Descripción del proyecto
Un dispositivo de diagnóstico portátil para detectar la trombosis venosa profunda
La trombosis venosa profunda (TVP) acecha insidiosamente, a menudo sin síntomas, hasta que ataca de forma catastrófica. Los coágulos de las extremidades inferiores pueden desprenderse sigilosamente y desencadenar embolias pulmonares mortales. Los métodos de diagnóstico actuales a menudo pasan por alto estas amenazas silenciosas, lo que pone en peligro vidas humanas. En este contexto, el proyecto ThrombUS, financiado con fondos europeos, reúne a un equipo diverso que abarca distintas industrias y disciplinas para desarrollar un dispositivo de diagnóstico portátil para el control continuo inmediato. Combinando la detección basada en inteligencia artificial con un «hardware» innovador, en ThrombUS se ofrece información en al instante sobre la formación de coágulos en las extremidades inferiores. Más allá de la detección, integra datos fisiológicos para la evaluación personalizada de los riesgos y las estrategias de prevención, como la participación en juegos formativos. Con su potencial para transformar la atención al paciente, ThrombUS augura una nueva era en el tratamiento de la TVP.
Objetivo
Deep vein thrombosis (DVT) is the formation of a blood clot within the deep veins, most commonly those of the lower limbs, causing obstruction of blood flow. In 50% of people with DVT, the clot eventually breaks off and travels to the lung to cause pulmonary embolism. Clinical assessment of DVT is notoriously unreliable because up to 2/3 of DVT episodes are clinically silent and patients are symptom free even when pulmonary embolism has developed. Early diagnosis of DVT is crucial and despite the progress made in ultrasound imaging and plethysmography techniques, there is a need for new methods to enable continuous monitoring DVT diagnosis at the point of care.
ThrombUS+ brings together an interdisciplinary team of industrial, technology, regulatory, social science and clinical trial experts to develop a novel wearable diagnostic device for point-of-care, operator free, continuous monitoring in patients with high DVT risk. The device will combine autonomous, AI driven DVT detection based on a novel wearable ultrasound hardware, impedance plethysmography and light reflection rheography for immediate detection of blood clot formation in the lower limb. Activity and other physiological measurements will be used to provide a continuous assessment of DVT risk and support DVT prevention via serious gaming. The aggregated data will drive an intelligence decision support unit that will provide accurate monitoring and alerts. Extended reality will be used to guide experts to design exercises and patients to use the device optimally. ThrombUS+ is intended for use by postoperative patients in the ward, during long surgical operations, cancer patients or otherwise bedridden patients at home or in care units, and women during pregnancy and postpartum. ThrombUS+ will use big data sets for AI training collected in the project via 3 large scale clinical studies and will validate the outcome in the clinical setting via 1 early feasibility study and 1 multi-center clinical trial.
Ámbito científico
- medical and health sciencesclinical medicineangiologyvascular diseases
- natural sciencescomputer and information sciencesdata sciencebig data
- medical and health sciencesclinical medicineobstetricspostnatal care
- medical and health sciencesclinical medicineoncology
- natural sciencesphysical sciencesacousticsultrasound
Palabras clave
Programa(s)
Régimen de financiación
HORIZON-IA - HORIZON Innovation ActionsCoordinador
151 25 Maroussi
Grecia