image-Guided computational and experimental Analysis of fractured Patients

Project Information

GAP

Grant agreement ID: 101120290

DOI

10.3030/101120290

EC signature date 22 June 2023

Start date 1 October 2023

End date 31 May 2028

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 2 679 933,60

Coordinated by

POLITECNICO DI MILANO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (4)

A quantitative framework based on neural network for bone micro-cracks description and classification

A quantitative framework based on neural network for bone micro-cracks description and classification: identification of crack parameters from convolutional neural network processing

A quantitative framework based on topological and geometry approach for bone micro-cracks description and classification

A quantitative framework based on topological and geometry approach for bone micro-cracks description and classification: Extraction of a topological score of bone quality, Morse smale complexes and persistent homology

Network-wide events

Network-wide events Preparation of different events with target audience ranging from scientists, to clinicians, patients, companiesThis deliverable is due to month 22 and 42 (for each periodic report)

Development of meso and micro-scale numerical analyses

Development of meso and micro-scale numerical analyses: Application of multi-scale modelling techniques to predict multi-scale damage evolution via fracture mechanics parameters

Websites, patent fillings, videos etc. (1)

Website

Generation of GAP social profiles, including GAP official website, LinkedIn, and other social media

Documents, reports (2)

Definition and validation of micro-scale fragility indices

Definition and validation of micro-scale fragility indices: A micro-scale fragility index able to predict fracture onset with accuracy>90% and experimental validation with histologies

Mechanical multi-scale and biological characterization of healthy and pathological bone samples

Mechanical multi-scale characterization of healthy and pathological bone samples: meso (10 mm, testing device), micro (1 µm, synchrotron, SEM), nano (10 nm, FIB, Raman spectroscopy)Biological characterization of healthy and pathological bone samples: Characterization of osteoporosis, osteoarthrosis and Covid-19 samples via cell parameters from histologies, immunohistochemical analyses

Publications

Peer reviewed articles (7)

Using crack face displacement to measure stress intensity: A practical approach

Author(s): Anis Allahdiniyan, David Taylor
Published in: Theoretical and Applied Fracture Mechanics, Issue 138, 2025, ISSN 0167-8442
Publisher: Elsevier BV
DOI: 10.1016/J.TAFMEC.2025.104940

Multifunctional in situ imaging of biological materials under load: A synchrotron-based platform for large-scale image-guided failure analysis

Author(s): L. Clementini, F. Buccino, R. Palazzetti, E. Longo, M.Kudrna Prasek, G. Banfi, Z. Qin, L.M. Vergani
Published in: Materials & Design, Issue 257, 2025, ISSN 0264-1275
Publisher: Elsevier BV
DOI: 10.1016/J.MATDES.2025.114408

Tuning mechanical response of nonuniform triangular lattice material via graph neural network based inverse design algorithm

Author(s): Giuseppe Bonfanti, Federica Buccino, Laura Maria Vergani, Chao Gao
Published in: Procedia Structural Integrity, Issue 68, 2025, ISSN 2452-3216
Publisher: Elsevier BV
DOI: 10.1016/J.PROSTR.2025.06.166

Exploring the Potential of ATUM-SEM for Enhanced Characterization of Human Trabecular Bone in Biomaterials Research

Author(s): Valeria Vistoso, Tom Ferté, Federica Buccino, Laura Vergani, Ovidiu Ersen, Adele Carradó
Published in: JOM, 2025, ISSN 1047-4838
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S11837-025-07212-6

Integration of Multi-Scale Predictive Tools of Bone Fragility: A Structural and Material Property Perspective

Author(s): Muhammad Ateeq, Laura Vergani, Federica Buccino
Published in: Materials, Issue 18, 2025, ISSN 1996-1944
Publisher: MDPI AG
DOI: 10.3390/MA18194639

Sustainable silk fibroin scaffolds for bone repair: assessing their osteogenic potential via AI-enhanced synchrotron imaging workflow

Author(s): G. Dei Rossi, F. Buccino, E. Longo, G. Tromba, L.M. Vergani
Published in: Biomaterials Advances, Issue 181, 2025, ISSN 2772-9508
Publisher: Elsevier BV
DOI: 10.1016/J.BIOADV.2025.214658

Structural influences on bone tissue engineering: A review and perspective

Author(s): Sara Sebastiani, Federica Buccino, Zhao Qin, Laura Maria Vergani
Published in: Matter, Issue 8, 2025, ISSN 2590-2385
Publisher: Elsevier BV
DOI: 10.1016/J.MATT.2025.102252