Development of an In-Vivo Brillouin Microscope (with application to Protein Aggregation-based Pathologies)

Informacje na temat projektu

IVBM-4PAP

Identyfikator umowy o grant: 101098989

DOI

10.3030/101098989

Data podpisania przez KE 16 Grudnia 2022

Data rozpoczęcia 1 Marca 2023

Data zakończenia 31 Sierpnia 2026

Finansowanie w ramach

• The European Innovation Council (EIC)

Koszt całkowity

€ 3 333 513,00

Wkład UE

€ 3 333 513,00

Koordynowany przez

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Data Management Plan (3)

RP2 update of the Data Management Plan
RP1 update of the Data Management Plan
Data Management Plan

Documents, reports (8)

Identification of MLL4 mutations affecting condensates formation
Tau and alpha-synuclein variants
Generation of four endoOpto-MLL4 modules in MSCs
Design of the RF cavity
Tau Biomolecular condensates
Plan for Dissemination and Exploitation including Communication Activities
Project website and logo

Website and project logo information with also social media links

Measurement of nuclear mechanical properties by standard BM

Demonstrators, pilots, prototypes (3)

Fast scanning implemented
Fast scanning simulated
RF cavity ready for the IVBM

Publikacje

Peer reviewed articles (29)

Ferritin nanocage-enabled detection of pathological tau in living human retinal cells

Autorzy: Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantonio
Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-62188-8

The RNA-Binding Properties of Annexins

Autorzy: Gian Gaetano Tartaglia, Hanne Holls, Bjarte Hvik, Anni Vedeler, Annalisa Pastore
Opublikowane w: Journal of Molecular Biology, Numer 437, 2025, ISSN 0022-2836
Wydawca: Elsevier BV
DOI: 10.1016/j.jmb.2024.168933

Stochastically structured illumination microscopy scan less super resolution imaging

Autorzy: Denzel Fusco, Emmanouil Xypakis, Ylenia Gigante, Lorenza Mautone, Silvia Di Angelantonio, Giorgia Ponsi, Giancarlo Ruocco, Marco Leonetti
Opublikowane w: npj Imaging, Numer 2, 2024, ISSN 2948-197X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S44303-024-00047-X

Journal of Molecular Biology

Autorzy: Gian Gaetano Tartaglia, Hanne Hollås, Bjarte Håvik, Anni Vedeler, Annalisa Pastore
Opublikowane w: Journal of Molecular Biology, Numer 437, 2025, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/J.JMB.2024.168933

Computational Approaches to Predict ProteinProtein Interactions in Crowded Cellular Environments

Autorzy: Greta Grassmann, Mattia Miotto, Fausta Desantis, Lorenzo Di Rienzo, Gian Gaetano Tartaglia, Annalisa Pastore, Giancarlo Ruocco, Michele Monti, Edoardo Milanetti
Opublikowane w: Chemical Reviews, Numer 124, 2024, ISSN 0009-2665
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/acs.chemrev.3c00550

Localised Therapies Using 3D‐Printed Collagen‐Based Micro‐Implant for Ocular Indications

Autorzy: Hamid Heidari Kashkooli, Arian Farokh, Sajad Mohammadi, Martina Marcotulli, Silvia Franco, Roberta Angelini, Giancarlo Ruocco, Hanieh Khalili, Gianluca Cidonio
Opublikowane w: Macromolecular Materials and Engineering, 2025, ISSN 1438-7492
Wydawca: Wiley
DOI: 10.1002/MAME.202400236

Rationalizing the effects of RNA modifications on protein interactions

Autorzy: Andrea Vandelli, Laura Broglia, Alexandros Armaos, Riccardo Delli Ponti, Gian Gaetano Tartaglia
Opublikowane w: Molecular Therapy - Nucleic Acids, Numer 35, 2024, ISSN 2162-2531
Wydawca: Elsevier BV
DOI: 10.1016/J.OMTN.2024.102391

Retinal Fingerprints of ALS in Patients: Ganglion Cell Apoptosis and TDP-43/p62 Misplacement.

Autorzy: Pediconi, Natalia; Gigante, Ylenia; Cama, Silvia; Pitea, Martina; Mautone, Lorenza; Ruocco, Giancarlo; Ghirga, Silvia; Di Angelantonio, Silvia
Opublikowane w: Frontiers in Aging Neuroscience, 2023, ISSN 1663-4365
Wydawca: Frontiers
DOI: 10.3389/fnagi.2023.1110520

Scientific Reports

Autorzy: Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantonio
Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-62188-8

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Autorzy: Claudia Testi, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli, Daniele Leso, Domitilla Pavia, Elisa Pistolesi, Flavio Scipione, Irene Cotronea, Marco Adinolfi Falcone, Marco Ierani, Alberto Boffi, Lorenzo Di Rienzo
Opublikowane w: Frontiers in Chemical Biology, Numer 3, 2025, ISSN 2813-530X
Wydawca: Frontiers Media SA
DOI: 10.3389/fchbi.2024.1517163

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Autorzy: Claudia Testi, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli, Daniele Leso, Domitilla Pavia, Elisa Pistolesi, Flavio Scipione, Irene Cotronea, Marco Adinolfi Falcone, Marco Ierani, Alberto Boffi, Lorenzo Di Rienzo
Opublikowane w: Frontiers in Chemical Biology, Numer 3, 2025, ISSN 2813-530X
Wydawca: Frontiers Media SA
DOI: 10.3389/FCHBI.2024.1517163

Nature Communications

Autorzy: Johanna Luige, Alexandros Armaos, Gian Gaetano Tartaglia, Ulf Andersson Vang Ørom
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-46731-9

Reference-less wavefront shaping in an Hopfield-like rough intensity landscape

Autorzy: Marco Leonetti; Luca Leuzzi; Giancarlo Ruocco
Opublikowane w: Optic Express, 2023, ISSN 1094-4087
Wydawca: Optica Publishing Group
DOI: 10.1364/oe.492055

Synchronized motion of interface residues for evaluating protein–<scp>RNA</scp> complex binding affinity: Application to aptamer‐mediated inhibition of <scp>TDP‐43</scp> aggregates

Autorzy: Francesco Paolo Panei, Lorenzo Di Rienzo, Elsa Zacco, Alexandros Armaos, Gian Gaetano Tartaglia, Giancarlo Ruocco, Edoardo Milanetti
Opublikowane w: Protein Science, Numer 33, 2024, ISSN 0961-8368
Wydawca: Wiley
DOI: 10.1002/PRO.5201

Predicting nuclear G-quadruplex RNA-binding proteins with roles in transcription and phase separation

Autorzy: Johanna Luige, Alexandros Armaos, Gian Gaetano Tartaglia, Ulf Andersson Vang rom
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41467-024-46731-9

Synchronized motion of interface residues for evaluating protein<scp>RNA</scp> complex binding affinity: Application to aptamermediated inhibition of <scp>TDP43</scp> aggregates

Autorzy: Francesco Paolo Panei, Lorenzo Di Rienzo, Elsa Zacco, Alexandros Armaos, Gian Gaetano Tartaglia, Giancarlo Ruocco, Edoardo Milanetti
Opublikowane w: Protein Science, Numer 33, 2024, ISSN 0961-8368
Wydawca: Wiley
DOI: 10.1002/pro.5201

High-Throughput Interactome Determination via Sulfur Anomalous Scattering

Autorzy: Mattia Miotto, Edoardo Milanetti, Riccardo Mincigrucci, Claudio Masciovecchio, Giancarlo Ruocco
Opublikowane w: The Journal of Physical Chemistry Letters, Numer 15, 2024, ISSN 1948-7185
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/acs.jpclett.3c03632

Osmolyte-induced protein stability changes explained by graph theory

Autorzy: Mattia Miotto, Nina Warner, Giancarlo Ruocco, Gian Gaetano Tartaglia, Oren A. Scherman, Edoardo Milanetti
Opublikowane w: Computational and Structural Biotechnology Journal, Numer 23, 2025, ISSN 2001-0370
Wydawca: Elsevier BV
DOI: 10.1016/J.CSBJ.2024.10.014

Differences in the organization of interface residues tunes the stability of the SARS-CoV-2 spike-ACE2 complex

Autorzy: Mattia, Miotto; Lorenzo, Di Rienzo; Greta, Grassmann; Fausta, Desantis; Gianluca, Cidonio; Giorgio, Gosti; Marco, Leonetti; Giancarlo, Ruocco; Edoardo, Milanetti
Opublikowane w: Frontiers in Molecular Biosciences, 2023, ISSN 2296-889X
Wydawca: Frontiers
DOI: 10.3389/fmolb.2023.1205919

Osmolyte-induced protein stability changes explained by graph theory

Autorzy: Mattia Miotto, Nina Warner, Giancarlo Ruocco, Gian Gaetano Tartaglia, Oren A. Scherman, Edoardo Milanetti
Opublikowane w: Computational and Structural Biotechnology Journal, Numer 23, 2025, ISSN 2001-0370
Wydawca: Elsevier BV
DOI: 10.1016/J.CSBJ.2024.10.014

Rationalizing the effects of RNA modifications on protein interactions

Autorzy: Andrea Vandelli, Laura Broglia, Alexandros Armaos, Riccardo Delli Ponti, Gian Gaetano Tartaglia
Opublikowane w: Molecular Therapy - Nucleic Acids, Numer 35, 2024, ISSN 2162-2531
Wydawca: Elsevier BV
DOI: 10.1016/j.omtn.2024.102391

A size-dependent division strategy accounts for leukemia cell size heterogeneity

Autorzy: Mattia Miotto, Simone Scalise, Marco Leonetti, Giancarlo Ruocco, Giovanna Peruzzi, Giorgio Gosti
Opublikowane w: Communications Physics, 2024, ISSN 2399-3650
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S42005-024-01743-1

Computational Approaches to Predict Protein–Protein Interactions in Crowded Cellular Environments

Autorzy: Greta Grassmann, Mattia Miotto, Fausta Desantis, Lorenzo Di Rienzo, Gian Gaetano Tartaglia, Annalisa Pastore, Giancarlo Ruocco, Michele Monti, Edoardo Milanetti
Opublikowane w: Chemical Reviews, Numer 124, 2024, ISSN 0009-2665
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMREV.3C00550

Journal of Physical Chemistry Letters

Autorzy: Mattia Miotto, Edoardo Milanetti, Riccardo Mincigrucci, Claudio Masciovecchio, Giancarlo Ruocco
Opublikowane w: The Journal of Physical Chemistry Letters, Numer 15, 2024, ISSN 1948-7185
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACS.JPCLETT.3C03632

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues

Autorzy: Chenchen Handler, Claudia Testi, Giuliano Scarcelli
Opublikowane w: Current Opinion in Cell Biology, Numer 88, 2024, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/J.CEB.2024.102341

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues

Autorzy: Chenchen Handler, Claudia Testi, Giuliano Scarcelli
Opublikowane w: Current Opinion in Cell Biology, Numer 88, 2024, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/j.ceb.2024.102341

A size-dependent division strategy accounts for leukemia cell size heterogeneity

Autorzy: Mattia Miotto, Simone Scalise, Marco Leonetti, Giancarlo Ruocco, Giovanna Peruzzi, Giorgio Gosti
Opublikowane w: Communications Physics, Numer 7, 2024, ISSN 2399-3650
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s42005-024-01743-1

Stochastically structured illumination microscopy scan less super resolution imaging

Autorzy: Denzel Fusco, Emmanouil Xypakis, Ylenia Gigante, Lorenza Mautone, Silvia Di Angelantonio, Giorgia Ponsi, Giancarlo Ruocco, Marco Leonetti
Opublikowane w: npj Imaging, Numer 2, 2024, ISSN 2948-197X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S44303-024-00047-X

Localised Therapies Using 3DPrinted CollagenBased MicroImplant for Ocular Indications

Autorzy: Hamid Heidari Kashkooli, Arian Farokh, Sajad Mohammadi, Martina Marcotulli, Silvia Franco, Roberta Angelini, Giancarlo Ruocco, Hanieh Khalili, Gianluca Cidonio
Opublikowane w: Macromolecular Materials and Engineering, 2025, ISSN 1438-7492
Wydawca: Wiley
DOI: 10.1002/mame.202400236