Descripción del proyecto
Un cambio sostenible en la conservación de las células
El coste medioambiental de los métodos convencionales de biobancos es innegable. La congelación en nitrógeno líquido (NL) tiene un coste elevado, tanto económico como ecológico, ya que exige instalaciones especializadas y contribuye a una huella de CO2 considerable. El equipo del proyecto WhyNotDry, que cuenta con el apoyo de las acciones Marie Skłodowska-Curie, pretende revolucionar los biobancos explorando el secado reversible en células y germoplasma, con el objetivo de sustituir la congelación de NL por una alternativa innovadora, rentable y respetuosa con el medio ambiente. En esta empresa multidisciplinar participa una red internacional de científicos empeñados en aprovechar el potencial de los biobancos secos para lograr un futuro sostenible en las ciencias de la vida. El equipo del proyecto no solo reconfigura los métodos de conservación, sino que también fomenta la colaboración interdisciplinar, prometiendo un cambio de paradigma «verde» en la comunidad científica.
Objetivo
WhyNotDry will deepen our knowledge on reversible drying in cells and germplasm toward the development of a dry biobanking as an alternative to the current freezing in Liquid Nitrogen (LN). LN is expensive, requires dedicated facilities and power supply, and has a high CO2 footprint. WhyNotDry will achieve its aims through a multidisciplinary, intersectoral, international network of scientists that will: i) Develop a drying/rehydration platform using naturally desiccation-tolerant midge (Polypedilum vanderplanki) Pv11 cell lines; ii) Identify the best combination of naturally occurring xeroprotectants (xero=dry) from desiccation-tolerant insect cell line and the best performing water subtraction platform. iii) To use the best xeroprotectants mix and the drying/rehydration protocol for mammalian cells/germplasm. vi) Develop a prototype for controlled dehydration of microvolumes of cell. The R&I activities leading to these aims will be carried out by knowhow sharing through Staff Exchanges between: 3 EU academies, 2 EU SMEs, 2 international partners (Japan, Thailand). Outcomes of WhyNotDry will be incorporated into a cheap, environmentally friendly, and easy biobanking for biodiversity conservation, assisted reproduction, stem cell/personalized medicine. Successful development of this technology will set the basis for a radically new, ‘green’ biobanking paradigm, simplifying the maintenance and shipping practices in life sciences, with enormous reduction in costs and carbon footprint. Moreover, knowledge generated in WhyNotDry would be applicable to other fields such as agriculture, environmental science, food processing, and the pharmaceutical industry, where elective or enforced (by climate change) drying is dealt with. Finally, WhyNotDry will empower young scientists with transferable skills, ensuring career prospects in academia/industry, and strengthen the international/sectorial network between disciplines, boosting European excellence.
Ámbito científico
- natural sciencesearth and related environmental sciencesenvironmental sciences
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- natural sciencesbiological sciencesbiodiversity conservation
- medical and health scienceshealth sciencespersonalized medicine
- natural sciencesearth and related environmental sciencesatmospheric sciencesclimatologyclimatic changes
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinador
64100 Teramo
Italia