Description du projet
Un dispositif de diagnostic portable pour détecter la thrombose veineuse profonde
La thrombose veineuse profonde (TVP) se tapi insidieusement, souvent sans symptômes, jusqu'à ce qu'elle frappe de manière catastrophique. Les caillots situés dans les membres inférieurs peuvent furtivement se détacher et déclencher des embolies pulmonaires mortelles. Les méthodes de diagnostic actuelles ne décèlent souvent pas ces menaces silencieuses, ce qui met des vies en danger. Dans ce contexte, le projet ThrombUS, financé par l'UE, réunit une équipe couvrant plusieurs secteurs et disciplines afin de développer un dispositif de diagnostic portable permettant une surveillance continue sur le lieu de soins. Combinant une détection optimisée par l'IA et un matériel innovant, ThrombUS offre un aperçu en temps réel de la formation de caillots dans les membres inférieurs. Au-delà de la détection, il intègre des données physiologiques pour une évaluation personnalisée des risques et des stratégies de prévention, y compris pour les cas les plus sérieux. Avec son potentiel de transformation des soins aux patients, ThrombUS inaugure une nouvelle ère de la gestion de la TVP.
Objectif
Deep vein thrombosis (DVT) is the formation of a blood clot within the deep veins, most commonly those of the lower limbs, causing obstruction of blood flow. In 50% of people with DVT, the clot eventually breaks off and travels to the lung to cause pulmonary embolism. Clinical assessment of DVT is notoriously unreliable because up to 2/3 of DVT episodes are clinically silent and patients are symptom free even when pulmonary embolism has developed. Early diagnosis of DVT is crucial and despite the progress made in ultrasound imaging and plethysmography techniques, there is a need for new methods to enable continuous monitoring DVT diagnosis at the point of care.
ThrombUS+ brings together an interdisciplinary team of industrial, technology, regulatory, social science and clinical trial experts to develop a novel wearable diagnostic device for point-of-care, operator free, continuous monitoring in patients with high DVT risk. The device will combine autonomous, AI driven DVT detection based on a novel wearable ultrasound hardware, impedance plethysmography and light reflection rheography for immediate detection of blood clot formation in the lower limb. Activity and other physiological measurements will be used to provide a continuous assessment of DVT risk and support DVT prevention via serious gaming. The aggregated data will drive an intelligence decision support unit that will provide accurate monitoring and alerts. Extended reality will be used to guide experts to design exercises and patients to use the device optimally. ThrombUS+ is intended for use by postoperative patients in the ward, during long surgical operations, cancer patients or otherwise bedridden patients at home or in care units, and women during pregnancy and postpartum. ThrombUS+ will use big data sets for AI training collected in the project via 3 large scale clinical studies and will validate the outcome in the clinical setting via 1 early feasibility study and 1 multi-center clinical trial.
Champ scientifique
- medical and health sciencesclinical medicineangiologyvascular diseases
- natural sciencescomputer and information sciencesdata sciencebig data
- medical and health sciencesclinical medicineobstetricspostnatal care
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical sciencesacousticsultrasound
Mots‑clés
Programme(s)
Régime de financement
HORIZON-IA - HORIZON Innovation ActionsCoordinateur
151 25 Maroussi
Grèce