Unraveling the dark matter of infectious diseases, environmental and genetic factors tipping the balance towards NCDs

Información del proyecto

ID-DarkMatter-NCD

Identificador del acuerdo de subvención: 101136582

DOI

10.3030/101136582

Fecha de la firma de la CE 11 Diciembre 2023

Fecha de inicio 1 Enero 2024

Fecha de finalización 31 Diciembre 2028

Financiado con arreglo a

• Health

Coste total

€ 7 185 870,01

Aportación de la UE

€ 7 185 361,00

Coordinado por

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

Ethics framework

Ethics and Governance framework (HRequirement No. 1 [9], POPD- Requirement no 3 [6])

Genetic data

Report on data curation & exchange

D,E,C plan

Plan for dissemination, exploit, comm

Data Management Plan (1)

DMP

Data management plan

Websites, patent fillings, videos etc. (1)

Public website

Public website of ID-DarkMatter-NCD

Publicaciones

Peer reviewed articles (25)

Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation

Autores: Lena K. Siewert, Kristina Berve, Elisabeth Pössnecker, Julia Dyckow, Amel Zulji, Ryan Baumann, Aida Munoz-Blazquez, Gurumoorthy Krishnamoorthy, David Schreiner, Sharon Sagan, Charlotte Nelson, Joseph J. Sabatino, Kazuki Nagashima, Médéric Diard, Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg, Michael A. Fischbach, Scott S. Zamvil, Lucas Schirmer, Sergio E. Baranzini, Anne-Katrin Pröbstel
Publicado en: Gut Microbes, Edición 18, 2026, ISSN 1949-0976
Editor: Informa UK Limited
DOI: 10.1080/19490976.2025.2601430

A journey to your self: The vague definition of immune self and its practical implications

Autores: Koncz, Balázs; Balogh, Gergő Mihály; Manczinger, Máté
Publicado en: Proceedings of the National Academy of Sciences, 2024, ISSN 1091-6490
Editor: National Academy of Sciences.
DOI: 10.1073/PNAS.2309674121

Molecular Systems Biology

Autores: Szilvia Juhász; Benjamin Tamás Papp; Anna Tácia Fülöp; Zoltán Farkas; Dávid Kókai; Dóra Alexandra Gyémánt; Franciska Tóth; Zsófia Nacsa; Dóra Spekhardt; Balázs Koncz; Péter Burkovics; Csaba Pál; Máté Manczinger
Publicado en: Molecular Systems Biology, 2026, ISSN 1744-4292
Editor: Nature Publishing Group
DOI: 10.1038/S44320-026-00193-X

Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease

Autores: Maximilian G Griesbaum, Thomas Vogl, Marijn C Visschedijk, Eleonora A M Festen, Gerard Dijkstra, Adina Weinberger, Eran Segal, Rinse K Weersma, Arno R Bourgonje
Publicado en: iScience, 2026, ISSN 2589-0042
Editor: Cell Press, an imprint of Elsevier
DOI: 10.1016/j.isci.2026.116828

Associations between HLA-II variation and antibody specificity are predicted by antigen properties

Autores: Innocenti G.; Andreu-Sánchez S.; Hörstke N.V.; Elabd H.; Barozzi I.; Franke A.; Manczinger M.; Vogl T.
Publicado en: Genome Medicine, 2025, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/S13073-025-01486-W

Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencing

Autores: Mahdy AKH, ElAbd H, Prinzensteiner M, Jebens H, Sivickis K, Bacher P, Vogl T, Franke A, et al
Publicado en: Journal of Crohn's and Colitis, 2026, ISSN 1876-4479
Editor: Oxford Academic
DOI: 10.1093/ECCO-JCC/JJAG015

Free Radical Biology and Medicine

Autores: Sem Geertsema; Hannah J. Holstein; Marian L.C. Bulthuis; Sofie de Jong; Marjan Reinders-Luinge; Karin Koerts-Steijn; Anneke C. Muller Kobold; Klaas Nico Faber; Harry van Goor; Gerard Dijkstra; Arno R. Bourgonje
Publicado en: Free Radical Biology and Medicine, 2026, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/J.FREERADBIOMED.2025.11.057

Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis

Autores: Tradite Neziraj, Elisabeth Pössnecker, Angela A. Wang, Paul Saary, Adrian-Minh Schumacher, Florian Ingelfinger, Amandine Mathias, Edoardo Galli, Marco Häfelfinger, Michelle Zuo, Samuel Jones, Vasiliki Pantazou, Joep Killestein, Sabine Schädelin, Pascal Benkert, Cristina Granziera, Caroline Pot, Antje Bischof, Jan Hendrik Niess, Magdalena Filipowicz Sinnreich, Tobias Derfuss, Charlotte E. Teunissen, Jens Kuhle, David A. Hafler, Renaud Du Pasquier, Yoshiaki Yasumizu, Jennifer L. Gommerman, Anne-Katrin Pröbstel
Publicado en: Science Translational Medicine, Edición 18, 2026, ISSN 1946-6234
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.AEE1580

Deciphering the prodrome of inflammatory bowel disease up to 10 years before disease onset by massively parallel serology

Autores: Arno R Bourgonje, Gabriel Innocenti, Alexandra E Livanos, Melanie Prinzensteiner, Jared S Magee, Mark S Riddle, Renee M Laird, Thierry Dervieux, Chad K Porter, Sacha Gnjatic, Francesca Petralia, Joana Torres, Mayte Suárez-Fariñas, Thomas Vogl, Jean-Frederic Colombel, Saurabh Mehandru
Publicado en: Gut, 2026, ISSN 0017-5749
Editor: BMJ
DOI: 10.1136/GUTJNL-2025-337762

Nature Communications

Autores: Manczinger, Innocenti, Vogl, Zhernakova, Weersma, Et Al.
Publicado en: Nature Communications 2026, 2026, ISSN 2041-1723
Editor: Springer Nature
DOI: 10.1038/s41467-019-14177-z

Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases

Autores: Michaela Fehringer; Thomas Vogl
Publicado en: Journal of Translational Autoimmunity, 2025, ISSN 2589-9090
Editor: Elsevier
DOI: 10.1016/J.JTAUTO.2025.100269

Patient-Derived Monoclonal Myelin Oligodendrocyte Glycoprotein Autoantibodies Mediate Cytotoxicity

Autores: Nora Sandrine Wetzel, Laila Kulsvehagen, Anne-Catherine Lecourt, Beata Filipek, Patrick Lipps, Laura Rieder, Kristina Berve, Gurumoorthy Krishnamoorthy, Bert A. 't Hart, Lucas Schirmer, Soumya S. Yandamuri, Kevin C. O'Connor, Anne-Katrin Pröbstel
Publicado en: Neurology Neuroimmunology & Neuroinflammation, Edición 13, 2025, ISSN 2332-7812
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200520

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation

Autores: Kim, Schneider, Raach, Karypidis, Roux, Perdikaris, Holdermann, Pröbstel, et al.
Publicado en: Cell, ISSN 1097-4172
Editor: Cell Press, an imprint of Elsevier
DOI: 10.1016/j.cell.2025.12.031

Nature Communications

Autores: Rakoff-Nahoum, Seth; Debelius, Justine; Valles-Colomer, Mireia; Noordzij, Hanna Theodora; Esteban-Torres, Maria; Zhernakova, Alexandra; Brusselaers, Nele; Pettersen, Veronika Kuchařová
Publicado en: Nature Communications, 2025, ISSN 2041-1723
Editor: Nature Publishing Group (Springer Nature)
DOI: 10.1038/S41467-025-61998-2

A reconceptualized framework for human microbiome transmission in early life

Autores: Seth Rakoff-Nahoum, Justine Debelius, Mireia Valles-Colomer, Hanna Theodora Noordzij, Maria Esteban-Torres, Alexandra Zhernakova, Nele Brusselaers, Veronika Kuchařová Pettersen
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61998-2

Elevated serum glutathione reflects endoscopic disease activity in inflammatory bowel disease

Autores: Sem Geertsema, Hannah J. Holstein, Marian L.C. Bulthuis, Sofie de Jong, Marjan Reinders-Luinge, Karin Koerts-Steijn, Anneke C. Muller Kobold, Klaas Nico Faber, Harry van Goor, Gerard Dijkstra, Arno R. Bourgonje
Publicado en: Free Radical Biology and Medicine, Edición 243, 2026, ISSN 0891-5849
Editor: Elsevier BV
DOI: 10.1016/J.FREERADBIOMED.2025.11.057

Modulator of VRAC Current 1 Is a Potential Target Antigen in Multiple Sclerosis

Autores: Johannes Raffael Dahl; Alicia Weier; Christopher Winter; Maik Hintze; Veit Rothhammer; Thanos Tsaktanis; Anne-Katrin Proebstel; Tradite Neziraj; Elisabeth Poessnecker; Johanna Oechtering; Jens Kuhle; Boris-Alexander Kallmann; Gabriele Luber; Thorsten Heider; Luisa Klotz; Rittika Chunder; Stefanie Kuerten
Publicado en: Neurology: Neuroimmunology & Neuroinflammation, 2025, ISSN 2332-7812
Editor: Ovid Technologies (Wolters Kluwer Health) — published on behalf of the American Academy of Neurology
DOI: 10.1212/NXI.0000000000200374

Genome Medicine

Autores: Innocenti, Gabriel; Andreu-Sánchez, Sergio; Hörstke, Nicolai V.; Elabd, Hesham; Barozzi, Iros; Franke, Andre; Manczinger, Máté; Vogl, Thomas
Publicado en: Genome Medicine, 2025, ISSN 1756-994X
Editor: BMC
DOI: 10.1186/S13073-025-01486-W

Digestive Diseases and Sciences

Autores: Bourgonje, Arno R.; Posner, Hannah; Carbonnel, Franck; Colombel, Jean-Frédéric; Kayal, Maia
Publicado en: Digestive Diseases and Sciences, 2025, ISSN 0163-2116
Editor: Springer Science and Business Media LLC (Springer)
DOI: 10.1007/S10620-024-08809-8

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

Autores: Jonas Schmid, Chiara Alberti, Laura Power, Nicolás G. Nuñez, Donatella De Feo, Sofia Tyystjärvi, Laila Kulsvehagen, Victor Kreiner, Ana Beatriz Ayroza Bleher, Patrick Lipps, Stijn Swinnen, Florian Ingelfinger, Can Ulutekin, Camille Chaubet, Susanne Unger, Stefanie Kreutmair, Romain Marignier, Thomas Korn, Anne-Katrin Pröbstel, Roland Liblau, Burkhard Becher
Publicado en: Science Translational Medicine, Edición 17, 2025, ISSN 1946-6234
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADW0358

Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases

Autores: Arnau Vich Vila, Jingwan Zhang, Moting Liu, Klaas Nico Faber, Rinse K Weersma
Publicado en: Gut, Edición 73, 2024, ISSN 0017-5749
Editor: BMJ
DOI: 10.1136/GUTJNL-2023-329969

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndrome

Autores: Bourgonje, Arno R.; Hörstke, Nicolai V.; Fehringer, Michaela; Innocenti, Gabriel; Vogl, Thomas
Publicado en: Microbiome, 2024, ISSN 2049-2618
Editor: BioMed Central
DOI: 10.1186/S40168-024-01858-1

Gut

Autores: Arnau Vich Vila; Jingwan Zhang; Moting Liu; Klaas Nico Faber; Rinse K Weersma
Publicado en: Gut, 2024, ISSN 0017-5749
Editor: BMJ
DOI: 10.1136/GUTJNL-2023-329969

Das Mikrobiom bei rheumatoider Arthritis und systemischem Lupus erythematodes

Autores: Michaela Fehringer; Thomas Vogl
Publicado en: rheuma plus, 2025, ISSN 1868-260X
Editor: Springer Verlag
DOI: 10.1007/S12688-025-00857-W

Five dominant amino acid substitution signatures shape tumour immunity

Autores: Szilvia Juhász, Benjamin Tamás Papp, Anna Tácia Fülöp, Zoltán Farkas, Dávid Kókai, Dóra Alexandra Gyémánt, Franciska Tóth, Zsófia Nacsa, Dóra Spekhardt, Balázs Koncz, Péter Burkovics, Csaba Pál, Máté Manczinger
Publicado en: Molecular Systems Biology, Edición 22, 2026, ISSN 1744-4292
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S44320-026-00193-X