Collaborative development and dissemination of workflows and techniques for using Correlative Light, Electron and X-ray Microscopy to progress research into the understanding and treatment of diseases

Project Information

CLEXM

Grant agreement ID: 101120151

DOI

10.3030/101120151

EC signature date 9 June 2023

Start date 1 September 2023

End date 31 August 2027

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 2 480 594,40

Coordinated by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Conference proceedings (4)

Integrating Cryo Soft X-Ray Tomography into CLEM and Volume EM Correlative Workflows

Author(s): Sergey Kapishnikov, Paul Sheridan, William Fyans, Fergal O’Reilly, Tony McEnroe, Kenneth Fahy
Published in: Microscopy and Microanalysis, Issue 31, 2025, ISSN 1431-9276
Publisher: Oxford University Press (OUP)
DOI: 10.1093/MAM/OZAF048.503

Spatially-Informed Multi-Stage Active Learning for Segmentation of Nucleus in Soft X-ray Tomography

Author(s): Ayse Erozan, Alexander Zeilmann, Anthoula Chatzimpinou, Fariha Mahzabin Annesha, Vincent Heuveline, Venera Weinhardt
Published in: 2025 IEEE Symposium on Computational Intelligence in Image, Signal Processing and Synthetic Media (CISM), 2025
Publisher: IEEE
DOI: 10.1109/CISM64958.2025.11060865

Elimination of HCV replication machinery early after antiviral treatment with DAA monitored by multimodal microscopy

Author(s): Victoria Castro, Gema Calvo, Ana Pérez-Berna, David Rogers, Stephen O'Connor, Sergey Kapishnikov, Paul Sheridan, Eva Pereiro, Kenneth Fahy, Pablo Gastaminza
Published in: BIO Web of Conferences, Issue 129, 2024, ISSN 2117-4458
Publisher: EDP Sciences
DOI: 10.1051/BIOCONF/202412918008

SARS-CoV-2 and HCV infection and antiviral treatment monitored by multimodal imaging

Author(s): Ana Joaquina Perez-Berna, Kevin Mamprin, Victoria Castro, Gema Calvo, Ricardo Valcárcel, Eva Pereiro, Pablo Gastaminza
Published in: BIO Web of Conferences, Issue 129, 2024, ISSN 2117-4458
Publisher: EDP Sciences
DOI: 10.1051/BIOCONF/202412916002

Peer reviewed articles (11)

Harnessing 3D cell models and high-resolution imaging to unveil the mechanisms of nanoparticle-mediated drug delivery

Author(s): Alannah S. Chalkley, Maëva T. Lopez, Margaritha M. Mysior, Madeleen C. Brink, Suainibhe Kelly, Jeremy C. Simpson
Published in: Frontiers in Bioengineering and Biotechnology, Issue 13, 2025, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/FBIOE.2025.1606573

The bacterial type three secretion system induces mechanoporation of vacuolar membranes

Author(s): Léa Swistak, Marvin Albert, Camila Valenzuela, Elif Begum Gokerkucuk, François Bontems, Stéphane Tachon, Keith T. Egger, Anastasia D. Gazi, Anna Sartori-Rupp, Cammie F. Lesser, Perrine Paul-Gilloteaux, Jean-Yves Tinevez, Matthijn Vos, Jost Enninga
Published in: PLOS Biology, Issue 23, 2025, ISSN 1545-7885
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PBIO.3003135

<scp>CELS</scp>‐<scp>3D</scp>—Cutting edge light source for exciting fluorescence in microtome‐based <scp>3D</scp> microscopy and targeted correlative microscopy

Author(s): Vladyslav Denyshchenko, Christopher Evans, Tiina O'Neill, Jakub Krstev, Emilia Filipczak, Silas O'Toole, Vladimir Lobaskin, Dimitri Scholz
Published in: Journal of Anatomy, Issue 246, 2024, ISSN 0021-8782
Publisher: Wiley
DOI: 10.1111/JOA.14164

Histidine-modified UiO-66(Zr) nanoparticles as an effective pH-responsive carrier for 5-fluorouracil drug delivery system: A possible pathway to more effective brain cancer treatments

Author(s): Alexandra Migasová, Ľuboš Zauška, Tomáš Zelenka, Dominik Volavka, Marta Férová, Terézia Gulyásová, Silvia Tomková, Michaela Saláková, Veronika Kuchárová, Tomáš Samuely, Jozef Bednarčík, Cyril Slabý, Mariana Máčajová, Boris Bilčík, Tim Schubert, Andreas Walter, Virginie Hornebecq, Veronika Huntošová, Miroslav Almáši
Published in: Chemical Engineering Journal, Issue 522, 2025, ISSN 1385-8947
Publisher: Elsevier BV
DOI: 10.1016/J.CEJ.2025.167857

Rapid HCV Replication Machinery Removal after Antiviral Treatment with DAA Monitored by Multimodal Imaging

Author(s): Victoria Castro, Gema Calvo, Ana Pérez-Berna, David Rogers, Stephen O’Connor, Sergey Kapishnikov, Paul Sheridan, Eva Pereiro, Kenneth Fahy, Pablo Gastaminza
Published in: Microscopy and Microanalysis, Issue 30, 2024, ISSN 1431-9276
Publisher: Oxford University Press (OUP)
DOI: 10.1093/MAM/OZAE044.1056

Cryogenic Super-Resolution Fluorescence, Electron, and X-ray Microscopy -- A Novel Correlative Nanoscale Imaging Workflow to Reveal Nanoparticle Internalization into Cancer Cells

Author(s): Pavitra Sokke Rudraiah, Louisa Herbsleb, Michaela Salakova, Henriette Gröger, Anna Maria Steyer, Frauke Alves, Claus Feldmann, Andreas Walter
Published in: 2025, ISSN 0362-4331
Publisher: Wiley
DOI: 10.22541/AU.174798562.25512020/V1

Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging

Author(s): Victoria Castro, Gema Calvo, Ana J. Pérez-Berná, Kevin Mamprin, Sergey Kapishnikov, David Rogers, Stephen O'Connor, Paul Sheridan, Kenneth Fahy, Eva Pereiro, Pablo Gastaminza
Published in: Structure, Issue 33, 2025, ISSN 0969-2126
Publisher: Elsevier BV
DOI: 10.1016/J.STR.2025.05.015

The VapBC Toxin–Antitoxin System Enhances<i>Shigella flexneri</i>Fitness Through Coordination of Metabolic Stress Adaptation and Virulence

Author(s): Estelle Saifi, Elisabeth Ageron, Keith Egger, Caroline Reisacher, Eric Frapy, Morgan Lamberioux, Shelley Payne, Jost Enninga, Laurence Arbibe
Published in: 2025, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2025.06.29.662172

Super-resolution mapping of the ankle link proteins ADGRV1 and PDZD7 in developing auditory hair cells

Author(s): Baptiste Colcombet-Cazenave, Gaël Moneron, Antonio El Helou, David DiGregorio, Vincent Michel, Nicolas Wolff
Published in: iScience, Issue 28, 2025, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/J.ISCI.2025.113190

Soft X-Ray Reveals Chromatin Remodeling in Human CD4 T Cells

Author(s): Fariha Mahzabin Annesha, Ayse Erozan, Swetha Ananth, Oliver T Fackler, Venera Weinhardt
Published in: Microscopy and Microanalysis, Issue 31, 2025, ISSN 1431-9276
Publisher: Oxford University Press (OUP)
DOI: 10.1093/MAM/OZAF048.393

Soft X-ray tomography reveals variations in B. subtilis biofilm structure upon tasA deletion

Author(s): Chatzimpinou, Anthoula; Diehl, Anne; Harhoff, A Tobias; Driller, Kristina; Vanslembrouck, Bieke; Chen, Jian-Hua; Kairišs, Kristaps; Loconte, Valentina; Le Gros, Mark A; Larabell, Carolyn; Turgay, Kürşad; Oschkinat, Hartmut; Weinhardt, Venera
Published in: npj Biofilms and Microbiomes, 2025, ISSN 2055-5008
Publisher: npj Biofilms Microbiomes
DOI: 10.1038/S41522-025-00659-0