Descrizione del progetto
Materiali bioibridi rivoluzionari per la ricerca farmaceutica
I materiali bioibridi e le interazioni fisiochimiche sono molto promettenti per il progresso del settore farmaceutico e di quello chimico; tuttavia, gli sviluppi attuali di queste tecnologie sono limitati, alla luce del numero ridotto di opzioni funzionali disponibili. In questo contesto, il progetto Bio-HhOST, finanziato dal CEI, mira a sviluppare un materiale bioibrido composto da cellule viventi e artificiali, consentendo un’ampia gamma di interazioni. L’incorporazione di cellule artificiali faciliterà la proliferazione, la funzione e la differenziazione delle cellule viventi, possedendo al tempo stesso metabolismi funzionali in grado di rivoluzionare il settore attraverso le interazioni chimiche. Inoltre, il progetto si avvale di modelli di tessuto e simulazioni in 3D per migliorare la comprensione del materiale e della sua risposta alle malattie, riducendo in tal modo la necessità di effettuare ricerche sugli animali.
Obiettivo
Bio-HhOST will build bio-hybrid materials that comprise living & artificial cells, in dynamic communication, such that artificial cells may influence the proliferation, differentiation and function of living cells. This will be accomplished by producing precision engineered, microscale, liquid and lipid bilayer-based, chemically compartmentalised artificial cells, co-localised with live cells. This will be done by an interdisciplinary team of biologists, engineers, mathematicians and entrepreneurs. The artificial cells will contain functional metabolisms, and the ability to respond to chemical stimuli in the environment to release signaling molecules, on demand, to regulate the neighboring living cells, as found in complex biological tissues. These new chemically programmable organoid-synthetic tissues will enable a paradigm shift, in both ability to elucidate and control the complexity of physio-chemical interactions within 3D tissues, and reduce animal use in pharmaceutical R&D.
To achieve these ambitions we have designed an integrated multistage workplan driving towards the following overarching aims:- Aim 1. Create 3D tissues where spatial regulation of living cell differentiation is determined by co-located (chemically programmable) artificial cells. Aim 2. Regulate and maintain such 3D tissues by dynamic communication between live and artificial cells. Aim 3. Develop multi-level, multi-approach models of organoid-synthetic tissues behavior. These will be applied to target applications; Aim4. Evaluating drug delivery vectors for next generation biological therapeutics. And Aim5. generation of complex tissues formed of distinct different regions, not achievable with current organoid protocols. These exemplify our wider ambitions for the Bio-HhOST approach including to, i) understand cell behavior in increasingly realistic 3D tissue models, ii) elucidate targets for the treatment of disease, and iii) enable the reduction of animal use in pharmacuetical research.
Campo scientifico
Programma(i)
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Invito a presentare proposte
HORIZON-EIC-2023-PATHFINDEROPEN-01
Vedi altri progetti per questo bandoMeccanismo di finanziamento
HORIZON-EIC - HORIZON EIC GrantsCoordinatore
38122 Trento
Italia