Unraveling the dark matter of infectious diseases, environmental and genetic factors tipping the balance towards NCDs

Informazioni relative al progetto

ID-DarkMatter-NCD

ID dell’accordo di sovvenzione: 101136582

DOI

10.3030/101136582

Data della firma CE 11 Dicembre 2023

Data di avvio 1 Gennaio 2024

Data di completamento 31 Dicembre 2028

Finanziato da

• Health

Costo totale

€ 7 185 870,01

Contributo UE

€ 7 185 361,00

Coordinato da

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

Ethics framework

Ethics and Governance framework (HRequirement No. 1 [9], POPD- Requirement no 3 [6])

Genetic data

Report on data curation & exchange

D,E,C plan

Plan for dissemination, exploit, comm

Data Management Plan (1)

DMP

Data management plan

Websites, patent fillings, videos etc. (1)

Public website

Public website of ID-DarkMatter-NCD

Pubblicazioni

Peer reviewed articles (25)

Antigen-specific activation of gut immune cells drives autoimmune neuroinflammation

Autori: Lena K. Siewert, Kristina Berve, Elisabeth Pössnecker, Julia Dyckow, Amel Zulji, Ryan Baumann, Aida Munoz-Blazquez, Gurumoorthy Krishnamoorthy, David Schreiner, Sharon Sagan, Charlotte Nelson, Joseph J. Sabatino, Kazuki Nagashima, Médéric Diard, Andrew J. Macpherson, Stephanie C. Ganal-Vonarburg, Michael A. Fischbach, Scott S. Zamvil, Lucas Schirmer, Sergio E. Baranzini, Anne-Katrin Pröbstel
Pubblicato in: Gut Microbes, Numero 18, 2026, ISSN 1949-0976
Editore: Informa UK Limited
DOI: 10.1080/19490976.2025.2601430

A journey to your self: The vague definition of immune self and its practical implications

Autori: Koncz, Balázs; Balogh, Gergő Mihály; Manczinger, Máté
Pubblicato in: Proceedings of the National Academy of Sciences, 2024, ISSN 1091-6490
Editore: National Academy of Sciences.
DOI: 10.1073/PNAS.2309674121

Molecular Systems Biology

Autori: Szilvia Juhász; Benjamin Tamás Papp; Anna Tácia Fülöp; Zoltán Farkas; Dávid Kókai; Dóra Alexandra Gyémánt; Franciska Tóth; Zsófia Nacsa; Dóra Spekhardt; Balázs Koncz; Péter Burkovics; Csaba Pál; Máté Manczinger
Pubblicato in: Molecular Systems Biology, 2026, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.1038/S44320-026-00193-X

Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease

Autori: Maximilian G Griesbaum, Thomas Vogl, Marijn C Visschedijk, Eleonora A M Festen, Gerard Dijkstra, Adina Weinberger, Eran Segal, Rinse K Weersma, Arno R Bourgonje
Pubblicato in: iScience, 2026, ISSN 2589-0042
Editore: Cell Press, an imprint of Elsevier
DOI: 10.1016/j.isci.2026.116828

Associations between HLA-II variation and antibody specificity are predicted by antigen properties

Autori: Innocenti G.; Andreu-Sánchez S.; Hörstke N.V.; Elabd H.; Barozzi I.; Franke A.; Manczinger M.; Vogl T.
Pubblicato in: Genome Medicine, 2025, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/S13073-025-01486-W

Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencing

Autori: Mahdy AKH, ElAbd H, Prinzensteiner M, Jebens H, Sivickis K, Bacher P, Vogl T, Franke A, et al
Pubblicato in: Journal of Crohn's and Colitis, 2026, ISSN 1876-4479
Editore: Oxford Academic
DOI: 10.1093/ECCO-JCC/JJAG015

Free Radical Biology and Medicine

Autori: Sem Geertsema; Hannah J. Holstein; Marian L.C. Bulthuis; Sofie de Jong; Marjan Reinders-Luinge; Karin Koerts-Steijn; Anneke C. Muller Kobold; Klaas Nico Faber; Harry van Goor; Gerard Dijkstra; Arno R. Bourgonje
Pubblicato in: Free Radical Biology and Medicine, 2026, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/J.FREERADBIOMED.2025.11.057

Anti-CD20 B cell depletion is associated with elevated mucosal-originating circulating regulatory IgA B cells in multiple sclerosis

Autori: Tradite Neziraj, Elisabeth Pössnecker, Angela A. Wang, Paul Saary, Adrian-Minh Schumacher, Florian Ingelfinger, Amandine Mathias, Edoardo Galli, Marco Häfelfinger, Michelle Zuo, Samuel Jones, Vasiliki Pantazou, Joep Killestein, Sabine Schädelin, Pascal Benkert, Cristina Granziera, Caroline Pot, Antje Bischof, Jan Hendrik Niess, Magdalena Filipowicz Sinnreich, Tobias Derfuss, Charlotte E. Teunissen, Jens Kuhle, David A. Hafler, Renaud Du Pasquier, Yoshiaki Yasumizu, Jennifer L. Gommerman, Anne-Katrin Pröbstel
Pubblicato in: Science Translational Medicine, Numero 18, 2026, ISSN 1946-6234
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.AEE1580

Deciphering the prodrome of inflammatory bowel disease up to 10 years before disease onset by massively parallel serology

Autori: Arno R Bourgonje, Gabriel Innocenti, Alexandra E Livanos, Melanie Prinzensteiner, Jared S Magee, Mark S Riddle, Renee M Laird, Thierry Dervieux, Chad K Porter, Sacha Gnjatic, Francesca Petralia, Joana Torres, Mayte Suárez-Fariñas, Thomas Vogl, Jean-Frederic Colombel, Saurabh Mehandru
Pubblicato in: Gut, 2026, ISSN 0017-5749
Editore: BMJ
DOI: 10.1136/GUTJNL-2025-337762

Nature Communications

Autori: Manczinger, Innocenti, Vogl, Zhernakova, Weersma, Et Al.
Pubblicato in: Nature Communications 2026, 2026, ISSN 2041-1723
Editore: Springer Nature
DOI: 10.1038/s41467-019-14177-z

Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases

Autori: Michaela Fehringer; Thomas Vogl
Pubblicato in: Journal of Translational Autoimmunity, 2025, ISSN 2589-9090
Editore: Elsevier
DOI: 10.1016/J.JTAUTO.2025.100269

Patient-Derived Monoclonal Myelin Oligodendrocyte Glycoprotein Autoantibodies Mediate Cytotoxicity

Autori: Nora Sandrine Wetzel, Laila Kulsvehagen, Anne-Catherine Lecourt, Beata Filipek, Patrick Lipps, Laura Rieder, Kristina Berve, Gurumoorthy Krishnamoorthy, Bert A. 't Hart, Lucas Schirmer, Soumya S. Yandamuri, Kevin C. O'Connor, Anne-Katrin Pröbstel
Pubblicato in: Neurology Neuroimmunology & Neuroinflammation, Numero 13, 2025, ISSN 2332-7812
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1212/NXI.0000000000200520

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation

Autori: Kim, Schneider, Raach, Karypidis, Roux, Perdikaris, Holdermann, Pröbstel, et al.
Pubblicato in: Cell, ISSN 1097-4172
Editore: Cell Press, an imprint of Elsevier
DOI: 10.1016/j.cell.2025.12.031

Nature Communications

Autori: Rakoff-Nahoum, Seth; Debelius, Justine; Valles-Colomer, Mireia; Noordzij, Hanna Theodora; Esteban-Torres, Maria; Zhernakova, Alexandra; Brusselaers, Nele; Pettersen, Veronika Kuchařová
Pubblicato in: Nature Communications, 2025, ISSN 2041-1723
Editore: Nature Publishing Group (Springer Nature)
DOI: 10.1038/S41467-025-61998-2

A reconceptualized framework for human microbiome transmission in early life

Autori: Seth Rakoff-Nahoum, Justine Debelius, Mireia Valles-Colomer, Hanna Theodora Noordzij, Maria Esteban-Torres, Alexandra Zhernakova, Nele Brusselaers, Veronika Kuchařová Pettersen
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61998-2

Elevated serum glutathione reflects endoscopic disease activity in inflammatory bowel disease

Autori: Sem Geertsema, Hannah J. Holstein, Marian L.C. Bulthuis, Sofie de Jong, Marjan Reinders-Luinge, Karin Koerts-Steijn, Anneke C. Muller Kobold, Klaas Nico Faber, Harry van Goor, Gerard Dijkstra, Arno R. Bourgonje
Pubblicato in: Free Radical Biology and Medicine, Numero 243, 2026, ISSN 0891-5849
Editore: Elsevier BV
DOI: 10.1016/J.FREERADBIOMED.2025.11.057

Modulator of VRAC Current 1 Is a Potential Target Antigen in Multiple Sclerosis

Autori: Johannes Raffael Dahl; Alicia Weier; Christopher Winter; Maik Hintze; Veit Rothhammer; Thanos Tsaktanis; Anne-Katrin Proebstel; Tradite Neziraj; Elisabeth Poessnecker; Johanna Oechtering; Jens Kuhle; Boris-Alexander Kallmann; Gabriele Luber; Thorsten Heider; Luisa Klotz; Rittika Chunder; Stefanie Kuerten
Pubblicato in: Neurology: Neuroimmunology & Neuroinflammation, 2025, ISSN 2332-7812
Editore: Ovid Technologies (Wolters Kluwer Health) — published on behalf of the American Academy of Neurology
DOI: 10.1212/NXI.0000000000200374

Genome Medicine

Autori: Innocenti, Gabriel; Andreu-Sánchez, Sergio; Hörstke, Nicolai V.; Elabd, Hesham; Barozzi, Iros; Franke, Andre; Manczinger, Máté; Vogl, Thomas
Pubblicato in: Genome Medicine, 2025, ISSN 1756-994X
Editore: BMC
DOI: 10.1186/S13073-025-01486-W

Digestive Diseases and Sciences

Autori: Bourgonje, Arno R.; Posner, Hannah; Carbonnel, Franck; Colombel, Jean-Frédéric; Kayal, Maia
Pubblicato in: Digestive Diseases and Sciences, 2025, ISSN 0163-2116
Editore: Springer Science and Business Media LLC (Springer)
DOI: 10.1007/S10620-024-08809-8

Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions

Autori: Jonas Schmid, Chiara Alberti, Laura Power, Nicolás G. Nuñez, Donatella De Feo, Sofia Tyystjärvi, Laila Kulsvehagen, Victor Kreiner, Ana Beatriz Ayroza Bleher, Patrick Lipps, Stijn Swinnen, Florian Ingelfinger, Can Ulutekin, Camille Chaubet, Susanne Unger, Stefanie Kreutmair, Romain Marignier, Thomas Korn, Anne-Katrin Pröbstel, Roland Liblau, Burkhard Becher
Pubblicato in: Science Translational Medicine, Numero 17, 2025, ISSN 1946-6234
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADW0358

Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases

Autori: Arnau Vich Vila, Jingwan Zhang, Moting Liu, Klaas Nico Faber, Rinse K Weersma
Pubblicato in: Gut, Numero 73, 2024, ISSN 0017-5749
Editore: BMJ
DOI: 10.1136/GUTJNL-2023-329969

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn’s disease and chronic fatigue syndrome

Autori: Bourgonje, Arno R.; Hörstke, Nicolai V.; Fehringer, Michaela; Innocenti, Gabriel; Vogl, Thomas
Pubblicato in: Microbiome, 2024, ISSN 2049-2618
Editore: BioMed Central
DOI: 10.1186/S40168-024-01858-1

Gut

Autori: Arnau Vich Vila; Jingwan Zhang; Moting Liu; Klaas Nico Faber; Rinse K Weersma
Pubblicato in: Gut, 2024, ISSN 0017-5749
Editore: BMJ
DOI: 10.1136/GUTJNL-2023-329969

Das Mikrobiom bei rheumatoider Arthritis und systemischem Lupus erythematodes

Autori: Michaela Fehringer; Thomas Vogl
Pubblicato in: rheuma plus, 2025, ISSN 1868-260X
Editore: Springer Verlag
DOI: 10.1007/S12688-025-00857-W

Five dominant amino acid substitution signatures shape tumour immunity

Autori: Szilvia Juhász, Benjamin Tamás Papp, Anna Tácia Fülöp, Zoltán Farkas, Dávid Kókai, Dóra Alexandra Gyémánt, Franciska Tóth, Zsófia Nacsa, Dóra Spekhardt, Balázs Koncz, Péter Burkovics, Csaba Pál, Máté Manczinger
Pubblicato in: Molecular Systems Biology, Numero 22, 2026, ISSN 1744-4292
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S44320-026-00193-X