA Social Lab

Autori: Yaghma B. V. (Ivett Jakab, Emad Yaghmaei)
Pubblicato in: 2025
Editore: Yaghma