Development of an In-Vivo Brillouin Microscope (with application to Protein Aggregation-based Pathologies)

Informacje na temat projektu

IVBM-4PAP

Identyfikator umowy o grant: 101098989

DOI

10.3030/101098989

Data podpisania przez KE 16 Grudnia 2022

Data rozpoczęcia 1 Marca 2023

Data zakończenia 31 Sierpnia 2026

Finansowanie w ramach

• The European Innovation Council (EIC)

Koszt całkowity

€ 3 868 938,00

Wkład UE

€ 3 868 938,00

Koordynowany przez

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Data Management Plan (3)

RP2 update of the Data Management Plan
RP1 update of the Data Management Plan
Data Management Plan

Documents, reports (8)

Identification of MLL4 mutations affecting condensates formation
Tau and alpha-synuclein variants
Generation of four endoOpto-MLL4 modules in MSCs
Design of the RF cavity
Tau Biomolecular condensates
Plan for Dissemination and Exploitation including Communication Activities
Project website and logo

Website and project logo information with also social media links

Measurement of nuclear mechanical properties by standard BM

Demonstrators, pilots, prototypes (3)

Fast scanning implemented
Fast scanning simulated
RF cavity ready for the IVBM

Publikacje

Peer reviewed articles (26)

Computational structural-based GPCR optimization for user-defined ligand: implications for the development of biosensors

Autorzy: L. DiRienzo, M. Miotto, E. Milanetti, and G. Ruocco.
Opublikowane w: Computational and Structural Biotechnology Journal, ISSN 2001-0370
Wydawca: Elsevier
DOI: 10.1016/J.CSBJ.2023.05.004

Journal of Molecular Biology

Autorzy: Gian Gaetano Tartaglia, Hanne Hollås, Bjarte Håvik, Anni Vedeler, Annalisa Pastore
Opublikowane w: Journal of Molecular Biology, Numer 437, 2025, ISSN 0022-2836
Wydawca: Academic Press
DOI: 10.1016/J.JMB.2024.168933

Localised Therapies Using 3D‐Printed Collagen‐Based Micro‐Implant for Ocular Indications

Autorzy: Hamid Heidari Kashkooli, Arian Farokh, Sajad Mohammadi, Martina Marcotulli, Silvia Franco, Roberta Angelini, Giancarlo Ruocco, Hanieh Khalili, Gianluca Cidonio
Opublikowane w: Macromolecular Materials and Engineering, 2025, ISSN 1438-7492
Wydawca: Wiley
DOI: 10.1002/MAME.202400236

Rationalizing the effects of RNA modifications on protein interactions

Autorzy: Andrea Vandelli, Laura Broglia, Alexandros Armaos, Riccardo Delli Ponti, Gian Gaetano Tartaglia
Opublikowane w: Molecular Therapy - Nucleic Acids, Numer 35, 2024, ISSN 2162-2531
Wydawca: Elsevier BV
DOI: 10.1016/J.OMTN.2024.102391

Retinal Fingerprints of ALS in Patients: Ganglion Cell Apoptosis and TDP-43/p62 Misplacement.

Autorzy: Pediconi, Natalia; Gigante, Ylenia; Cama, Silvia; Pitea, Martina; Mautone, Lorenza; Ruocco, Giancarlo; Ghirga, Silvia; Di Angelantonio, Silvia
Opublikowane w: Frontiers in Aging Neuroscience, 2023, ISSN 1663-4365
Wydawca: Frontiers
DOI: 10.3389/fnagi.2023.1110520

Scientific Reports

Autorzy: Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantonio
Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41598-024-62188-8

Two receptor binding strategy of SARS-CoV-2 is mediated by both the N-terminal and receptor-binding spike domain

Autorzy: M. Monti, E. Milanetti, M. T. Frans, M. Miotto, L. DiRienzo, M. V. Baranov, G. Gosti, A. K. Somavarapu, M. Nagaraj, T. W. Golbeck, E. Rossing, S. J. Moons, T. J. Boltje, G. van der Bogaart,..., G. G. Tartaglia, G. Ruocco, and S. J. Roeters
Opublikowane w: Journal of Physical Chemistry B, ISSN 1520-5207
Wydawca: American Chemical Society
DOI: 10.1021/ACS.JPCB.3C06258

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

Autorzy: Claudia Testi, Roberta Piacentini, Alessandro Perrone, Chiara Bartoli, Daniele Leso, Domitilla Pavia, Elisa Pistolesi, Flavio Scipione, Irene Cotronea, Marco Adinolfi Falcone, Marco Ierani, Alberto Boffi, Lorenzo Di Rienzo
Opublikowane w: Frontiers in Chemical Biology, Numer 3, 2025, ISSN 2813-530X
Wydawca: Frontiers Media SA
DOI: 10.3389/FCHBI.2024.1517163

Nature Communications

Autorzy: Johanna Luige, Alexandros Armaos, Gian Gaetano Tartaglia, Ulf Andersson Vang Ørom
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41467-024-46731-9

Molecular dynamics analysis of Superoxide Dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression

Autorzy: M. Kalia, M. Miotto, ..., G. Ruocco, E. Milanetti, R. Dobson, A. Al Chalabi, and A. Iacoangeli.
Opublikowane w: Computational and Structural Biotechnology Journal, ISSN 2001-0370
Wydawca: ScienceDirect
DOI: 10.1016/J.CSBJ.2023.09.016

Reference-less wavefront shaping in an Hopfield-like rough intensity landscape

Autorzy: Marco Leonetti; Luca Leuzzi; Giancarlo Ruocco
Opublikowane w: Optic Express, 2023, ISSN 1094-4087
Wydawca: Optica Publishing Group
DOI: 10.1364/oe.492055

Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and ACE2-derived peptides

Autorzy: G. Parisi, R. Piacentini, A. Incocciati, A. Bonamore, A. Macone, J. Rupert, E. Zacco, M. Miotto, E. Milanetti, G. G. Tartaglia, G. Ruocco, A. Boffi, and L. Di Rienzo.
Opublikowane w: Frontiers in Molecular Biosciences, ISSN 2296-889X
Wydawca: Frontiers
DOI: 10.3389/FMOLB.2023.1332359

Synchronized motion of interface residues for evaluating protein–<scp>RNA</scp> complex binding affinity: Application to aptamer‐mediated inhibition of <scp>TDP‐43</scp> aggregates

Autorzy: Francesco Paolo Panei, Lorenzo Di Rienzo, Elsa Zacco, Alexandros Armaos, Gian Gaetano Tartaglia, Giancarlo Ruocco, Edoardo Milanetti
Opublikowane w: Protein Science, Numer 33, 2024, ISSN 0961-8368
Wydawca: Wiley
DOI: 10.1002/PRO.5201

RNA sequestration driven by amyloid formation: the alpha synuclein case

Autorzy: Jakob Rupert, Michele Monti, Elsa Zacco, Gian Gaetano Tartaglia
Opublikowane w: NAR, ISSN 1362-4962
Wydawca: Oxford University Press
DOI: 10.1093/NAR/GKAD857

A Model Eye for fluorescent characterization of retinal cultures and tissues

Autorzy: G. Ferraro, Y. Gigante, M. Pitea, L. Mautone, G. Ruocco, S. Di Angelantonio, and M. Leonetti.
Opublikowane w: Scientific Reports, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/S41598-023-37806-6

Computational evidences of a misfolding event in an aggregation-prone light chain preceding the formation of the non-native pathogenic dimer

Autorzy: F. Desantis, M. Miotto, E. Milanetti, G. Ruocco, and L. Di Rienzo.
Opublikowane w: Proteins: Structure Function and Bioinformatics, ISSN 1097-0134
Wydawca: Wiley
DOI: 10.1002/PROT.26672

Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy

Autorzy: Laura Martinez-Vidal, Claudia Testi, Emanuele Pontecorvo, Filippo Pederzoli, Elisa Alchera, Irene Locatelli, Chiara Venegoni, Antonello Spinelli, Roberta Lucianò, Andrea Salonia, Alessandro Podestà, Giancarlo Ruocco & Massimo Alfano
Opublikowane w: Scientific Reports, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/S41598-023-51006-2

Differences in the organization of interface residues tunes the stability of the SARS-CoV-2 spike-ACE2 complex

Autorzy: Mattia, Miotto; Lorenzo, Di Rienzo; Greta, Grassmann; Fausta, Desantis; Gianluca, Cidonio; Giorgio, Gosti; Marco, Leonetti; Giancarlo, Ruocco; Edoardo, Milanetti
Opublikowane w: Frontiers in Molecular Biosciences, 2023, ISSN 2296-889X
Wydawca: Frontiers
DOI: 10.3389/fmolb.2023.1205919

Osmolyte-induced protein stability changes explained by graph theory

Autorzy: Mattia Miotto, Nina Warner, Giancarlo Ruocco, Gian Gaetano Tartaglia, Oren A. Scherman, Edoardo Milanetti
Opublikowane w: Computational and Structural Biotechnology Journal, Numer 23, 2025, ISSN 2001-0370
Wydawca: Elsevier BV
DOI: 10.1016/J.CSBJ.2024.10.014

A size-dependent division strategy accounts for leukemia cell size heterogeneity

Autorzy: Mattia Miotto, Simone Scalise, Marco Leonetti, Giancarlo Ruocco, Giovanna Peruzzi, Giorgio Gosti
Opublikowane w: Communications Physics, 2024, ISSN 2399-3650
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S42005-024-01743-1

Computational Approaches to Predict Protein–Protein Interactions in Crowded Cellular Environments

Autorzy: Greta Grassmann, Mattia Miotto, Fausta Desantis, Lorenzo Di Rienzo, Gian Gaetano Tartaglia, Annalisa Pastore, Giancarlo Ruocco, Michele Monti, Edoardo Milanetti
Opublikowane w: Chemical Reviews, Numer 124, 2024, ISSN 0009-2665
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMREV.3C00550

Journal of Physical Chemistry Letters

Autorzy: Mattia Miotto, Edoardo Milanetti, Riccardo Mincigrucci, Claudio Masciovecchio, Giancarlo Ruocco
Opublikowane w: The Journal of Physical Chemistry Letters, Numer 15, 2024, ISSN 1948-7185
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACS.JPCLETT.3C03632

Prediction of protein-RNA interactions from single-cell transcriptomic data

Autorzy: Jonathan Fiorentino, Alexandros Armaos, Alessio Colantoni, Gian Gaetano Tartaglia
Opublikowane w: Nucleic Acids Research, ISSN 1362-4962
Wydawca: Oxford University Press
DOI: 10.1093/NAR/GKAE076

Electrostatic complementarity at the interface drives transient protein-protein interactions

Autorzy: G. Grassmann, L. Di Rienzo, G. Gosti, M. Leonetti, G. Ruocco, M. Miotto, and E. Milanetti.
Opublikowane w: Scientific Reports, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/S41598-023-37130-Z

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues

Autorzy: Chenchen Handler, Claudia Testi, Giuliano Scarcelli
Opublikowane w: Current Opinion in Cell Biology, Numer 88, 2024, ISSN 0955-0674
Wydawca: Elsevier BV
DOI: 10.1016/J.CEB.2024.102341

Stochastically structured illumination microscopy scan less super resolution imaging

Autorzy: Denzel Fusco, Emmanouil Xypakis, Ylenia Gigante, Lorenza Mautone, Silvia Di Angelantonio, Giorgia Ponsi, Giancarlo Ruocco, Marco Leonetti
Opublikowane w: npj Imaging, Numer 2, 2024, ISSN 2948-197X
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S44303-024-00047-X

Other (2)

Collective behavior and self-organization in neural rosette morphogenesis

Autorzy: M. Miotto, M. Rosito, M. Paoluzi, V. de Turris, V. Folli, M. Leonetti, G. Ruocco, A. Rosa, and G. Gosti.
Opublikowane w: Frontiers in Cell and Developmental Biology, ISSN 2296-634X
Wydawca: Frontiers
DOI: 10.3389/FCELL.2023.1134091

May the force be with you: Nuclear condensates function beyond transcription control: Potential nongenetic functions of nuclear condensates in physiological and pathological conditions

Autorzy: Negri Maria Luce, D'Annunzio Sarah, Vitali Giulia, Zippo Alessio
Opublikowane w: BioEssays, ISSN 1521-1878
Wydawca: WILEY Online Library
DOI: 10.1002/BIES.202300075