Development of an In-Vivo Brillouin Microscope (with application to Protein Aggregation-based Pathologies)

Información del proyecto

IVBM-4PAP

Identificador del acuerdo de subvención: 101098989

DOI

10.3030/101098989

Fecha de la firma de la CE 16 Diciembre 2022

Fecha de inicio 1 Marzo 2023

Fecha de finalización 31 Agosto 2026

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 3 333 513,00

Aportación de la UE

€ 3 333 513,00

Coordinado por

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (3)

RP2 update of the Data Management Plan
RP1 update of the Data Management Plan
Data Management Plan

Documents, reports (8)

Identification of MLL4 mutations affecting condensates formation
Tau and alpha-synuclein variants
Generation of four endoOpto-MLL4 modules in MSCs
Design of the RF cavity
Tau Biomolecular condensates
Plan for Dissemination and Exploitation including Communication Activities
Project website and logo

Website and project logo information with also social media links

Measurement of nuclear mechanical properties by standard BM

Demonstrators, pilots, prototypes (3)

Fast scanning implemented
Fast scanning simulated
RF cavity ready for the IVBM

Publicaciones

Peer reviewed articles (29)

Ferritin nanocage-enabled detection of pathological tau in living human retinal cells

Autores: Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantonio
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-62188-8

The RNA-Binding Properties of Annexins

Autores: Gian Gaetano Tartaglia, Hanne Holls, Bjarte Hvik, Anni Vedeler, Annalisa Pastore
Publicado en: Journal of Molecular Biology, Edición 437, 2025, ISSN 0022-2836
Editor: Elsevier BV
DOI: 10.1016/j.jmb.2024.168933

Stochastically structured illumination microscopy scan less super resolution imaging

Autores: Denzel Fusco, Emmanouil Xypakis, Ylenia Gigante, Lorenza Mautone, Silvia Di Angelantonio, Giorgia Ponsi, Giancarlo Ruocco, Marco Leonetti
Publicado en: npj Imaging, Edición 2, 2024, ISSN 2948-197X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S44303-024-00047-X

Journal of Molecular Biology

Autores: Gian Gaetano Tartaglia, Hanne Hollås, Bjarte Håvik, Anni Vedeler, Annalisa Pastore
Publicado en: Journal of Molecular Biology, Edición 437, 2025, ISSN 0022-2836
Editor: Academic Press
DOI: 10.1016/J.JMB.2024.168933

Computational Approaches to Predict ProteinProtein Interactions in Crowded Cellular Environments

Autores: Greta Grassmann, Mattia Miotto, Fausta Desantis, Lorenzo Di Rienzo, Gian Gaetano Tartaglia, Annalisa Pastore, Giancarlo Ruocco, Michele Monti, Edoardo Milanetti
Publicado en: Chemical Reviews, Edición 124, 2024, ISSN 0009-2665
Editor: American Chemical Society (ACS)
DOI: 10.1021/acs.chemrev.3c00550

Localised Therapies Using 3D‐Printed Collagen‐Based Micro‐Implant for Ocular Indications

Autores: Hamid Heidari Kashkooli, Arian Farokh, Sajad Mohammadi, Martina Marcotulli, Silvia Franco, Roberta Angelini, Giancarlo Ruocco, Hanieh Khalili, Gianluca Cidonio
Publicado en: Macromolecular Materials and Engineering, 2025, ISSN 1438-7492
Editor: Wiley
DOI: 10.1002/MAME.202400236

Rationalizing the effects of RNA modifications on protein interactions

Autores: Andrea Vandelli, Laura Broglia, Alexandros Armaos, Riccardo Delli Ponti, Gian Gaetano Tartaglia
Publicado en: Molecular Therapy - Nucleic Acids, Edición 35, 2024, ISSN 2162-2531
Editor: Elsevier BV
DOI: 10.1016/J.OMTN.2024.102391

Retinal Fingerprints of ALS in Patients: Ganglion Cell Apoptosis and TDP-43/p62 Misplacement.

Autores: Pediconi, Natalia; Gigante, Ylenia; Cama, Silvia; Pitea, Martina; Mautone, Lorenza; Ruocco, Giancarlo; Ghirga, Silvia; Di Angelantonio, Silvia
Publicado en: Frontiers in Aging Neuroscience, 2023, ISSN 1663-4365
Editor: Frontiers
DOI: 10.3389/fnagi.2023.1110520

Scientific Reports

Autores: Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantonio
Publicado en: Scientific Reports, Edición 14, 2024, ISSN 2045-2322
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-62188-8

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Autores: Claudia Testi, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli, Daniele Leso, Domitilla Pavia, Elisa Pistolesi, Flavio Scipione, Irene Cotronea, Marco Adinolfi Falcone, Marco Ierani, Alberto Boffi, Lorenzo Di Rienzo
Publicado en: Frontiers in Chemical Biology, Edición 3, 2025, ISSN 2813-530X
Editor: Frontiers Media SA
DOI: 10.3389/fchbi.2024.1517163

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Autores: Claudia Testi, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli, Daniele Leso, Domitilla Pavia, Elisa Pistolesi, Flavio Scipione, Irene Cotronea, Marco Adinolfi Falcone, Marco Ierani, Alberto Boffi, Lorenzo Di Rienzo
Publicado en: Frontiers in Chemical Biology, Edición 3, 2025, ISSN 2813-530X
Editor: Frontiers Media SA
DOI: 10.3389/FCHBI.2024.1517163

Nature Communications

Autores: Johanna Luige, Alexandros Armaos, Gian Gaetano Tartaglia, Ulf Andersson Vang Ørom
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-46731-9

Reference-less wavefront shaping in an Hopfield-like rough intensity landscape

Autores: Marco Leonetti; Luca Leuzzi; Giancarlo Ruocco
Publicado en: Optic Express, 2023, ISSN 1094-4087
Editor: Optica Publishing Group
DOI: 10.1364/oe.492055

Synchronized motion of interface residues for evaluating protein–<scp>RNA</scp> complex binding affinity: Application to aptamer‐mediated inhibition of <scp>TDP‐43</scp> aggregates

Autores: Francesco Paolo Panei, Lorenzo Di Rienzo, Elsa Zacco, Alexandros Armaos, Gian Gaetano Tartaglia, Giancarlo Ruocco, Edoardo Milanetti
Publicado en: Protein Science, Edición 33, 2024, ISSN 0961-8368
Editor: Wiley
DOI: 10.1002/PRO.5201

Predicting nuclear G-quadruplex RNA-binding proteins with roles in transcription and phase separation

Autores: Johanna Luige, Alexandros Armaos, Gian Gaetano Tartaglia, Ulf Andersson Vang rom
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41467-024-46731-9

Synchronized motion of interface residues for evaluating protein<scp>RNA</scp> complex binding affinity: Application to aptamermediated inhibition of <scp>TDP43</scp> aggregates

Autores: Francesco Paolo Panei, Lorenzo Di Rienzo, Elsa Zacco, Alexandros Armaos, Gian Gaetano Tartaglia, Giancarlo Ruocco, Edoardo Milanetti
Publicado en: Protein Science, Edición 33, 2024, ISSN 0961-8368
Editor: Wiley
DOI: 10.1002/pro.5201

High-Throughput Interactome Determination via Sulfur Anomalous Scattering

Autores: Mattia Miotto, Edoardo Milanetti, Riccardo Mincigrucci, Claudio Masciovecchio, Giancarlo Ruocco
Publicado en: The Journal of Physical Chemistry Letters, Edición 15, 2024, ISSN 1948-7185
Editor: American Chemical Society (ACS)
DOI: 10.1021/acs.jpclett.3c03632

Osmolyte-induced protein stability changes explained by graph theory

Autores: Mattia Miotto, Nina Warner, Giancarlo Ruocco, Gian Gaetano Tartaglia, Oren A. Scherman, Edoardo Milanetti
Publicado en: Computational and Structural Biotechnology Journal, Edición 23, 2025, ISSN 2001-0370
Editor: Elsevier BV
DOI: 10.1016/J.CSBJ.2024.10.014

Differences in the organization of interface residues tunes the stability of the SARS-CoV-2 spike-ACE2 complex

Autores: Mattia, Miotto; Lorenzo, Di Rienzo; Greta, Grassmann; Fausta, Desantis; Gianluca, Cidonio; Giorgio, Gosti; Marco, Leonetti; Giancarlo, Ruocco; Edoardo, Milanetti
Publicado en: Frontiers in Molecular Biosciences, 2023, ISSN 2296-889X
Editor: Frontiers
DOI: 10.3389/fmolb.2023.1205919

Osmolyte-induced protein stability changes explained by graph theory

Autores: Mattia Miotto, Nina Warner, Giancarlo Ruocco, Gian Gaetano Tartaglia, Oren A. Scherman, Edoardo Milanetti
Publicado en: Computational and Structural Biotechnology Journal, Edición 23, 2025, ISSN 2001-0370
Editor: Elsevier BV
DOI: 10.1016/J.CSBJ.2024.10.014

Rationalizing the effects of RNA modifications on protein interactions

Autores: Andrea Vandelli, Laura Broglia, Alexandros Armaos, Riccardo Delli Ponti, Gian Gaetano Tartaglia
Publicado en: Molecular Therapy - Nucleic Acids, Edición 35, 2024, ISSN 2162-2531
Editor: Elsevier BV
DOI: 10.1016/j.omtn.2024.102391

A size-dependent division strategy accounts for leukemia cell size heterogeneity

Autores: Mattia Miotto, Simone Scalise, Marco Leonetti, Giancarlo Ruocco, Giovanna Peruzzi, Giorgio Gosti
Publicado en: Communications Physics, 2024, ISSN 2399-3650
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S42005-024-01743-1

Computational Approaches to Predict Protein–Protein Interactions in Crowded Cellular Environments

Autores: Greta Grassmann, Mattia Miotto, Fausta Desantis, Lorenzo Di Rienzo, Gian Gaetano Tartaglia, Annalisa Pastore, Giancarlo Ruocco, Michele Monti, Edoardo Milanetti
Publicado en: Chemical Reviews, Edición 124, 2024, ISSN 0009-2665
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMREV.3C00550

Journal of Physical Chemistry Letters

Autores: Mattia Miotto, Edoardo Milanetti, Riccardo Mincigrucci, Claudio Masciovecchio, Giancarlo Ruocco
Publicado en: The Journal of Physical Chemistry Letters, Edición 15, 2024, ISSN 1948-7185
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.JPCLETT.3C03632

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues

Autores: Chenchen Handler, Claudia Testi, Giuliano Scarcelli
Publicado en: Current Opinion in Cell Biology, Edición 88, 2024, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/J.CEB.2024.102341

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues

Autores: Chenchen Handler, Claudia Testi, Giuliano Scarcelli
Publicado en: Current Opinion in Cell Biology, Edición 88, 2024, ISSN 0955-0674
Editor: Elsevier BV
DOI: 10.1016/j.ceb.2024.102341

A size-dependent division strategy accounts for leukemia cell size heterogeneity

Autores: Mattia Miotto, Simone Scalise, Marco Leonetti, Giancarlo Ruocco, Giovanna Peruzzi, Giorgio Gosti
Publicado en: Communications Physics, Edición 7, 2024, ISSN 2399-3650
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s42005-024-01743-1

Stochastically structured illumination microscopy scan less super resolution imaging

Autores: Denzel Fusco, Emmanouil Xypakis, Ylenia Gigante, Lorenza Mautone, Silvia Di Angelantonio, Giorgia Ponsi, Giancarlo Ruocco, Marco Leonetti
Publicado en: npj Imaging, Edición 2, 2024, ISSN 2948-197X
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S44303-024-00047-X

Localised Therapies Using 3DPrinted CollagenBased MicroImplant for Ocular Indications

Autores: Hamid Heidari Kashkooli, Arian Farokh, Sajad Mohammadi, Martina Marcotulli, Silvia Franco, Roberta Angelini, Giancarlo Ruocco, Hanieh Khalili, Gianluca Cidonio
Publicado en: Macromolecular Materials and Engineering, 2025, ISSN 1438-7492
Editor: Wiley
DOI: 10.1002/mame.202400236