Descrizione del progetto
Un dispositivo diagnostico indossabile per rilevare la trombosi venosa profonda
La trombosi venosa profonda (TVP) si manifesta in modo insidioso, spesso senza sintomi, fino a quando non colpisce in modo catastrofico. I coaguli negli arti inferiori possono liberarsi in modo inaspettato, scatenando embolie polmonari mortali. I metodi diagnostici attuali spesso non riescono a rilevare queste silenziose minacce, mettendo a rischio la vita dei pazienti. In questo contesto, il progetto ThrombUS, finanziato dall’UE, riunisce un team eterogeneo che abbraccia diverse industrie e discipline al fine di sviluppare un dispositivo diagnostico indossabile per garantire un monitoraggio decentrato continuativo. Combinando un metodo di rilevamento basato sull’intelligenza artificiale con un hardware innovativo, ThrombUS offre una visione in tempo reale della formazione di coaguli negli arti inferiori. Oltre al rilevamento, il progetto integra dati fisiologici per la valutazione personalizzata del rischio e strategie di prevenzione, compresa la realizzazione di giochi seri. Forte del suo potenziale di trasformazione dell’assistenza ai pazienti, ThrombUS preannuncia una nuova era nella gestione della TVP.
Obiettivo
Deep vein thrombosis (DVT) is the formation of a blood clot within the deep veins, most commonly those of the lower limbs, causing obstruction of blood flow. In 50% of people with DVT, the clot eventually breaks off and travels to the lung to cause pulmonary embolism. Clinical assessment of DVT is notoriously unreliable because up to 2/3 of DVT episodes are clinically silent and patients are symptom free even when pulmonary embolism has developed. Early diagnosis of DVT is crucial and despite the progress made in ultrasound imaging and plethysmography techniques, there is a need for new methods to enable continuous monitoring DVT diagnosis at the point of care.
ThrombUS+ brings together an interdisciplinary team of industrial, technology, regulatory, social science and clinical trial experts to develop a novel wearable diagnostic device for point-of-care, operator free, continuous monitoring in patients with high DVT risk. The device will combine autonomous, AI driven DVT detection based on a novel wearable ultrasound hardware, impedance plethysmography and light reflection rheography for immediate detection of blood clot formation in the lower limb. Activity and other physiological measurements will be used to provide a continuous assessment of DVT risk and support DVT prevention via serious gaming. The aggregated data will drive an intelligence decision support unit that will provide accurate monitoring and alerts. Extended reality will be used to guide experts to design exercises and patients to use the device optimally. ThrombUS+ is intended for use by postoperative patients in the ward, during long surgical operations, cancer patients or otherwise bedridden patients at home or in care units, and women during pregnancy and postpartum. ThrombUS+ will use big data sets for AI training collected in the project via 3 large scale clinical studies and will validate the outcome in the clinical setting via 1 early feasibility study and 1 multi-center clinical trial.
Campo scientifico
- medical and health sciencesclinical medicineangiologyvascular diseases
- natural sciencescomputer and information sciencesdata sciencebig data
- medical and health sciencesclinical medicineobstetricspostnatal care
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical sciencesacousticsultrasound
Parole chiave
Programma(i)
Meccanismo di finanziamento
HORIZON-IA - HORIZON Innovation ActionsCoordinatore
151 25 Maroussi
Grecia