Acoustofluidic thin-film actuated chip for exosome separation from blood

Informazioni relative al progetto

AcouSome

ID dell’accordo di sovvenzione: 101099787

DOI

10.3030/101099787

Progetto chiuso

Data della firma CE 11 Novembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2025

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 2 498 421,25

Contributo UE

€ 2 498 419,00

Coordinato da

ACOUSORT AB
Sweden

Periodic Reporting for period 1 - AcouSome (Acoustofluidic thin-film actuated chip for exosome separation from blood)

Periodo di rendicontazione: 2023-01-01 al 2023-12-31

Sintesi del contesto e degli obiettivi generali del progetto

Exosomes are tiny vesicles budded of from all cells of the body and can be found in body fluids such as blood. They carry information from the cells they are budded of from and have been found to be useful for diagnostics of a wide range of diseases, including cancer infectious and cardiac diseases. Their clinical usefulness is therefore researched intensely. One big hurdle for this research and the diagnostics that is expected to come out of it is that it is challenging to find these virus-sized vesicles in body fluids such as blood. We therefore want to develop a module that can pick out and enrich them directly from blood, for use both in the research lab and in the resulting diagnostic instruments.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

During the first year of the project we have investigated how well our technologies using ultrasound to move cells and vesicles in microscopic channels can be used to pick out exosomes from blood. The results are promising and we are now focusing on making them even better and possible to produce on a larger scale to reach all the research and diagnostic labs that would need them. We are for instance investigating new materials to make our devices.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

We have for instance made our exosome capturing device capable of capturing many more exosomes by scaling it up, and already released it as an upgrade to our current exosome capturing instrument. We have also found a new method that is likely to increase the capacity even further, and are looking into if we can patent it. We also have promising results using new materials for the devices to make them easier to produce, less expensive and more environmentally friendly.

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