Objectif The African Great Lakes region is one of the most densely populated areas in Africa and also one of the areas globally with the highest biodiversity, and forced or voluntary migrations. Very limited information is available on the prevalence and epidemiology of infectious diseases, especially gastrointestinal diseases and antimicrobial resistance that has been very understudied.Logistically it is difficult to sample and conventionally study infectious diseases in the area and such studies have limited real-time value locally. In this study we will take full advantage of the potential offered by combining field-deployable nanopore sequencing combined with metagenomics and lap-top bioinformatics, to establish frontline sequencing at remote sites and linking this with central sharing of analytic output. Newly developed bioinformatics solutions by us have made it possible to perform simple bioinformatics analyses in real-time using lap-tops and subsequently share the analytic output simply using the mobile net, avoiding the need of transferring large amounts of data and access to high-performance computing.In GREAT-LIFE we will establish sequencing across six countries in the region and use this to study the abundances of AMR in villages and refugee camps. Linking this with spatial and temporal epidemiological data will enable us to identify locally relevant drivers for AMR and provide data for changing empiric treatment and policies. In addition, we will utilize sequencing directly on GI samples to identify the causative agents (and their AMR) both to provide data for policies, but also to provide immediate results for direct patient care in the frontline. We will educate a number of people in the very frontline to utilize field-sequencing and bioinformatics, as well as more advanced bioinformaticians and epidemiologist centrally. The data generated will be linked in real-time through a central hub in Tanzania to public health authorities for actions. Champ scientifique sciences médicales et de la santésciences de la santésanté publique et environnementaleépidémiologiesciences médicales et de la santésciences de la santémaladie infectieusesciences socialessociologiedémographiemigration humainesciences médicales et de la santémédecine fondamentalepharmacologie et pharmacierésistance aux médicamentsrésistance aux antibiotiquessciences médicales et de la santémédecine cliniquegastroentérologie Mots‑clés Antimicrobial Resistance Epidemiology Programme(s) HORIZON.2.1 - Health Main Programme Thème(s) HORIZON-JU-GH-EDCTP3-2022-CALL1-01-03 - Genomic epidemiology for surveillance and control of poverty-related and emerging/re-emerging infections in sub-Saharan Africa Appel à propositions HORIZON-JU-GH-EDCTP3-2022-01 Voir d’autres projets de cet appel Régime de financement HORIZON-JU-RIA - HORIZON JU Research and Innovation Actions Coordinateur DANMARKS TEKNISKE UNIVERSITET Contribution nette de l'UE € 1 356 250,00 Adresse Anker engelunds vej 101 2800 Kongens lyngby Danemark Voir sur la carte Région Danmark Hovedstaden Københavns omegn Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 Participants (9) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire THE GOOD SAMARITAN FOUNDATION Tanzanie Contribution nette de l'UE € 1 142 500,00 Adresse Po box 545 - Moshi Voir sur la carte Type d’activité Other Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 STANSILE LTD Rwanda Contribution nette de l'UE € 456 250,00 Adresse Kc 622 st 4th fl fairview building kimihurura 622 Kigali Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 INSTITUT NATIONAL DE SANTE PUBLIQUE Burundi Contribution nette de l'UE € 412 500,00 Adresse Avenue de l'hopital 3 Bujumbura Voir sur la carte Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 UGANDA NATIONAL HEALTH RESEARCH ORGANISATION Ouganda Contribution nette de l'UE € 412 500,00 Adresse Berkeley lane plot 2 465 Entebbe Voir sur la carte Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 AFRICA RESEARCH EXCELLENCE FUND Royaume-Uni Contribution nette de l'UE € 112 500,00 Adresse 99 charterhouse street EC1M 6HR London Voir sur la carte Région London Inner London — East Haringey and Islington Type d’activité Other Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 KENYA MEDICAL RESEARCH INSTITUTE Kenya Contribution nette de l'UE € 495 000,00 Adresse Off mbagathi way 00200 Nairobi Voir sur la carte Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 NATIONAL INSTITUTE FOR MEDICAL RESEARCH Tanzanie Contribution nette de l'UE € 513 750,00 Adresse Sokoine luthuli drive ocean road 255 Dar es salaam Voir sur la carte Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 KOBENHAVNS UNIVERSITET Danemark Contribution nette de l'UE € 100 000,00 Adresse Norregade 10 1165 Kobenhavn Voir sur la carte Région Danmark Hovedstaden Byen København Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00 ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Pays-Bas Contribution nette de l'UE € 206 250,00 Adresse Dr molewaterplein 40 3015 GD Rotterdam Voir sur la carte Région West-Nederland Zuid-Holland Groot-Rijnmond Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Autres sources de financement € 0,00
