Acoustofluidic thin-film actuated chip for exosome separation from blood

Projektinformationen

AcouSome

ID Finanzhilfevereinbarung: 101099787

DOI

10.3030/101099787

Projekt abgeschlossen

EK-Unterschriftsdatum 11 November 2022

Startdatum 1 Januar 2023

Enddatum 31 Dezember 2025

Finanziert unter

• The European Innovation Council (EIC)

Gesamtkosten

€ 2 498 421,25

EU-Beitrag

€ 2 498 419,00

Koordiniert durch

ACOUSORT AB
Sweden

Periodic Reporting for period 1 - AcouSome (Acoustofluidic thin-film actuated chip for exosome separation from blood)

Berichtszeitraum: 2023-01-01 bis 2023-12-31

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Exosomes are tiny vesicles budded of from all cells of the body and can be found in body fluids such as blood. They carry information from the cells they are budded of from and have been found to be useful for diagnostics of a wide range of diseases, including cancer infectious and cardiac diseases. Their clinical usefulness is therefore researched intensely. One big hurdle for this research and the diagnostics that is expected to come out of it is that it is challenging to find these virus-sized vesicles in body fluids such as blood. We therefore want to develop a module that can pick out and enrich them directly from blood, for use both in the research lab and in the resulting diagnostic instruments.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

During the first year of the project we have investigated how well our technologies using ultrasound to move cells and vesicles in microscopic channels can be used to pick out exosomes from blood. The results are promising and we are now focusing on making them even better and possible to produce on a larger scale to reach all the research and diagnostic labs that would need them. We are for instance investigating new materials to make our devices.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

We have for instance made our exosome capturing device capable of capturing many more exosomes by scaling it up, and already released it as an upgrade to our current exosome capturing instrument. We have also found a new method that is likely to increase the capacity even further, and are looking into if we can patent it. We also have promising results using new materials for the devices to make them easier to produce, less expensive and more environmentally friendly.

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